• Biotechnology and Bioprocess Engineering:BBE
• /
• 제9권1호
• /
• pp.7-11
• /
• 2004

Leukotactin-1 (Lkn-1), a human CC chemokine, has been demonstrated to induce chemotaxis of neutrophils, monocytes, eosinophils and Iym phocytes and has been shown to suppress colony formation of hematopoietic stem and progenitor cells (HSPC) in vitro and in vivo. The temporal suppression of HSPC by chemokines could potentially be applicable for various indications, such as the protection of HSPC from the several anti-proliferating chemotherapeutics in cancer treatments. In order to evaluate the protective effects on myeloid progenitor cells, the recombinant Lkn-1 was produced by Pichia pastoris and tested with cyclophosphamide, cytotoxic chemotherapeutics. The pretreatment of Lkn-1 increased the number of HSPC in bone marrow as well as the potency of resulting progenitor cells after the treatment of cyclophosphamide. Af-ter the first cycle of cyclophosphamide treatment these protections of HSPC correlated with the increased number of white blood cells and neutrophils in the peripheral blood. In lethal conditions created by the repeated administration of cyclophosphamide, the treatment of Lkn-1 enhanced the survival of mice, suggesting the potential use of Lkn-1 as the protective agent for HSPC from various cytotoxic insults.

• 대한치과의사협회지
• /
• 제45권6호통권457호
• /
• pp.362-369
• /
• 2007

The aim of this study was to investigate the effect of the hybrid instrumentation method with ProTaper and ProFile on the change of root canal area and distance from the canal to the root surface after canal shaping. The mesial canals of twenty extracted mandibular first molars having $10-20^{\circ}\Delta$ curvature were scanned using X-ray microcomputed tomography (XMCT)-scanner before root canals were instrumented. They were divided into four groups (n=10 canals ter group). In Group 1, root canals were instrumented by the step-back technique with stainless steel K-Flexofile after coronal flaring. The remainders were instrumented by the crown-down technique with, ProTaper system (Group 2), ProFile (Group 3) or ProTaper (Group 4). All canals were prepared up to size 25 at the end-point of preparation and scanned again. Pre- and post-operative cross-sectional images of 1, 3, 5, and 7 mm from the apical foramen were compared. For each level, change of cross-sectional canal are and distance to the nearest external root surface was calculated using Adobe Photoshop 6.0 and image software program. In the change of cross-sectional area, Group 4 was less than Group 2 at 3 mm and 5 mm level (p<0.05). In the difference of the distance from the canal to the root surface after canal shaping, Group 4 was least among the other groups at 7 mm level (p<0.05). According to the results, the methods using ProFile or K file only and the hybrid instrumentation technique using ProTaper and ProFile are more appropriate methods of canal preparation than ProTaper system for narrow of curved canals.

• 한국산학기술학회논문지
• /
• 제21권11호
• /
• pp.349-356
• /
• 2020

ISO 9705 룸코너 시험을 통해 복합소재 고체 가연물의 화재발생시 발생되는 열방출률을 측정하고 화재성장율을 계산하여 Fire Dynamics Simulator (FDS)에서 제공하는 열방출률 예측 모델을 사용자가 시험을 통해 얻어진 질량 소모율을 직접 입력하고 점화원에 의해 가연물의 표면 온도가 점화 온도에 도달하게 되면 정해진 연료를 소모하게 됨으로써 열방출률이 계산되는 단순 모델 (Simple model)과 질량 소모율을 직접 계산하는 방식으로 고체 가연물의 온도를 계산하고 고체 가연물의 열분해율을 조절하여 직접 열방출률을 계산하는 열분해 모델 (Pyrolysis model)로 구분하고 각각의 열방출률 모델에 필요한 입력 인자를 적용하여 동일한 조건에서 밀폐된 구획 환경에 따라 FDS 전산 해석을 수행하였다. 복합소재 고체 가연물로는 PU 폼과 PP, 철재로 대부분 구성되어있는 영화관 의자를 선정하였다. 동일한 조건에서 밀폐된 구획 환경에 따라 각각의 열방출률 예측 모델을 해석한 결과, 밀폐된 구획에서 단순 모델을 통해 예측된 열방출률과 화재성장율이 열분해 모델을 이용하는 경우에 비해 다소 과예측되는 것을 확인 할 수 있었다.

• Strategy21
• /
• 통권32호
• /
• pp.97-122
• /
• 2013

The basic stance of the Republic of Korea Ministry of Foreign Affairs was 'quiet diplomacy'. However, there had been demands for specific plans for practical protection of Dokdo. In 2011, Prime Minister Kim Hwang Sik mentioned that they are reviewing measures of stationing marines on Dokdo, while on August 10th, 2012, former president Lee Myung Bak visited Dokdo. The visit itself was meaningful as he was the first supreme commander to visit Dokdo. This paper studies on the necessity of naval power on Dokdo to maintain its effective control. The effective control must be done by a national organization in a peaceful and unimpaired method. If so, can stationing naval power, whether directly or indirectly, on Dokdo be considered a violation of 'peaceful' method? A 'peaceful' effective of control meas the right of sovereignty over a territory without other country's protest. In such terms, protecting a territory falls under practicing the right of sovereignty, and therefore does not violate 'peaceful'. In addition, looking at international cases such as Ligitan/Sipadan Case and Pedra Blanca Case, evidences such as 'navy activity', 'flyng ensign', and 'military communication facility installation' was used. In ter case of Yemen-Eritrea dispute over Hanish, methods on effective control over island and sea was also ruled by the installation of military posts and military surveillance activities. Thus, stationing naval power on Dokdo can be a way of maintaining effective control per international law. To station naval poer on Dokdo, Presidential Instruction 24 integrated Defense Guideline Enforcement Ordinance, which is domestic law, must be revised. Reason being, the Enforcement Ordinance states that the navy area of responsibility excluded Ullundo, where Dokdo is under jurisdiction of Ullungdim thus excluding navy control. In addition, considering the diplomatic situation, it is more fut to install navy radar site on Dokdo rather than 'stationing marines'. In other words, enforcing surveillance in the vicinity of Dokdo and installing radar site instead of stationing direct combatants is one way of practicing effective control without stimulating diplomatic disputes.

• 한국분말재료학회지
• /
• 제10권6호
• /
• pp.406-414
• /
• 2003

In order to produce good wear resistance powder metallurgy Al-Si alloys with high strength, addition of glass forming elements of Ni and Ce in $Al_{81}$Si$_{19}$ alloy was examined using SEM, TEM, tensile strength and wear testing. The solubility of Si in aluminum increased with increasing Ni and Ce contents for rapidly solidified powders. These bulk alloys consist of a mixed structure in which fine Si particles with a particle size below 500 nm and very fine A1$_3$Ni, A1$_3$Ce compounds with a particle size below 200 nm are homogeneously dispersed in aluminum matrix with a grain size below 600 nm. The tensile strength at room temperature for $Al_{81}$Si$_{19}$, $Al_{78}$Si$_{19}$Ni$_2$Ce$_{0.5}$, and $Al_{76}$Si$_{19}$Ni$_4$Ce$_1$ bulk alloys extruded at 674 K and ratio of 10 : 1 is 281,521, and 668 ㎫ respectively. Especially, $Al_{73}$Si$_{19}$Ni$_{7}$Ce$_1$ bulk alloy had a high tensile strength of 730 ㎫. These bulk alloys are good wear-resistance bel ter than commercial I/M 390-T6. Specially, attactability for counterpart is very little, about 15 times less than that of the I/M 390-T6. The structural refinement by adding glass forming elements such as Ni and Ce to hyper eutectic $Al_{81}$Si$_{19}$ alloy is concluded to be effective as a structural modification method.d.tion method.

• Clinical and Experimental Reproductive Medicine
• /
• 제41권4호
• /
• pp.168-173
• /
• 2014

The purpose of this study is to report a successful twin pregnancy and delivery in a female patient with X-linked dominant incontinentia pigmenti (IP) who underwent assisted reproductive technology followed by preimplantation genetic screening (PGS). A 29-year-old female with IP had a previous history of recurrent spontaneous abortion. A molecular analysis revealed the patient had a de novo mutation, 1308_1309insCCCCTTG(p.Ala438ProfsTer26), in the inhibitor of the kappa B kinase gamma gene located in the Xq28 region. IVF/ICSI and PGS was performed, in which male embryos were sexed using array-based comparative genomic hybridization (aCGH). After IVF/ICSI and PGS using aCGH on seven embryos, two euploid male blastocysts were transferred with a 50% probability of a viable male pregnancy. The dizygotic twin pregnancy was confirmed and the amniocentesis results of each twin were normal with regard to the mutation found in the mother. The patient delivered healthy twin babies during the 37th week of gestation. This case shows the beneficial role of PGS in achieving a successful pregnancy through euploid male embryo gender selection in a woman with X-linked dominant IP with a history of multiple male miscarriages.

• 펄프종이기술
• /
• 제31권4호
• /
• pp.76-83
• /
• 1999

This study was carried to investigate optimum conditions of charcoal added paper in making cigarette filter for the removal of smoke contents of cigarettes. We investigated the physical properties of charcoal added paper according to the ratio of pulps, the amounts of characoal , the weight of sheets and crimping conditions in dry method, and then analyzed the smoke contents of cigarettes. The results obtained were as follows. 1. Sw-BKP was higher than Hw-BKP in methylene blue absorption by UV test. 2. Charcoal had an effect on stiffness for decreasing factor greatly , while the addition amounts of Sw-BKP and high weigth of sheets increased it, and the interaction of weight of sheets and charcoal was higher than other factors. 3. Tear index decreased by charcoal addition greatly, on the other hand high weight of sheets and Sw-BKP/Hw-BKP ratio increased ter, and the interaction of pulps and chacoal acted on major factors. 4. We estimated crimp index with sensory evaluation , and charcoal hand an effect on decreasing factor in crimping greatly, while the interaction of weight of sheets and pulp ratio was higher than others. 5. In the case of charcoal added paper filter, tar removal efficiency of smoke contents was higher but about 6% than cigarette filter. Especially vapour phase(aldehyde) in smoke contents was removed greatly.

• 컴퓨터교육학회논문지
• /
• 제7권2호
• /
• pp.25-34
• /
• 2004

전국의 167개 시,도에 있는 교육과학연구원에서는 지역의 교사들이 개발한 각종 멀티미디어 교육 자료를 웹 서비스를 통해 전국의 교사들에게 제공하고 있다. 또한 한국교육학술정보원과 한국교육과정평가원에서도 교육 자료를 개발하고, 더불어 전국의 교육과학연구원에서 제공하는 교육 자료를 통합하려는 계획을 세우고 있다. 그 첫 출발점이 바로 2001년 개발된 한국교육학술정보원의 국가표준 교육정보 메타데이터 형식과 전국의 교육청이 작성하고 있는 교육자료 메타데이터이다. 이 메타데이터를 통해 전국의 교육 자료가 통합되어 서비스될 수 있을 것이다. 하지만 각 시도별로 작성된 메타데이터를 어떻게 통합하고 관리하느냐의 문제는 전국의 교육 자료를 통합하여 서비스하는데 있어, 먼저 해결해야 될 중요한 문제이다. 따라서 본 연구는 분산되어 있는 각 시도의 교육정보 메타데이터를 통합하여 서비스하는 방법으로 XML 웹 서비스 방법과 JDBC를 도입한 3 단계 (-ter) 시스템을 제안해 보았다. 제안된 두 방법을 MS SQL Server 2000과 Oracle 9i에 각각 적용하여 성능평가 한 결과 두 방법이 서로 비슷한 응답시간을 보였다. 따라서 XML 형태의 메타데이터를 검색하는 방법으로 기존의 JDBC를 사용하는 것 이외에 웹 서비스를 이용하는 방법도 고려해 볼 수 있다는 결론을 얻었다.

• Journal of Evidence-Based Herbal Medicine
• /
• 제2권2호
• /
• pp.17-24
• /
• 2009

Poria cocos has been traditionally used for the treatment of edema, scanty urine, dizziness due to retention of fluid, reduced appetite due to asthenia of spleen, loose stool, diarrhea, distraction, sudden palpitation and insomnia in East Asia. The aim of this study was to confirm whether Poria cocos wonfire whethe(PCWE) and Poria cocos ointment (PCO) have a preventive e of ter Pthe development of afire wdethe(PCWE (AD) in 2,4-Diniwhochlorobenzene (oria)-applied Balb/ wme e. Oral administration (12.5wmg/kg, 25wmg/kg) of PCWE and fire al application (O.5wmg/mouse, 1.0mg/mouse) of PCO decreased the development of AD-like skin lesions, ear swelling, spleen weight, total serum IgE. PCWE and PCO significantly also inhibited the infiltration of mast cells in the dorsal skin.

• 한국동물위생학회지
• /
• 제18권1호
• /
• pp.57-71
• /
• 1995

During the period of 2 years from 1993 to 1994, epidemiological investigation were carried out each time the outbreak of rabies suspected cases were informed and all specimens were transported to the Kangwon-do Veterinary Service Lab. At the Lab., autopsy and laboratory examinations were conducted as well. The results obtained as follows 1. The dogs and cattles were confirmed to be infected with rabies virus by routine histopathological findings, indirect flulrescent antibody technique, and mouth inoculation test. 2. The total numbers of rabies occured in dogs and cattles were 9, 5 heads, respectively. The regional distribution of total of 14 heads were 9 heads in Chulwon, 2 heads in Hwachun, 1 head Yangku, 2 heads in Inje and the highest number of outbreaks were orrured in Chulwon. 3. Most of dogs showed furious type and dumb type found in only one dog. 4. Cattles showed the symtoms of uneasiness feeling, excitement, disturbance howling, the change of voice, sexual accelaration, foreign body swatting and attacked to human and ani-mal and found to be died after two or four days. 5. In the seasonal outbreaks of rabies, 8 heads of the highest incidence were occured in win-ter followed by 4 heads in autumn, 1 head in spring and 1 head in summer. 6. The first outbreaks of rabies was reported in Chulwon and then transmitted into Hwachun, Yangku and Inje in turn. 7 The infectious source was supposed to be wild animals such as laccon dog, badger etc. living around the D. M. Z.