• Title/Summary/Keyword: Terminalia Chebula

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Combination Dyeing of Juniperus Chinensis and Terminalia Chebula Retzius (향나무와 가자열매의 혼합 염색)

  • Sa, A-Na;Choi, Hyo Jin;Lee, Jung Soon
    • Journal of the Korean Society of Clothing and Textiles
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    • v.38 no.3
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    • pp.415-426
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    • 2014
  • This study investigated the color change, enhancement of dye uptake, washing fastness, and light fastness of cotton and silk when dyed with Juniperus chinensis and Terminalia chebula (combination dyeing) using various methods. The dyeing methods were 1) dyeing Juniperus chinensis extract and Terminalia chebula Retzius extract sequentially (J-T), 2) dyeing Terminalia chebula Retzius extract and Juniperus chinensis extract sequentially (T-J), 3) dyeing Juniperus chinensis extract and Terminalia chebula Retzius extract simultaneously (J+T), and 4) dyeing Juniperus chinensis extract 4 times repeatedly and followed by a dyeing Terminalia chebula Retzius extract in sequence. In terms of increased dyeing uptake, combination dyeing (dyeing 2 times like method 1, 2, 3) had the same impact as the repeated dyeing (method 4). The color of J, T combination dyeing showed wide range of mixed YR series, Y series resulting from Terminalia chebula Retzius, and R series resulting from Juniperus chinensis. In cotton, J-T dyeing method showed superior enhancement of dye uptake, and T-J method in silk. In both of the cases, Y series color from Terminalia chebula Retzius extract was mainly shown (Y series color was superior to R series color after dyeing). Therefore, it is recommended for cotton to implement T-J method and for silk to implement J-T method in order to enhance both dyeing uptake and emphasize the color of R series. The K/S value of combination dyed fabrics was decreased by increasing washing time; however, the K/S value of combination dyed fabrics was increased by increasing UV irradiation time. But after repeated washing and longer UV irradiation, ${\Delta}E$ value of combination dyed fabric became smaller compared to fabric dyed with Juniperus chinensis only. Thus, it was found that after J, T combination dyeing, fabric became less prone to fading by washing and UV than after Juniperus chinensis single dyeing was done.

IN-VITRO STUDY OF CO2 EXTRACT OF TERMINALIA CHEBULA IN BREAST CANCER CELL LINE MD-MBA-231

  • Chandil, Shachi;Bamoriya, Harikishan;More, D.B.
    • CELLMED
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    • v.11 no.3
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    • pp.16.1-16.7
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    • 2021
  • Cancer is an abnormal growth of cells in body which leads to death. These cells are born due to imbalance in cell proliferation mechanism. In 2018, WHO released new statistics on cancer incidence, mortality, and prevalence worldwide i.e., GLOBOCAN 2018 estimates for 28 types of cancer in which more prevalence of cervix and breast cancer. According to survey, in India about 7.8 million cancer deaths and 11.5 million new cases arise in 2018, which will increase to 19.3 million new cases per year by 2025. Though breast cancer as such is not explained anywhere in Ayurvedic compendia, correlations can be done with the Stana Arbuda. Ayurveda, the ancient system of medicine came into existence 1000's of years ago with an objective of maintaining the health of people and treating diseases. Many herbs used in Ayurveda have been screened for activity against cancer and in-vitro and in-vivo studies have given promising leads. The plant, called as "Mother of Medicine", Haritaki has been extensively studied for its various ailments because of its extraordinary healing potency. Haritaki (Terminalia chebula Retz.), Family: Combretaceae have a great therapeutic value and is widely distributed in India. Dried fruit of Terminalia chebula contains high quantities phenolic compounds consist of ellagic acid, gallic acid and chebulic acid. The fruit extract of T. chebula is having different biological properties like anticancer, antioxidant, hepatic and renal protective activities etc. In this study, we focus on the use of CO2 extract of Terminalia chebula, on the breast cancer cell line MDA-MB-231. All tests proved that CO2 extract of Terminalia chebula containing active chemical component, therefore our experiment showed the positive results for CO2 extract of Terminalia chebula against breast cancer cell line cancer MDA-MB-231. The MTT assay results were used to evaluate the anti-cancer activity of the extract. The percentage of cell growth and cell viability were calculated from tabulated result values of MTT assay. Cell viability MTT assay also showed significant growth inhibition, at the same time statistical analysis of MTT assay also proved significant results.

Identification of phenolic antioxidative components in Terminalia Chebula Retz (가자 항산화성 물질의 분리 및 확인)

  • Kim, Jeong-Sook;Lee, Gee-Dong;Kwon, Joong-Ho;Yoon, Hyung-Sik
    • Applied Biological Chemistry
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    • v.36 no.4
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    • pp.239-243
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    • 1993
  • Chemical structures of phenolic antioxidative components of defatted Terminalia chebula R. were elucidated by used MS and H-NMR. The results showed that the phenolic antioxidative components were identified as ferulic acid, vanillic acid, p-coumaric acid in free-acid extracts, and caffecic acid, vanillic acid and p-coumaric acid in soluble-acid extracts, and caffeic acid, phloroglucinol and pyrogallol in insoluble-bound extracts, respectively.

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Inhibitory Effects of Terminalia chebula, Sanguisorba officinalis, Rubus coreanus and Rheum palmatum on Hepatitis B Virus Replication in HepG2 2.2.15 Cells (HepG2 2.2.15 세포주를 이용한 가자, 지유, 복분자, 대황의 B형 간염바이러스 증식 억제 효과)

  • 김태균;박민수;한형미;강석연;정기경;류항묵;김승희
    • YAKHAK HOEJI
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    • v.43 no.4
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    • pp.458-463
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    • 1999
  • This study was undertaken to test for antiviral activity of the aqueous extracts prepared from 4 medicinal plants of Korea (Terminalia chebula, Sanguisorba officinalia, Rubus coreanus, Rheum palmatum). Aqueous extracts were assayed for the inhibition of hepatitis B virus (HBV) replication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to $128{\;}\mu\textrm{g}/ml$ and inhibited the production of HBsAg dose-dependently. Among the 4 tested plants, Terminalia chebula exhibits the most prominent anti-HBV activities. Our findings suggest that these 4 medicinal plants may have potential to develop as specific anti-HBV drugs in the future.

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Physico-phytochemical Evaluation of Raw Material and CO2 extract of Fruits of Terminalia chebula

  • Chandil, Shachi;Bamoriya, Harikishan
    • CELLMED
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    • v.12 no.1
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    • pp.4.1-4.13
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    • 2022
  • The present communication attempts to evaluate the physicochemical and preliminary phytochemical studies on the fruit of Terminalia chebula Retz. Combretaceae family. Haritaki is one of the most celebrated herbs in the Indian traditional medicine system, Ayurveda. Terminalia chebula is known to exhibit different properties like anticancer, anti-inflammatory, anti-protozoal, antimicrobial, antioxidant, hepato and renal protective activities, and in the management of metabolic syndrome. As there is no detailed standardisation work reported on fruit, the physicochemical parameters, preliminary phytochemical constants, heavy metals, analysis are carried out. The phytochemical screening indicated the presence Tannin, Alkaloid, Phenol, Carbohydrate, Steroids, Protein and Resin compounds in CO2 extract of Haritaki. The present investigation will helpful in assessing the quality and purity of a crude drug. Thus, the study provides facts that CO2 extract of Haritaki contains medicinally important bioactive phytochemical compounds which justifies the use of plant species as conventional medicine for treatment of many diseases.

Antibacterial Activity of Terminalia chebula Retz. Extract Against Food Spoilage Microorganisms (식품부패세균에 대한 가자(Terminalia chebula Retz.) 추출물의 항균활성)

  • Kim, Ki-Ju;Do, Jeong-Ryong;Jo, Jin-Ho;Kim, Young-Myoung;Kim, Byeong-Sam;Lim, Sang-Dong;Kang, Suk-Nam
    • Korean Journal of Food Science and Technology
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    • v.37 no.3
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    • pp.498-503
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    • 2005
  • Antibacterial activities of water and 70% ethanol extracts of Terminalia chebula Retz were investigated. Fractions were prepared by step-wise fractionation of water and 70% ethanol extracts using acetone, hexane, chloroform and butanol. Butanol fraction showed best antibacterial activities. Water and 70% ethanol extracts of T. chebula Retz. had significantly high pyrogallol content among 13 phenolic compound analysed by HPLC, and pyrogallol (standard) showed highest activities against several food spoilage microorganism.

The Inhibitory Effect on Androgen Receptor-Dependent Prostate Cancer Cell Growth by Anti-Histone Acetyltransferase Activity from Terminalia chebula Retz. Fruit Methanol Extract (가자(Terminalia chebula Retz.) 열매 메탄올 추출물의 Histone Acetyltransferase 활성 저해에 따른 항전립선암 효과)

  • Lee, Yoo-Hyun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.10
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    • pp.1539-1543
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    • 2013
  • The inhibitory effect of histone acetyltransferase from methanol extract of Terminalia chebula Retz. fruit (TCME) was investigated in prostate cancer cell. TCME significantly inhibited histone acetyltransferase (HAT) activity by over 50% at 100 ${\mu}g/mL$ concentration. TCME treatment repressed androgen receptor (AR) mediated transcription, mRNA level of AR target genes, prostate specific antigen (PSA) and NKX-3.1, as well as AR acetylation. Finally, the prostate cancer cell viability was dramatically reduced by TCME treatment at 0~100 ${\mu}g/mL$ concentration. These results indicated that TCME, as a potent HAT inhibitor, could suppress prostate cancer cell growth by AR mediated transcription regulation.

Antioxidative effectiveness of ether extract in Crataegus pinnatifida Bunge and Terminalia chebula Rets (산사 및 가자 에테르 추출물의 항산화 효과)

  • Kim, Jeong-Sook;Lee, Gee-Dong;Kwon, Joong-Ho;Yoon, Hyung-Sig
    • Applied Biological Chemistry
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    • v.36 no.3
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    • pp.203-207
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    • 1993
  • Free phenolic acid, soluble ester and insoluble phenolic acid were extracted from defatted Crataegus pinnatifida and Terminalia chebula. Their antioxidative effectiveness was compared with BHA and BHT for soybeen oils by measuring peroxide and thiobarbituric acid values at $45^{\circ}C$ for 25 days. The patterns of these extracts were compared by using high performance liquid chromatography. Ether extracts from Crataegus and Terminalia showed a higher antioxidative effectiveness than BHA and BHT, and the latter was more effective than the former Among phenolic extracts, free phenolic acid and soluble phenolic acid ester were found most effective in Crataegus and Terminalia, respervively, Each phenolic extract was confirmed to be composed of two or three individual compounds.

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Effect of Terminalia chebula on Immediate Hypersensitivity Reaction in Mice and Rats

  • Lee, Jae-Kwan;Kim, Sang-Yong;Shin, Tae-Yong
    • Natural Product Sciences
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    • v.7 no.4
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    • pp.95-101
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    • 2001
  • We investigated the effect of aqueous extract of Terminalia chebula (Combretaceae)(TCAE) on the immediate hypersensitivity reaction in vivo and in vivo. TCAE (0.01 to 1 g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in mice. When TCAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. TCAE (0.001 to 1 mg/ml) also dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) IgE. TCAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis $factor-{\alpha}$ production from RPMC. These results indicate that TCAE inhibits immediate hypersensitivity reaction in vivo and in vitro.

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Hydrolysable Tannins and Related Compound having Cytotoxic Activity from the Fruits of Terminalia chebula

  • Lee, Seung-Ho;Ryu, Shi-Yong;Choi, Sang-Un;Lee, Chong-Ock;No, Zaesung;Kim, Seong-Kie;Ahn, Jong-Woong
    • Archives of Pharmacal Research
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    • v.18 no.2
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    • pp.118-120
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    • 1995
  • The cytotoxicity-directed fractionation of MeOH extract of Terminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(1), $1,2,3,4,6-penta-O-galloy-{\beta}-_D/-glucopyranose(II)$,. chebulagic acid (III) and chebulinic acid(IV), as active principles. They were shoen to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, Sk-MEL-2, XF-498 and HCT-15 in vitro.

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