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Head and neck cancer: gene therapy approaches. Part II: genes delivered
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DOI ScienceOn |
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Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression
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DOI |
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Efficient and nontoxic adenoviral purging method for autologous transplantation in breast cancer patients
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Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine
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DOI ScienceOn |
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Synergistic effects of adenovirus expressing wild-type p53 on chemosensitivity of nonsmall cell lung cancer cells
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DOI ScienceOn |
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Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: [aradigm for a prospective cancer control strategy
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Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
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DOI ScienceOn |
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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
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DOI |
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Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells
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DOI ScienceOn |
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Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
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DOI |
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Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer
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DOI |
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Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
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Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging
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Efficient induction of apoptosis by ONYX-015 adenovirus in human colon cancer cell lines regardless of p53 status
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DOI ScienceOn |
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Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas
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DOI ScienceOn |
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The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified
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Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 millon-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation
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Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer results of a multicenter phase II study.
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DOI |
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Temozolomide enhances herpes simplex virus thymidine kinase/ganciclovir therapy of malignant glioma
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DOI ScienceOn |
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A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group
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DOI ScienceOn |
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Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo
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In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase
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DOI ScienceOn |
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Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
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DOI |
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In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase
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Progress towards gene therapy for cancer
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Center for Biologics Evaluation and Research, Biological Response Modifiers Advisory Committee
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Chemotherapy immediately following autologous stem-cell transplantation in patients with advanced breast cancer
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Clinical protocol. A Phase 1 open-label clinical trial of the safety and tolerability of single escalating doses of autologous CD4 T cells transduced with VRX496 in HIV-positive subjects
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The cytotoxic effect of replication competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the Breast, ovary and colon
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DOI ScienceOn |
30 |
Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer
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DOI ScienceOn |
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Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
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Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
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DOI ScienceOn |
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Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
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DOI ScienceOn |
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A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy
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DOI ScienceOn |
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Center for Biologics Evaluation and Research, Biological Response Modifiers Advisory Committee
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Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model
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DOI |
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Cancer gene therapy: fringe or cutting edge?
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DOI ScienceOn |
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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
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DOI |
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p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication
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Gene therapy death prompts review of adenovirus vector
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DOI |
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Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer. a pilot trial
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DOI ScienceOn |
42 |
Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
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DOI |
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Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colonyforming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy
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DOI ScienceOn |
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Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal inteference in a malignant gloma model
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DOI ScienceOn |
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