• Journal of the Economic Geographical Society of Korea
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• v.15 no.2
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• pp.274-291
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• 2012

Since the advent of the internet as representative of the development of information communication technology (ICT), information transfer forms have changed rapidly these days. In the new techno-economic paradigms, I would ultimately consider how spatial structures of a knowledge-based service industry have been altered dynamically. To delve into this background, this study conducts an empirical case study of the internet advertising industry, particularly, among the whole advertising industry. Therefore, the primary objective of this study is to identify dynamic characteristics of spatial networks among actors for knowledge creation in Korea's internet advertising industry. In addition, it also is to analyze the formative elements of spatial networks which would have an influence on constructing the space of new economic activities. There are multilateral approaches. This research is classified into types of actors such as inter-firm, intra-firm, and firm-customer, and categorized according to spatial ranges such as local, regional, global levels. In the meanwhile, formative factors of the spatial networks could draw a conclusion from two aspects: inter-firm networks in the process of business in the internet advertising industry, and individual networks in the nonoccupational aspect. Accordingly, the results of this study suggest that actors' networks of two perspectives would make mutually complementary relationships and create new relational spaces in the digital economy.

• Molecules and Cells
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• v.25 no.3
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• pp.390-396
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• 2008

Calreticulin (CRT) is one of the major $Ca^{2+}$ binding chaperone proteins of the endoplasmic reticulum (ER) and an unusual luminal ER protein. Postnatally elevated expression of CRT leads to impaired development of the cardiac conductive system and may be responsible for the pathology of complete heart block. In this study, the molecular mechanisms that affect $Ca^{2+}$-dependent signal cascades were investigated using CRT-overexpressing cardiomyocytes. In particular, we asked whether calreticulin plays a critical role in the activation of $Ca^{2+}$-dependent apoptosis. In the cells overexpressing CRT, the intracellular calcium concentration was significantly increased and the activity of PKC and level of SECAR2a mRNA were reduced. Phosphorylation of Akt and ERKs decreased compared to control. In addition the activity of the anti-apoptotic factor, Bcl-2, was decreased and the activities of pro-apoptotic factor, Bax, p53 and caspase 8 were increased, leading to a dramatic augmentation of caspase 3 activity. Our results suggest that enhanced CRT expression in mature cardiomyocytes disrupts intracellular calcium regulation, leading to calcium-dependent apoptosis.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.33 no.3
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• pp.95-102
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• 2015

This study conducted the survey on the resources of traditional villages based on AHP in the subjects with the specialists in Korea and China to seek the resource evaluation standards to apply the preservation and development of traditional villages, and the differences of the importance on the resources among the specialists in both countries. We classified three levels of evaluation items to aim the deductions of the importance and priority in the resources of traditional villages. Upon the analysis results, natural resources were important in the level 1; environmental, historical, facility resources were important in the level 2; and the factors such as air, topography, traditional houses, agricultural landscape, shared community facilities, interchanges between urban and rural areas, family activities, and so on were important in the level 3. The factors that both Korean and Chinese groups evaluated as the most important ones were the same. In terms of overall importance by evaluation items, the factors such as air, water quality, noise, traditional houses, topography, shared community facilities, and so on were rated as relatively important in both Korean and Chinese groups. That is, the traditional villages have the necessity to preserve the cultural resources like their duties, however, it is required to control the natural environment with good quality preferentially. This study results can compare the importance on the resources of traditional village between Korea and China. Moreover, with calculation of the priority and scores for the preservation and management of traditional villages, they are expected to be used as the tool to apply the quantitative data in the evaluation process of traditional village resources in both countries.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.37 no.3
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• pp.219-226
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• 2011

The Echinacea, which has been commonly known as a species of composite herb of dicotyledonous plant, has been used in native American traditional medicine for the treatment of diseases like colds or other infections in North America. We artificially cultured the adventitious roots of Echinacea angustifolia using the bioreactor culture system from Echinacea angustifolia and evaluated the efficacy as a cosmetic ingredient for skin care. Several studies previously have reported neogenesis, wound healing and inflammatory inhibition effect of Echinacea angustifolia but other efficacies were not well known. In the present study, we investigated the cosmetic efficacy to know applicable value of adventitious roots cultured from Echinacea angustifolia as a cosmetic ingredient. The adventitious roots extract of Echinacea angustifolia has superior anti-oxidant effect and matrix metalloproteinase-2 inhibitory effect, compared to natural Echinacea angustifolia. These results indicate that the adventitious roots extract cultured from Echinacea angustifolia presents a new possibility of being applicable to skin care and anti-wrinkle products as a cosmetic ingredient.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.2
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• pp.27-40
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• 2016

This paper aims to analyze the business types of 237 IoT based smart home companies in the world (launched during 1999~2014) which got global investment last few years. For this, the previous literatures trying to analze technology and service types of smart home are searched and the typology of the platform is discussed. Based on it, this research conceptualizes an analysis framework that includes three areas of smart home like home automation, home security, and energy efficiency with the three platform types like product, software, and service. This study concludes that the development of business type for IoT based smart home ecosystem is from the product to software and it can be a platform or not. In current status, there are a few platforms of product and software, but in the device management (16%) and thermostat (11%), companies are persuing more platform like. It is difficult to find the service platform in overall areas, for application based service has a few attractions in the investment market due to the lack of cloud infrastructure and data analytics. The following three are the implication to domestic market: 1) More active offering of API and SDK, 2) more active introduction of wireless Intenet network protocols, and 3) more active interoperability efforts and alliance activities are needed.

• Journal of Korean Academy of Nursing Administration
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• v.3 no.2
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• pp.95-107
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• 1997

For nursing as a science to establish a unique system of knowledge, nursing researchers should include the philosophical activities such as establish of nursing philosophy. For establish of philosophy nursing, the nature and realms and essential characteristics of nursing science should be made clear at first. The purpose of this study identify alienation and the situation of happen to alienation and Martin Buber Philosophy(I and Thou). Understanding of this concept should enlighten nurses to interaction and relationship problems between patients and nurse and thus lead to further toward enhancing these interaction and relationship. The alienation was serious problem in present society which was cultural, political, economical, mechanical, religious classified. The overcome of alienation in nursing situation was caring and interpersonal relationship based on Martin Buber philosophy. The essential philosophy of Martin Buber was "I and Thou" relationship. I and Thou relationship are consist of five characteristics ; 1)mutuality 2)directness 3)presentness 4)intensity 5)ineffability As health care technology becomes more sophisticated, there is a tendency to rely on monitors and machines to assess the patient's status. Therefore focus on the functioning and care of machine can result in less meaningful communication with patients. This study points to the need for health professional and patient relationship based on Martin Buber philosophy(I and Thou). This relationship may suggest that professional shoud have sincerity, concerning, respect and warm emotional toward their patients. Ultimately this study provide the basic information to contribute understanding of "I and Thou" relationship and nursing philosophy development in nursing education.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.12
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• pp.1858-1864
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• 2014

In the present investigation, the anti-diabetic potential of 80% ethanol extract of Eleutherococcus senticosus leaves (EEES) was examined based on ${\alpha}$-glucosidase inhibitory activities. EEES was sequentially fractionated with n-hexane, chloroform, ethyl acetate (EtAOc), n-butanol, and $H_2O$. Of the various fractions, EtAOc fraction effectively inhibited ${\alpha}$-glucosidase activity by 68.05%. Therefore, EtAOc fraction was selected for further isolation and identification studies. EtAOc fraction was separated by medium pressure liquid chromatography with silica and ODS gel to yield eight fractions (EAA~EAH). Based on the results of ${\alpha}$-glucosidase inhibitory activity, EAH fraction was re-chromatographed to yielded four more fractions (EAHA~EAHD). Of these, EAHC fraction showed higher ${\alpha}$-glucosidase inhibitory activity of 93.60%. EAHC fraction was re-chromatographed and yielded EAHCA and EAHCB fractions. Further, identification and chemical structures of these two fractions were analyzed using $^1H$-NMR, $^{13}C$-NMR, and mass spectra data. Based on the results of the spectral data, the isolated compounds were identified as hyperoside and isoquercetin. Results of the present study indicate that the isolated compounds, hyperoside, and isoquercetin from leaves of E. senticosus could be used for the development of new anti-diabetic drugs.

• Journal of Service Research and Studies
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• v.2 no.1
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• pp.47-59
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• 2012

With the rapid development of the Internet, public agencies and private companies introduced 'IT outsourcing in order to maintain and repair the information systems. Also they have utilized the SLA in order to manage it. Although IT outsourcing as a way to promote effective SLA are being introduced, the introduction of service level agreements or those introduced universal effectiveness did not demonstrate in the public agencies. The importance of outsourcing in the information systems is growing, but the increase in size of the business information, IT technology diversification, expansion of information between systems interconnection, information system operating and maintenance costs with the increase of information systems to streamline operations, increase the need for versatility is growing gradually. In this paper we investigates IT outsourcing in public agencies as a way to promote effective service level agreement(SLA) with the introduction and consideration, and through the application of SLA mutual customers and IT service organizations make a clear point of management and IT service levels and IT services for improved mind and strengthen the effectiveness of preventive activities can be seen.

• The Korean Journal of Mycology
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• v.34 no.1
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• pp.15-21
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• 2006

Extracts from 63 kinds of Pholiota sp. fruiting bodies were prepared using water and methanol, and then their physiological functionalities were investigated. The methanol extracts from Pholiota adiposa PAD030 showed high fibrinolytic activity and those of P. adiposa ASI PAD-022 showed potential inhibitory activity of 76.8% against ${\beta}-hydroxy-{\beta}-methylglutaryl(HMG)-CoA$ reductase. The highest antioxidant and tyrosinase inhibitory activities were found in the water extracts of Pholiota sp. PSP-015 (72.7%) and methanol extracts of P. nameko PNA-024 (69.5%), respectively. However, superoxide dismutase(SOD)-like activity and elastase inhibitory activity were low in almost of the extracts. The HMG-CoA reductase inhibitor from the fruiting body of P. adiposa PAD-022 which showed the highest functionality was extracted maximally when powder of the fruiting body was shaked at $30^{\circ}C$ for 12 h by methanol and its HMG-CoA reductase inhibitory activity was 80.2%.

• Korean Journal of Construction Engineering and Management
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• v.15 no.4
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• pp.11-19
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• 2014

Construction VE activities has occupies an important position as a key tool of the project in terms of budget and performance improvements. Reflecting this situation, VE application scope is being expanded than before. Thus, construction projects are required the continued research and development for effective use of construction VE. VE target choice method is the central part in the construction VE work. But, this has a problem with low utilization in practical terms. Accordingly, this study was developed the new methodology(PVTCM) for VE target selection of the construction VE work. Its contents are as follows: First, to analyze practical problem for VE target choice method through VE practical data. Second, to extract the high potential VE object based on the cost model and ideas similarity by excellent VE cases analysis. Third, to implement standardized VE object item by using affinity diagram for each construction type items. This research were conducted to experts interviews for comparison analysis with the cost model as one of a representative target selection method. As a result, proposed method were implemented significantly higher performance in terms of practical effectiveness than conventional method.