Journal of Evidence-Based Herbal Medicine

The Korean Society of Oriental Pharmacy (대한한약학회)
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Effects of Poria cocos Water Extract on DNCB-induced Atopic Dermatitis

  • Im, Lee-Rang (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Ahn, Ji-Young (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Jun-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Xin, Mingjie (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Yoo, Jae-Soo (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Song, Bong-Suk (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Song, Bong-Jun (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Dae-Keun (College of Life Science and Natural resources) ;
  • Kim, Ok-Jin (College of Life Science and Natural resources) ;
  • Lee, Hyun-A (College of Life Science and Natural resources) ;
  • Kim, Dae-Ki (Department of Immunology, Medical School, Chonbuk National University) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
  • Received : 2009.10.28
  • Accepted : 2009.12.07
  • Published : 2009.12.31
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Abstract

Poria cocos has been traditionally used for the treatment of edema, scanty urine, dizziness due to retention of fluid, reduced appetite due to asthenia of spleen, loose stool, diarrhea, distraction, sudden palpitation and insomnia in East Asia. The aim of this study was to confirm whether Poria cocos wonfire whethe(PCWE) and Poria cocos ointment (PCO) have a preventive e of ter Pthe development of afire wdethe(PCWE (AD) in 2,4-Diniwhochlorobenzene (oria)-applied Balb/ wme e. Oral administration (12.5wmg/kg, 25wmg/kg) of PCWE and fire al application (O.5wmg/mouse, 1.0mg/mouse) of PCO decreased the development of AD-like skin lesions, ear swelling, spleen weight, total serum IgE. PCWE and PCO significantly also inhibited the infiltration of mast cells in the dorsal skin.

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