• 해양환경안전학회지
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• 제18권4호
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• pp.336-344
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• 2012

해양에서 발생하는 사고는 선박, 선원 및 해운기업뿐만 아니라 사회 전반에도 매우 큰 영향을 미치며, 따라서 해양사고가 발생하였을 경우, 이를 신속하고 효율적으로 구난하는 것은 매우 중요하다. 특히, 대규모 해양오염이나 인명사고를 수반하는 해양사고는 매우 심각한 피해를 발생시킬 수 있기 때문에 해양사고를 당한 인명, 선박 및 재산을 효율적이고, 신속하게 구난하는 것은 특히 중요하다. 그러나 국내의 해양구난을 위한 역량은 매우 빈약한 상황이며, 비교적 좋은 장비 등을 갖추고 있는 해양경찰 또는 해군 등 공공부문과는 달리 민간구난업은 매우 열악한 기술적 및 경제적 상황에 처해 있다. 해양구난은 단순히 경제적 측면의 중요성뿐만 아니라 국가 안보적 측면에서의 중요성도 있기 때문에 이를 활성화하는 것은 매우 중요한 문제이다. 이에 본고에서 해양구난을 활성화하기 위한 방안을 법제도적 측면에서 검토하고 관련 개선방안을 제시하고자 한다. 개선안은 민간 및 공공부문을 포함한 전체적 활성화 방안과 민간부문의 활성화 방안을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4759-4768
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• 2015

Background: Several studies have investigated predictive and prognostic biomarkers for patients treated with anti-epidermal growth factor receptor (EGFR) agents in lung cancer. However, the conclusion is controversial. Materials and Methods: A meta-analysis was conducted to evaluate the associations of mutant K-ras, PIK3CA and PTEN deficiency with the efficacy of anti-EGFR agents in lung cancer. The primary endpoint was objective response rate (ORR). The secondary endpoints were overall survival (OS) and progression-free survival (PFS). Results: A total of 61 studies were included in the final meta-analysis. The result showed that K-ras mutation was a good predictor for ORR (RR=0.42, 95%CI, 0.33-0.55, p=0.000) and an effective prognostic marker for OS (HR=1.37, 95%CI, 1.15-1.65, p=0.001) and PFS (HR=1.33, 95%CI, 1.05-1.69, p=0.019). However, PTEN deficiency or PIK3CA mutation did not show any significance predictive value for ORR (PTEN, RR=0.82, 95%CI, 0.56-1.19, p=0.286; PIK3CA, RR=1.08, 95%CI, 0.17-6.66, P=0.938). And PTEN deficiency or expression of PIK3CA did not show significance prognostic value for OS (PTEN, HR=0.88, 95%CI, 0.31-2.46,P=0.805; PIK3CA, HR=0.79, 95%CI: 0.23-2.68, P=0.706). Conclusions: Our meta-analysis showed that K-ras mutation may be an effective predictor in lung cancer patients treated with anti-EGFR agents. Whereas, the predictive and prognostic value of PTEN deficiency and PIK3CA mutation need to be further investigated.

• 동아시아식생활학회지
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• 제20권1호
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• pp.1-10
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• 2010

This was conducted to investigate the dietary assessment, food preferences, snack intake, priority order in food purchase, and knowledge of diet of full-time housewives and working housewives through the use of a questionnaire. The participants (127 working housewives and 86 housewives) were selected at random from Seoul and its vicinity. The predominant job reported by working housewives was saleswomen and specialized job (20.7%). The average monthly income of both housewives and working housewives ranged from 3,000,000 to 5,000,000 won. Forty percent of housewives consumed more meat, fish, eggs, beans, and tofu, while 50.0% of housewives ate vegetables other than kimchi at every meal, 51.2% of housewives consumed one serving of fruit and one cup of fruit juice, 45.3% of housewives consumed three regular meals, and 60.5% of housewives consumed a balanced diet when compared with working housewives (p<0.05). Working housewives consumed beverages, ice cream, milk, and dairy products, while housewives consumed breads, sweet potato, potato, and fruit as snacks. The preference that most often led to food selection was flavor among working housewives (67.7%) and housewives (64.0%). Both working housewives and housewives always confirmed the day of food production. Generally, housewives were more interested in learning about food, creating a dietary plan, nutrient loss during cooking and reducing waste food when compared with working housewives. Housewives appeared to have better dietary assessment and knowledge than working housewives. Accordingly, it is advisable to prepare more systemic education programs for working housewives.

• Journal of Periodontal and Implant Science
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• 제44권1호
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• pp.33-38
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• 2014

Purpose: Autogenous bones are frequently used because of their lack of antigenicity, but good osteoconductive and osteoinductive properties. This study evaluated the biological behavior of perforated and nonperforated cortical block bone grafts. Methods: Ten nonsmoking patients who required treatment due to severe resorption of the alveolar process and subsequent implant installation were included in the study. The inclusion criteria was loss of one or more teeth; the presence of atrophy of the alveolar process with the indication of reconstruction procedures to allow rehabilitation with dental implants; and the absence of systemic disease, local infection, or inflammation. The patients were randomly divided into two groups based on whether they received a perforated (inner surface) or nonperforated graft. After a 6-month healing period, a biopsy was performed and osseointegrated implants were installed in the same procedure. Results: Fibrous connective tissue was evident at the interface in patients who received nonperforated grafts. However, full union between the graft and host bed was visible in those who had received a perforated graft. Conclusions: We found that cortical inner side perforations at donor sites increased the surface area and opened the medullary cavity. Our results indicate an increased rate of graft incorporation in patients who received such perforated grafts.

• Journal of Periodontal and Implant Science
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• 제24권3호
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• pp.529-540
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• 1994

Rapidly progressive periodontitis is known to be usually associated with systemic problems and improved with antibiotic therapy. Recent experiments in which bioresorbable polycaprolactone was polymerized with minocycline has shown that the system released effective antibiotic concentration during the 7 days' period. This clinical trial was to compare the efficacy of a minocycline film(poly-caprolactone+polyglycol+10% minocycline) insertion plus supragingival scaling(MS) or subgingival scaling & root planing(MSRP) with the scaling(S) or subgingival scaling & root planing alone(SRP), at improving the periodontal condition in RPP. Fifteen patients were examined for plaque accumulation, gingival inflammation, probing depth and attachment loss at baseline, then 1, 2, 4 and 8 weeks after 4 treatment regimens were randomly undergone in 4 comparable sites(PD>5mm, LA>3mm) in each subject. Results revealed statistically significant treatement effect with a reduction in a probing depth in SRP(2.0mm), MS(1.8mm), and MSRP(2.1mm). There was no significant reduction in the supragingival scaling alone group(0.6mm). Similarly, attachment levels were significantly improved in the SRP(1.5mm), MS(2.0mm) and MSRP(2.0mm) groups. Net % BOP reduction at 8 week compared to baseline was 6.7% (S), 26.7% (MS), 26.7% (SRP), and 33.3% (MSRP). MSRP produced the greatest improvement in BOP at 8 week. This data suggests that a subgingival minocycline delivery system as a adjunct to scaling alone or scaling & root planing may produce significant clinical benefits over scaling alone in rapidly progressive periodontitis patients.

• 한국전산구조공학회논문집
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• 제26권6호
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• pp.415-421
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• 2013

본 논문에서는 면진시스템이 원전에 적용될 경우 원전구조물의 생애주기 성능에 미치는 영향을 소개한다. 최근 내진설계와 더불어 강진발생 예상 지역에 적용을 목적으로 개발되는 면진시스템은 구조물을 장주기화하여 응답가속도를 줄이고 상대변위를 늘려줌으로써 구조물의 안전성을 증진시키는 것으로 알려져 있다. 따라서, 구조물의 안전성이 중요시되는 원전구조물에 면진시스템을 적용하기 위한 연구가 국내에서 진행 중에 있다. 본 연구에서는 원전구조물의 생애주기 성능분석에 있어서 특징을 분석하고, 면진시스템이 적용될 경우 원전구조물의 생애주기성능에 있어서 미치는 영향을 평가함으로써, 도출된 결과를 면진시스템 적용의 정량적인 타당성 평가에 활용할 수 있다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권2호
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• pp.107-111
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• 2013

Careful examination of the oral cavity may reveal findings indicative of an underlying systemic condition, and allow for early diagnosis and treatment. Examination should include evaluation for mucosal changes, periodontal inflammation and bleeding, and general condition of the teeth. A 12-year-old man visited for molar pain during 3 months. He was diagnosed with having a possibility of hematopoietic malignancy, showing the loss of lamina dura, destruction of bony crypt, and high attenuation in the bone marrow. He was referred to department of pediatrics, additional study, including peripheral cell morphology and bone marrow exam, were performed, and diagnosed as acute lymphoblastic anemia. Despite chemotherapy to cure leukemia, he was expired 8 months after initial diagnosis. The purpose of this report is to promote and evoke the awareness regarding an initial examination of the dentist to make an effort to acquire accurate knowledge and information about life-threatening disease in usual dental practice.

• 한국임상수의학회지
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• 제23권2호
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• pp.186-189
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• 2006

7개월된 암컷 Cocker spaniel견이 3주전부터 체중감소, 구토, 탈수, 식욕저하를 보이면서 지속적인 미열을 동반한 다음과 다뇨를 주증상으로 시내 병원에 내원하였다. 담당 수의사의 진료내역을 검토한 결과 복수와 간종대, 혈액 도말 검사에서 비재생성빈혈과 흉부방사선 사진에서 좌측 중심부에 불규칙한 음영이 관찰된 것으로 기록되었다. 이후 prednisolone으로 치료하였지만 증상의 경과가 호전되지 않아 정밀진단을 위하여 환자의 혈액을 강원대학교 부속동물 병원에 분석, 의뢰하였다. 혈액화학검사에서 고칼슘혈증, 고질소혈증, 콜레스테롤혈증, 고인혈증, 저알부민혈증 및 대사성 산증을 보였으며 뇨검사에서 단백뇨를 동반한 약산성의 등장뇨가 관찰되었다. 임상증상과 실험실 소견에 근거하여 간과 신장에 대한 정밀한 검사를 위하여 입원을 요청하였으나 다음 날 환자는 폐사한 상태로 병원에 후송되었다. 보호자의 동의를 얻어 부검과 조직병리학적인 검사를 실시한 결과 간, 신장, 비장 등의 전신 장기에 과량의 아밀로이드가 침착되어 있음을 확인하였다.

• Biomolecules & Therapeutics
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• 제23권5호
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• pp.449-457
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• 2015

The present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and mice, respectively. Male ICR mice were orally administered MB12662 (5, 10, 25 or 50 mg/kg) for 10 days, during which intraperitoneally challenged with cisplatin (3.5 mg/kg) from day 4 to 7, and sacrificed on day 10 for the pathological examination. Male ferrets were orally administered MB12662 (25, 50 or 100 mg/kg) for 7 days, subcutaneously challenged with cisplatin (5 mg/kg), and monitored for vomiting reflexes and survival of the animals. Four-day injection of cisplatin (3.5 mg/kg) to mice caused body weight loss and degeneration and atrophy of intestinal villi, reducing villi/crypt ratio to a half level of control animals. Cisplatin also induced renal and hepatic toxicities, and depletion of splenocytes and bone marrow progenitor cells. The systemic toxicities including decreased villi/crypt ratio, immune system atrophy, splenocyte depletion, and decreased cellularity in bone marrow were improved by MB12662. Cisplatin (5 mg/kg) induced retching and emetic responses of ferrets, which were remarkably attenuated by MB12662 in a dose-dependent manner. All the ferrets pretreated with MB12662 survived the challenge of cisplatin, in comparison with 40% mortality in vehicle-treated animals, and blood parameters of nephrotoxicity and hepatotoxicity were markedly recovered. It is expected that MB12662 could be a candidate for the body protection against burden, including emesis, of chemotherapeutic agents.

• Journal of Chest Surgery
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• 제25권2호
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• pp.176-182
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• 1992

From April 1977 to March 1991, 44 patients have undergone excision of intracardiac myx-omas, 36 cases were located in the left atrium[81.6%], 3 cases in the right atrium[6.6%], 2 cases in the right ventricle[4.5%], 3 cases in the left ventricle[6.6%], There were 32 female and 12 male. The mean age of patients was 39.6$\pm$12.3 years[ranged 11 to 67 years]. The major preoperative symptoms included exertional dyspnea in 35[79.6%], palpitation in 23[52.3%], syncopal episodes in 9[20.4%], and signs of systemic illness; low-grade fever, weight loss, arthralgia, headache and so on. The diagnosis was made by echocardiography alone in 7[15.9%], and by combination of angiography and echocardiography in 37[84.1%]. The weight of the tumor ranged from 15 to 115gm[mean weight, 47.6$\pm$27.6gm], and the volum of the tumor was 129.1cm3[$\pm$149.0]. Follow-up time ranged from 0.6 to 9 years[mean follow-up, 65$\pm$3.22 years]. There were no early and late deaths during the follow-up period. Tumor recurred in one patient with left atrial myxoma 8 years later, who underwent successful reoperation. Postoperative complications occurred in 12 patients: episodes of sup-raventricular arrhythmia in 7, convulsion in 2, wound problem in 2, tricuspid valve regurgitation in 1, massive bleeding in 1, and intubation granuloma in one. In conclusion, surgical excision of the myxoma can be considered curative with excellent long-term result.