• Asian-Australasian Journal of Animal Sciences
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• v.30 no.3
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• pp.328-337
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• 2017

Objective: An experiment was conducted to determine the relationship between the KAP11.1 and the regulation wool fineness. Methods: In previous work, we constructed a skin cDNA library and isolated a full-length cDNA clone termed KAP11.1. On this basis, we conducted a series of bioinformatics analysis. Tissue distribution of KAP11.1 mRNA was performed using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis. The expression of KAP11.1 mRNA in primary and secondary hair follicles was performed using real-time PCR (real-time polymerase chain reaction) analysis. The expression location of KAP11.1 mRNA in primary and secondary hair follicles was performed using in situ hybridization. Results: Bioinformatics analysis showed that KAP11.1 gene encodes a putative 158 amino acid protein that exhibited a high content of cysteine, serine, threonine, and valine and has a pubertal mammary gland) structural domain. Secondary structure prediction revealed a high proportion of random coils (76.73%). Semi-quantitative RT-PCR showed that KAP11.1 gene was expressed in heart, skin, and liver, but not expressed in spleen, lung and kidney. Real time PCR results showed that the expression of KAP11.1 has a higher expression in catagen than in anagen in the primary hair follicles. However, in the secondary hair follicles, KAP11.1 has a significantly higher expression in anagen than in catagen. Moreover, KAP11.1 gene has a strong expression in inner root sheath, hair matrix, and a lower expression in hair bulb. Conclusion: We conclude that KAP11.1 gene may play an important role in regulating the fiber diameter.

• Journal of Digital Contents Society
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• v.16 no.3
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• pp.389-395
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• 2015

Digital image provides many conveniences at the internet environment recently. A great number of applications, like Digital Library, Stock Image, Personal Image and Important Information, require the use of digital image. However it has fatal defect which is easy to be modified because digital image is only electronic file. Numerous digital image forgeries have become a serious problem due to the sophistication and accessibility of image editing software. Copy-Move forgery is the simplest type of forgery that involves copying portion of an image and paste it on different location within the image. There are many approaches to detect Copy-Move forgery, but all of them have their own limitations. In this paper, visual and invisible feature based forgery detection techniques are tested and analyzed. The analysis shows that pros and cons of these two techniques compensate each other. Therefore, a hybrid of visual based and invisible feature based forgery detection that combine the merits of both techniques is proposed. The experimental results show that the proposed algorithm has enhanced performance compared to individual techniques. Moreover, it provides more information about the forgery, like identifying copy and duplicate regions.

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.211-221
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• 2005

Objective : The aim of this study is to review clinical trials on the effectiveness of acupuncture in stroke rehabilitation. Methods : Computerized literature searches was carried out on three electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Results : 1) Sixteen articles of clinical trials were collected and reviewed. Among these articles, randomized controlled trials were achieved in nine articles. 2) In three articles, statically significant results in improvement of mobile abilities, activities of daily life and Quality of life were reported after acupuncture treatment applied as a part of stroke rehabilitation. In three articles no statically significant changes were reported. 3) Among two articles about spasticity, One about the upper limbs and the results showed statically significant improvement of the spasticity after acupuncture treatment as stroke rehabilitation, and the other was about the lower limbs and the results showed no statically significant changes. 4) One article about acupuncture and postural control showed statically significant results suggesting that acupuncture promotes normalization of postural control after stroke.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.5
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• pp.102-111
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• 2013

In this paper, we proposed a $4{\times}4$ block parallel architecture of interpolation for high-performance H.264/AVC Motion Compensation in 4K UHD($3840{\times}2160$) video real time processing. To improve throughput, we design $4{\times}4$ block parallel interpolation. For supplying the $9{\times}9$ reference data for interpolation, we design 2D cache buffer which consists of the $9{\times}9$ memory arrays. We minimize redundant storage of the reference pixel by applying the Search Area Stripe Reuse scheme(SASR), and implement high-speed plane interpolator with 3-stage pipeline(Horizontal Vertical 1/2 interpolation, Diagonal 1/2 interpolation, 1/4 interpolation). The proposed architecture was simulated in 0.13um standard cell library. The maximum operation frequency is 150MHz. The gate count is 161Kgates. The proposed H.264/AVC Motion Compensation can support 4K UHD at 72 frames per second by running at 150MHz.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.1
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• pp.100-108
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• 2018

This paper describes a design of scalable RSA public-key cryptography processor supporting four key lengths of 512/1,024/2,048/3,072 bits. The modular multiplier that is a core arithmetic block for RSA crypto-system was designed with 32-bit datapath, which is based on the CIOS (Coarsely Integrated Operand Scanning) Montgomery modular multiplication algorithm. The modular exponentiation was implemented by using L-R binary exponentiation algorithm. The scalable RSA crypto-processor was verified by FPGA implementation using Virtex-5 device, and it takes 456,051/3,496347/26,011,947/88,112,770 clock cycles for RSA computation for the key lengths of 512/1,024/2,048/3,072 bits. The RSA crypto-processor synthesized with a $0.18{\mu}m$ CMOS cell library occupies 10,672 gate equivalent (GE) and a memory bank of $6{\times}3,072$ bits. The estimated maximum clock frequency is 147 MHz, and the RSA decryption takes 3.1/23.8/177/599.4 msec for key lengths of 512/1,024/2,048/3,072 bits.

• Journal of Digital Convergence
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• v.16 no.7
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• pp.35-45
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• 2018

Research on the establishment of new governance aimed at efficient policy planning and the implementation thereof by the government has been conducted in response to social changes. Nonetheless, governance is comprehensive and encompasses different meanings; it takes various forms in the process of its actual application. Therefore, systematic classification of research on governance and analysis on its research trend are required. Accordingly, three researchers who majored in policy sciences, business informatics, and library and information science, respectively, searched for theses related to governance published since 2016 from Research Information Sharing Service and conducted a social network analysis (SNA) on them. According to their research results, the main research topics were largely classified into collaborative governance and local governance. Keywords throughout the topics included network, participation, conflict, and trust in line with the characteristics of governance. Representative subjects of governance included education, urban regeneration, and the environment. Further, measurement of betweenness centrality showed local governance was a main topic for convergent research. This study will lead to a greater understanding of research on governance and help activate such research. One limitation of this study is that it analyzed only theses with the keywords but not all theses on governance. Follow-up research should analyze all theses on governance and statistically verify them with SNA indexes.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.11
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• pp.2093-2099
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• 2016

This paper describes a design of crypto-processor that supports multiple block cipher algorithms of PRESENT, ARIA, and AES. The crypto-processor integrates three cores that are PRmo (PRESENT with mode of operation), AR_AS (ARIA_AES), and AES-16b. The PRmo core implementing 64-bit block cipher PRESENT supports key length 80-bit and 128-bit, and four modes of operation including ECB, CBC, OFB, and CTR. The AR_AS core supporting key length 128-bit and 256-bit integrates two 128-bit block ciphers ARIA and AES into a single data-path by utilizing resource sharing technique. The AES-16b core supporting key length 128-bit implements AES with a reduced data-path of 16-bit for minimizing hardware. Each crypto-core contains its own on-the-fly key scheduler, and consecutive blocks of plaintext/ciphertext can be processed without reloading key. The crypto-processor was verified by FPGA implementation. The crypto-processor implemented with a $0.18{\mu}m$ CMOS cell library occupies 54,500 gate equivalents (GEs), and it can operate with 55 MHz clock frequency.

• Journal of Internet Computing and Services
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• v.22 no.5
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• pp.47-55
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• 2021

Analysis of research trends in specific subject areas is performed by examining related topics and subject changes by using topic modeling techniques through keyword extraction for most of the literature information (paper, patents, etc.). Unlike existing research methods, this paper extracts topics related to the research topic using the LDA topic modeling technique for the project information of national R&D projects provided by the National Science and Technology Knowledge Information Service (NTIS) in the field of artificial intelligence. By analyzing these topics, this study aims to analyze research topics and investment directions for national R&D projects. NTIS provides a vast amount of national R&D information, from information on tasks carried out through national R&D projects to research results (thesis, patents, etc.) generated through research. In this paper, the search results were confirmed by performing artificial intelligence keywords and related classification searches in NTIS integrated search, and basic data was constructed by downloading the latest three-year project information. Using the LDA topic modeling library provided by Python, related topics and keywords were extracted and analyzed for basic data (research goals, research content, expected effects, keywords, etc.) to derive insights on the direction of research investment.

• Clinical and Experimental Pediatrics
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• v.61 no.12
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• pp.403-406
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• 2018

Floating-Harbor syndrome is a rare autosomal dominant genetic disorder associated with SRCAP mutation. To date, approximately 50 cases of Floating-Harbor syndrome have been reported, but none have been reported in Korea yet. Floating-Harbor syndrome is characterized by delayed bony maturation, unique facial features, and language impairment. Here, we present a 6-year-old boy with a triangular face, deep-set protruding eyes, low-set ears, wide nose with narrow nasal bridge, short philtrum, long thin lips, clinodactyly, and developmental delay that was transferred to our pediatric clinic for genetic evaluation. He showed progressive delay in the area of language and cognition-adaption as he grew. He had previously undergone chromosomal analysis at another hospital due to his language delay, but his karyotype was normal. We performed targeted exome sequencing, considering several syndromes with similar phenotypes. Library preparation was performed with the TruSight One sequencing panel, which enriches the sample for about 4,800 genes of clinical relevance. Massively parallel sequencing was conducted with NextSeq. An identified variant was confirmed by Sanger sequencing of the patient and his parents. Finally, the patient was confirmed as the first Korean case of Floating-Harbor syndrome with a novel SRCAP (Snf2 related CREBBP activator protein) mutation (c.7732dupT, p.Ser2578Phefs*6), resulting in early termination of the protein; it was not found in either of his healthy parents or a control population. To our knowledge, this is the first study to describe a boy with Floating-Harbor syndrome with a novel SRCAP mutation diagnosed by targeted exome sequencing in Korea.

• Journal of Korean Neurosurgical Society
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• v.64 no.2
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• pp.297-308
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• 2021

Objective : Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce shunt infection rate. A meta-analysis was conducted to study the effectiveness of AISCs in reduction of shunt infection in terms of age, follow-up time and high-risk patient population. Methods : This study reviewed literature from three databases including PubMed, EMBASE, and Cochrane Library (from 2000 to March 2019). Clinical studies from controlled trials for shunt operation were included in this analysis. A subgroup analysis was performed based on the patient's age, follow-up time and high-risk population. The fixed effect in RevMan 5.3 software (Cochrane Collaboration) was used for this meta-analysis. Results : This study included 19 controlled clinical trials including 10105 operations. The analysis demonstrated that AISC could reduce the infection rate in shunt surgery compared to standard shunt catheter (non-AISC) from 8.13% to 4.09% (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.40-0.58; p=0.01; I2=46%). Subgroup analysis of different age groups showed that AISC had significant antimicrobial effects in all three groups (adult, infant, and adolescent). Follow-up time analysis showed that AISC was effective in preventing early shunt infections (within 6 months after implant). AISC is more effective in high-risk population (OR, 0.24;95% CI, 0.14-0.40; p=0.60; I2=0%) than in general patient population. Conclusion : The results of meta-analysis indicated that AISC is an effective method for reducing shunt infection. We recommend that AISC should be considered for use in infants and high-risk groups. For adult patients, the choice for AISC could be determined based on the treatment cost.