• Title/Summary/Keyword: Test Validation

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REPEATED DOSE (28 DAYS) ORAL TOXICITY STUDY IN RATS, BASED ON THE PROTOCOL (OECD TEST GUIDELINE NO. 407) TO SCREEN ENDOCRINE-DISRUPTING CHEMICALS

  • Shin, Jae-Ho;Kim, Hyung-Sik;Moon, Hyun-Ju;Kim, Tae-Sung;Kang, Il-Hyun;Seok, Ji-Hyun;Ki, Ho-Yun;Shim, Eun-Yong;Jang, Hae-Jin;Jeung, Eui-Bae;Han, Soon-Young
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.128-128
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    • 2002
  • In association with the international validation project to establish a test protocol for the "Enhanced OECD Test Guideline 407", we performed a 28-day repeated-dose toxicity study of vinclozolin (VCZ), an androgen antagonist, and ketoconazole (KCZ), a biosynthesis inhibitor of testosterone (T), and assessed the sensitivity of new parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

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Validation Test Codes Development of Static Analysis Tool for Secure Software (안전한 소프트웨어 개발을 위한 정적분석 도구 시험코드 개발)

  • Bang, Jiho;Ha, Rhan
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.38C no.5
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    • pp.420-427
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    • 2013
  • Recently, for secure software development, static analysis tools have been used mostly to analyze the source code of the software and identify software weaknesses caused of vulnerabilities. In order to select the optimal static analysis tool, both weaknesses rules and analysis capabilities of the tool are important factors. Therefore, in this paper we propose the test codes developed for evaluating the rules and analysis capabilities of the tools. The test codes to involve 43 weaknesses such as SQL injection etc. can be used to evaluate the adequacy of the rules and analysis capabilities of the tools.

Case study comparisons of computational fluid dynamics modeling versus tracer test to evaluate the hydraulic efficiency of clearwell (정수지 내 추적자 실험과 CFD(전산유체역학)의 상관관계 분석)

  • Kim, Tae-Kyun;Choi, Young-June;Jo, Young-Mahn
    • Journal of Korean Society of Water and Wastewater
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    • v.25 no.5
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    • pp.635-642
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    • 2011
  • Hydraulic efficiency was a vital component in evaluating the disinfection capability of clearwell. Current practice evaluates these system based on the tracer test only. In this paper, CFD(Computational Fluid Dynamics) was applied on the clearwell for alternating or supplementing the tracer test. The baffle factor derived from the CFD modeling closely matched the values obtained from full scale tracer testing. And, for suggesting proper numerical model in clearwell; the turbulence model, discretization scheme, convergence criteria were investigated through separate simulation runs. The model validation was conducted by comparing the simulated data with experimental data. In the turbulence model, the realizable ${\kappa}-{\varepsilon}$ model and the standard ${\kappa}-{\varepsilon}$ model were found to be more appropriate than RNG ${\kappa}-{\varepsilon}$ model. The residuals of convergence criteria should be used as not $10^{-3}$ but $10^{-4}$ or $10^{-5}$. In discretization scheme, the difference of simulated values in 1st, 2nd, 3rd upwind scheme was found to be insignificant. Moreover, the result of this study suggest that CFD modeling can be a reliable alternative to tracer testing for evaluating the hydraulic efficiency.

Validation of the Korean Version of the End-Stage Renal Disease Adherence Questionnaire (한국어판 말기신부전 환자의 치료순응도 측정 도구의 타당도와 신뢰도 검증)

  • Kim, Youngmee;Park, Young Mi
    • Journal of Korean Clinical Nursing Research
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    • v.18 no.2
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    • pp.307-316
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    • 2012
  • Purpose: The purpose of this study was to develop and test psychometric properties the Korean version of the End-Stage Renal Disease Adherence Questionnaire (KESRD-AQ). The ESRD-AQ, a 46-item, multidimensional, self-administrated questionnaire which was developed to assess treatment adherence to hemodialysis (HD) attendance, medications, fluid restrictions, and diet prescription among patients on maintenance hemodialysis, has been validated. Methods: The KESRD-AQ was developed by performing both translation and backtranslation. The content validity and test- retest reliability of the KESRD-AQ were evaluated by establishing item-level content validity index (I-CVI) and intra-class correlation coefficients (ICC), respectively. Construct validity was assessed by adopting a known-group analysis comparing adheres and non-adherers using Mann-Whitney U Test. Results: 41 Korean-American patients with ESRD on HD from 3 outpatient dialysis centers in California participated in the study. The KESRD-AQ showed excellent content validity (average I-CVI=.96) and test-retest reliability (ICC=.917, p=.004). The construct validity indicated that the KESRD-AQ distinguished adheres and non-adheres (p=.02~.047). Conclusion: The KESRD-AQ is a valid and reliable instrument to measure treatment adherence.

Development of Vehicle Evaluation System for Pedestrian Protection (보행자 보호를 위한 차량평가시스템 개발)

  • Yong, Boo-Joong;Cho, Hyun-Deog;Lee, Jae-Wan
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.5 no.4
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    • pp.53-58
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    • 2006
  • IHRA Pedestrian Working Group has investigated and analyzed the current status of pedestrian-vehicle accidents in IHRA member countries. According to the results, European countries and Japan are working on new regulations to improve passive pedestrian protection on passenger cars significantly. Although IHRA proposed pedestrian test procedures, which may provide a basis of technical regulations in the future, further research and development are necessary to refine the procedures. In order to prepare and satisfy the pedestrian protection requirements, domestic passenger vehicles also should be tested. Among various safety-related studies based on accident data analysis, dealing with pedestrian head injury would be considered one of the keen interests. In this study, the pedestrian headform impact test system is developed. The developed system will be useful to carry out validation study of the test procedures through actual tests using sample vehicles, and to explore the car feasibility level prior to the use of the test methods in legislation.

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A Study on Injector Durability Test with Diesel and BD20 Using Common Rail (커먼레일을 이용한 디젤과 BD20 연료가 인젝터에 미치는 영향에 관한 연구)

  • JEONG, YUNHO;LIM, OCKTAECK
    • Transactions of the Korean hydrogen and new energy society
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    • v.26 no.5
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    • pp.393-401
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    • 2015
  • The characteristics of diesel and biodiesel are similar like as cetane number and auto-ignition temperature. High cetane number of diesel and BD could make possible to compression ignition. but BD showed different atomization from diesel due to component like density, viscosity and iodine value etc. Because of this, the biodiesel requires validation. This study using diesel and BD20 investigated effect to durability injector. Durability test were used common rail and bosch solenoid type 5-hole injector. Total test was 672hr but actual running time was 200hr. Spray experiments for spray characteristics were carried out using constant volume combustion chamber. Spray characteristics of diesel and BD showed different result up to durability test time. After 100hr, diesel showed spray shapes were stable but BD was not. After 200hr, difference of diesel and BD spray shapes were grow serious.

Research on Correlation Method of ABS Interior Operational Noise via HILS Rig Test (HILS Rig 시험을 통한 실차 ABS 실내작동소음 예측 기법에 대한 연구)

  • Kim, Seunghwan;Yook, Jiyong;Han, Mingyu;Jeon, Namill
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2013.10a
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    • pp.483-488
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    • 2013
  • The psychoacoustic quality of ABS is now considered more important than before as the focus of recent ABS function is expanded to basic function from typical emergency function. Thus, the automotive parts manufacturing companies are actively working to improve NVH (Noise, Vibration, and Harshness) in ABS module. In terms of time, test place, and cost, however, it is very inefficient to have all the operating noise validation test in real vehicle configuration especially for partially improved ABS module. To contribute to reducing the development period and to grasping the improvements faster, this research presents the study of a correlation to predict ABS operating noise inside vehicle via HILS rig test. The regression equation in this paper was statistically drawn from using Minitab S/W, and based on that equation, the noise spectrum of vehicle interior was analogized.

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Reliability and validity of free software for the analysis of locomotor activity in mice

  • Hong, Yoo Rha;Moon, Eunsoo
    • Journal of Yeungnam Medical Science
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    • v.35 no.1
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    • pp.63-69
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    • 2018
  • Background: Kinovea software that tracking semi-automatically the motion in video screen has been used to study motion-related tasks in several studies. However, the validation of this software in open field test to assess locomotor activity have not been studied yet. Therefore, this study aimed to examine the reliability and validity of this software in analyzing locomotor activities. Methods: Thirty male Institute Cancer Research mice were subjected in this study. The results examined by this software and the classical method were compared. Test-retest reliability and inter-rater reliability were analyzed with Pearson's correlation coefficient and intraclass correlation coefficient (ICC). The validity of this software was analyzed with Pearson's correlation coefficient. Results: This software showed good test-retest reliability (ICC=0.997, 95% confidence interval [CI]=0.975-0.994, p<0.001). This software also showed good inter-rater reliability (ICC=0.987, 95% CI=0.973-0.994, p<0.001). Furthermore, in three analyses for the validity of this software, there were significant correlations between two methods (Pearson's correlation coefficient=0.928-0.972, p<0.001). In addition, this software showed good reliability and validity in the analysis locomotor activity according to time interval. Conclusion: This study showed that this software in analyzing drug-induced locomotor activity has good reliability and validity. This software can be effectively used in animal study using the analysis of locomotor activity.

Development and Validation of MARS-KS Input Model for SBLOCA Using PHWR Test Facility (중수로 실증 실험설비를 이용한 소형냉각재상실사고의 MARS-KS 입력모델 개발 및 검증계산)

  • Baek, Kyung Lok;Yu, Seon Oh
    • Journal of the Korean Society of Safety
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    • v.36 no.2
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    • pp.111-119
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    • 2021
  • Multi-dimensional analysis of reactor safety-KINS standard (MARS-KS) is a thermal-hydraulic code to simulate multiple design basis accidents in reactors. The code has been essential to assess nuclear safety, but has mainly focused on light water reactors, which are in the majority in South Korea. Few previous studies considered pressurized heavy water reactor (PHWR) applications. To verify the code applicability for PHWRs, it is necessary to develop MARS-KS input decks under various transient conditions. This study proposes an input model to simulate small-break loss of coolant accidents for PHWRs. The input model includes major equipment and experimental conditions for test B9802. Calculation results for selected variables during steady-state closely follow test data within ±4%. We adopted the Henry-Fauske model to simulate break flow, with coefficients having similar trends to integrated break mass and trip time for the power supply. Transient calculation results for major thermal-hydraulic factors showed good agreement with experimental data, but further study is required to analyze heat transfer and void condensation inside steam generator u-tubes.

Development of a seismic retrofit system made of steel frame with vertical slits

  • Kang, Hyungoo;Adane, Michael;Chun, Seungho;Kim, Jinkoo
    • Steel and Composite Structures
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    • v.44 no.2
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    • pp.283-294
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    • 2022
  • In this study, a new seismic retrofit scheme of building structures is developed by combining a steel moment frame and steel slit plates to be installed inside of an existing reinforced concrete frame. This device has the energy dissipation capability of slit dampers with slight loss of stiffness compared to the conventional steel frame reinforcement method. In order to investigate the seismic performance of the retrofit system, it was installed inside of a reinforced concrete frame and tested under cyclic loading. Finite element analysis was carried out for validation of the test results, and it was observed that the analysis and the test results match well. An analytical model was developed to apply the retrofit system to a commercial software to be used for seismic retrofit design of an example structure. The effectiveness of the retrofit scheme was investigated through nonlinear time-history response analysis (NLTHA). The cyclic loading test showed that the steel frame with slit dampers provides significant increase in strength and ductility to the bare structure. According to the analysis results of a case study building, the proposed system turned out to be effective in decreasing the seismic response of the model structure below the given target limit state.