• 산업경영시스템학회지
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• 제43권3호
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• pp.61-67
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• 2020

The fourth industrial revolution encourages manufacturing industry to pursue a new paradigm shift to meet customers' diverse demands by managing the production process efficiently. However, it is not easy to manage efficiently a variety of tasks of all the processes including materials management, production management, process control, sales management, and inventory management. Especially, to set up an efficient production schedule and maintain appropriate inventory is crucial for tailored response to customers' needs. This paper deals with the optimized inventory policy in a steel company that produces granule products under supply contracts of three targeted on-time delivery rates. For efficient inventory management, products are classified into three groups A, B and C, and three differentiated production cycles and safety factors are assumed for the targeted on-time delivery rates of the groups. To derive the optimized inventory policy, we experimented eight cases of combined safety stock and data analysis methods in terms of key performance metrics such as mean inventory level and sold-out rate. Through simulation experiments based on real data we find that the proposed optimized inventory policy reduces inventory level by about 9%, and increases surplus production capacity rate, which is usually used for the production of products in Group C, from 43.4% to 46.3%, compared with the existing inventory policy.

• Genomics & Informatics
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• 제12권2호
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• pp.50-57
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• 2014

We present a new next-generation sequencing-based method to identify somatic mutations of lung cancer. It is a comprehensive mutation profiling protocol to detect somatic mutations in 30 genes found frequently in lung adenocarcinoma. The total length of the target regions is 107 kb, and a capture assay was designed to cover 99% of it. This method exhibited about 97% mean coverage at $30{\times}$ sequencing depth and 42% average specificity when sequencing of more than 3.25 Gb was carried out for the normal sample. We discovered 513 variations from targeted exome sequencing of lung cancer cells, which is 3.9-fold higher than in the normal sample. The variations in cancer cells included previously reported somatic mutations in the COSMIC database, such as variations in TP53, KRAS, and STK11 of sample H-23 and in EGFR of sample H-1650, especially with more than $1,000{\times}$ coverage. Among the somatic mutations, up to 91% of single nucleotide polymorphisms from the two cancer samples were validated by DNA microarray-based genotyping. Our results demonstrated the feasibility of high-throughput mutation profiling with lung adenocarcinoma samples, and the profiling method can be used as a robust and effective protocol for somatic variant screening.

• BMB Reports
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• 제47권3호
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• pp.173-178
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• 2014

There is rapidly growing interest in the human microbiome because of its implication in metabolic disorders and inflammatory diseases. Consequently, understanding the biology of short chain fatty acids and their receptors has become very important for identifying novel therapeutic avenues. GPR41 and GPR43 have been recognized as the cognate receptors for SCFAs and their roles in metabolism and inflammation have drawn much attention in recent years. GPR43 is highly expressed on immune cells and has been suggested to play a role in inflammatory diseases such as inflammatory bowel disease. Both GPR41 and GPR43 have been implicated in diabetes and obesity via the regulation of adipose tissue and gastrointestinal hormones. So far, many studies have provided contradictory results, and therefore further research is required to validate these receptors as drug targets. We will also discuss the synthetic modulators of GPR41 and GPR43 that are critical to understanding the functions of these receptors.

• BMB Reports
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• 제51권3호
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• pp.119-125
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• 2018

The Hippo pathway plays prominent and widespread roles in various forms of human carcinogenesis. Specifically, the Yes-associated protein (YAP), a downstream effector of the Hippo pathway, can lead to excessive cell proliferation and the inhibition of apoptosis, resulting in tumorigenesis. It was reported that the YAP is strongly elevated in multiple types of human malignancies such as breast, lung, small intestine, colon, and liver cancers. Recent work indicates that, surprisingly, Hippo signaling components' (SAV1, MST1/2, Lats1/2) mutations are virtually absent in human cancer, rendering this signaling an unlikely candidate to explain the vigorous activation of the YAP in most, if not all human tumors and an activated YAP promotes the resistance to RAF-, MAPK/ERK Kinase (MEK)-, and Epidermal growth factor receptor (EGFR)-targeted inhibitor therapy. The analysis of YAP expressions can facilitate the identification of patients who respond better to an anti-cancer drug treatment comprising RAF-, MEK-, and EGFR-targeted inhibitors. The prominence of YAP for those aspects of cancer biology denotes that these factors are ideal targets for the development of anti-cancer medications. Therefore, our report strongly indicates that the YAP is of potential prognostic utility and druggability in various human cancers.

• 한국의류산업학회지
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• 제17권2호
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• pp.258-264
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• 2015

This study provides abasis for the development of high functional cycle wear with clothing comfort and fitness for highschool boy cyclists by a comparison of the somatotype of highschool boys cyclists and general highschool boys. This study directly measured 44 anthropometric targeted cyclists across Korea. "The sixth national standard physical survey" data targeted 16 to 18-year-old male adolescents; subsequently, anthropometric measurement data was provided by 766 people for research. Highschool boy cyclists used t-test to compare the differences in body type. The results in this study are follows. Highschool boys cyclists(compared to regular highschool boys) indicated a great somatotype stature and weight. The differences in the cervical height and the acromion height results of, cyclist appeared smaller. Cyclists angle of shoulder was smaller. The upper body of highschool boys cyclist was greater than the difference between chest breadth and bust breadth with along biacromion length. The waist front length of the cyclist was a short cycle ride upon the attitude of the streamlined. Highschool boy cyclists indicated that the muscles of the arm portion was more developed compared to general highschool boys. The lower body had less abdominal fat with a significantly developed thigh and calf.

• East Asian Economic Review
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• 제21권1호
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• pp.3-27
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• 2017

This paper studied the effects of anti-dumping measures on the imports to investigate whether the trade restriction effect of an anti-dumping duty is dominant. Our results indicate that a 1% increase in the anti-dumping duties decreases the import of the targeted product by about 0.43~0.51%. The actual statistics, however, show that the total import of the targeted products increased by about 30 percent while an anti-dumping duty was in force. That indicates that an anti-dumping duty is just a temporary import relief. This paper also investigated whether an anti-dumping duty is terminated in the case that the injury would not be likely to continue or recur if the duty were removed. The hazards model estimates show that increase in market share, MFN tariff rate, and dumping margin decrease the hazard of termination of an anti-dumping duty, but the increase in value added increases the hazard of termination. Generally speaking, this result indicates that the WTO member countries have regulated the overuse of an anti-dumping measure. The findings of this paper show that there is a country- and industry-wise heterogeneous characteristic in the effect as well as termination of an anti-dumping duty.

• Journal of Microbiology and Biotechnology
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• 제13권2호
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• pp.317-320
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• 2003

Genome-wide systematic deletion mutants were generated using a PCR-based targeted mutagenesis of Schizosacchaaromyces pombe. In a drug-sensitivity assay using thiabendazole(TBZ), an inhibitor of microtubule assembly, a heterozygous nda2 mutant ($nda2^+/nda2^-$), deleting one copy of nda2 encoding the microtubule subunit alpha1 demonstrated a distinct sensitivity to TBZ, indicating TBZ-induced haploinsufficiency. This result suggests that profiling drug-induced haploinsufficiency can be exploited to identify target genes for drugs and discover new drugs.

• Communications for Statistical Applications and Methods
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• 제17권6호
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• pp.879-889
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• 2010

본 논문은 국민계정의 문화부문 위성계정인 문화위성계정의 체계와 우리나라가 문화위성계정을 작성하기 위해 필요한 사항 등을 내용으로 한다. 문화위성계정은 각기 개별적 기능을 갖는 5개 부문으로 구성하도록 권고되고 있다. 동 권고안에 의하면 제 1부문부터 제 4부문까지는 각각 해당부문의 공급과 수요측면의 통계를 수록하도록 되어 있고, 제 5부문은 참고사항 모듈(documentation module)로 편제하도록 권고되고 있다. 문화위성계정의 제 1부문은 문화활동 개요 모듈(macro-information module), 제 2부문은 문화생산량 모듈(quantity/volume output module), 제 3부문은 특성 모듈(characterization module), 제 4부문은 목표분석 모듈(targeted analysis/analytical module)로 구성된다.

• Nuclear Engineering and Technology
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• 제48권2호
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• pp.505-517
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• 2016

The structural integrity of a dual-purpose metal cask currently under development by the Korea Radioactive Waste Agency (KORAD) was evaluated, through numerical simulations and a model test, under high-speed missile impact reflecting targeted aircraft crash conditions. The impact conditions were carefully chosen through a survey on accident cases and recommendations from literature. In the impact scenario, a missile flying horizontally hits the top side of the cask, which is freestanding on a concrete pad, with a velocity of 150 m/s. A simplified missile simulating a commercial aircraft engine was designed from an impact loade-time function available in literature. In the analyses, the dynamic behavior of the metal cask and the integrity of the containment boundary were assessed. The simulation results were compared with the test results for a 1:3 scale model. Although the dynamic behavior of the cask in the model test did not match exactly with the prediction from the numerical simulation, other structural responses, such as the acceleration and strain history during the impact, showed very good agreement. Moreover, the containment function of the cask survived the missile impact as expected from the numerical simulation. Thus, the procedure and methodology adopted in the structural numerical analyses were successfully validated.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2007년도 Proceedings of The Convention
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• pp.19-27
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• 2007

An important potential of metabolomics-based approach is the possibility to develop fingerprints of diseases or cellular responses to classes of compounds with known common biological effect. Such fingerprints have the potential to allow classification of disease states or compounds, to provide mechanistic information on cellular perturbations and pathways and to identify biomarkers specific for disease severity and drug efficacy. Metabolic profiles of biological fluids contain a vast array of endogenous metabolites. Changes in those profiles resulting from perturbations of the system can be observed using analytical techniques, such as NMR and MS. $^1H$ NMR was used to generate a molecular fingerprint of serum or urinary sample, and then pattern recognition technique was applied to identity molecular signatures associated with the specific diseases or drug efficiency. Several metabolites that differentiate disease samples from the control were thoroughly characterized by NMR spectroscopy. We investigated the metabolic changes in human normal and clinical samples using $^1H$ NMR. Spectral data were applied to targeted profiling and spectral binning method, and then multivariate statistical data analysis (MVDA) was used to examine in detail the modulation of small molecule candidate biomarkers. We show that targeted profiling produces robust models, generates accurate metabolite concentration data, and provides data that can be used to help understand metabolic differences between healthy and disease population. Such metabolic signatures could provide diagnostic markers for a disease state or biomarkers for drug response phenotypes.