• Proceedings of the Korean Society of Applied Pharmacology
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• 2005.04a
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• pp.5-14
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• 2005

Recently, data from several groups have raised the concept of 'checkpoint' in transcription. As capping of nascent RNA transcript is tightly coupled to RNA polymerase II transcription, we seek to obtain direct evidence that transcripiton checkpoint via capping enzyme functions in this early regulatory step. One of temperature sensitive (ts) alleles of ceg1, a guanylyltransferase subunit of the Saccharomyces cerevisiaecapping enzyme, showed 6-azauracil (6AU) sensitivity at the permissive growth temperature, which is a phenotype that is correlated with a transcription elongational defect. This ts allele, ceg1-63 also has an impaired ability to induce PUR5 in response to a 6AU treatment. However, this cellular and molecular defect is not due to the preferential degradation of the transcript attributed from a lack of guanylyltransferase activity. On the contrary, the data suggests that the guanylyltransferase subunit of the capping enzyme plays a role in transcription elongation. First, in addition to the 6AU sensitivity, ceg1-63is synthetically lethal with elongation defective mutations of the largest subunit of RNA polymerase II. Secondly, it exhibited a lower GAL1 mRNA turn-over after glucoseshut off. Third, it decreased the transcription read through a tandem array of promoter proximal pause sites in an orientation dependent manner. Interestingly, this mutant also showed lower pass through a pause site located further downstream of the promoter. Taken together, these results suggest that the capping enzyme plays the role of an early transcription checkpoint possibly in the step of the reversion of repression by stimulating polymerase to escape from the promoter proximal arrest once RNA becomes appropriately capped.

• Journal of the Korea Fashion and Costume Design Association
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• v.9 no.2
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• pp.49-57
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• 2007

The purpose of this study was to research the efficient tool of the exclusive fabric simulation in Jacquard Textile CAD system. For performing this design study, it designed the surface design of the abstract images of flowers through EAT Designscope CAD system and simulated the interior fabric. To merchandise the fashion items and see the visual image, these fabric simulations was effected by two or three-dimension modeling through EAT designscope, YongWoo CNI, Alias and so on. The result of this study can be summarized as follows. Before the step of weaving the samples from the surface design works, jacquard fabric design can be done very efficiently to apply the design step of the fabric simulation in CAD(Computer Aided Design). As the usage of the simulation tool in CAD system, jacquard design can be easily feed-back to modify for the right fabrics and produced the various designs in the short running time very efficiently. Therefore, this jacquard design system ultimately can be saved cost and developed the higher value-added goods in more response to consumer demands.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.12 s.117
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• pp.1192-1200
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• 2006

Viscoelastic damping materials are widely used to reduce noise and vibration because of its low cost and easy implementation, for examples, on the body structure of passenger cars, air planes, electric appliances and ships. To design the damped structures, the material property such as elastic modulus and loss factor is essential information. The four-parameter fractional derivative model well describes the dynamic characteristics of the viscoelastic damping materials with respect to both frequency and temperature. However, the identification procedure of the four-parameter is very time-consuming one. In this study a new identification procedure of the four-parameters is proposed by using an FE model and a gradient-based numerical search algorithm. The identification procedure goes two sequential steps to make measured frequency response functions(FRF) coincident with simulated FRFs: the first one is a peak alignment step and the second one is an amplitude adjustment step. A numerical example shows that the proposed method is useful in identifying the viscoelastic material parameters of fractional derivative model.

• Journal of Biomedical Engineering Research
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• v.29 no.4
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• pp.278-285
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• 2008

In this study the complex-valued continuous wavelet transform (CWT) has been applied in detection of Electrocardiograms (ECG) as response to various signal classification methods such as Fourier transforms and other tools of time frequency analysis. Experiments have shown that CWT may serve as a detector of non-stationary signal changes as ECG. The tested signal is corrupted by short time events. We applied CWT to detect short-time event and the result image representation of the signal has showed us that one can easily find the discontinuity at the time scale representation. Analysis of ECG signal using complex-valued continuous wavelet transform is the first step to detect possible changes and alternans. In the second step, modulus and phase must be thoroughly examined. Thus, short time events in the ECG signal, and other important characteristic points such as frequency overlapping, wave onsets/offsets extrema and discontinuities even inflection points are found to be detectable. We have proved that the complex-valued CWT can be used as a powerful detector in ECG signal analysis.

• Steel and Composite Structures
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• v.18 no.6
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• pp.1541-1555
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• 2015

In this paper mechanical behavior of the functional gradient materials (FGM) micro-gripper under thermal load and DC voltage is numerically investigated taking into account the effect of intermolecular forces. In contrary to the similar previous works, which have been conducted for homogenous material, here, the FGM material has been implemented. It is assumed that the FGM micro-gripper is made of metal and ceramic and that material properties are changed continuously along the beam thickness according to a given function. The nonlinear governing equations of the static and dynamic deflection of microbeams have been derived using the coupled stress theory. The equations have been solved using the Galerkin based step-by-step linearization method (SSLM). The solution procedure has been evaluated against available data of literature showing good agreement. A parametric study has been conducted, focusing on the combined effects of important parameters included DC voltage, temperature variation, geometrical dimensions and ceramic volume concentration on the dynamic response and stability of the FGM micro-gripper.

• Elastomers and Composites
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• v.37 no.3
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• pp.151-158
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• 2002

An elastomeric bushing which has been considered in this research is a device used in automotive suspension systems to reduce the forte transmitted iron the wheel to the frame of the vehicle. A bushing is modeled at a hollow cylinder which is bonded to a solid metal shaft at its inner surface and a metal sleeve at its outer surface. Lianis constitutive equation for a nonlinear viscoelastic incompressible material is used to model the elastomeric material of the bushing. It is used to derive a force-displacement relation for axial response of the bushing. The displacement dependent force relaxation function for the bushing is obtained from the ramp displacement control tests with an extrapolation method. This is compared with the exact result obtained from the step displacement control test and the results are in very good agreement.

• International Journal of Internet, Broadcasting and Communication
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• v.7 no.2
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• pp.79-83
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• 2015

The Response to Intervention(RTI) approaches is the method to help students who are at risk for learning difficulties in advance and provide an appropriate level of intervention. In this article, the characteristics of model RTI were reviewed for students with achievement of below basic proficiency level. We considered RTI as supporting system to document students' progress and its applicability for the general educational setting in Korean school. The tier of RTI make it possible the evidence based individual instruction and counseling, differentiated step-by step approach for students with achievement of below basic proficiency level. In conclusion, RTI can be used as educational tools for dealing with improvement of academic subjects learning, behavioral and emotional problem for students with achievement of below basic proficiency level. For building high quality implementing for RTI it is needed the collaboration of teachers, counselors and learning consultants and related educators.

• Structural Engineering and Mechanics
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• v.18 no.5
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• pp.591-607
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• 2004

The substance of the use of the derived non-linear creep constitutive equations under variable stress levels (see first part of the paper, Kmet 2004) is explained and the strategy of their application is outlined using the results of one-step creep tests of the steel spiral strand rope as an example. In order to investigate the creep strain increments of cables an experimental set-up was originally designed and a series of tests were carried out. Attention is turned to the individual main steps in the production and application procedure, i.e., to the one-step creep tests, definition of loading history, determination of the kernel functions, selection and definition of constitutive equation and to the comparison of the resulting values considering the product and the additive forms of the approximation of the kernel functions. To this purpose, the parametrical study is performed and the results are presented. The constitutive equations of non-linear creep of cable under variable stress history offer a strong tool for the real simulation of stochastic variable load history and prediction of realistic time-dependent response (current deflection and stress configuration) of structures with cable elements. By means of suitable stress combination and its gradual repeating various loads and times effects can be modelled.

• Journal of the Korean Institute of Telematics and Electronics
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• v.21 no.4
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• pp.78-83
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• 1984

A method is proposed for the adaptive control of linear time varying discrete systems. The stability problem of the model reference adaptive control systems is considered by means of the properties of hypergtability, The hyperstability approach also allows for solutions to the adaptation mechanism. Employing the principles of the continuous time case with output feedback renders it to the discrete case which simplified the system design. The system response is obtained by applying the ramp and step input as a reference signal to the system respectively. With checking the adaptation time for ramp and step input the validity of proposed algorithm was confirmed by the computer simulation.

• Journal of Mechanical Science and Technology
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• v.17 no.5
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• pp.654-667
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• 2003

This paper presents a consequence of the systematic approach to identify the aerodynamic parameters of an unmanned aerial vehicle (UAV) equipped with the automatic flight control system. A 3-2-1-1 excitation is applied for the longitudinal mode while a multi-step input is applied for lateral/directional excitation. Optimal time step for excitation is sought to provide the broad input bandwidth. A fully automated programmed flight test method provides high-quality flight data for system identification using the flight control computer with longitudinal and lateral/directional autopilots, which enable the separation of each motion during the flight test. The accuracy of the longitudinal system identification is improved by an additional use of the closed-loop flight test data. A constrained optimization scheme is applied to estimate the aerodynamic coefficients that best describe the time response of the vehicle. An appropriate weighting function is introduced to balance the flight modes. As a result, concurrent system models are obtained for a wide envelope of both longitudinal and lateral/directional flight maneuvers while maintaining the physical meanings of each parameter.