• Journal of the Korean Society for Precision Engineering
• /
• v.11 no.5
• /
• pp.33-41
• /
• 1994

For the establishment of large force standard and the accurate measurement of large force, 2MN hydraulic force standard machine which consists of loading frame, deadweight machine, two ram/cylinder systems and hydraulic control system was designed and fabricated. Measurement results of shapes for tow ram/cylinders reveal that the ratio of effective area is 200.094. The relative deviation of force stability for the machine is about .+-. 0.01% at 2MN and is less than .+-. 0.005% below 2MN. This machine may be widely used to calibrate the force measuring devices in industry and to test the force sensors.

• Biomolecules & Therapeutics
• /
• v.16 no.2
• /
• pp.168-172
• /
• 2008

The present study is to determine of sensitive nicorandil analysis method using HPLC and measure the pharmacokinetics parameters (bioavailability, $C_{max}$, $T_{max}$, Ke, $T_{1/2}$) of nicorandil (5 mg, Tab; Choongwae Pharma Corporation). Plasma (500 ul) was mixed with furosemide (internal standard, 500 ug/ml). Detection wavelength was 256 nm. The mixture of 0.01 M ammonium acetate and acetonitrile 80:20 (v/v) was used mobile phase. The HPLC separation was accomplished on ODC reverse HPLC column. The nicorandil was analyzed by a HPLC system, which consists of CAPCELL PAK C18 column (5 ${\mu}$m, 4.6 × 150 mm) and a chromatography data analysis S/W, using a isocratic mobile phase (mixture of 0.01 M ammonium acetate and acetonitrile 80:20 ) at 1.0 ml/min. Its sensitivity, selectivity, accuracy and precision must be adequate for the bioavailabilty study of nicorandil, and the linearity ($r^2$ ≥ 0.9994) of nicorandil was also proved in the range of 0.05 ug/ml . 3 ug/ml. The pharmacokinetic parameters of nicorandil (5 mg) tablets were measured as the follow. AUC: 0.19 ug/ml·hr, $C_{max}$: 0.14 ug/ml, $t_{max}$: 0.58 hr, Ke: 0.11 hr., $t_{1/2\beta}$: 6.76 hrs. This method is simple and sensitive HPLC method using UV detector for determination of nicorandil in human plasma.

• Journal of the Korean institute of surface engineering
• /
• v.39 no.2
• /
• pp.49-56
• /
• 2006

In this study, the movable flame hardening process of 12Cr steel for a uniform hardness and desirable residual stress have been investigated. For this, the temperature cycles have been controlled accurately as a function of the three processing variables, the flame intensity $I_f$, the scanning velocity $V_s$, and the initial flame holding time $t_h$, where the standard surface temperature $T_{s,\;max}$, was maintained at $960^{\circ}C$. The optimized conditions were $V_s=0.68mn/s\;and\;t_h=67sec$ for the $C_3H_8:O_2\;=\;5:20l/min,\;V_s=0.80mm/s$ and $t_h=56sec$ for the $C_3H_8:O_2=6:24l/min,\;V_s=1.01mm/s\;and\;t_h=48sec$ for the $C_3H_8:O_2=7:28l/min,\;and\;V_s=1.15mm/s$ and $t_h=39sec$ for the $C_3H_8:O_2$=8:32 l/min. The optimally flame-hardened surface exhibited uniform distributions of the hardness and residual compressive stress over the treated area with moderate levels of $470{\sim}490HV_{0.2}$in hardness and $-300{\sim}-450MPa$ in residual stress, which were acceptable on the basis of the acceptance criteria of Siemens AG-KWU and GE Power Generation Engineering.

• Journal of the Korean Professional Engineers Association
• /
• v.27 no.6
• /
• pp.72-84
• /
• 1994

This is about an environmental study of groundwater interference by hydrodynamic dispersion between the well A and well C in Dongsam-dong, the Yeongdo Island, Pusan, Korea. The groundwater in the study wells come from the fracture zones deeply seated in welded lapilli rhyodacitic tuff of the Late Cretaceous Yucheon Group. The boring depth at the well A is 190 meters, and the optimal pumping rate of the well A is about 100 cubic meters per day therein. The fractured aquifers in impermeable welded tuff show the conjugate fracturing type and are of anisotropic. The aquifers along two fracture zones in the well A are 80 and 100 meters in depth, respectively. It is not suggested that those fractured aquifers are simply connected between the well A and C. The sea level fluctuation by ebb and high tides in a day is not effective to the groundwater table in the well A. The pumping for 15 days at the well A doesn't give rise to any changes of the groundwater levels in the neighbor well C. The radius of influence of the well A is measured as less than 200 meters. The measuring electric conductivity for the test of salt tracer doesn't testify any relationship between the well A and the well C. There is the main difference between the well A and the well C on the basis of the water analysis of those wells. the well A is located in the high content zone of salt much over the standard value for drinking, whereas the other wells B. C. D are in the low content area of salt below the standard value. It is elucidated for the high content zone of salt in Yeongdo around the well A to have been uplifted over 20 meters.

• Transactions of the Korean Society of Pressure Vessels and Piping
• /
• v.11 no.1
• /
• pp.39-44
• /
• 2015

The fracture toughness of 2.25Cr-1Mo cast steel (SA217-WC9) samples which were taken from the check valves of feed water piping of Korean Standard Nuclear Power Plant(KSNPP) was measured by Master Curve method. The measured $T_0$ reference temperature of SA217-WC9 steel was $-30^{\circ}C$. The obtained $T_0$ was compared to the derived value from Charpy impact test data following to SINTEP procedure. The heat-to-heat variation in fracture toughness of SA217-WC9 steel was observed. It was found that the low toughness of a heat of SA217-WC9 steel was attributed to the coarse MnS inclusion originated by high sulfur content as the results of microanalyses.

• Archives of Pharmacal Research
• /
• v.17 no.2
• /
• pp.80-86
• /
• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).

• Proceedings of the Korean Geotechical Society Conference
• /
• 2010.09a
• /
• pp.269-281
• /
• 2010

The cone penetration test(CPT) has been increasingly used for in situ site characterization. However, the use of CPT is often limited due to specific site conditions depending on the cone size, geometry, and capacity of the CPT system used. In South Korea, it has generally been considered that the CPT could be satisfactorily performed only in soft soils. Louisiana State University/ Louisiana Transportation Research Center has implemented a field-rugged continuous intrusion miniature cone penetration test (CIMCPT) system since the 1990s. The miniature cone penetrometer of the CIMCPT system has a cross-sectional cone area of $2cm^2$ allowing finer soil profiles compared to the standard $10cm^2$. The reduced cross-sectional area also enables a system capacity reduction leading to cost saving and ease in maintenance. In addition, the continuous intrusion mechanism allows fast and economic site investigations. Samsung C&T Corporation has recently implemented a similar CIMCPT system. In this study, case studies on the field application of Samsung CIMCPT system for the last 2 years are presented to illustrate its performance investigation and its usefulness and limitation. Results of the case studies show that the CIMCPT system can be applied to soils with cone tip resistance($q_c$) values up to about 30MPa and allows a reliable and useful way to characterize soft soils. The results also show that the rod buckling limits the investigation depth by the system and the large contact pressure of the CIMCPT truck prevents the use of the system at sites with soft surface soils. According to the results of the case studies, the Samsung CIMCPT system has been being upgraded with a miniature cone with a longer rod, a crawler-type transportation system, a pre-boring system, and so on.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.17 no.2
• /
• pp.165-168
• /
• 2008

The hybrid ($CSR2{\times}CSR4$) eggs treated with acid were taken up for the study with an objective to develop long-term preservation schedule. The hybrid eggs obtained with two mating duration (3 h and 6 h) and oviposition period (6 h and 24 h) with two age groups of eggs (24 h and 36 h) were treated with Hydrochloric acid. These eggs were subjected to preservation at $5^{\circ}C$ in single step refrigeration and at $5^{\circ}C$ and $2.5^{\circ}C$ under double step refrigeration from $10{\sim}120$ days. These eggs were released from the cold storage as per the specified durations and incubated at standard conditions and allowed 2 h for hatching at 450 lux light. Hatchability was found to be significantly higher or on par with the control in three treatments (T1, T2 and T4) where the eggs are preserved continuously at $5^{\circ}C$ up to 30 days. However under double step refrigeration, hatching was not significantly affected in 20+60 day's combination of T1 treatment up to 80 days. Bioassay studies of the promising treatment i.e.. T1 with (20+60) days indicated that early stage loss and cocoon yield was found to be on par with the control. Hence this treatment was recommended for preservation of acid treated new bivoltine hybrid layings. Details of the hatchability and rearing performance of long term preservation of acid treated eggs are discussed.

• Proceedings of the KIEE Conference
• /
• 1998.11b
• /
• pp.460-462
• /
• 1998

In this study, we deal with a multivariable system which its input and output are coupled. This study presents a method for designing a controller which allows a coupled system to be transformed to a decoupled system in a standard model adopting 2DOF controller. And Wiener-Hopf($H_2$) approach is used so that the designed controller can minimize given cost function.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.61 no.5
• /
• pp.753-756
• /
• 2012

In this paper, a modified low-votlage CMOS bandgap voltage reference with CTAT compensation is presented. The proposed structure doesn't use PTAT current. The proposed structure is more simple than the existing structure and doesn't use the eighteen BJT. The modified low-votlage CMOS bandgap voltage reference with CTAT compensation has been successfully verified in a standard 0.18um CMOS process. The simulation results have confirmed that, with the minimum supply voltage of 1.25V, the output reference voltage at 549mV has a temperature coefficient of 12$ppm/^{\circ}C$ from $0^{\circ}C$ to $100^{\circ}C$.