Browse > Article
http://dx.doi.org/10.15230/SCSK.2022.48.2.181

Structure and Function of Tight Junctions in the Skin  

Song, Mee (DERMAPRO Bio Research Center, DERMAPRO Ltd.)
Baek, Ji Hwoon (DERMAPRO Bio Research Center, DERMAPRO Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.48, no.2, 2022 , pp. 181-188 More about this Journal
Abstract
The skin protects the body from excessive water loss and the invasion of harmful substances, such as chemicals and microbes. The stratum corneum, is recognized as a very important physical barrier. However, in recent years evidence emerged that tight junctions (TJ) might also play a crucial role in barrier function of the skin. In the present study, TJ proteins including transmembrane proteins and plaque proteins, skin permeability barrier function and skin diseases of TJ were reviewed.
Keywords
epidermis; barrier; tight junction;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 J. M. Brandner, Importance of tight junctions in relation to skin barrier function, Curr. Probl. Dermatol., 49, 27 (2016).   DOI
2 J. Chen and M. Zhang, The Par3/Par6/aPKC complex and epithelial cell polarity, Exp. Cell Res., 319(10), 1357 (2013).   DOI
3 D. Gunzel and A. S. Yu, Claudins and the modulation of tight junction permeability, Physiol. Rev., 93(2), 525 (2013).   DOI
4 M. S. Balda, and K. Matter, Tight junctions and the regulation of gene expression, Biochim. Biophys. Acta -Biomembr., 1788(4), 761 (2009).   DOI
5 J. M. Brandner, Tight junctions and tight junction proteins in mammalian epidermis, Eur. J. Pharm. Biopharm., 72(2), 289 (2009).   DOI
6 J. A. Guttman, and B. B. Finlay, Tight junctions as targets of infectious agent, Biochim. Biophys. Acta., 1788(4), 832 (2009).   DOI
7 H. A. Ed ens, B. P. Levi, D. L. Jaye, S. Walsh, T. A. Reaves, J. R. Turner, A. Nusrat, and C. A. Parkos, Neutrophil transepithelial migration: evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration, J. Immun., 169(1), 476 (2002).   DOI
8 A. Fukui, Y. Naito, O. Handa, M. Kugai, T. Tsuji, H. Yoriki, Y. Qin, S. Adachi, Y. Higashimura, K. Mizushima, K. Kamad a, K. Katad a, K. Uchiyama, T. Ishikawa, T. Takagi, N. Yagi, S. Kokura, and T. Yoshikawa, Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1, Am. J. Physiol. - Gastrointest. Liver Physiol., 303(8), G927 (2012).   DOI
9 J. M. Brandner, S. Kief, C. Grund, M. Rendl, P. Houdek, C. Kuhn, E. Tschachler, W. W. Franke, and I. Moll, Organization and formation of the tight junction system in human epidermis and cultured keratinocytes, Eur. J. Cell Biol., 81(5), 253 (2002).   DOI
10 E. S. Barton, J. C. Forrest, J. L. Connolly, J. D. Chappell, Y. Liu, F. J. Schnell, A. Nusrat, C. A. Parkos, and T. S. Dermody, Junction adhesion molecule is a receptor for reovirus, Cell, 104(3), 441 (2001).   DOI
11 Y. Hashimoto, K. Tachibana, S. M. Krug, J. Kunisawa, M. Fromm, and M. Kondoh, Potential for tight junction protein-directed drug development using claudin binders and angubindin-1, Int. J. Mol. Sci., 20(16), 4016 (2019).   DOI
12 E. Proksch, J. M. Brandner, and J. M. Jensen, The skin: an indispensable barrier, Exp. Dermatol., 17(12), 1063 (2008).   DOI
13 C. M. Van Itallie and J. M. Anderson, The molecular physiology of tight junction pores, Physiology (Bethesda), 19, 331 (2004).   DOI
14 J. M. Brandner, S. Kief, E. Wladykowski, P. Houdek, and I. Moll, Tight junction proteins in the skin, Skin Pharmacol. Physiol., 19(2):71 (2006).   DOI
15 A. Arabzadeh, T. C. Troy, and K. Turksen, Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis, BMC cancer, 7, 196 (2007).   DOI
16 M. Reithofer and B. Jahn-Schmid, Allergens with protease activity from house dust mites, Int. J. Mol. Sci., 18(7), 1368 (2017).   DOI
17 J. Shi, M. Barakat, D. Chen, and L. Chen, Bicellular tight junctions and wound healing, Int. J. Mol. Sci., 19(12), 3862 (2018).   DOI
18 T. Yuki, A. Haratake, H. Koishikawa, K. Morita, Y. Miyachi, and S. Inoue, Tight junction proteins in keratinocytes: localization and contribution to barrier function, Exp. Dermatol., 16(4), 324 (2007).   DOI
19 A. Veshnyakova, J. Protze, J. Rossa, I. E. Blasig, G. Krause, and J. Piontek, On the interaction of Clostridium perfringens enterotoxin with claudins, Toxins (Basel)., 2(6), 1336 (2010).   DOI
20 S. Maher, T. W. Leonard, J. Jacobsen, and D. J. Brayden, Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic, Adv. Drug Deliv. Rev., 61(15), 1427 (2009).   DOI
21 J. A. Palatinus, M. P. O'Quinn, R. J. Barker, B. S. Harris, J. Jourdan, and R. G. Gourdie, ZO-1 determines adherens and gap junction localization at intercalated disks, Am. J. Physiol. - Heart Circ. Physiol., 300(2), H583 (2011).   DOI
22 J. S. Kim and H. S. Jang, The expression pattern of the tight junction protein occludin in the epidermal context when comparing various physical samples, Korean Journal of Clinical Laboratory Science, 47(4), 267 (2015).   DOI
23 J. M. Anderson, and C. M. Van Itallie, Physiology and function of the tight junction, Cold Spring Harb. Perspect. Biol., 1(2), a002584 (2009).   DOI
24 M. Lal-Nag and P. J. Morin, The claudins, Genome Biol., 10(8), 1 (2009).
25 I. Benedicto, F. Molina-Jimenez, B. Bartosch, F. L. Cosset, D. Lavillette, J. Prieto, R. Moreno-Otero, A. ValenzuelaFernandez, R. Aldabe, M. Lopez-Cabrera, and P. L. Majano, The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection, J. Virol., 83(16), 8012 (2009).   DOI
26 M. Furuse, M. Hata, K. Furuse, Y. Yoshida, A. Haratake, Y. Sugitani, T. Noda, A. Kubo, and S. Tsukita, Claudinbased tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice, J. Cell Biol., 156(6), 1099 (2002).   DOI
27 I. Helfrich, A. Schmitz, P. Zigrino, C. Michels, I. Haase, A. le Bivic, M. Leitges, and C. M. Niessen, Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation, J. Invest. Dermatol., 127(4), 782 (2007).   DOI
28 A. E. Mertens, T. P. Rygiel, C. Olivo, R. van der Kammen, and J. G. Collard, The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex, J. Cell Biol., 170(7), 1029 (2005).   DOI
29 M. Kondoh, T. Yoshida, H. Kakutani, and K. Yagi, Targeting tight junction proteins-significance for drug development, Drug Discov., 13(3-4), 180 (2008).
30 J. Brunner, S. Ragupathy, and G. Borchard, Target specific tight junction modulators, Adv. Drug Deliv. Rev., 171, 266 (2021).   DOI
31 M. A. Deli, Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery, Biochim. Biophys. Acta, 1788(4), 892 (2009).   DOI
32 E. K. Anderberg, T. Lindmark, and P. Artursson, Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route, Pharm. Res., 10(6), 857 (1993).   DOI
33 N. N. Salama, N. D. Eddington, and A. Fasano, Tight junction modulation and its relationship to drug delivery, Adv. Drug Deliv. Rev., 58(1), 15 (2006).   DOI
34 T. Otani and M. Furuse, Tight junction structure and function revisited, Trends Cell Biol., 30(10), 805 (2020).   DOI
35 C. M. Niessen, Tight junctions/adherens junctions: basic structure and function, J. Invest. Dermatol., 127(11), 2525 (2007).   DOI
36 R. Gruber, C. Bornchen, K. Rose, A. Daubmann, T. Volksd orf, E. Wlad ykowski, S. Vid al-Y-Sy, E. M. Peters, M. Danso, J. A. Bouwstra, H. C. Hennies, I. Moll, M. Schmuth, and J. M. Brandner, Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis, Am. J. Clin. Pathol., 185(10), 2777 (2015).   DOI
37 M. Furuse, M. Hata, K. Furuse, Y. Yoshida, A. Haratake, Y. Sugitani, T. Noda, A. Kubo, and S. Tsukita, Claudinbased tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice, J. Cell Biol., 156(6), 1099 (2002).   DOI
38 C. Leyvraz, R. P. Charles, I. Rubera, M. Guitard, S. Rotman, B. Breiden, K. Sandhoff, and E. Hummler, The epidermal barrier function is dependent on the serine protease CAP1/Prss8, J. Cell Biol., 170(3), 487 (2005).   DOI
39 J. M. Brandner, Pores in the epidermis: aquaporins and tight junctions, Int. J. Cosmet. Sci., 29(6), 413 (2007).   DOI
40 U. Ohnemus, K. Kohrmeyer, P. Houdek, H. Rohde, E. Wladykowski, S. Vidal, M. A. Horstkotte, M. Aepfelbacher, N. Kirschner, M. J. Behne, I. Moll, and J. M. Brandner, Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains, J. Invest. Dermatol., 128(4), 906 (2008).   DOI
41 C. Gorzelanny, C. Mess, S. W. Schneid er, V. Huck, and J. M. Brandner, Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?, Pharmaceutics, 12(7), 684 (2020).   DOI
42 M. Kopecna, M. Machacek, A. Novackova, G. Paraskevopoulos, J. Roh, and K. Vavrova, Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers, Sci. Rep., 9(1), 14617 (2019).   DOI
43 T. C. Troy, A. Arabzadeh, N. M. Lariviere, A. Enikanolaiye, and K. Turksen, Dermatitis and agingrelated barrier dysfunction in transgenic mice overexpressing an epidermal-targeted claudin 6 tail deletion mutant, PLoS One, 4(11), e7814 (2009).   DOI
44 J. M. Brandner, M. Zorn-Kruppa, T. Yoshida, I. Moll, L. A. Beck, and A. De Benedetto, Epidermal tight junctions in health and disease. Tissue barriers, 3(1-2), e974451 (2015).   DOI
45 K. Nagasawa, H. Chiba, H. Fujita, T. Kojima, T. Saito, T. Endo, and N. Sawada, Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells, J. Cell. Physiol, 208(1), 123 (2006).   DOI
46 H. Lan, K. Hosomi, and J. Kunisawa, Clostridium perfringens enterotoxin-based protein engineering for the vaccine design and delivery system, Vaccine, 37(42), 6232 (2019).   DOI
47 K. Basler, S. Bergmann, M. Heisig, A. Naegel, M. Zorn-Kruppa, and J. M. Brandner, The role of tight junctions in skin barrier function and dermal absorption, J. Control Release, 242, 105 (2016).   DOI