Browse > Article
http://dx.doi.org/10.5999/aps.2014.41.3.231

Nanotechnology Biomimetic Cartilage Regenerative Scaffolds  

Lim, Erh-Hsuin (The Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London)
Sardinha, Jose Paulo (Department of Materials and Institute of Biomedical Engineering, Imperial College London)
Myers, Simon (The Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London)
Publication Information
Archives of Plastic Surgery / v.41, no.3, 2014 , pp. 231-240 More about this Journal
Abstract
Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery.
Keywords
Nanotechnology; Biomimetics; Cartilage; Tissue scaffolds; Guided tissue regeneration;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Buttafoco L, Kolkman NG, Engbers-Buijtenhuijs P, et al. Electrospinning of collagen and elastin for tissue engineering applications. Biomaterials 2006;27:724-34.   DOI   ScienceOn
2 Chen G, Sato T, Ushida T, et al. The use of a novel PLGA fiber/collagen composite web as a scaffold for engineering of articular cartilage tissue with adjustable thickness. J Biomed Mater Res A 2003;67:1170-80.
3 Mukaida T, Urabe K, Naruse K, et al. Influence of three-dimensional culture in a type II collagen sponge on primary cultured and dedifferentiated chondrocytes. J Orthop Sci 2005;10:521-8.   DOI
4 Li WJ, Cooper JA Jr, Mauck RL, et al. Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater 2006;2:377-85.   DOI   ScienceOn
5 Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000;21:2335-46.   DOI   ScienceOn
6 Fuchs JR, Nasseri BA, Vacanti JP. Tissue engineering: a 21st century solution to surgical reconstruction. Ann Thorac Surg 2001;72:577-91.   DOI   ScienceOn
7 Kim TG, Park TG. Biomimicking extracellular matrix: cell adhesive RGD peptide modified electrospun poly(D,L-lactic-co-glycolic acid) nanofiber mesh. Tissue Eng 2006;12: 221-33.   DOI   ScienceOn
8 Yannas IV, Burke JF, Gordon PL, et al. Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res 1980;14:107-32.   DOI   ScienceOn
9 Poole AR, Kojima T, Yasuda T, et al. Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res 2001;(391 Suppl):S26-33.
10 Malda J, van Blitterswijk CA, van Geffen M, et al. Low oxygen tension stimulates the redifferentiation of dedifferentiated adult human nasal chondrocytes. Osteoarthritis Cartilage 2004;12:306-13.   DOI   ScienceOn
11 Homicz MR, McGowan KB, Lottman LM, et al. A compositional analysis of human nasal septal cartilage. Arch Facial Plast Surg 2003;5:53-8.   DOI
12 Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect 1998;47:477-86.
13 Nishimura M, Kawata M, Yan W, et al. Quantitative analysis of the effects of hyaluronan and aggrecan concentration and hyaluronan size on the elasticity of hyaluronan-aggrecan solutions. Biorheology 2004;41:629-39.
14 Alkrad JA, Mrestani Y, Stroehl D, et al. Characterization of enzymatically digested hyaluronic acid using NMR, Raman, IR, and UV-Vis spectroscopies. J Pharm Biomed Anal 2003;31:545-50.   DOI   ScienceOn
15 Ng L, Grodzinsky AJ, Patwari P, et al. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. J Struct Biol 2003;143:242-57.   DOI   ScienceOn
16 de Chalain T, Phillips JH, Hinek A. Bioengineering of elastic cartilage with aggregated porcine and human auricular chondrocytes and hydrogels containing alginate, collagen, and kappa-elastin. J Biomed Mater Res 1999;44:280-8.   DOI   ScienceOn
17 Bhattarai N, Edmondson D, Veiseh O, et al. Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials 2005;26:6176-84.   DOI   ScienceOn
18 Langer R, Vacanti JP. Tissue engineering. Science 1993;260: 920-6.   DOI   ScienceOn
19 Wheater PR, Burkitt HG. Skeletal tissues. In: Wheater PR, Burkitt HG, Daniels VG, editors. Functional histology. 2nd ed. Edinburgh: Churchill Livingston; 1987. p.142-60.
20 Lane AP. Nasal anatomy and physiology. Facial Plast Surg Clin North Am 2004;12:387-95.   DOI   ScienceOn
21 Ross MH, Kaye GI, Pawlina W. Cartilage. In: Ross MH, Pawlina W, editors. Histology: a text and atlas. Baltimore: Lippincott Williams & Wilkins; 2002. p.16479.
22 Chung C, Burdick JA. Engineering cartilage tissue. Adv Drug Deliv Rev 2008;60:243-62.   DOI   ScienceOn
23 Stoop R. Smart biomaterials for tissue engineering of cartilage. Injury 2008;39 Suppl 1:S77-87.
24 Hunter CJ, Imler SM, Malaviya P, et al. Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. Biomaterials 2002;23:1249-59.   DOI   ScienceOn
25 Sohier J, Hamann D, Koenders M, et al. Tailored release of TGF-beta1 from porous scaffolds for cartilage tissue engineering. Int J Pharm 2007;332:80-9.   DOI   ScienceOn
26 Chou CH, Cheng WT, Lin CC, et al. TGF-beta1 immobilized tri-co-polymer for articular cartilage tissue engineering. J Biomed Mater Res B Appl Biomater 2006;77:338-48.
27 Ma Z, Gao C, Gong Y, et al. Cartilage tissue engineering PLLA scaffold with surface immobilized collagen and basic fibroblast growth factor. Biomaterials 2005;26:1253-9.   DOI   ScienceOn
28 Sohier J, Moroni L, van Blitterswijk C, et al. Critical factors in the design of growth factor releasing scaffolds for cartilage tissue engineering. Expert Opin Drug Deliv 2008;5:543-66.   DOI   ScienceOn
29 Elisseeff J, McIntosh W, Fu K, et al. Controlled-release of IGF-I and TGF-beta1 in a photopolymerizing hydrogel for cartilage tissue engineering. J Orthop Res 2001;19:1098-104.   DOI   ScienceOn
30 Li Z, Zhang M. Chitosan-alginate as scaffolding material for cartilage tissue engineering. J Biomed Mater Res A 2005; 75:485-93.
31 Zhao H, Ma L, Gong Y, et al. A polylactide/fibrin gel composite scaffold for cartilage tissue engineering: fabrication and an in vitro evaluation. J Mater Sci Mater Med 2009; 20:135-43.   DOI
32 Woo KM, Chen VJ, Ma PX. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A 2003;67:531-7.
33 Woo KM, Jun JH, Chen VJ, et al. Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 2007;28:335-43.   DOI   ScienceOn
34 Heijkants RG, van Calck RV, De Groot JH, et al. Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration. J Mater Sci Mater Med 2004;15:423-7.   DOI   ScienceOn
35 Smith LA, Ma PX. Nano-fibrous scaffolds for tissue engineering. Colloids Surf B Biointerfaces 2004;39:125-31.   DOI   ScienceOn
36 Deitzel JM, Kleinmeyer J, Harris D, et al. The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 2001;42:261-72.   DOI   ScienceOn
37 Yang F, Murugan R, Wang S, et al. Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005; 26:2603-10.   DOI   ScienceOn
38 Dzenis Y. Material science. Spinning continuous fibers for nanotechnology. Science 2004;304:1917-9.   DOI   ScienceOn
39 Xu CY, Inai R, Kotaki M, et al. Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. Biomaterials 2004;25:877-86.   DOI   ScienceOn
40 Goddard JM, Hotchkiss JH. Polymer surface modification for the attachment of bioactive compounds. Prog Polym Sci 2007;32:698-725.   DOI   ScienceOn
41 Hartgerink JD, Beniash E, Stupp SI. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 2001;294:1684-8.   DOI   ScienceOn
42 Zhang S. Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol 2003;21:1171-8.   DOI   ScienceOn
43 Barnes CP, Sell SA, Boland ED, et al. Nanofiber technology: designing the next generation of tissue engineering scaffolds. Adv Drug Deliv Rev 2007;59:1413-33.   DOI   ScienceOn
44 Whitesides GM, Grzybowski B. Self-assembly at all scales. Science 2002;295:2418-21.   DOI   ScienceOn
45 Ratner BD, Bryant SJ. Biomaterials: where we have been and where we are going. Annu Rev Biomed Eng 2004;6:41-75.   DOI   ScienceOn
46 Holmes TC, de Lacalle S, Su X, et al. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci U S A 2000;97:6728-33.   DOI   ScienceOn
47 Kisiday J, Jin M, Kurz B, et al. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A 2002;99:9996-10001.   DOI   ScienceOn
48 Schneider A, Garlick JA, Egles C. Self-assembling peptide nanofiber scaffolds accelerate wound healing. PLoS One 2008;3:e1410.   DOI   ScienceOn
49 Mujeeb A, Miller AF, Saiani A, et al. Self-assembled octapeptide scaffolds for in vitro chondrocyte culture. Acta Biomater 2013;9:4609-17.   DOI   ScienceOn
50 Chen Y, Bilgen B, Pareta RA, et al. Self-assembled rosette nanotube/hydrogel composites for cartilage tissue engineering. Tissue Eng Part C Methods 2010;16:1233-43.   DOI   ScienceOn
51 Ma PX, Zhang R. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 1999;46:60-72.   DOI   ScienceOn
52 Ma PX. Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 2008;60:184-98.   DOI   ScienceOn
53 Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet 2008;372:2023-30.   DOI   ScienceOn
54 Yannas IV, Lee E, Orgill DP, et al. Synthesis and character ization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc Natl Acad Sci U S A 1989;86:933-7.   DOI
55 Dagalakis N, Flink J, Stasikelis P, et al. Design of an artificial skin. Part III. Control of pore structure. J Biomed Mater Res 1980;14:511-28.   DOI   ScienceOn
56 Cao Y, Vacanti JP, Paige KT, et al. Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg 1997;100:297-302.   DOI   ScienceOn
57 Stevens MM, George JH. Exploring and engineering the cell surface interface. Science 2005;310:1135-8.   DOI   ScienceOn
58 Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 2005;23:47-55.   DOI   ScienceOn
59 Cukierman E, Pankov R, Stevens DR, et al. Taking cell-matrix adhesions to the third dimension. Science 2001;294: 1708-12.   DOI   ScienceOn
60 Wimpenny I, Ashammakhi N, Yang Y. Chondrogenic potential of electrospun nanofibres for cartilage tissue engineering. J Tissue Eng Regen Med 2012;6:536-49.   DOI   ScienceOn
61 Li WJ, Danielson KG, Alexander PG, et al. Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds. J Biomed Mater Res A 2003;67:1105-14.
62 Li WJ, Jiang YJ, Tuan RS. Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng 2006;12:1775-85.   DOI   ScienceOn
63 Lisignoli G, Cristino S, Piacentini A, et al. Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold. Biomaterials 2005;26:5677-86.   DOI   ScienceOn