• Biomolecules & Therapeutics
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• v.23 no.3
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• pp.207-217
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• 2015

Skin is the first line of defense for protecting our bodies against external perturbations, including ultraviolet (UV) irradiation, mechanical/chemical stress, and bacterial infection. Nutrition is one of many factors required for the maintenance of overall skin health. An impaired nutritional status alters the structural integrity and biological function of skin, resulting in an abnormal skin barrier. In particular, the importance of micronutrients (such as certain vitamins and minerals) for skin health has been highlighted in cell culture, animal, and clinical studies. These micronutrients are employed not only as active compounds in therapeutic agents for treating certain skin diseases, but also as ingredients in cosmetic products. Here, the author describes the barrier function of the skin and the general nutritional requirements for skin health. The goal of this review is to discuss the potential roles and current knowledge of selected micronutrients in skin health and function.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.2 s.33
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• pp.179-186
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• 2007

Objective : Skin barrier protects skin against harmful environment. Its function includes antimicrobial barrier as well as physical barrier. But there are few studies about skin barrier function about men and women who don't have skin disease. The aim of this study is to investigate skin barrier function healthy men and women show. Method : There are many ways to measure skin barrier function, but lately transepidermal water loss is mainly used to know skin barrier function. Transepidermal water loss was measured over eight four the Korean twenties and thirties who don't have skin disease from March 14th, 2007 to March 16th 2007. We surveyed cubital fossa and cheek beside nose to measure transepidermal water loss and used vapometer. Result : After analyzed data, we concluded that cheek showed higher transepidermal water loss than cuital fossa. At cheek, the thirties had higher transepidermal water loss than the twenties. The male got higher transepidermal water loss than the female at cheek and in the average. And temperature and humidity effected on transepidermal water loss. Conclusion: In our study, it was observed that temperature and humidity effected on transepidermal water loss. In traditional korean medicine, the inbalance of cold(寒), heat(熱), dryness(燥), wetness(濕) makes many diseases and the inbalance of them induces dameum(痰飮) and the disorder of blood flow. Dameum(痰飮) and the disorder of blood flow make skin diseases made by abnormal skin barrier function in many ways. So we need to study dameum(痰飮) and the disorder of blood flow to take care of patients who have abnormal skin barrier function.

• The Journal of Korean Medicine
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• v.28 no.4
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• pp.18-26
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• 2007

Objective : To study the effect of the Insamyangyoung-tang(ISYT) extract on the skin barrier function, the skin pH, skin humidity and transepidermal water loss(TEWL) were measured and histological changes were observed in DNCB(2,4-dinitrochloro-benzen)-induced contact dermatitis(CD) hairless mice. Methods : The male hairless mice were divided into three groups. Each group consisted of 15 mice. The normal group which had acetone- olive oil applied. The control group which had intentionally induced CD by DNCB and it was fed normal saline orally. The ISYT group which had intentionally induced CD by DNCB and it was fed ISYT extract orally for 7 days. The three groups were checked 24h, 48h and 72h later after inducing CD, and the skin pH, skin humidity and TEWL were observed. Tissue samples were taken, and damage to the epithelial cell was observed. Statistical analysis was performed by using one way-ANOVA: significance was set at p values less than 5% (p<0.05). Results : ISYTextract efficiently maintained the pH balance, it kept the skin humidity at a normal level, and it inhibited TEWL of the DNCB-induced CD hairless mouse. The damage to the epithelium was decreased and the regeneration power of the skin was increased in the ISYT group. Conclusion : Insamyangyoung-tang has a good effect on the skin barrier function of DNCB induced contact dermatitis hairless mice.

• Journal of the Korean Society of Clothing and Textiles
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• v.29 no.7 s.144
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• pp.959-967
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• 2005

The color of apparels has the interaction of the face skin colors of the wearers. This study was carried out to classify the face skin colors of Korean males into several similar face skin colors in order to extract favorable colors which flatter to their face skin colors. The criterion that select the new subjects who have the classified face skin colors have to be decided. With color spectrometer, JX-777, face skin colors of subjects were measured quantitatively and classified into three clusters that had similar hue, value and chroma with Munsell Color System. Sample size was 418 Korean males and other 15 of new males subjects. Data were analyzed by K-means cluster analysis, ANOVA, Duncan multiple range test, Stepwise discriminant analysis using SPSS Win. 12. Findings were as follows: 1. 418 subjects who have YR colors were clustered into 3 kinds of face skin color groups. 2. Discriminant variables of face skin colors was 4 variables : L value of forehead, v value of cheek, c value of forehead, and b value of cheek from standardized canonical discriminant function coefficient 1 and c value of forehead, L value of forehead, b value of cheek. and L value of cheek from standardized canonical discriminant function coefficient 2. 3. Hit ratio of type 1 was $92.3\%$, of type 2 was $96.5\%$ and of type 3 was $92.6\%$ by the canonical discriminant function of 4 variables. 4. The canonical discriminant function equation 1 and 2 were calculated with the unstandardized canonical discriminant function coefficient and constant, the cutting score, and range of the score were computed. 5. The criterion that select the new subjects who have the classified face skin colors was decided.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.49.1-49
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• 2001

The skin color model is a very important concept in face detection, face recognition and face tracking. Usually, this model is obtained by estimating a probability density function of skin color distribution. In many cases, it is assumed that the underlying density function follows a Gaussian distribution. In this paper, a new method for non-parametric estimation of the probability density function, by using feed-forward neural network, is used to estimate the underlying skin color model. By using this method, the resulting skin color model is better than the Gaussian estimation and substantially approaches the real distribution. Applications to face detection and face ...

• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.3
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• pp.151-158
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• 2010

Media Skin is in form extended of TV or computer monitor that is digital media picture or digital output of graphic. Mean reflex or graphics applied in LCD Window of portable phone or LED display etc. of city environment mainly. Draft and study skill development trend and studied about role as graphic modeling to Media Skin. Media Skin that inflect LED over inside and outside of the country impulse to steal current is embodied. It is situating from modern society to one media trend. Progressed general investigation about Media Skin's connection skill in research. As culture contents progressed determinate research to graphic modeling element etc. As graphic modeling of new media special quality is construed by 4 as following. Contact, Real time, Nonlinear, Multi-Communication are it. Media Skin has function as symbol of city or media construction facade. Also, have enough value as function new media as information offer function, art.

• Journal of the Korean Society of Clothing and Textiles
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• v.29 no.7 s.144
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• pp.978-986
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• 2005

The color of apparel products have a close relationship with the face skin colors of consumers. In order to extract the favorable colors which flatter to consumer's face skin colors, this study was carried our to classify the face skin colors of Korean females. The criteria that select new subjects who have the classified face skin colors have to be decided. With color spectrometer, JX-777, face skin colors of subjects were measured and classified into three clusters that had similar hue, value and chroma with Munsell Color System. Sample size was 324 Korean females and other new 10 college girls. Data were analyzed by K-means cluster analysis, ANOVA, Duncan multiple range test, Stepwise discriminant analysis using SPSS Win. 12. Findings were as follows: 1. 324 subjects who have YR colors were clustered into 3 face skin color groups. 2. Discriminant variables of face skin colors were 5 variables : b value of cheek, V value of forehead, L value of cheek, C value of forehead and H value of cheek by the standardized canonical discriminant function coefficient 1. 3. Hit ratio of type 1 was $96.8\%$, of type 2 was $94.9\%$, of type 3 was $100.0\%$ and mean of hit ratio was $96.9\%$ by canonical discriminant function of 5 variables. 4. With the unstandardized canonical discriminant function coefficient and constant, canonical discriminant function equation 1 and 2 were calculated. And cutting score and range of score of the classified types were computed. The criteria that select the new subjects were decided.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.388-394
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• 2023

Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune cells and is involved in skin functions such as vasodilation, pigmentation, hair growth, wound healing, and immune responses. NO modulates both innate and adaptive immune responses. As a signaling molecule and cytotoxic effector, NO influences the function of immune cells and production of cytokines. NO is a key mediator that protects against or contributes to skin inflammation. Moreover, NO has been implicated in skin sensitization, a process underlying contact dermatitis. It modulates the function of dendritic cells and T cells, thereby affecting the immune response to allergens. NO also plays a role in contact dermatitis by inducing inflammation and tissue damage. NO-related chemicals, such as nitrofatty acids and nitric oxide synthase (NOS) inhibitors, have potential therapeutic applications in skin conditions, including allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). Further research is required to fully elucidate the therapeutic potential of NO-related chemicals and develop personalized treatment strategies for skin conditions.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.2
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• pp.181-188
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• 2022

The skin protects the body from excessive water loss and the invasion of harmful substances, such as chemicals and microbes. The stratum corneum, is recognized as a very important physical barrier. However, in recent years evidence emerged that tight junctions (TJ) might also play a crucial role in barrier function of the skin. In the present study, TJ proteins including transmembrane proteins and plaque proteins, skin permeability barrier function and skin diseases of TJ were reviewed.

• Archives of Pharmacal Research
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• v.27 no.11
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• pp.1177-1182
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• 2004

The effect of poly[2-methacryloyloxyethyl phosphorylcholine] (pMPC) on the skin permeation property was investigated by performing in vitro skin permeation study of a model drug, nicotinic acid (NA). Effect of pMPC polymer in donor solution on skin permeation rates was evaluated using side-by-side diffusion cells. Also, the structural alterations in the stratum corneum (SC), inter-lamellar bilayer (ILB) and dermis layers in pMPC-treated and -untreated skin sections were investigated with transmission electron microscopy (TEM). The permeation profile of NA without pMPC in donor solution showed biphasic mode: initial $1^{st} phase and 2^{nd}$ hydration phase. The sudden, more than 10-fold increase in flux from the initial steady state (43.5 $\mu g/cm^2$/hr) to the $2^{nd}$ hydration phase (457.3 $\mu g/cm^2$/hr) suggests the disruption of skin barrier function due to extensive hydration. The permeation profile of NA with 3% pMPC in the donor solution showed monophasic pattern: the steady state flux (10.9 $\mu g/cm^2$/hr) without abrupt increase of the flux. The degree of NA permeation rate decreased in a concentration-dependent manner of pMPC. TEM of skin equilibrated with water or 2% pMPC for 12 h showed that corneocytes are still cohesive and epidermis is tightly bound to dermis in 2% pMPC-treated skin, while wider separation between corneocytes and focal dilations in inter-cellular spaces were observed in water-treated skin. This result suggests that pMPC could protect the barrier property of the stratum corneum by preventing the disruption of ILB structure caused by extensive skin hydration during skin permeation study.