• 한국운동역학회지
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• 제15권1호
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• pp.207-219
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• 2005

The purpose of this study was to determine the effect of the foot rotation on the lower limb muscles. Fourteen subjects performed step-up/step-down at a cadence of 80 beats/min, exercises with the foot neutral, $35^{\circ}$ internally rotated, and $35^{\circ}$ externally rotated, respectively. For each variable, a one-way analysis of variance (ANOVA) was used to determine whether there were significant differences between genders and among the eight types of jump. When a significant difference was found in jump type, post hoc analyses were performed using the Tukey procedure. A confidence level of p < .05 was used to determine statistical significance. The results showed that significant changes in averaged IEMG values occurred with the internal rotation of the foot in the lateral gastrocnemius during the knee extension, and in the semitendinosus during the knee flexion. During the knee extension, however, the internal rotation of the foot produced a significantly lower Averaged IEMG values than the neutral foot position in the medial gastrocnemius. The results also found that the peak IEMG activity of the rectus femoris during the knee extension for the external rotation of the foot was Significantly higher than the corresponding values in the neutral position of the foot, while the intenal rotaion of the foot exhibited a significant difference with the neutral position of the foot in the semitendinosus during the knee flexion. In general, the foot rotation position did not influence the average IEMG and Peak IEMG values of most muscles. The practice of adopting foot rotation to selectively strengthen individual muscles of the lower limb was not supported by this study. The external rotation of the foot produced high muscle activities in the quadriceps during the knee extension. For the knee extension, therefore, maintaining a laterally rotated position should be need for stable and comfortable position.

• 한국산학기술학회논문지
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• 제19권5호
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• pp.587-592
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• 2018

AMOLED는 흐르는 전류에 의해 밝기가 결정되므로 AMOLED의 각 픽셀은 전류 구동 방식으로 동작하므로 AMOLED 구동을 위해서는 사용자의 요구에 의해 전류의 양을 조절할 수 있는 전원이 필요하다. 이에 본 논문에서는 사용자에 의해 설정된 전원을 공급하는 AMOLED 디스플레이용 IP의 driver 블록을 설계하고 이에 대한 시뮬레이션을 수행하였다. 설계된 IP의 driver는 전압에 대해 다이오드 전류 곡선을 가지는 AMOLED의 특성 때문에 출력 전압 레귤레이션에 중점을 두었고, low load시에는 PSM(Pulse-skipping mode)로 동작하고 medium/high load시에는 1.5MHz PWM(Pulse-width modulation) mode로 동작한다. 설계된 IP의 driver는 step-up converter의 DCM(Dis-Continue Mode)에서 발생하는 ringing 현상을 제거하도록 설계하였다. Ringing 현상은 IC내의 power switch를 파괴하거나 주위의 소자들에 EMI를 증가시키는 역할을 하게 된다. 설계된 IP의 driver에서는 ringing killer 회로를 통해 이를 최소화하였다. Mobile applications를 고려하여 disable시에는 standby current를 $1{\mu}A$이하로 설계하여 true shut-down이 가능하도록 하였다. 본 논문에서 제안한 드라이버는 AMOLED의 디스플레이용 듀얼 파워 매니지먼트회로와 같은 시스템에 효율적으로 적용할 수 있을 것으로 사료된다.

• Journal of Microbiology and Biotechnology
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• 제27권4호
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• pp.844-855
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• 2017

Phosphate-solubilizing bacteria (PSB) have the ability to dissolve insoluble phosphate and enhance soil fertility. However, the growth and mineral phosphate solubilization of PSB could be affected by exogenous soluble phosphate and the mechanism has not been fully understood. In the present study, the growth and mineral phosphate-solubilizing characteristics of PSB strain Burkholderia multivorans WS-FJ9 were investigated at six levels of exogenous soluble phosphate (0, 0.5, 1, 5, 10, and 20 mM). The WS-FJ9 strain showed better growth at high levels of soluble phosphate. The phosphate-solubilizing activity of WS-FJ9 was reduced as the soluble phosphate concentration increased, as well as the production of pyruvic acid. Transcriptome profiling of WS-FJ9 at three levels of exogenous soluble phosphate (0, 5, and 20 mM) identified 446 differentially expressed genes, among which 44 genes were continuously up-regulated when soluble phosphate concentration was increased and 81 genes were continuously down-regulated. Some genes related to cell growth were continuously up-regulated, which would account for the better growth of WS-FJ9 at high levels of soluble phosphate. Genes involved in glucose metabolism, including glycerate kinase, 2-oxoglutarate dehydrogenase, and sugar ABC-type transporter, were continuously down-regulated, which indicates that metabolic channeling of glucose towards the phosphorylative pathway was negatively regulated by soluble phosphate. These findings represent an important first step in understanding the molecular mechanisms of soluble phosphate effects on the growth and mineral phosphate solubilization of PSB.

• Journal of Ginseng Research
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• 제31권1호
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• pp.1-13
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• 2007

We found that the main bacterial metabolite M1 is an active component of orally administered protopanxadiol-type ginsenosides, and that the anti-metastatic effect by oral administration of ginsenosides may be primarily mediated through the inhibition of tumor invasion, migration and growth of tumor cells by their metabolite M1. Pharmacokinetic study after oral administration of ginsenoside Rb1 revealed that M1 was detected in serum for 24 h by HPLC analysis but Rb1 was not detected. M1, with anti-metastatic property, inhibited the proliferation of murine and human tumor cells in a time- and concentration-dependent manner in vitro, and also induced apoptotic cell death (the ladder fragmentation of the extracted DNA). The induction of apoptosis by M1 involved the up-regulation of the cyclin-dependent kinase(CDK) inhibitor $p27^{Kip1}$ as well as the down-regulation of a proto-oncogene product c-Myc and cyclin D1 in a time-dependent manner. Thus, M1 might cause the cell-cycle arrest (G1 phase arrest) in honor cells through the up/down-regulation of these cell-growth related molecules, and consequently induce apoptosis. The nucleosomal distribution of fluorescence-labeled M1 suggests that the modification of these molecules is induced by transcriptional regulation. Tumor-induced angiogenesis (neovascularization) is one of the most important events concerning tumor growth and metastasis. Neovascularization toward and into tumor is a crucial step for the delivery of nutrition and oxygen to tumors, and also functions as the metastatic pathway to distant organs. M1 inhibited the tube-like formation of hepatic sinusoidal endothelial (HSE) cells induced by the conditioned medium of colon 26-L5 cells in a concentration-dependent manner. However, M1 at the concentrations used in this study did not affect the growth of HSE cells in vitro.

• 한국정밀공학회지
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• 제28권8호
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• pp.975-983
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• 2011

A microfin on a heated surface and its effects of the heat transfer has been investigated. The thickness of the fin is about 8 micrometer to allow the flexible up-down motion of the fin. Two-way complete FSI (Fluid-Structure Interaction) method has been applied for the analysis. Firstly, the deformation of a microfin due to the pulsating flow is evaluated using structure analysis. The flow and temperature patterns are predicted by CFD (Computational Fluid Dynamics) method. At each time step, using the pressure force and temperature distribution from CFD, the deformation of the wing is evaluated by FEM. Also in order to estimate the resonance probability, the natural frequency of the wing structure is calculated by modal analysis. The proposed numerical procedure was validated through experiment using a single fin. Through this work, we show that the increase of 40% in heat transfer capacity using the microfin has been compared with that of flat plate case.

• Journal of Oral Medicine and Pain
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• 제30권3호
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• pp.301-317
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• 2005

전 세계적으로 구강암의 빈도는 점점 증가 추세이며, 특히 한국인의 있어 혀(tongue)는 구강암이 가장 호발하는 장소이다. 구강암은 발암 단계에서부터 과증식 병소(hyperplastic lesion), 이형성(dysplasia) 및 상피내암(carcinoma in situ) 을 거쳐 악성 암종으로 발전하는 다단계 발암과정을 보이며, 분자 생물학적 변이가 구강암을 진행시킴이 널리 알려져 있다. 또한, 구강암은 일반적으로 암세포의 증식 및 고사(apoptosis)의 억제가 중요한 역할을 하고 있다 알려져 있다. 그리고, Bcl-2 family 는 세포 고사에 주요한 역할을 하고 있음이 알려져 있다. 그러나, 이들과 관련한 구강암 발생과정의 변화에 대해서는 널리 연구된 바가 없다. 본 연구는 백서에서 발암 물질인 4-NQO로 구강암을 유도시키고, 구강암 발생 다단계별로 Bcl-2 family의 mRNA 변화를 RT-PCR을 이용해 살펴보았다. Bcl-2 family는 크게 3군, 즉 1) anti-apoptotic, 2) pro-apoptotic, 그리고 3) BH3 only protein으로 분류할 수 있으며, 본 연구에서 anti-apoptotic molecules인 Bcl-w는 모든 군에서 발현이 감소되었으며, Bcl-2는 발현이 증가 되었다. pro-apoptotic molecules에서는 Bad가 제 3군 (편평세포암종)에서 발현이 증가 되었고, 나머지는 감소하였다. BH-3 only protein에서는 Bmf가 제 2군에서, BBC3가 제 3군에서 발현이 증가하였고, 나머지는 모든 군에서 감소하였다. 결론적으로, 4-NQO로 유도된 백서의 발암단계에서, Bcl-2 family의 mRNA 양상은 다양하게 관찰되었으나, Bad 및 BBC3 mRNA가 제 3군에서, Bmf mRNA가 제 2군에서의 발현이 특별함을 알 수 있어, 다단계 발암과정에서의 구강암을 진단하는데 유용하리라 사료된다.

• 대한통합의학회지
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• 제10권4호
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• pp.241-250
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• 2022

Purpose : The purpose of this study was to investigate the effect of backward walking exercise on changes in the cervical angle and gait parameters in subjects with moderate forward head posture. Methods : Four subjects were selected for this study. In particular, subjects with an average of 43 subjects with moderate craniovertebral angles were selected as the criteria for subject selection. The exercise program consisted of a 5 minutes warm-up exercise, 20 minutes main exercise, and 5 minutes cool-down exercise. In the main exercise, the treadmill speed was 2.5 km/h for men, 2.0 km/h for women in the first week, from the 2nd week to the 4th week, it was increased by 0.5 km/h every week. Results : Craniovertebral angle increased by 2.06±2.46 ° before and after the backward walking exercise, and craniorotational angle decreased by -1.69±3.33 ° before and after exercise. As for the gait parameters, in the amount of change before and after the backward walking exercise, the left foot pressure was 4.58±5.70 % from front to back and the right foot pressure was 5.08±3.06 % from front to back. The left step length and right step length showed a change of -.33±4.43 cm and -2.08±7.26 cm, respectively. stride length showed a change of -2.59±11.18 cm. The left and right stance phase showed a change of -1.02±2.03 % and -1.23±1.54 %, respectively. The left and right swing phase showed changes of 1.02±2.03 % and 1.22±1.53 %, respectively. The left and right step times were -.01±.06 sec and -.02±.12 sec, respectively. The stride time showed a change of -.03±.18 sec. Conclusion : Changes in cervical angle and gait parameters were confirmed by performing backward walking exercise for subjects with moderate forward head posture for 4 weeks. Therefore, additional research should be conducted based on this case study.

• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3295-3305
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• 2011

Thermal behavior of poly (methyl methacrylate) was analyzed in the presence of tin (IV) chloride. Five different proportions - polymer to additive - were selected for casting films from common solvent. TG, DTG and DTA were employed to monitor thermal degradation of the systems. IR and py-GC-MS helped identify the decomposition products. The blends start degrading at a temperature lower than that of the neat polymer and higher than that of the pure additive. Complex formation between tin of additive and carbonyl oxygen (pendent groups of MMA units) was noticed in the films soon after the mixing of the components in the blends. The samples were also heated at three different temperatures to determine the composition of residues left after the expulsion of volatiles. The polymer, blends and additive exhibited a one step, two-step and three-step degradation, respectively. $T_0$ is highest for the polymer, lowest for the additive and is either $60^{\circ}C$ or $70^{\circ}C$ for the blends. The amount of residue increases down the series [moving from blend-1 (minimum additive concentration) to blend-5 (maximum additive concentration)]. For blend-1, it is 7% of the original mass whereas it is 16% for blend-5. $T_{max}$ also goes up as the concentration of additive in the blends is elevated. The complexation appears to be the cause of observed stabilization. Some new products of degradation were noted apart from those reported earlier. These included methanol, isobutyric acid, acid chloride, etc. Molecular-level mixing of the constituents and "positioning effect" of the additive may have brought about the formation of new compounds. Routes are proposed for the appearance of these substances. Horizontal burning tests were also conducted on polymer and blends and the results are discussed. Activation energies and reaction orders were calculated. Activation energy is highest for the polymer, i.e., 138.9 Kcal/mol while the range for blends is from 51 to 39 Kcal/mol. Stability zones are highlighted for the blends. The interaction between the blended parts seems to be chemical in nature.

• Restorative Dentistry and Endodontics
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• 제32권1호
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• pp.61-68
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• 2007

이 연구의 목적은 네 종류 file systems의 중심유지능과 근관성형 전후의 상아질 삭제량을 비교하는 것이다. 10-20도의 만곡을 갖는 발거된 20개의 하악 제1대구치의 근심근관(총 40개의 근관)을 근관성형 전에 X선 미세단층촬영 스캐너를 이용하여 스캔하였다. 제 1군은 근관부를 넓힌 후 stainless steel K-Flexofile을 사용하여 step-back technique으로 근관성형하였고, 나머지 군들은 각 제조사의 추천대로 ProFile system (2군), ProTaper system (3군), K3 system (4군)을 사용하여 crown-down technique으로 근관성형하였다. 모든 근관의 근단부 기구조작은 #25 크기까지 시행하였고 근관성형 후 스캔하였다. 3차원 영상 소프트웨어로 근관성형 전후의 스캔된 이미지들을 재구성하여 근관의 전체적 부피 변화를 측정하였다. 또한, 근단공으로부티 1, 3, 5, 7 mm되는 지점의 근관 횡단면을 비교하여 근관성형 전후의 단면적 변화와 중심변위율을 산출하였다. 그 결과, ProTaper와 K3가 다른 file systems보다 상아질을 더 많이 삭제하는 경향을 보였고 모든 실험군에서 중심 변위율은 근단공으로부터 3 mm 지점에서 가장 낮은 수치를 나타냈으며, 3 mm 지점을 제외하고는 ProTaper가 다른 file systems보다 중심유지능이 떨어지는 결과를 얻을 수 있었다 (P < 0.05).

• Journal of Power Electronics
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• 제16권5호
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• pp.1763-1772
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• 2016

To reduce system complexity and implementation costs, fully-controlled H-bridge (FHB) modules and diode H-bridge PFC (DHB) modules are cascaded to form a hybrid cascaded H-bridge rectifier (HCHR). In this paper, the advantages of such a HCHR over other cascaded rectifiers are analyzed depending on the numbers of FHB modules and DHB modules. Therefore, to assign proper numbers to these two kinds of modules for the HCHR, a configuration determination method is investigated under balanced and imbalanced loads. Three principles are also presented to guide the configuration determination for the HCHR. In addition, the constraints for selecting the step-up ratio and filter inductance are derived based on a phasor diagram analysis. The proposed configuration determination method is validated by simulations under three different conditions in the PSIM environment. Finally, experiments are carried out on a scaled-down prototype where the configuration can be easily adjusted. The feasibility of the proposed theory is then verified by experimental results.