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Prevalence-based Interpretation of Predictive Values of Diagnostic Tests: An Example for Detection of Canine Heartworm Infection (진단키트 검사결과에 대한 유병율 위주 해석: 개 심장사상충의 예)

  • Park, Choi-Kyu;Pak, Son-Il
    • Journal of Veterinary Clinics
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    • v.26 no.2
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    • pp.130-133
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    • 2009
  • The use of screening tests as part of a diagnostic work-up is common in domestic canine practice, but understanding of the diagnostic test characteristics and factors affecting diagnostic accuracy is not clear among clinicians. This article was aimed to provide clinicians with a better understanding on the selection of test kits and with a proper interpretation of test results using an example from heartworm(Dirofilaria immitis) studies. From the literatures, diagnostic accuracy varied depending on the kits: percent average sensitivity and specificity of ELISA antigen-detecting kits were DiroChek(Synbiotics, USA) 78.1 and 95.2, SNAP(IDEXX, USA) 66.3 and 98.1, and Solo Step(Heska, Switzerland) 69.5 and 97.5, respectively, while the values for three hematological methods(Modified Knott's, direct smear and capillary tube) ranged from 38.4 to 81.8% and from 96.9 to 100%, respectively. Furthermore, it was also reported that the prevalence of heartworm disease in domestic dog populations varied depending on the regions studied: 2.5-22.8% for microfilarial test and 2.2-66.3% by ELISA. The values of predictive values for positive(PPV) and negative(NPV) provide useful information to clinicians on the probability of heartworm infection, but the PPV and NPV are greatly dependent on the heartworm prevalence. This suggests that PPV or NPV values of a test should be interpreted carefully in different clinical settings. Practical methods on the interpretation taking into account heartworm prevalence were discussed.

The Optimal Solid Print Density Setting Method for Sheetfed Offset Printing (오프셋 매엽 인쇄의 최적 민인쇄 농도 설정 방법)

  • Seo, Suck-Jin;Kang, Sang-Hoon
    • Journal of the Korean Graphic Arts Communication Society
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    • v.27 no.1
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    • pp.15-27
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    • 2009
  • Since domestic offset print quality control depends on the experience of persons in charge rather than objective data, the standards from the data are needed for the well-organized quality management of high-quality prints. Based on the ISO standards, now the standard specifications, such as GRACoL 7, SWOP 11, SNAP, G7 in America, and EURO Color, ECI, BVDM in Europe, and Japan Color 2001, Japan Color 2004 in Japan, are employed. There exists KS for domestic standards. However, since it has been directly imported from ISO Standards, there are discrepancies in printing materials and media. Although the quality management of commercial prints has been focused and studied. For this circumstance, standards are needed for the production of prints to meet international standards. This paper aims to find out suitable ways to approach domestic printing standards using densitometric method and colorimetric method. Printing experiments on this study were performed with domestic process color inks(Cyan, Magenta, Yellow, Black) and domestic coated papers, under the same conditions as the actual commercial printing processes. In densitometric method, how to set up the optimal solid print density was studied through three tests such as the ways to match solid print density and print contrast to GRACoL standards respectively, and the way to get the highest contrast. In colorimetric method, how to get solid print density with the minimum color difference between the $CIEL^*a^*b^*$ color specification values in GRACoL standards and the measured color specification values in prints, was studied.

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A Study on the Unstable behavior According to rise-span ratio of dome type space frame (돔형 공간 구조물의 Rise-span 비에 따른 불안정 거동 특성에 관한 연구)

  • Shon, Su-Deok;Kim, Seung-Deog;Kang, Moon-Myung
    • 한국공간정보시스템학회:학술대회논문집
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    • 2004.05a
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    • pp.75-82
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    • 2004
  • Many researcher's efforts have made a significant advancement of space frame structure with various portion, and it becomes the most outsanding one of space structures. However, with the characteristics of thin and long term of spacing, the unstable behavior of space structure is shown by initial imperfection, erection procedure or joint, especially space frame structure represents more. This kind of unstable problem could not be set up clearly and there is a huge difference between theory and experiment. Moreover, the discrete structure such as space frame has more complex solution, this it is not easy to derive the formulation of design about space structure. In this space frame structure, the character of rise-span ratio or load mode is represented by the instability of space frame structure with initial imperfection, and snap-through or bifurcation might be the main phenomenon. Therefore, in this study, space frame structure which has a lot of aesthetic effect and profitable for large space covering single layer is dealt. And because that the unstable behavior due to variation of inner force resistance in the elastic range is very important collapse mechanism, I would like to investigate unstable character as a nonlinear behavior with a geometric nonlinear. In order to study the instability. I derive tangent stiffness matrix using finite element method and with displacement incremental method perform nonlinear analysis of unit space structure, star dome and 3-ring star dome considering rise-span $ratio(\mu}$ and load $ratio(R_L)$ for analyzing unstable phenomenon.

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Comparison of Jumper and Jacket Preference of Senior Females according to their Ages (노인여성의 연령별 점퍼와 재킷선호도 비교)

  • Kim, Jeam-Hae;Lee, Young-Ju
    • Fashion & Textile Research Journal
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    • v.14 no.1
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    • pp.90-99
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    • 2012
  • The purpose of this study is to compare female members's jumper and jacket preferences for five different styles of Fall/Winter jumpers and jackets, divided into three age groups(65-69 yr, 70-74 yr, over 75 yr). Total 324 senior females, ages over 65 in Kimhae and Busan area were chosen for the study. The major findings of this study were as follow; For the age group, 65 to 69, in the jumper category, it was important for them to look slender and sophisticated. Jumpers with quilted thin fabrics, jumpers with hooded jumpers zippers, and short chinese collar in the short blouson style were preferred in the age group. Jacket needed to be designed in A-line styles, short or long with one or two buttons and of various length. For those in the 70 to 74 age group, the jumper designs need to be tidy and clean with box-shaped pockets. In addition, various formal style jumpers with increasing length up to hip lines. For jackets, it is necessary to increase the number of designs with convertible collars with three button in front, elegantly covered pocket, long enough to cover the hip line. For those in the age group of 75 or over, it was essential for jumpers and jackets to be of increasing length in box style, loose-fit with, front-closure or snap buttons and out pockets that allows one to put their hands in the jumper. They preferred jacket length down to the hip-line, wing collar for jumpers, tailored collar for jackets more than the other age groups.

A Delphi Study the Appropriateness of Commercial Maternity Wear -Focusing on Designs Preferred during Pregnancy and Postpartum- (델파이 기법을 활용한 시판 마터니티웨어 디자인의 적합성 연구 -임신기 및 출산 후 선호하는 디자인을 중심으로-)

  • Lee, Yeonji;Nam, Youngran;Um, Sohee
    • Journal of Fashion Business
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    • v.24 no.4
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    • pp.1-18
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    • 2020
  • The purpose of this study is to identify the design features appropriate for the altered physical characteristics of pregnant women and formulate the direction of future design and development of maternity wear. A Delphi research method based on a panel of experts and pregnant women was used and the survey was conducted to determine the suitability of maternity wear. The survey found that A-line silhouette outerwear with round necklines, with wide sleeves and snap-button fastening on the front with a formal and decent look was considered appropriate as maternity and postpartum wear. Shirts and blouses long enough to cover the hip area to complement women's curvy and full figures, especially around the bust, waist, and hip areas during the later stages of pregnancy were found to be appropriate. Calf-length pleated skirts were comfortable to wear during pregnancy due to the abundant freedom of movement and space offered by pleats. Ankle-length straight leg pants were rated appropriate in terms of comfort and style both during late stages of pregnancy and at work postpartum. Dresses decorated with pleats from the armholes all the way down to the knees were found to provide high levels of comfort at the abdomen, chest, and hips, and considered appropriate. Based on this study results, a follow-up study will be conducted to examine the design of maternity wear during pregnancy as well as at work after pregnancy.

The Design and Application of Vibrator Type(AM) Combination Apparatus for Improving Police Equipment for Fugitive Prevention (도주방지용 경찰장구의 기능개선을 위한 진동자 방식(AM) 결속장치 설계 및 응용)

  • Choi, Ki-Nam;Lee, Seon-Jeh
    • Convergence Security Journal
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    • v.11 no.2
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    • pp.13-24
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    • 2011
  • Policemen judge the situations rationally and use their equipment such as handcuffs and rope within the purview, finding them needed to arrest criminals in the act who commit crimes which conforms to death penalty, life imprisonment or long imprisonment for over 3 years in accordance with Clause 10-2, Article 1 of the Police Mandate Law and prevent fleeing from them, defend their and others' lives and bodies, or if there are probable causes to be recognized that using equipment is necessary to restrain the interference with government officials in the execution of their duties. However, as the cases which the criminals run away in handcuffs or with both hands tied occur, it results in the waste of police force, distrust and enormous trouble in the pursuit of their duties. Therefore, if the way to perceive fleeing of criminals who have already worn the police equipment by some simple assistive devices without developing other new equipment, it will be very effective for police duties. This study is about the combination apparatus for fugitive prevention attached to the existing handcuffs and rope whose alert sounds let the staffs working inside the office perceive the fleeing of wanted criminals and examined suspects who wear the handcuffs or are tied up with rope, providing that they go through the exit where a transmitter and a receiver were set. The combination apparatus for fugitive prevention which the study introduces contains the connecting parts which connect a flexible tube(cognition tags inside of the tube) of connector equipped with the police equipment with the ends of the tube and the part where these two meet and which connect them inside of the tube. The connecting parts are easy to be attached to the police equipment such as handcuffs and rope, but hard to be dismantled by the people tied up with the equipment. It enables watchers to perceive the fleeing of wanted criminals and examined suspects who wear the handcuffs or are tied up with rope, providing that they go through the exit where a transmitter and a receiver were set. Plus, if it is combined together with the portable receiver, it can be installed on the patrol cars and easily adopted to supervise illegally accessing of evidences. It is also avaliable to be adjunctively utilized for the handcuffs provided and the cost is so reasonable. Owing to its snap-on way to the cuffs, it can clear up any invasion of privacy and it can not be used as a self-injury tool because of the soft tube. Using AM Tag minimizes the lack of malfunction.

A Study on the Critical Point and Bifurcation According to Load Mode of Dome-Typed Space Frame Structures (돔형 스페이스 프레임 구조물의 하중모드에 따른 분기점 특성에 관한 연구)

  • Shon, Su-Deok;Kim, Seung-Deog;Lee, Seung-Jae;Kim, Jong-Sik
    • Journal of Korean Association for Spatial Structures
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    • v.11 no.1
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    • pp.121-130
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    • 2011
  • Space frame structures have the advantage of constructing a large space structures without column and it may be considered as a shell structure. Nevertheless, with the characteristics of thin and long term of spacing, the unstable problem of space structure could not be set up clearly, and there is a huge difference between theory and experiment. Therefore, in this work, the tangential stiffness matrix of space frame structures is studied to solve the instability problem, and the nonlinear incremental analysis of the structures considering rise-span ratio(${\mu}$) and the ratio of load($R_L$) is performed for searching unstable points. Basing on the results of the example, global buckling can be happened by low rise-span ratio(${\mu}$), nodal buckling can be occurred by high rise-span ratio(${\mu}$). And in case of multi node space structure applying the ratio of load($R_L$), the nodal buckling phenomenon occur at low the ratio of load($R_L$), the global buckling occur a1 high the ratio of load($R_L$). In case of the global buckling, the load of bifurcation is about from 50% to 70% of perfect one's snap-through load.

Monitoring of Chicken RNA Integrity as a Function of Prolonged Postmortem Duration

  • Malila, Yuwares;Srimarut, Yanee;U-chupaj, Juthawut;Strasburg, Gale;Visessanguan, Wonnop
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.11
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    • pp.1649-1656
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    • 2015
  • Gene expression profiling has offered new insights into postmortem molecular changes associated with meat quality. To acquire reliable transcript quantification, high quality RNA is required. The objective of this study was to analyze integrity of RNA isolated from chicken skeletal muscle (pectoralis major) and its capability of serving as the template in quantitative real-time polymerase chain reaction (qPCR) as a function of postmortem intervals representing the end-points of evisceration, carcass chilling and aging stages in chicken abattoirs. Chicken breast muscle was dissected from the carcasses (n = 6) immediately after evisceration, and one-third of each sample was instantly snap-frozen and labeled as 20 min postmortem. The remaining muscle was stored on ice until the next rounds of sample collection (1.5 h and 6 h postmortem). The delayed postmortem duration did not significantly affect $A_{260}/A_{280}$ and $A_{260}/A_{230}$ ($p{\geq}0.05$), suggesting no altered purity of total RNA. Apart from a slight decrease in the 28s:18s ribosomal RNA ratio in 1.5 h samples (p<0.05), the value was not statistically different between 20 min and 6 h samples ($p{\geq}0.05$), indicating intact total RNA up to 6 h. Abundance of reference genes encoding beta-actin (ACTB), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), hypoxanthine-guanine phosphoribosyltransferase (HPRT), peptidylprolylisomerase A (PPIA) and TATA box-binding protein (TBP) as well as meat-quality associated genes (insulin-like growth factor 1 (IGF1), pyruvate dehydrogenase kinase isozyme 4 (PDK4), and peroxisome proliferator-activated receptor delta (PPARD) were investigated using qPCR. Transcript abundances of ACTB, GAPDH, HPRT, and PPIA were significantly different among all postmortem time points (p<0.05). Transcript levels of PDK4 and PPARD were significantly reduced in the 6 h samples (p<0.05). The findings suggest an adverse effect of a prolonged postmortem duration on reliability of transcript quantification in chicken skeletal muscle. For the best RNA quality, chicken skeletal muscle should be immediately collected after evisceration or within 20 min postmortem, and rapidly preserved by deep freezing.

Evaluation of Diagnostic Performance of a Polymerase Chain Reaction for Detection of Canine Dirofilaria immitis (개 심장사상충을 진단하기 위한 중합연쇄반응검사 (PCR)의 진단적 특성 평가)

  • Pak, Son-Il;Kim, Doo
    • Journal of Veterinary Clinics
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    • v.24 no.2
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    • pp.77-81
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    • 2007
  • Diagnostic performance of polymerase chain reaction (PCR) for detecting Dirofilaria immitis in dogs was evaluated when no gold standard test was employed. An enzyme-linked immunosorbent assay test kit (SnapTM, IDEXX, USA) with unknown parameters was also employed. The sensitivity and specificity of the PCR from two-population model were estimated by using both maximum likelihood using expectation-maximization (EM) algorithm and Bayesian method, assuming conditional independence between the two tests. A total of 266 samples, 133 samples in each trial, were randomly retrieved from the heartworm database records during the year 2002-2004 in a university animal hospital. These data originated from the test results of military dogs which were brought for routine medical check-up or testing for heartworm infection. When combined 2 trials, sensitivity and specificity of the PCR was 96.4-96.7% and 97.6-98.8% in EM and 94.4-94.8% and 97.1-98% in Bayesian. There were no statistical differences between estimates. This finding indicates that the PCR assay could be useful screening tool for detecting heartworm antigen in dogs. This study was provided further evidences that Bayesian approach is an alternative approach to draw better inference about the performance of a new diagnostic test in case when either gold test is not available.