• 대한본초학회지
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• 제29권2호
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• pp.7-13
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• 2014

Objectives : Chronic mild stress (CMS) model is currently recognized as a better animal model of depression. The purpose of this study was to investigate the antidepressant-like effects of the Nelumbo nucifera leave extract using CMS model. Methods : The antidepressant-like effects of Nelumbo nucifera leaves extract was determined by using animal models of depression. Male ICR mice were divided into four groups: saline-treated normal, without CMS; saline-treated stress control; CMS+ Imipramine(20mg/kg); CMS+Nelumbo nucifera leaves extract(200mg/kg). All mice except the normal group exposed an unpredicted sequence of chronic mild stressors for 5 weeks. The behavior of mice were detected by sucrose preference test, forced swim test and tail suspension test. Then concentration of corticosterone in serum was detected by enzyme immunoassay. Results : Nelumbo nucifera leaves extract administration by daily gavage from the 3rd week exhibited an antidepressant-like effect on CMS-induced depression in mice. Nelumbo nucifera leaves extract administration at dose of 200 mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. Conclusions : Chronic mild stress can affect mouse behavior and corticosterone level and cause depression. The present experiments not only further confirm the antidepressant-like effects of Nelumbo nucifera leaves extract in the sucrose preference test, forced swimming test and tail suspension test, but also the improving effects of Nelumbo nucifera leaves extract on the depression-like symptoms in the CMS model. Nelumbo nucifera leaves extract has the antagonism on CMS and produce antidepressive effects.

• 환경생물
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• 제40권3호
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• pp.247-254
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• 2022

본 연구는 자연에서 채집한 불볼락(Sebastes thompsoni)을 대상으로 고 수온 노출에 따른 생물의 행동반응 및 내성 한계(tolerance limit)를 규명하기 위하여 연속적으로 행동관찰이 가능한 추적시스템을 사용하여 노출 수온구간별 행동패턴의 변화, 임계 수온범위 및 아치사 행동반응을 분석하였다. 실험 결과, 대조수온(15.0℃)을 20.0℃로 높였을 때, BI (behavioral index)는 노출 초기 10시간 동안 일시적으로 증가하였으나 60~70시간 동안 뚜렷한 행동의 변화 없이 일정한 속도로 안정된 유영 패턴을 보였다. 그러나, 25℃에서는 활동량의 급격한 저하, 30℃에서는 활동성 지연과 정지행동 등과 같은 비정상적 유영 및 대사활동 교란이 확인되었으며, 온도의 상승에 따라 개체의 사망률이 높아지는 경향을 보였다. 이러한 결과는, 불볼락의 수온에 대한 내성한계는 25.0~30.0℃이며 생존에 큰 영향을 미치는 수온은 30.0℃ 부근임을 나타낸다. 본 연구의 결과가 효과적인 불볼락의 양식을 위한 환경 조건 설정에 도움을 줄 것으로 기대한다.

• Nutritional Sciences
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• 제8권2호
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• pp.118-124
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• 2005

To examine the eating attitudes, weight concerns, dietary intake, and menstrual function of Korean female elite athletes, 109 subjects in seven sports disciplines (rhythmic gymnastics, synchronized swimming, badminton, volleyball, Taekwondo, field hockey, and soccer) responded to a questionnaire consisted of three parts; eating attitudes and behavior(Eating Attitude Test-26; EAT26), body weight perception (Body Dissatisfaction Index: BDI) and weight control behavior, and menstrual history and status. They also recorded three-day dietary intake. Body weight (43.6$\pm$4.3 kg) and body mass index (16.7$\pm$1.4 kg/$m^2$) in rhythmic gymnasts were lower than those in other athletes (P<0.05). EAT26 scores were not different among sport events (12.3$\pm$6.5 total), however, eating disturbances (EAT26 score$\geq$20) were highly prevalent in aesthetic athletes ($30\%$) than in others ($5\%$). More than half of the athletes perceived themselves overweight and four fifth of the athletes desired to reduce weight about 4.4 kg. The gymnasts consumed the lowest caloric intake (1028:t371) while the volleyball players did the highest (2995$\pm$342 kcal/d) (P<0.05). The BDI score was not different among sport events. Three fourth of the athletes experienced weight control, and the most frequently used weight reduction method was exercise followed by using robber suits, diet, and sauna. About $40\%$ of the subjects reported irregular menstrual cycles, but menstrual dysfunction ($\leq$6 menses/yr) was only $5\%$. Generally, the Korean female elite athletes desired to reduce weight from their current body weight. No differences in eating attitude and body dissatisfaction were noticed among athletic disciplines. However, eating disturbances were highly prevalent in aesthetic athletes who also reported much less energy intake than the recommend daily energy intake. It appeared that weight reduction methods were not properly practiced in these population. Menstrual dysfunction was minimally reported.

• 한국지역사회생활과학회지
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• 제17권4호
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• pp.57-66
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• 2006

This study was performed to investigate the effectiveness of nutrition education and exercise intervention in a weight management program. The subjects were 24 obese women whose body mass index (BMI) was over $25kg/m^2$. Nutrition education was given once a week, and subjects did swimming three times a week. The program lasted for 12 weeks. Nutrient intakes were assessed by 24 hour recall method. Also food habits, dietary behavior and nutrition knowledge were examined by self-administered questionnaires before and after the weight control program. Height, weight, body composition and blood composition were measured before and after the weight control program. Over the 12 weeks in the weight control program, body weight significantly decreased from 69.7kg to 65.8kg(p<0.001). Body fat and BMI also significantly decreased(p<0.001). Cholesterol level significantly decreased at p<0.001 and blood sugar also significantly decreased (p<0.05). After taking nutrition education, dietary behavior and nutritional knowledge scores increased, energy intakes decreased from 1426.5kcal to 1408.5kcal and calcium from animal products significantly increased(p<0.05). A negative correlation between nutrition knowledge and BMI(r=-0.42) existed(p<0.05). A negative correlation of eating behavior with EER(r=-0.48) showed(p<0.05). We concluded that combined nutrition education and exercise was an optimal method for reducing weight.

• 생명과학회지
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• 제14권1호
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• pp.72-81
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• 2004

TBTCl(0.1, 0.32, 1, 3.2, 10, 25, 32, 50, 75 및 100 $\mug/l$)을 구피에게 144시간 동안 노출시켜 TBTCl의 구피 생체 내 축적정도 및 구피의 번식과 행동에 미치는 영향에 대해서 조사하였다. 0.1 $\mug/l$ 이상의 모든 TBTCl 실험군에서 $\SigmaBTs\; (TBT:\SigmaBTs)$가 67% 이상으로 매우 높았고, 고농도 실험군일수록 이 비율이 높아져, 고농도의 TBTCl에 노출될수록 구피의 대사능력이 저해됨을 알 수 있었다. 또한 TBTCl은 구피의 번식력을 약화시키고 행동이상을 유발함이 밝혀졌다. 즉, 0.1$\mug/l$의 실험군부터 수컷의 구애행동과 수출관 내 정포의 수가 감소되었고, 0.32∼10 $\mug/l$의 실험군에서는 정소 내 전체 생식세포낭에 대한 정포낭의 수도 점차 감소하여 TBTCl이 정자변태 과정에 영향을 미치는 내분비계 장애물질로서 작용하고 있음이 시사되었다. 더욱이 25 $\mug/l$이상의 고농도군에서는 단기간 내에 치사율이 증가하고, 생식세포가 괴사되고, 정소의 지지세포와 수출관 내의 상피세포가 상해되고, 유영행동 이상이 급증하고, 섭식이 중단되는 등 급성독성이 관찰되어, TBTCl이 구피의 번식 뿐 아니라 생존을 저해하고 있음이 시사되었다.

• 한국실내디자인학회논문집
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• 제27권2호
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• pp.166-174
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• 2018

This study examined the indoor exercise environment use and needs of older adults. The target population was seniors aged 60 years and older living in a newly developed apartment complex. Variables include demographic and housing characteristics, status of exercise, and indoor exercise environmental evaluation and needs. A total of 102 data items were analyzed using frequency, t-test and ANOVA. Noteworthy results are as below. First, community centers and community welfare centers were the most desirable exercise environments because of affordability, exercise programs/spaces. Such exercise environments should be developed in more locations for increasing numbers of seniors. Second, indoor exercise environments need to be improved based on seniors' physical capabilities and environmental behavior. Third, supportive spaces such as restrooms, shower rooms, locker rooms should be carefully designed. Fourth, seniors wanted to have walking trails and indoor swimming pools, the most desirable exercise spaces, within ten to 15 minutes walking distance.

• 수산해양기술연구
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• 제50권4호
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• pp.551-555
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• 2014

ADCPs have been widely used to estimate the dynamic characteristics and biomass of sound scattering layers (SSLs), and swimming speed of fish schools for analyzing SSLs spatial distribution and/or various behavior patterns. This result showed that the verification of the mean volume backscattering strength (MVBS or averaged SV, dB) acquired by the ADCP would be necessary for a quantitative analysis on the spatial distribution and the biomass estimation of the SSLs or fish school when ADCP is used for estimating their biomass. In addition, the calibrated sphere method was used to verify values of each MVBS obtained from 4 beams of ADCP (153.6 kHz) on the base of 3 frequencies (38, 120, 200 kHz) of Scientific echo sounder's split beam system. Then, the measured SV values were compared and analyzed in its Target Strength (TS, dB) values estimated by a theoretical acoustic scattering model.

• Biomolecules & Therapeutics
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• 제26권4호
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• pp.368-373
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• 2018

Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations. In the present study, we examined whether linalool elicited an anti-stress effect, reversing the behavioral alterations observed following REM-sleep deprivation in mice. Furthermore, we investigated the underlying mechanism of the effect of linalool. Spatial memory and learning memory were assessed through Y maze and passive avoidance tests, respectively, and the forced swimming test was used to evaluate anti-stress activity. The mechanisms through which linalool improves memory loss and behavioral alterations in sleep-deprived mice appeared to be through an increase in the serotonin levels. Linalool significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived animals. Moreover, linalool led to serotonin release, and cortisol level reduction. Our findings suggest that linalool has beneficial effects on the memory loss and behavioral alterations induced by REM-sleep deprivation through the regulation of serotonin levels.

• Smart Structures and Systems
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• 제8권1호
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• pp.39-52
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• 2011

We are developing a biomimetic robot based on the Sea Lamprey. The robot consists of a cylindrical electronics bay propelled by an undulatory body axis. Shape memory alloy (SMA) actuators generate propagating flexion waves in five undulatory segments of a polyurethane strip. The behavior of the robot is controlled by an electronic nervous system (ENS) composed of networks of discrete-time map-based neurons and synapses that execute on a digital signal processing chip. Motor neuron action potentials gate power transistors that apply current to the SMA actuators. The ENS consists of a set of segmental central pattern generators (CPGs), modulated by layered command and coordinating neuron networks, that integrate input from exteroceptive sensors including a compass, accelerometers, inclinometers and a short baseline sonar array (SBA). The CPGs instantiate the 3-element hemi-segmental network model established from physiological studies. Anterior and posterior propagating pathways between CPGs mediate intersegmental coordination to generate flexion waves for forward and backward swimming. The command network mediates layered exteroceptive reflexes for homing, primary orientation, and impediment compensation. The SBA allows homing on a sonar beacon by indicating deviations in azimuth and inclination. Inclinometers actuate a bending segment between the hull and undulator to allow climb and dive. Accelerometers can distinguish collisions from impediment to allow compensatory reflexes. Modulatory commands mediate speed control and turning. A SBA communications interface is being developed to allow supervised reactive autonomy.

• The Korean Journal of Physiology and Pharmacology
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• 제18권1호
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• pp.55-59
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• 2014

Dehydroevodiamine HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.