• Tuberculosis and Respiratory Diseases
• /
• v.46 no.2
• /
• pp.273-280
• /
• 1999

This is a report of gastric metastases secondary from a primary small cell carcinoma of the lung in two men. Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the reports in the literature the prevalence of metastasis to the stomach occurs in 0.4% and the most common cell type of the primary lung carcinoma is large cell type(3.7%) followed by adenocarcinoma(2.4%), small cell carcinoma(1.7%) and squamous cell carcinoma(0.7%). The most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Most of the gastrointestinal tract metastases had no specific symptoms because of its submucosal involvement. The prognosis was poor and the mean survival period from the onset of symptoms was 49 days. The first patient was a 56-year-old man who had primary lung carcinoma with brain metastasis. Gastroscopic findings showed two elevated mass lesions in the anterior wall of the mid body with central ulcer and the posterior wall of the fundus with intact surface mucosa. Pathologic examination of stomach tissue revealed small cell type tumor cells infiltrate in the stomach wall segmentally without destruction of the glands. The second patient was a 67-year-old man who had no other evidence of the distant metastasis. Gastroscopic findings showed a huge, oval shaped, ulcerofungating mass with deep penetrating central ulcer coated with dirty exudate in the anterior wall from mid to upper body of the stomach, and thickened elevated rugal folds in the posterior wall of the fundus. Pathologic examination of stomach tissues revealed the small cell type tumor cells showing small smudged nucleus infiltrate into the mucosa of the stomach and the architecture of mucosa intact. We report the two cases of metastatic gastric cancer from the primary small cell lung carcinoma with the literature review.

• Journal of Chest Surgery
• /
• v.30 no.6
• /
• pp.566-572
• /
• 1997

A major obstacles to evaluation of newly-developed treatment strategy for human lung cancer has been the lack of appropriate experimental animal models. We describe a new experimental model of orthotopically-developed non-small cell lung cancer in nude rat, involving inoculation of tumor cell suspension by thoracotomy. Over 40 direct implantation to the periphery of the lung has been performed to date, each requiring less than'1 hour for completion. This model has been used to perform a series of experiments to investigate whether the rat lung and surrounding structures trapped tumor cells with 2 different non-small cell lung cancer cell lines(NCI-H46O and NCI-H1299). Every animal showed development of tumor masses, which were loculated at the periphery of the lung karenchyma and identified also by radiography. After 3 weetu of the inoculation, tumor develop meat at the mediastinal strutures were identified. The life expectancies of the victims were different between the cell lines, but were approximately 5 weeks when NCI-H46O cell line was used. This new orthotopic lung cancer model may be facilitate future studies of the new therapeutics of localized non-small cell lung cancer .

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.39A no.5
• /
• pp.280-292
• /
• 2014

Recently, heterogeneous networks consisting of small-cells on top of traditional macro-cellular network has attracted much attention, because traditional macro-cellular network is not suitable to support more demanding mobile data traffic due to its limitation of spatial reuse. However, due to the transmit power difference between macro- and small-cells, most users are associated with macro-cells rather than small-cells. To solve this problem, enhanced inter-cell interference coordination (eICIC) has been introduced. Particularly, in eICIC, the small-cell coverage is forcibly expanded to associate more users with small-cells. Then, to avoid cross-tier interference from macro-cells, these users are allowed to receive the data during almost blank subframe (ABS) in which macro-cells almost remain silent. However, this approach is not sufficient to balance the load between macro- and small-cells because it only expands the small-cell coverage. In this paper, we propose a load balance scheme improving proportional fairness for heterogeneous networks employing eICIC. In particular, the proposed scheme combines the greedy-based user association and the ABS rate determination in a recursive manner to perform the load balance.

• Biomolecules & Therapeutics
• /
• v.12 no.2
• /
• pp.92-100
• /
• 2004

Effect of the depletion or oxidation of GSH on mitomycin c (MMC)-induced mitochondrial damage and cell death was assessed in small cell lung cancer (SCLC) cells. MMC induced cell death and the decrease in the GSH contents in SCLC cells, which were inhibited by z-LEHD.fmk (a cell permeable inhibitor of caspase-9), z-DQMD.fmk (a cell permeable inhibitor of caspase-3) and thiol compound, N-acetylcysteine. MMC caused nuclear damage, release of cytochrome c and activation of caspase-3, which were reduced by N-acetylcysteine. The depletion of GSH due to L-butionine-sulfoximine enhanced the MMC-induced cell death and formation of reactive oxygen species in SCLC cells, whereas the oxidation of GSH due to diamide or $NH_2Cl$ did not affect cytotoxicity of MMC. The results show that MMC may cause cell death in SCLC cells by inducing mitochondrial dysfunction, leading to activation of caspase-9 and -3. The MMC-induced change in the mitochondrial membrane permeability, followed by cell death, in SCLC cells may be significantly enhanced by the depletion of GSH. In contrast, the oxidation of GSH may not affect cytotoxicity of MMC.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.21
• /
• pp.9113-9116
• /
• 2014

Purpose: : To assess the clinic value of application of laparospic ultrasonography (LU) in partial nephrectomy of small renal cell carcinoma. Materials and Methods: From 2007 to 2011, 28 small renal cell carcinoma patients in ou clinic underwent laparoscopic partial nephrectomy with LU. For comparison with preoperative conventional ultrasound and CT, we collected ultrasonic performance of the affected side kidney, renal tumor location, size, echo change, blood supply situation and the relationship with the surrounding tissue. Results: LU could more clearly show the tumor interior structure and blood supply, as well as the relationship with the surrounding tissue. It also can provided doctor assistance with real-time tumor resection, reducing operative complications. Conclusions: LU can clearly show tumor internal structure and blood supply, which is helpful for explicit diagnosis. Moreover, it supplies accurate information for surgeons and assists surgery. Therefore LU has an important guiding value in partial nephrectomy for small renal cell carcinoma.

• Journal of Internet Computing and Services
• /
• v.23 no.5
• /
• pp.9-15
• /
• 2022

This paper proposes a coordinated multi-point communication (CoMP) method with channel selection to improve performance of a macro user equipment (MUE) in a dense small-cell network environment in a building located within coverage of a macro base station (MBS). In the proposed CoMP method, in order to improve the performance of the MUE located in the building, A small-cell base station (SBS) selects a channel with lower interference to the neighboring MUE and transmits appropriate signals to the MUE requiring CoMP. Simulation results show that the proposed CoMP method improves the performance of the MUE by up to 164% and 51%, respectivley, compared to a random channel allocation based traditional SBS network and CoMP method.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.13 no.5
• /
• pp.75-80
• /
• 2004

Feasibility of the small capacity fuel cell powered vehicle is carried out for system design with loading characteristics. The major design concepts which include battery, driving motor, and fuel cell module are analyzed and discussed for the future development. A load characteristics program is developed in order to calculate the traction power of fuel cell vehicle according to the driving courses specified. Further, the small capacity fuel cell vehicle is analyzed to determine the capacity of stack as a function of the velocity for an appropriate power required.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2011.04a
• /
• pp.219-221
• /
• 2011

This paper reports the development trend of small fuel cell unmanned aerial vehicles. Development method of a fuel cell propulsion system for small unmanned aerial vehicles is proposed and discussed, such as the lightweight fuel cell stack development, liquid fuel-based hydrogen storage/generation, and fuel cell system technology.

• The Journal of Korean Medicine
• /
• v.32 no.6
• /
• pp.117-121
• /
• 2011

Objectives: We report one patient with pleural effusion and effusion-related symptoms in small cell lung cancer (SCLC) successfully treated with Gunreyngtang-gagambang. Methods: Gunreyngtang-gagambang was administered at 30 minutes after mealtime, three times a day, for two months. Except for herbal medicine, the patient did not take any treatment including pharmaceutical or non pharmaceutical for effusion. Result: Two months later, the symptoms and the pleural effusion had disappeared from chest X-ray. Conclusion: Gunreyngtang-gagambang was effective for treatment of malignant pleural effusion due to small cell lung cancer.

• ETRI Journal
• /
• v.40 no.2
• /
• pp.227-236
• /
• 2018

Ultra-dense small cell networks (UD-SCNs) have been identified as a promising scheme for next-generation wireless networks capable of meeting the ever-increasing demand for higher transmission rates and better quality of service. However, UD-SCNs will inevitably suffer from severe interference among the small cell base stations, which will lower their spectral efficiency. In this paper, we propose a software-defined networking (SDN)-based hierarchical agglomerative clustering (SDN-HAC) framework, which leverages SDN to centrally control all sub-channels in the network, and decides on cluster merging using a similarity criterion based on a suitability function. We evaluate the proposed algorithm through simulation. The obtained results show that the proposed algorithm performs well and improves system payoff by 18.19% and 436.34% when compared with the traditional network architecture algorithms and non-cooperative scenarios, respectively.