• Toxicological Research
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• v.19 no.3
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• pp.247-257
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• 2003

Medicine is undergoing a revolution in the understanding of the mechanisms through which disease processes develop. The advent of genetics and molecular biology to oncology not only is providing surrogate predictors of therapy response and survival which are forming the basis for selection among established treatment options, but is providing targets for new directions in therapy as well. Molecular modification of somatic cells for the purposes of protecting the normal cells from the toxicity of cancer chemotherapy, for the sensitization of the tumor cells to therapy and use of conditionally replicating viral vector have been new directions of cancer treatment which have reached the clinical arena. Advances in molecular pharmacology and vector design summarized in this paper may provide solutions to some of the existing problems in the technology of gene transfer therapy. Continued basic research into the biological basis of human disease, systemic studies of the application of these discoveries to therapy and the improvement of vector for gene delivery all combined may result in advances in this important field of therapy over the next few years.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.1
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• pp.93-103
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• 1999

Recent advances in the biotechnology of ruminal bacteria have been made in the characterization of enzymes involved in plant cell wall digestion, the exploration of mechanisms of gene transfer in ruminal bacteria, and the development of vectors. These studies have culminated in the introduction and expression of heterologous glucanase and xylanase genes and a fluoroacetate dehalogenase gene in ruminal bacteria. These recent studies show the strategy of gene and vector construction necessary for the production of genetically engineered bacteria for introduction into ruminants. Molecular research on proteolytic turnover of protein in the rumen is in its infancy, but a novel protein high in essential amino acids designed for intracellular expression in ruminal organisms provides an interesting approach for improving the amino acid profile of ruminal organisms.

• Archives of Plastic Surgery
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• v.41 no.3
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• pp.231-240
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• 2014

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery.

• ETRI Journal
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• v.42 no.2
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• pp.292-304
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• 2020

As side-channel analysis and machine learning algorithms share the same objective of classifying data, numerous studies have been proposed for adapting machine learning to side-channel analysis. However, a drawback of machine learning algorithms is that their performance depends on human engineering. Therefore, recent studies in the field focus on exploiting deep learning algorithms, which can extract features automatically from data. In this study, we survey recent advances in deep learning-based side-channel analysis. In particular, we outline how deep learning is applied to side-channel analysis, based on deep learning architectures and application methods. Furthermore, we describe its properties when using different architectures and application methods. Finally, we discuss our perspective on future research directions in this field.

• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.128-140
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• 2014

Anxiety disorders are characterized by dysregulation of neuroendocrine, neurotransmitter and neuroanatomical functions. Substantial advances in research method offered new insights into the neurobiologic mechanisms in anxiety disorders. Advances in molecular biology have enabled illumination of hormone and neurotransmitters that have important roles in anxiety. The neuroanatomic circuits related to anxiety are also being elucidated by improvements in neuroimaging technology such as structural and functional magnetic resonance imaging. This article reviews the research data in relation to the neurobiology underlying fear and pathologic anxiety and discusses their implications for development of biological treatments for anxiety disorders.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.20 no.43
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• pp.381-392
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• 1997

Korea and Japan have maintained an intimate relationship of economic exchange. However, even though both countries have made sound advances in the ASIAN market, they have not established mutually remarkable cooperative relations and advances in the ASIAN market. If korean companies with abundant experience and management ability provide able managers and skilled labor and if Japanese companies provide construction technology, capital and information, they could enjoy enomorous mutual benefits by advancing in the area of plant construction in foreign countries. Therefore, if they cooperate with each other by establishing complementary cooperation, both countries can gain an advantage in international competitiveness with western advanced countries.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.14 no.24
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• pp.7-13
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• 1991

Recently, in FMS composing of various automatic equipments, the machines with lower operating costs, and with higher operating costs and replacement costs resulting from deterioration have been appearing successively as a result of rapidly advances in technology. "Control Limit Policy" [1] by using Markov decision policy, a kind of optimal economic replacement decision, well reflects and represents this environment. In this paper, it is reviewed that the decision method of the forecasted replacement alternatives in planning horizon under technological advances is derived. The proposed method is applied to a numerical example and some characteristics are examined by sensitivity. It is clarified that the method is relatively insensitive to changes of parameters at the present decision. decision.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.6
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• pp.483-500
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• 2007

Emerging sensor-based structural health monitoring (SHM) technology can play an important role in inspecting and securing the safety of aging civil infrastructure, a worldwide problem. However, implementation of SHM in civil infrastructure faces a significant challenge due to the lack of suitable sensors and reliable methods for interpreting sensor data. This paper reviews recent efforts and advances made in addressing this challenge, with example sensor hardware and software developed in the author's research center. It is proposed to integrate real-time continuous monitoring using on structure sensors for global structural integrity evaluation with targeted NDE inspection for local damage assessment.

• Journal of Korean Neurosurgical Society
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• v.43 no.2
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• pp.69-78
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• 2008

Recently, due to the evolution of technology, the field of neurosurgery is receiving spotlight. In particular endovascular neurosurgery has gained a great interest along with the advancement of the modern neurosurgery. The most remarkable advances were made in embolization of the cerebral aneurysms, arteriovenous malformations and intracranial stenosis during the past 10 years. These advances will further change the role of neurosurgeons in treating cerebrovascular disease. Because interventional neuroradiologists have performed most of procedures in the past, neurosurgeons have been deprived of chances to learn endovascular procedure. This article discusses the development of technological aspect of endovascular neurosurgery in chronological order. By understanding the history and current status of the endovascular surgery, the future of neurosurgery will be promising.

• Advances in nano research
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• v.17 no.1
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• pp.87-94
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• 2024

Nanotechnology is one of the leading edges of science and technology today, holding out the promise for revolutionary advances in just about any discipline. With the integration of nanoscale concepts into K-12 STEM education comes a special opportunity pertaining to the cultivation of future innovators and scientists who are more adept at traveling in this burgeoning field. It discusses some strategies and frameworks for effectively bringing nanotechnology into the K-12 curriculum. Hands-on activities, interdisciplinary approaches, and age-appropriate educational materials have been used with an emphasis on improving student engagement and enhancing understanding in nanoscale phenomena. Thus, early exposure to the principles of nanotechnology can be effectively used by teachers to develop curiosity, critical thinking, and problem-solving skills, which are necessary for technological advancement. These results highlight the potential of nanotechnology education integration in the development of future STEM professionals. It results in an increase in the enrollment rate. Hence, this proves that there is a lasting impact of the intervention on the choice that students made while in school.