• KSBB Journal
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• 제31권4호
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• pp.219-227
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• 2016

Valsartan, a drug for the treatment of cardiovascular disease, exhibited low bioavailability which was caused by, at least in part, limited solubility at low pH. Present investigation deals with the preparation and characterization of gastro-retentive drug delivery system (GRDDS) using valsartan solid dispersion. We prepared solid dispersion using surfactants (Poloxamer 407) and alkalizer ($Na_2CO_3$) which may to be useful for improving solubility of valsartan at low pH and evaluated by saturated solubility of valsartan in distilled water. Valsartan gastro-retentive (GR) tablets containing solid dispersion prepared and evaluated by weight variation, floating time and dissolution rate. Compression at lower pressures resulted in the tablets floating over simulated gastric fluid (pH 1.2) for more than 17 h. In vitro release of valsartan from GR tablet was dependent on the amount of poloxamer 407 and hydroxypropyl methylcellulose. On the basis of evaluation parameter, formulation E-3 was selected as a final formulation. Therefore, it can be concluded that the GR tablets containing solid dispersion may be exploited successfully for the delivery of poorly drug such as valsartan.

• Membrane and Water Treatment
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• 제9권3호
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• pp.173-179
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• 2018

Microcystin-LR, one of algal toxins induced by the eutrophication of a reservoir, is known to be harmful to human by adversely affecting our liver and brain. Hypochlorous acid is very efficient to remove Microcystin-LR in a clear well. The previous researches showed that CT, pH and temperature affected removal rate in batch tests. It was noted that hydrodynamic properties of clear well could also influence its removal rate. A mathematical model was built using an axial dispersion reactor model and software was used to simulate the removal rate. The model consisted of the second order differential equations including dispersion, convection, Microcystin-LR reaction with chlorine. Kinetic constants were obtained through batch tests with chlorine. They were $0.430{\times}10^{-3}L/mg/sec$ and $0.143{\times}10^{-3}L/mg/sec$ for pH 7.0 and 8.1, respectively. The axial dispersion reactor model was shown to be useful for the numerical model through conservative tracer tests. The numerical model successfully estimated the removal rate of Microcyctin-LR in a clear well. Numerical simulations showed that a small dispersion number, low pH and long hydraulic retention time were critical for higher removal rate with same chlorine dosage. This model could be used to optimize the operation of a clear well during an eutrophication season.

• 한국분말재료학회지
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• 제20권6호
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• pp.479-486
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• 2013

In the present work, physicochemical treatments were introduced for de-aggregation and stable dispersion of detonation nanodiamonds (DND) in polar solvents. The DNDs in water exhibited a particle size of 138 nm and high dispersion stability without particular treatment. However, the DNDs in ethanol were severely aggregated to several micrometers in size and showed poor dispersion stability with time. To break down aggregates of DNDs and enhance the dispersion stability of them in ethanol, mechanical force and chemical surfactant were introduced as functions of zirconia ball size, kind of surfactant and amount of surfactant added. From the analyses of average particle size and Turbiscan results, it was suggested that the size of DNDs in ethanol can be reduced by only mechanical force; however, the DNDs were re-aggregated due to high surface activity. The long-term dispersion stability can be achieved by applying mechanical force to break down the aggregates of DNDs and by preventing re-aggregation of them using proper surfactant.

• 한국결정성장학회지
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• 제15권6호
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• pp.239-243
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• 2005

The effect of pH and particle size on the dispersion stability of ultra-fine $BaTiO_3$ suspensions in aqueous medium have been investigated by means of zeta potential, sediment experiments, and powder properties (particle analysis, specific surface area) etc. Zeta potential as a function of pH for two particles of different size increases from -75 to +10 mV with decreasing pH from 8.5 to 1.4. The curve of zeta potential for small particle (150 nm) has slow slope than that of large particle (900nm), giving IEP (isoelectric point) value of pH=1.6 for small particle and pH=1.9 for large particle respectively, which means that it is more difficult to control zeta potential with pH fur small particle than large particle. The dispersion stability of $BaTiO_3$ particles in aqueous medium was found to be strongly related with the agglomeration of colloidal suspensions with time through the sedimentation behaviors of colloidal particles with time and pH value.

• 한국전자파학회논문지
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• 제29권3호
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• pp.225-232
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• 2018

본 논문은 H(2,4) 기법을 기반으로 한 저분산 유한차분 시간영역법(Finite-Difference Time-Domain: FDTD)을 이용하여 상수 도전율과 비유전율을 갖는 유전체의 광대역 전자기 특성을 정확하게 해석하는 방법을 제안했다. 수치분산오차를 최소화하기 위해서 제안한 FDTD 기법에서 이용하는 세 개의 변수의 최적값을 계산하였다. 잘 알려진 정확한 FDTD 기법들과 제안한 FDTD 방법으로 2차원 원형 유전체 실린더의 광대역 산란 문제를 계산하였고, 그 결과를 이론값과 비교하여 제안한 방법의 우수성을 검증하였다.

• 한국전자파학회논문지
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• 제17권2호
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• pp.165-170
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• 2006

본 논문에서는 시간 영역 유한 차분법에 있어 비등방성 분산 특성을 보이는, 기존의 Yee 기법을 개선하기 위해 2차원의 새로운 유한 차분식을 제안하였다. 이 기법은 6개 지점의 샘플링을 통해 공간에 대한 편미분식을 근사화하게 된다. 제안하는 기법의 분산 특성을 보기 위해 분산 관계식을 구하였고 그 관계식에서 수치적 전파 상수를 계산하여 제안하는 기법의 분산 특성이 등방성임을 확인하였다. 또한 기존 기법들에 비해 보다 큰 시간 증분의 모의 실험환경에서 안정함을 수학적으로 확인할 수 있었다.

• 해양환경안전학회지
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• 제5권1호
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• pp.9-18
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• 1999

To predict the oil spill dispersion phenomena in the ocean, the oil spill response model, which can be used for strategic purpose on the oil spill site, based on Lagrangian particle-tracking method was formulated and applied to the neighboring area with Pusan port where the oil spill incident occurred when the tanker ship No.1 Youil struck on a small rock near the Namhyungjeto on September 21, 1995. The real-time tidal currents to be required as input data of the oil spill model were obtained by the two-dimensional hydrodynamic model and the tide prediction model. Evaluation of tidal currents using observation data was successful. For wind data, other input data of oil spill model, observed data on the spot were used. To verify the oil spill model, the oil spill modelling results were compared with the field data obtained from the spill site. Compared the modelling results with the observation data, there exist some discrepancies but the general pattern of modelling results was similar to that of field observation. The modelling results on 7 days after spill occurred showed that the 40% of spilled oil is in floating, 36% in evaporated, 23% at shore, and 1% in out of boundary, respectively. According to the evaluation of weighting curves of effective components to the dispersion of oil, the winds make a 37% of contribution to the dispersion of oil, turbulent diffusion 39.5%, and tidal currents 23.5%, respectively. Provided the more accurate wind data are supported, more favorable results might be obtained.

• 한국재료학회지
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• 제27권1호
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• pp.1-7
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• 2017

Zirconia nanoparticles were widely used as filler in order to get high refractive index layer. However, dispersion of nanoparticles is difficult due to their agglomeration in solvent. In this study, the dispersibility of the zirconia suspension is promoted by controlling the steric hindrance and electrostatic interactions through the adsorption of PEI according to alkali treatment time. Also, to induce improved dispersibility on suspension, we changed the dispersion conditions variously and fabricated an ink formulation method for the coating layer. Zirconia suspension was characterized by dynamic light scattering (DLS), Zeta potential measurement, Transmission Electron Microscope (TEM) and FT-IR. We were able to confirm that good dispersion of zirconia suspension by alkali treatment and PEI led to high refractive index.

• 한국정보통신학회논문지
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• 제17권8호
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• pp.1755-1760
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• 2013

본 논문에서는 마이크로스트립 선로를 따라 펄스가 전송될 때 분산에 의한 펄스의 왜곡특성을 시간영역에서 해석 하였다. 전송선로의 구조, 유전율에 따른 분산특성을 비교 분석하였고, 구형펄스와 가우시안 펄스에 대해 펄스의 폭과 진폭, 그리고 전송속도에 따라 분산특성을 분석하였다. 구형 펄스의 경우 더 높은 고차 고조파 성분을 가지고 있기 때문에 이에 따른 저차 고조파 성분과의 위상 속도 차이가 선로를 따라 진행함에 따라 급격히 나타나서 분산이 심하게 나타났다. 본 연구의 결과는 MIC 또는 MMIC를 설계할 때 펄스전송에서 왜곡을 최소화하기 위해 펄스 폭, 선로의 폭, 기판의 높이 그리고 유전율을 결정하는데 유용하게 사용될 것이다.

• 물과 미래
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• 제29권4호
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• pp.187-198
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• 1996

난류전단 흐름에서의 비정상 수평 선오염원의 확산에 관한 수치모형을 개발하였다. 계산기법으로는 비정상 이송확산 방정식을 종방향 이송 및 연직방향 확산으로 분리하고, 이들 방정식을 방시간 간격에 대하여 번갈아 계산하는 단계분리 유한차분기법을 사용하였다. 종방향 이송방정식에 대해서는 Holly-Preissmann 기법을, 연직방향 확산방정식에 대해서는 Crank-Nicholson 기법을 각각 적용하였다. 개발된 모형을 난류전단 흐름에서의 정상 수평 선오염원의 확산 문제에 적용하여 계산결과를 반해석해와 비교함으로써 모형을 검증하였다. 또한 난류전단 흐름내로 순간적으로 방류된 면오염원의 확산문제에 계산모형을 적용하였다. 마찰계수에 대한 민감도 분석 결과, 동일한 무차원 시각에서의 혼합 정도는 마찰계수에 관계없이 거의 일정한 것으로 나타났다. 또한 동일한 정도의 혼합상태에 도달하는 데 소요되는 유하거리는 마찰계수의 제곱근에 반비례함을 알 수 있었다.