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http://dx.doi.org/10.4196/kjpp.2014.18.1.55

Dehydroevodiamine.HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats  

Kim, Hee Jin (Department of Pharmacology, College of Medicine, Seoul National University)
Shin, Ki Young (Department of Pharmacology, College of Medicine, Seoul National University)
Chang, Keun-A (Department of Pharmacology, Gachon University of Medicine and Science)
Ahn, Sangzin (Department of Pharmacology, College of Medicine, Seoul National University)
Choi, Hee Soon (Korea Brain Research Institute (KBRI))
Kim, Hye-Sun (Department of Pharmacology, College of Medicine, Seoul National University)
Suh, Yoo-Hun (Korea Brain Research Institute (KBRI))
Publication Information
The Korean Journal of Physiology and Pharmacology / v.18, no.1, 2014 , pp. 55-59 More about this Journal
Abstract
Dehydroevodiamine HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.
Keywords
Depression; DHED; Fluoxetine; Memory; Stress;
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