Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Structure and Function of Tight Junctions in the Skin

피부에서의 치밀이음의 구조와 기능

  • Song, Mee (DERMAPRO Bio Research Center, DERMAPRO Ltd.) ;
  • Baek, Ji Hwoon (DERMAPRO Bio Research Center, DERMAPRO Ltd.)
  • Received : 2022.06.28
  • Accepted : 2022.06.30
  • Published : 2022.06.30
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Abstract

The skin protects the body from excessive water loss and the invasion of harmful substances, such as chemicals and microbes. The stratum corneum, is recognized as a very important physical barrier. However, in recent years evidence emerged that tight junctions (TJ) might also play a crucial role in barrier function of the skin. In the present study, TJ proteins including transmembrane proteins and plaque proteins, skin permeability barrier function and skin diseases of TJ were reviewed.

피부는 과도한 수분 손실과 화학물질, 미생물과 같은 해로운 물질의 침입으로부터 신체를 보호한다. 특히 표피의 각질층은 매우 중요한 물리적 장벽으로 인식되고 있다. 그러나 최근 몇 년 동안 치밀이음(tight junctions, TJ)이 피부의 장벽 기능에 중요한 역할을 할 수 있다는 증거가 보고되고 있다. 본 논문에서는 치밀이음을 구성하는 단백질의 종류, 치밀이음의 피부투과장벽으로서의 기능과 피부질환, permeation enhancer로서의 역할에 대해 살펴보고자 한다.

Keywords

References

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