DOI QR코드

DOI QR Code

Differential Diagnosis of Oral Lesions for the Initial Diagnosis of Acute Lymphoblastic Leukemia

급성림프모구성 백혈병의 조기진단 시 구강병변 양상을 통한 감별의 중요성

  • Seo, Mi Hyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Ha, Ji Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Huh, Kyung Hoe (Department of Oral and Maxillofacial Radiology, School of Dentistry, Seoul National University) ;
  • Cho, Young Ah (Department of Oral Pathology, School of Dentistry, Seoul National University) ;
  • Kim, Soung Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Choi, Jin Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
  • 서미현 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 하지영 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 허경회 (서울대학교 치의학대학원 구강악안면방사선학교실) ;
  • 조영아 (서울대학교 치의학대학원 구강병리학교실) ;
  • 김성민 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 최진영 (서울대학교 치의학대학원 구강악안면외과학교실)
  • Received : 2012.10.30
  • Accepted : 2013.03.20
  • Published : 2013.03.31

Abstract

Careful examination of the oral cavity may reveal findings indicative of an underlying systemic condition, and allow for early diagnosis and treatment. Examination should include evaluation for mucosal changes, periodontal inflammation and bleeding, and general condition of the teeth. A 12-year-old man visited for molar pain during 3 months. He was diagnosed with having a possibility of hematopoietic malignancy, showing the loss of lamina dura, destruction of bony crypt, and high attenuation in the bone marrow. He was referred to department of pediatrics, additional study, including peripheral cell morphology and bone marrow exam, were performed, and diagnosed as acute lymphoblastic anemia. Despite chemotherapy to cure leukemia, he was expired 8 months after initial diagnosis. The purpose of this report is to promote and evoke the awareness regarding an initial examination of the dentist to make an effort to acquire accurate knowledge and information about life-threatening disease in usual dental practice.

Keywords

References

  1. Chi AC, Neville BW, Krayer JW, Gonsalves WC. Oral manifestations of systemic disease. Am Fam Physician 2010;82:1381-8.
  2. Sapp JP, Eversole LR, Wysocki GP, editors. Contemporary oral & maxillofacial pathology. St. Louis: Mosby; 1998.
  3. Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer 1995;75:2186-95. https://doi.org/10.1002/1097-0142(19950415)75:8<2186::AID-CNCR2820750825>3.0.CO;2-F
  4. Margolin JF, Steuber CP, Poplack DG. Acute lymphoblastic leukemia. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 4th ed. Philadelphia: Lippincott-Raven; 2001. p.489.
  5. Buffler PA, Kwan ML, Reynolds P, Urayama KY. Environmental and genetic risk factors for childhood leukemia: appraising the evidence. Cancer Invest 2005;23:60-75. https://doi.org/10.1081/CNV-46402
  6. Brunning RD, Flandrin G, Borowitz M, et al. Precursor B lymphoblastic leukemia/lymphoblastic lymphoma (precursor Bcell acute lymphoblastic leukemia). In: Jaffe ES, Harris NL, Stein H, et al ; World Health Organization Classification of Tumors, editors. Pathology and genetics of tumors of hematopoietic and lymphoid tissues. Lyon: IARC Press; 2001. p.111.
  7. McKenna SJ. Leukemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:137-9. https://doi.org/10.1067/moe.2000.102386
  8. Aster J, Kumar V. White cells and lymph nodes. In: Cotran RS, Kumar V, Collins T, editors. Robbins pathologic basis of disease. 6th ed. Kidlington, Oxford: WB Saunders; 1999. p.657-8.
  9. Barrett AP. A long-term prospective clinical study of oral complications during conventional chemotherapy for acute leukemia. Oral Surg Oral Med Oral Pathol 1987;63:313-6. https://doi.org/10.1016/0030-4220(87)90196-4
  10. Adeyemo TA, Adeyemo WL, Adediran A, Akinbami AJ, Akanmu AS. Orofacial manifestation of hematological disorders: hemato-oncologic and immuno-deficiency disorders. Indian J Dent Res 2011;22:688-97. https://doi.org/10.4103/0970-9290.93458
  11. Lund DI, Rodd H, Craig GT. Burkitt's lymphoma presenting with jaw lesions in a young white girl. Br J Oral Maxillofac Surg 1997;35:438-41. https://doi.org/10.1016/S0266-4356(97)90723-3