• Title/Summary/Keyword: Structure and function

Search Result 6,670, Processing Time 0.034 seconds

Functional Analysis and Selection of Second-site Revertant of Escherichia coli 16S rRNA of C770G (Escherichia coli 16S rRNA 상의 770 위치에 염기치환을 가진 변이체 리보솜의 단백질 합성 능력을 회복시키는 이차복귀돌연변이체의 발췌)

  • Ha, Hye-Jeong;Ryou, Sang-Mi;Lee, Kang-Seok;Jeon, Che-Ok
    • Microbiology and Biotechnology Letters
    • /
    • v.39 no.1
    • /
    • pp.93-96
    • /
    • 2011
  • It has been shown that a nucleotide substitution at position 770 in Escherichia coli 16S rRNA, which is implicated in forming the evolutionary conserved B2c intersubunit bridge, has a detrimental effect on ribosome function. In order to isolate second-site revertants that complement ribosomes containing C770G, we performed a random mutagenesis of the 16S rRNA gene and selected clones that could produce more CAT protein translated by specialized ribosome. One of the clones contained two nucleotide substitutions at positions 569 and 904 (C569G and U904C) and these mutations partially complemented the loss of protein-synthesis ability caused by C770G. Further studies using the isolated revertant will provide information about which part of 16S rRNA is interacting with C770 and the consequence of the structure formed by these interactions in the process of protein synthesis.

Integrated Optimal Design of Hybrid Structural Control System using Multi-Stage Goal Programming Technique (다단계 목표계획법을 이용한 복합구조제어시스템의 통합최적설계)

  • 박관순;고현무;옥승용
    • Journal of the Earthquake Engineering Society of Korea
    • /
    • v.7 no.5
    • /
    • pp.93-102
    • /
    • 2003
  • An optimal design method for hybrid structural control system of building structures subject to earthquake excitation is presented in this paper. Designing a hybrid structural control system may be defined as a process that optimizes the capacities and configuration of passive and active control systems as well as structural members. The optimal design proceeds by formulating the optimization problem via a multi-stage goal programming technique and, then, by finding reasonable solution to the optimization problem by means of a goal-updating genetic algorithm. In the multi-stage goal programming, design targets(or goals) are at first selected too correspond too several stages and the objective function is th n defined as the sum of the normalized distances between these design goals and each of the physical values, that is, the inter-story drifts and the capacities of the control system. Finally, the goal-updating genetic algorithm searches for optimal solutions satisfying each stage of design goals and, if a solution exists, the levels of design goals are consecutively updated to approach the global optimal solution closest too the higher level of desired goals. The process of the integrated optimization design is illustrated by a numerical simulation of a nine-story building structure subject to earthquake excitation. The effectiveness of the proposed method is demonstrated by comparing the optimally designed results with those of a hybrid structural control system where structural members, passive and active control systems are uniformly distributed.

International Comparison Study on Essential Concepts of Science Curriculum: Focus on the United States, Canada, Australia and England (과학과 교육과정의 핵심 개념 국제 비교 -미국, 캐나다, 호주, 영국을 중심으로-)

  • Kim, Jihyeon;Chung, Are Jun
    • Journal of The Korean Association For Science Education
    • /
    • v.37 no.1
    • /
    • pp.215-223
    • /
    • 2017
  • This study aims to find an effective way to present essential science concepts in national science curriculum through international comparisons. Next Generation Science Standard (US), Ontario Science Curriculum (Canada), Australia Science Curriculum, and British/English Science Curriculum were selected for comparison. In science curriculum documents, these countries used terms such as 'Key ideas,' 'Big ideas,' 'Key concepts,' 'Disciplinary core ideas.' and 'Fundamental concepts' to present essential concepts of science. This study reviewed the characteristics of the meaning, the status, and the role of essential concepts country by country. The result shows essential concepts have been used with different meanings and statutes in each case. Furthermore, various roles were performed through essential concepts in order to organize their science curriculum. From these foreign nation's cases, this study proposes several ways to present essential science concepts based on results. First, interdisciplinary integrated concepts were needed to organize an integrated science curriculum. In science curriculum documents of the United States, Canada, Australia and England, two types of terms were used in order to structuralize an integrated science curriculum. Second, essential concepts should include concepts related with function and value as well as scientific knowledge. Third, essential concepts need to be presented in such a way as to show specific contexts. Therefore, selecting appropriate contents and structure are needed to be able to improve the way to present essential concepts in Korea's educational environment.

Decomposition Analysis of Regional Governments in Foreign Direct Investment Increase or Decrease (우리나라 지방자치단체의 외국인직접투자 증감요인 분해 분석)

  • Lee, Sang-Chun;Kim, Yoon-Sun
    • International Commerce and Information Review
    • /
    • v.14 no.3
    • /
    • pp.159-183
    • /
    • 2012
  • Promoted in places like Korea, the central government and the local governments that can provide information on which to base investment policy to attract foreign direct mutation-specific gravity model (Shift-Share Model) In this study, the decrease of foreign direct investment performance using factors looked up in the industry. The sample period of 2009, 2010, 2011 nationwide (metropolitan and non-metropolitan separated) of foreign direct investment performance for Industry Standard Industrial Classification (Division) was conducted. Factors to look at the results of the National Growth Effect(NS), the industrial structure effect (IM), local allocation effect(RS) to decrease foreign direct investment in 2010 and 2011 non-metropolitan, metropolitan national growth effect(RS) is negative(-) has a value. Because it appears to be the aftermath of the global recession, the impact on the domestic economy Metropolitan area and the Industrial Mix Effect(IM) to the development of education, culture, business, and transportation, etc. in the development of service industries than in non-metropolitan valid environment. In the sector of services (food accommodation, business services, entertainment), We did it, was able to find the function. However, the Regional Share Effect(RS) be competitive in the manufacturing sector in metropolitan areas in the metal and chemical sectors have been identified. These results seems to enhance the competitiveness of the region, such as the metropolitan area's excellent workforce. Shift-Share analysis technique based on competitive factors of the region, to find the failure has limitations.

  • PDF

Assessment of System Reliability and Capacity-Rating of Concrete Box-Girder Highway Brdiges (R.C 박스거교의 체계신뢰성 해석 및 안전도 평가)

  • 조효남;신재철
    • Magazine of the Korea Concrete Institute
    • /
    • v.7 no.3
    • /
    • pp.187-198
    • /
    • 1995
  • This paper develops practical and reallstic reliabllity models and methods for the evaluation of system rehability and system rellabllity based ratlng of R.C box glrder bridge superstructures. The precise prediction of reberved carrying capacity of bridge as d system is extremely difficult especially when the brldges are highly redundant and slgnlficantly deter 1or;itcd or dainagetl. Thls papel proposes a nt2w approach for the evaluation of reseived system c,drrying capaaty of br~dges in terms ot equ~vdleiit system strength, which may b~ ddcflned as a brtdge system strength correipcmdlng tu the system rehability of the bridge. This cm be ticrAvcd from an Inverse process bami or1 the con~ept of FOSM(F1rst Order Second Moment) form of system reliabihty index. The sf rength llmt state models for K C box girder br~dges suggested In the paper dre based on the basi~ bending and shear strength And thc system reliatxllty pro,~lerri of box gritier super structure 1s formuldted as parallel serles models obtalncd f ~ o m thc FMA(Fdilure blode Rp proath) based on major failure mc>clmusrns or c~itlcal fdure ,>tatcs of each nuder .WOSM(Ad-vanced First Order Second Moment) and IST(1mportance Sampling Technique) simulation algorithm are used for the reliability analysis of the proposed models.

Examination of Applicability of Liquefaction Potential Index to Seismic Vulnerability Evaluation of the Korean River Levees (액상화 가능 지수의 국내 하천제방 지진취약도 평가 적용성 검토)

  • Ha, Iksoo;Moon, Injong;Yun, Jungwon;Han, Jintae
    • Journal of the Korean GEO-environmental Society
    • /
    • v.18 no.4
    • /
    • pp.31-40
    • /
    • 2017
  • In this study, a simple method to evaluate the seismic vulnerability of river levees was examined considering the structural characteristic of river levee, that is long, and the functional characteristic of river levee that performs temporary function against flood but is a permanent structure in the ordinary way. Considering the fact that one of the main failure modes of the levee during the earthquake are the settlement due to the strength reduction of the ground caused by the increase of the excess pore pressure in the levee body and foundation and the settlement due to liquefaction, the 2-dimensional section of the levee was regarded as the 1-dimensional section and the liquefaction potential index (LPI) for the regarded section was estimated. The estimated LPI was correlated with the seismic vulnerability of river levees. The relationship between the displacement of the levee crest caused by the earthquake and the seismic vulnerability of the levees was obtained from the results of previous researches and the correlation between the displacements of the levee crest computed by 2-dimensional dynamic coupled analyses and LPIs based on the results of 1-dimensional seismic response analyses was investigated. In connection with this correlation, as a result of examination of the correlation between LPI and the seismic vulnerability of the levee, it was concluded that the method for evaluation of the seismic vulnerability of the Korean river levee using LPI is applicable.

Application of Artificial Neural Network to Improve Quantitative Precipitation Forecasts of Meso-scale Numerical Weather Prediction (중규모수치예보자료의 정량적 강수추정량 개선을 위한 인공신경망기법)

  • Kang, Boo-Sik;Lee, Bong-Ki
    • Journal of Korea Water Resources Association
    • /
    • v.44 no.2
    • /
    • pp.97-107
    • /
    • 2011
  • For the purpose of enhancing usability of NWP (Numerical Weather Prediction), the quantitative precipitation prediction scheme was suggested. In this research, precipitation by leading time was predicted using 3-hour rainfall accumulation by meso-scale numerical weather model and AWS (Automatic Weather Station), precipitation water and relative humidity observed by atmospheric sounding station, probability of rainfall occurrence by leading time in June and July, 2001 and August, 2002. Considering the nonlinear process of ranfall producing mechanism, the ANN (Artificial Neural Network) that is useful in nonlinear fitting between rainfall and the other atmospheric variables. The feedforward multi-layer perceptron was used for neural network structure, and the nonlinear bipolaractivation function was used for neural network training for converting negative rainfall into no rain value. The ANN simulated rainfall was validated by leading time using Nash-Sutcliffe Coefficient of Efficiency (COE) and Coefficient of Correlation (CORR). As a result, the 3 hour rainfall accumulation basis shows that the COE of the areal mean of the Korean peninsula was improved from -0.04 to 0.31 for the 12 hr leading time, -0.04 to 0.38 for the 24 hr leading time, -0.03 to 0.33 for the 36 hr leading time, and -0.05 to 0.27 for the 48 hr leading time.

Ion beam irradiation for surface modification of alignment layers in liquid crystal displays (액정 디스플레이 배향막을 위한 이온빔 표면조사에 관한 연구)

  • Oh, Byeong-Yun;Kim, Byoung-Yong;Lee, Kang-Min;Kim, Young-Hwan;Han, Jeong-Min;Lee, Sang-Keuk;Seo, Dae-Shik
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • 2008.04a
    • /
    • pp.41-41
    • /
    • 2008
  • In general, polyimides (PIs) are used in alignment layers in liquid crystal displays (LCDs). The rubbing alignment technique has been widely used to align the LC molecules on the PI layer. Although this method is suitable for mass production of LCDs because of its simple process and high productivity, it has certain limitations. A rubbed PI surface includes debris left by the cloth, and the generation of electrostatic charges during the rubbing induces local defects, streaks, and a grating-like wavy surface due to nonuniform microgrooves that degrade the display resolution of computer displays and digital television. Additional washing and drying to remove the debris, and overwriting for multi-domain formation to improve the electro-optical characteristics such as the wide viewing angle, reduce the cost-effectiveness of the process. Therefore, an alternative to non-rubbing techniques without changing the LC alignment layer (i.e, PI) is proposed. The surface of LC alignment layers as a function of the ion beam (IE) energy was modified. Various pretilt angles were created on the IB-irradiated PI surfaces. After IB irradiation, the Ar ions did not change the morphology of the PI surface, indicating that the pretilt angle was not due to microgrooves. To verify the compositional behavior for the LC alignment, the chemical bonding states of the ill-irradiated PI surfaces were analyzed in detail by XPS. The chemical structure analysis showed that ability of LCs to align was due to the preferential orientation of the carbon network, which was caused by the breaking of C=O double bonds in the imide ring, parallel to the incident 18 direction. The potential of non-rubbing technology for fabricating display devices was further conformed by achieving the superior electro-optical characteristics, compared to rubbed PI.

  • PDF

Redesign Application Architecture for Advanced Volcanic Disaster Response System (화산재해대응시스템 고도화를 위한 응용아키텍처 재설계)

  • Youn, Junhee;Kim, Tae-Hoon;Kim, Dusik
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.19 no.3
    • /
    • pp.90-95
    • /
    • 2018
  • The Korean Peninsula is no longer safe from volcanic disasters. Therefore, the Korean government has been developing a spatial information-based system implementation technology since 2014. VDRS (Volcanic Disaster Response System), which is the result of the technology, was implemented in 2016 as Phase I. Since then, phase II implementation technology has been developed for an advanced system reflecting the user's requirements. To advance the system, redesign architecture is essential. This paper examined the redesign application architecture for an advanced VDRS. First, existing application architecture, which was implemented in phase I, was analyzed. Second, the user's requirements for advanced VDRS were analyzed. The analyzed user's requirements were categorized as a transforming service oriented to a business-oriented architecture, improving accuracy, and expanding the spatial range and target disaster. Third, application architecture was redesigned based on gap analysis between the existing architecture and user's requirements. The results of the proposed redesign architecture are presented as the application system structure and description of the application function based on owner's point of view in the enterprise architecture. The results of this paper can be used to derive the application module design and provide a detailed description of the application module based on the designer's point of view. Further research focused on structuring the HW/SW architecture will be required for system implementation.

Application of CNN for steering control of autonomous vehicle (자율주행차 조향제어를 위한 CNN의 적용)

  • Park, Sung-chan;Hwang, Kwang-bok;Park, Hee-mun;Choi, Young-kiu;Park, Jin-hyun
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
    • /
    • 2018.05a
    • /
    • pp.468-469
    • /
    • 2018
  • We design CNN(convolutional neural network) which is applicable to steering control system of autonomous vehicle. CNN has been widely used in many fields, especially in image classifications. But CNN has not been applied much to the regression problem such as function approximation. This is because the input of CNN has a multidimensional data structure such as image data, which makes it is not applicable to general control systems. Recently, autonomous vehicles have been actively studied, and many techniques are required to implement autonomous vehicles. For this purpose, many researches have been studied to detect the lane by using the image through the black box mounted on the vehicle, and to get the vanishing point according to the detected lane for control the autonomous vehicle. However, in detecting the vanishing point, it is difficult to detect the vanishing point with stability due to various factors such as the external environment of the image, disappearance of the instant lane and detection of the opposite lane. In this study, we apply CNN for steering control of an autonomous vehicle using a black box image of a car.

  • PDF