Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.128-128
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- 2002
REPEATED DOSE (28 DAYS) ORAL TOXICITY STUDY IN RATS, BASED ON THE PROTOCOL (OECD TEST GUIDELINE NO. 407) TO SCREEN ENDOCRINE-DISRUPTING CHEMICALS
- Shin, Jae-Ho (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
- Kim, Hyung-Sik (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
- Moon, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
- Kim, Tae-Sung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
-
Kang, Il-Hyun
(Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA)
;
- Seok, Ji-Hyun (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
- Ki, Ho-Yun (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
- Shim, Eun-Yong (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
- Jang, Hae-Jin (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
-
Jeung, Eui-Bae
(College of Veterinary Medicine, Chungbuk National University)
;
- Han, Soon-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA)
- Published : 2002.05.01
Abstract
In association with the international validation project to establish a test protocol for the "Enhanced OECD Test Guideline 407", we performed a 28-day repeated-dose toxicity study of vinclozolin (VCZ), an androgen antagonist, and ketoconazole (KCZ), a biosynthesis inhibitor of testosterone (T), and assessed the sensitivity of new parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)