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Preparation of Natural Compounds-tripeptides Derivatives and Their Melanogensis Inhibitory Activity  

Shin, Kyong-Hoon (Central Research, Aekyung R&D Center)
Lee, Jae-Ho (Structural Biology Lab., Gwangju Institute of Science and Technology)
Ryu, Geun-Seok (Central Research, Aekyung R&D Center)
Jee, Kyung-Yup (Central Research, Aekyung R&D Center)
Park, Soo-Nam (Research Center for Development of Green Cosmetic, Seoul National University of Science and Technology)
Kim, Jae-Il (Structural Biology Lab., Gwangju Institute of Science and Technology)
Cho, In-Shik (Central Research, Aekyung R&D Center)
Kim, Han-Young (Central Research, Aekyung R&D Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.36, no.3, 2010 , pp. 233-240 More about this Journal
Abstract
Derivatives of a novel natural compunds, melanostatin (PLG-$NH_2$) were prepared by solid phase synthesis[1,2] and assayed to evaluate their melanogensis inhibitory activity. Also, a small library (natural compound-XLG-$NH_2$, natural compound-X LG-OH) was prepared with same method for increasing synthetic yield and cost-reduction. PLG-$NH_2$ (Proline-Leucine-Glycine-$NH_2$) was well-known tripeptide as its $\alpha$-MSH release-inhibiting activity and tyrosinase inhibitory activity[3-5]. In order to choose best candidate for peptide derivatization, various natural compounds were screened by their tyrosinase inhibitory activity. As a result, caffeic acid and coumaric acid were selected. Most of these derivatives showed better activities than the parent natural compound, melanostatin.
Keywords
melanostatin; caffeic acid; coumaric acid; melanogenesis;
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