• Structural Engineering and Mechanics
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• v.36 no.5
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• pp.575-598
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• 2010

The shape and size of the plastic zone around the crack tip are analyzed under pure mode I, pure mode II and mixed mode (I+II) loading for small scale yielding and for both plane stress and plane strain conditions. A new analytical formulation is presented to determine the radius of the plastic zone in a non-dimensional form. In particular, the effect of T-stress on the plastic zone around the crack tip is studied. The results of this investigation indicate that the stress field with a T-stress always yields a larger plastic zone than the field without a T-stress. It is found that under predominantly mode I loading, the effect of a negative T-stress on the size of the plastic zone is more dramatic than a positive T-stress. However, when mode II portion of loading is dominating the effect of both positive and negative T-stresses on the size of the plastic zone is almost equal. For validating the analytical results, several finite element analyses were performed. It is shown that the results obtained by the proposed analytical formulation are in very good agreements with those obtained from the finite element analyses.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.2
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• pp.135-144
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• 2009

In this present work, spline FEA for the trimmed NURBS surface of the 2D linear elasticity problem is presented. The main benefit of the proposed method is that no additional efforts for modeling of trimmed NURBS surfaces are needed and the information of the trimming curves and trimmed surfaces exported from the CAD system can be directly used for analysis. For this, trimmed elements are searched by using NURBS projection scheme. The integration of the trimmed elements is performed by using the NURBS-enhanced integration scheme. The formulation of constructing stiffness matrix of trimmed elements is presented. In this formulation, the information of the trimming curve is used for calculating the Jacobian as well as for obtaining integration points. The robustness and effectiveness of the proposed method are investigated through various numerical examples.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.6
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• pp.384-395
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• 2018

The aim of this study was to investigate whether a novel formulation of an herbal extracts has an inhibitory effect on obesity. To determine its anti-obesity effects, we performed anti-obesity-related experiments in vitro and in vivo. Thus, our present study was carried out to evaluate the anti-obesity effect of herbal extracts using a high fat diet (HFD)-induced obese mouse model and 3T3-L1 adipose cells. The effects of each herbal extracts on lipid accumulation in 3T3-L1 cells were examined using Oil Red O staining. Results showed that treatment with each herbal extracts at $10{\sim}100{\mu}g/ml$ had no effect on cell morphology and viability. Without evidence of toxicity, herbal extracts treatment decreased lipid accumulation compared with the untreated adipocytes controls as shown by the lower absorbance of Oil Red O stain. Futhermore, compared with control-differentiated mature adipocytes, each herbal extracts significantly inhibited lipid accumulation in mature 3T3-L1 adipocytes. In the HFD-fed obese mice, body weight, liver weight and white adipose tissue weights were significantly reduced by mixture of herbal extracts administration in mouse skin. Futhermore, we found that mixture of herbal extracts administration suppressed serum triglyceride (TG), and total cholesterol (TCHO) in HFD-induced obese mouse model. The mixture of herbal extracts of permeability was estimated by measuring the transepithelial electrical resistance (TEER) value in pig skin. The optimized formulations of herbal extracts (Test 3 formulation) showed skin permeation. However, test 1 formulation containing essential oil as enhancer showed maximum skin permeation. After confirming the enhanced skin permeability, in vivo studies were performed to assess whether skin irritation potential on the basis of a primary irritation index (PII) in rabbit skin. Reactions were scored for erythema/edema reactions at 24 h, 48 h and 72 h post-application. It was concluded that the test 1 formulation was not irritation (PII = 0). The present study suggests that the test 1 formulation might be of therapeutic interest with respect to the treatment of obesity.

• Structural Engineering and Mechanics
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• v.15 no.1
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• pp.1-19
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• 2003

This paper presents the formulation of a new bridge-vehicle system with validation using the field data. Both pitching and twisting modes of the vehicle are considered in the contribution of the dynamic effects in the bridge responses. A heavy vehicle was hired as a control vehicle with known axle weight, axle spacing and spring coefficients. The measured responses were generated from the control vehicle running at a particular speed at a test span at Ma Tau Wai Flyover. The measured responses were acquired using strain gauges installed beneath the girder beams of the test bridge. The simulated responses were generated using BRVEAN that is a self-developed program based on the proposed bridge-vehicle system. The validation shows that the bridge model is valid for representing the test bridge and the governing equations are valid for representing the motion of moving vehicles.

• The Journal of Internal Korean Medicine
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• v.42 no.6
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• pp.1349-1355
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• 2021

Objectives: The aim of this study was to evaluate the effectiveness of additional administration of Banha-sasim-tang formulation to patients with gastrointestinal symptoms that did not improve with Western medicines. Methods: The patients who met the inclusion and exclusion criteria were analyzed retrospectively. A paired t-test was performed on the Nepean Dyspepsia Index-Korean version (NDI-K) scores before and after administering the Banha-sasim-tang formulation. Results: A total of 27 subjects were included. The mean duration of taking the Banha-sasim-tang formulation was 15.6±3.1 days. The most commonly used Western medicine before taking the Banha-sasim-tang formulation was rebamipide. The means of the NDI-K score were 57.4±21.8 before administering Banha-sasim-tang formulation and 34.9±16.5 after administration, and the difference was statistically significant (p<0.0001). No serious side effects were encountered while taking the Banha-sasim-tang formulation. Conclusions: For patients whose gastrointestinal symptoms do not improve with Western medicines, additional administration of Banha-sasim-tang formulation may be an option. However, as this study is a retrospective chart review, prospective, large-scale, double-blind studies are needed in the future.

• Computational Structural Engineering
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• v.9 no.1
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• pp.101-113
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• 1996

In this paper, the finite element formulation for the thermal analysis of quasi-static, uncoupled, homogeneous, isotropic and linear viscoelastic problems is presented based on the principle of virtual work. The viscoelastic material is assumed to be thermorheologically simple, which is well known material property in a large class of high polymers. The variational formulation and the finite element equation in matrix from are derived. Effective generation and storage of the hereditary stiffness matrices are given in detail especially for the case of the steady state temperature distribution T=T(x). Some numerical examples are given and compared with published results to show the versatility of the derived finite element formulations.

• Journal of the Korean Operations Research and Management Science Society
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• v.19 no.1
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• pp.201-206
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• 1994

The linear search problem is concerned with finding a hiden target on the real line R. The position of the target governed by some probability distribution. It is desired to find the target in the least expected search time. This problem has been formulated as an optimization problem by a number of authors without making use of Markov Decision Process (MDP) theory. It is the aim of the paper to give a (MDP) formulation to the search problem which we feel is both natural and easy to follow.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.7
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• pp.1159-1169
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• 2003

This paper investigates the effects of T-stress and plastic hardening mismatch on the interfacial crack-tip stress field via finite element analyses. Plane strain elastic-plastic crack-tip fields are modeled with both MBL formulation and a full SEC specimen under pure bending. Modified Prandtl slip line fields illustrate the effects of T-stress on crack-tip constraint in homogeneous material. Compressive T-stress substantially reduces the interfacial crack-tip constraint, but increases the J-contribution by lower hardening material, J$\_$L/. For bimaterials with two elastic-plastic materials, increasing plastic hardening mismatch increases both crack-tip stress constraint in the lower hardening material and J$\_$L/. The fracture toughness for bimaterial joints would consequently be much lower than that of lower hardening homogeneous material. The implication of unbalanced J-integral in bimaterials is also discussed.

• Journal of Microbiology and Biotechnology
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• v.32 no.2
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• pp.160-169
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• 2022

In the present study we evaluated the efficacy of a bioformulation of Streptomyces cameroonensis for control of black pod disease in cocoa and enhancement of seedling growth. The formulation developed using talc powder and cassava starch as carriers showed high shelf-life of 1.07 × 10⁶ CFU/g after six months storage at 4℃. The formulation was tested for inhibition of spore germination in Phytophthora megakarya and showed 100% inhibition at 10% (w/v) of formulation. To determine the efficacy of the formulation, we performed an in planta assay in the greenhouse on two hybrids of cocoa seedlings, the tolerant SNK413 × (♂) T79/467 and the susceptible UPA 134× (♂) SCA 12. Detached leaf assay showed a significant reduction in the disease severity index of about 67% for the tolerant hybrid and 55% for the susceptible hybrid compared to non-treated plants. A significant enhancement in stem length, leaf surface area and root weight was observed. Analysis of biochemical markers of defense showed a significant increase in total polyphenol, flavonoid, and total protein contents. There was also significant upregulation of PR-proteins such as chitinases, peroxidases and β-1, 3-glucanases following treatment of both tolerant and susceptible hybrids, though with a higher level of synthesis in the tolerant hybrids. A significant increase was also observed in polyphenol oxidase activities in plants treated with the formulation. This work demonstrated the stability and effectiveness of the S. cameroonensis powder formulation in suppressing black pod disease in cocoa and subsequently enhancing the growth of seedlings.

• Journal of Pharmaceutical Investigation
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• v.38 no.1
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• pp.73-78
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• 2008

To evaluate the bioequivalence of two ramipril formulations, a standard 2-way randomized cross-over study was conducted in twenty-six healthy male Korean volunteers. A single oral dose of 10 mg of test formulation $Ramiprin^{(R)}$ (tablet) or reference formulation Tritace $Protect^{(R)}$ (tablet) was administered with one-week washout period. Plasma concentrations of ramipril were assayed over a period of 12 hr with a well validated method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The values of area under the plasma concentration-time curve, from time zero to last sampling time $(AUC_t)$ and from time zero to time infinity $(AUC_{inf})$ were $77.45{\pm}44.78\;and\;78.96{\pm}45.64$ for test, and $70.30{\pm}42.27\;and\;71.99{\pm}43.55ng\;hr/mL$ for reference formulation, respectively. Similarly, maximum concentration $(C_{max})$ and elimination half-life $(t_{1/2})$ were $65.61{\pm}19.96ng/mL$ and $2.15{\pm}0.75hr$ for test, and $63.63{\pm}25.50ng/mL$ and $2.16{\pm}0.73hr$ for reference formulations, respectively. Time to reach maximum concentration $(T_{max})$ for the test and the reference, were $0.51{\pm}0.22hr\;and\;0.52{\pm}0.18hr$, respectively. The parametric 90% confidence intervals on the mean of the differences between the two formulations (test-reference) of the log-transformed values of $AUC_t\;and\;C_{max}$ were 1.03 to 1.19 and 0.98 to 1.17, respectively. The overall results indicate that the two formulations are bioequivalent and can be prescribed interchangeably.