Natural Product Sciences
- Volume 7 Issue 4
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- Pages.95-101
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- 2001
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- 1226-3907(pISSN)
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- 2288-9027(eISSN)
Effect of Terminalia chebula on Immediate Hypersensitivity Reaction in Mice and Rats
- Lee, Jae-Kwan (College of Pharmacy, Woosuk University) ;
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Kim, Sang-Yong
(College of Agriculture, Chonbuk National University) ;
- Shin, Tae-Yong (College of Pharmacy, Woosuk University)
- Published : 2001.12.01
Abstract
We investigated the effect of aqueous extract of Terminalia chebula (Combretaceae)(TCAE) on the immediate hypersensitivity reaction in vivo and in vivo. TCAE (0.01 to 1 g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in mice. When TCAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. TCAE (0.001 to 1 mg/ml) also dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) IgE. TCAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis
Keywords
- Terminalia chebula;
- Immediate hypersensitivity reaction;
- Compound 48/80;
- anti-DNP IgE;
- Tumor necrosis $factor-{\alpha}$