• Journal of Ginseng Research
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• v.47 no.2
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• pp.199-209
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• 2023

Background: Due to the interrupted blood supply in cerebral ischemic stroke (CIS), ischemic and hypoxia results in neuronal depolarization, insufficient NAD+, excessive levels of ROS, mitochondrial damages, and energy metabolism disorders, which triggers the ischemic cascades. Currently, improvement of mitochondrial functions and energy metabolism is as a vital therapeutic target and clinical strategy. Hence, it is greatly crucial to look for neuroprotective natural agents with mitochondria protection actions and explore the mediated targets for treating CIS. In the previous study, notoginseng leaf triterpenes (PNGL) from Panax notoginseng stems and leaves was demonstrated to have neuroprotective effects against cerebral ischemia/reperfusion injury. However, the potential mechanisms have been not completely elaborate. Methods: The model of middle cerebral artery occlusion and reperfusion (MCAO/R) was adopted to verify the neuroprotective effects and potential pharmacology mechanisms of PNGL in vivo. Antioxidant markers were evaluated by kit detection. Mitochondrial function was evaluated by ATP content measurement, ATPase, NAD and NADH kits. And the transmission electron microscopy (TEM) and pathological staining (H&E and Nissl) were used to detect cerebral morphological changes and mitochondrial structural damages. Western blotting, ELISA and immunofluorescence assay were utilized to explore the mitochondrial protection effects and its related mechanisms in vivo. Results: In vivo, treatment with PNGL markedly reduced excessive oxidative stress, inhibited mitochondrial injury, alleviated energy metabolism dysfunction, decreased neuronal loss and apoptosis, and thus notedly raised neuronal survival under ischemia and hypoxia. Meanwhile, PNGL significantly increased the expression of nicotinamide phosphoribosyltransferase (NAMPT) in the ischemic regions, and regulated its related downstream SIRT1/2/3-MnSOD/PGC-1α pathways. Conclusion: The study finds that the mitochondrial protective effects of PNGL are associated with the NAMPT-SIRT1/2/3-MnSOD/PGC-1α signal pathways. PNGL, as a novel candidate drug, has great application prospects for preventing and treating ischemic stroke.

• Journal of the Korean Society for Library and Information Science
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• v.57 no.3
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• pp.325-350
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• 2023

This study focuses on the impact of research data metadata quality evaluation index on the revitalization of K-BDS, a research data platform in the bio field, and examines the mediating effect of motivation factors for utilizing the platform. The investigation employs a structural equation model analysis and bootstrap analysis to explore the interrelationships among the three variables. The findings demonstrate that researchers who prioritize the quality of metadata display higher motivation to use the research data platform, leading to an intention to activate the platform. The study also confirms the mediating effect of motivation factors. Moreover, a comprehensive understanding of the sub-factors within each variable is attained through regression analysis and Sobel test. The results highlight that enhancing searchability is crucial to activate research data sharing in the bio field, while improving discoverability is vital for research data reuse. Interestingly, the study reveals that citationability does not significantly impact platform activation. As a conclusion, to foster platform activation, it is imperative to provide systematic support by enhancing metadata quality. This improvement can not only increase trust in the platform but also institutionally solidify the benefits of citation.

• Nuclear Engineering and Technology
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• v.55 no.8
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• pp.2773-2784
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• 2023

It is essential to evaluate the blasting-enhanced permeability (BEP) feasibility of a low-permeability sandstone-type uranium deposit. In this work, the mineral composition, reservoir physical properties and rock mechanical properties of samples from sandstone-type uranium deposits were first measured. Then, the reformability evaluation method was established by the analytic hierarchy process-entropy weight method (AHP-EWM) and the fuzzy mathematics method. Finally, evaluation results were verified by the split Hopkinson Pressure Bar (SHPB) experiment and permeability test. Results show that medium sandstone, argillaceous sandstone and siltstone exhibit excellent reformability, followed by coarse sandstone and fine sandstone, while the reformability of sandy mudstone is poor and is not able to accept BEP reservoir stimulation. The permeability improvement and the distribution of damage fractures before and after the SHPB experiment confirm the correctness of evaluation results. This research provides a reformability evaluation method for the BEP of the low-permeability sandstone-type uranium deposit, which contributes to the selection of the appropriate regional and stratigraphic horizon of the BEP and the enhanced ISL of the low-permeability sandstone-type uranium deposit.

• Journal of Korea Entertainment Industry Association
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• v.13 no.2
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• pp.207-217
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• 2019

The purpose of this study is to examine the physical and psychological effects of lifelong physical activity and the role of leader capacity, to provide practical basic data on intangible benefits and to suggest ways to activate the value of lifelong physical education. This study was conducted from September 1, 2018 to September 30, 2018, with a total of 206 questionnaires centering on men and women participating in sports in Jeollanam do. The two-step approach proposed by Anderson & Gerbing (1988) was used to examine the structural relationships between physical benefits, social benefits, mental benefits, self efficacy benefits, leisure cultural benefits, physical effects, mental effects, Respectively. The conclusions of this study are summarized as follows. First, physical and leisure cultural benefits have a positive(+) direct effect on leader capacity. Second, self-efficacy benefits, physical benefits, and leisure cultural benefits have positive direct effects on physical effects. Third, self-efficacy and leisure culture benefits have a direct positive effect on mental effects. Fourth, leadership competence plays a mediating role in the relationship between leisure cultural benefits and physical effects. In addition, it has a mediating role in the relationship between leisure cultural benefits and mental effects. In order to maximize the quantitative expansion and qualitative improvement of living sports and to enhance intangible value of participants in sports for all, the private capital investment such as the training of competent leaders, the development of various programs, and the investment support in the public sector, We hope that the role of the new welfare service delivery system shared with welfare will be provided.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.3
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• pp.145-151
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• 2023

3D-CNN is one of the deep learning techniques for learning time series data. Such three-dimensional learning can generate many parameters, so that high-performance machine learning is required or can have a large impact on the learning rate. When learning dynamic hand-gestures in spatiotemporal domain, it is necessary for the improvement of the efficiency of dynamic hand-gesture learning with 3D-CNN to find the optimal conditions of input video data by analyzing the learning accuracy according to the spatiotemporal change of input video data without structural change of the 3D-CNN model. First, the time ratio between dynamic hand-gesture actions is adjusted by setting the learning interval of image frames in the dynamic hand-gesture video data. Second, through 2D cross-correlation analysis between classes, similarity between image frames of input video data is measured and normalized to obtain an average value between frames and analyze learning accuracy. Based on this analysis, this work proposed two methods to effectively select input video data for 3D-CNN deep learning of dynamic hand-gestures. Experimental results showed that the learning interval of image data frames and the similarity of image frames between classes can affect the accuracy of the learning model.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3C
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• pp.115-125
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• 2009

The preconsolidation pressure has been commonly determined by oedometer test. However, it can also be determined by insitu test, such as piezocone test with theoretical and(or) empirical correlations. Recently, Neural Network (NN) theory was applied and some models were proposed to estimate the preconsolidation pressure or OCR. It was already found that NN model can come over the site dependency and prediction accuracy is greatly improved when compared with present theoretical and empirical models. However, since the optimization process of synaptic weights of NN model is dependent on the initial synaptic weights, NN models which are trained with different initial weights can't avoid the variability on prediction result for new database even though they have same structure and use same transfer function. In this study, Committee Neural Network (CNN) model is proposed to improve the initial weight dependency of multi-layered neural network model on the prediction of preconsolidation pressure of soft clay from piezocone test result. Prediction results of CNN model are compared with those of conventional empirical and theoretical models and multi-layered neural network model, which has the optimized structure. It was found that even though the NN model has the optimized structure for given training data set, it still has the initial weight dependency, while the proposed CNN model can improve the initial weight dependency of the NN model and provide a consistent and precise inference result than existing NN models.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.9-20
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• 2023

For highway concrete structures, the deterioration of the structure is accelerated due to the increase in the use of deicing materials, and sectional repair work is being frequently carried out to restore performance. However, after the repair work, re-damage such as cracks, delamination, and poor bond performance is exhibited in the repaired sectional area. In this study, overseas repair material requirements were first analyzed, and present domestic requirements were improved repair material performance through field surveys of common concrete structures, laboratory experiments, and test construction on a disused concrete bridge. In addition, performancebased quality requirements were presented so that all materials that meet the required performance can be applied, and different test methods for each material were unified into concrete test methods for consistent test results analysis. The considered performance requirements were compression strength, bending strength, and bond strength for structural properties, and length change rate, crack resistance, thermal expansion coefficient, and elasticity coefficient were for dimensional behavior. For resistance to chloride penetration resistance and freeze-thaw resistance were presented as durability. The proposed requirements for concrete repair materials are expected to contribute to the improvement of the quality of concrete sectional repair work in Korea.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.2A
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• pp.93-102
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• 2010

The numerical analysis and safety assessment by construction stages were considered the essential examination particular in order to solving the unstability of long-span bridges in the middle a construction. When estimating structural response characteristics by the construction stage analysis of long-span bridges, the influence of the near-field ground motion (NFGM) would be evaluated as a critical factor for the seismic design because it indicates clearly different aspects from the existing input earthquake motion data. Therefore, this study re-examined the response aspect of long-span bridges considering NFGM characteristics based on the response spectrum result, and advanced the presented numerical analysis program by the related research for conducting the construction stage analysis and reliability assessment of long-span bridges efficiently. The excellency of various construction schemes was assessed using the time history analysis result of critical member considering NFGM characteristics. For evaluating quantitative safety level, the reliability analysis was conducted considering the influence of external uncertainties included in random variables, and presented the safety index and failure probability of the critical construction stage by NFGM characteristics. In addition, the reliability result was examined the influence of internal uncertainties using monte carlo simulation (MCS), and assessed the distribution aspect of the essential analysis result. It is expected that this study will provide the basic information for the construction safety improvement when performing seismic design of long-span bridges considering NFGM characteristics.

• Korean Journal of Social Welfare Studies
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• v.41 no.3
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• pp.29-56
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• 2010

One of the most popular keywords in 21th century is "Information Society". Information Society improves the overall quality of human life, but increases the negative aspects such as internet addiction and digital divide. The purpose of this study is to understand the vicious cycle between socio-economic disparities and digital divide. This study analyzed the effects of poverty on school maladjustment and academic achievement and mediation effects by using parental monitoring and internet use types as mediators. Data were obtained from the Korea Youth Panel Survey(KYPS). Structural equation modeling was employed for statistical analyses. The result showed that poverty reduced parental monitoring and information-oriented type of internet use. Youth who used less information-oriented type showed more school maladjustment and less academic achievement. However, the relationship between poverty and entertainment-oriented type was non-significant. Thus, parental monitoring and the internet use types were one of the main pathways which can affect school maladjustment and academic achievement among youth in poverty. There was the possible vicious cycle between poverty and digital divide. Based on this study, we strongly suggest improvement of the media competence to solve the problem of digital divide among youth in poverty.

• Journal of the Korean Recycled Construction Resources Institute
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• v.11 no.4
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• pp.433-439
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• 2023

In this study, the bonding performance of repair materials was evaluated on concrete repair surface to develop concrete repair materials based on UHPC (Ultra High Performance Concrete) which has high mechanical and durability performance. The ten test variables were applied considering the roughness and wet condition of the concrete surface subject to repair, the addition of polymer, and the use PP and PVA fibers in repair materials. The addition of the polymer caused a significant decrease in strength, which was thought to be due to the effect of the additional super plasticizer used to adjust workability. Also, flow was reduced by up to 13.8 % with the use of plastic-based fibers. As a result of evaluating the bond strength of the repair material considering the condition of the surface subject to repair, it was thought that in the case of using UHPC-based repair material, high bonding performance could be secured without any additional surface treatment as long as the surface of the base material was sound. In addition, UHPC-based repair materials showed high bonding performance even when the attachment surface was wet. In the future, research will be conducted on shot-crete application and gradient pouring for the development of UHPC-based repair materials, and continuous improvement in the repair material mixing property will be carried out to ensure economic efficiency and performance as a concrete structural repair material.