• Animal cells and systems
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• 제6권2호
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• pp.171-180
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• 2002

Nitric oxide has high affinity for iron, and thus it can cause intracellular iron loss. We tested the idea that intracellular iron can be the primary target of NO toxicity by comparing the signaling mechanisms involved in cell death caused by iron depletion and that caused by NO. Treatment of HL-60 cells with a NO donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP), decreased the intracellular iron level rapidly as that observed with the iron chelator deferoxamine (DFO). Iron chelators such as DFO and mimosine could induce death of human leukemic HL-60 cells by a mechanism requiring activation of p38 kinase, c-Jun N-terminal kinase, caspase-3 and caspase-8. DFO and SNAP also caused release of cytochrome c from mitochondria. Inhibition of p38 kinase by a selective inhibitor, SB203580, abolished the NO and DFO-induced cell death, release of cytochrome c, and activation of caspase-3 and caspase-8, thus indicating that p38 kinase lies upstream in the cell death processes. In a parallel situation, the cells that are sensitive to NO showed similar sensitivity to DFO. Moreover, simultaneous addition of ferric citrate, an iron-containing compound, inhibited the SNAP and DFO-induced activation of caspases and also blocked the NO-mediated cell cycle arrest at $G_1$ phase. Collectively, our data implicate that the NO-induced cell death of tumor cells including HL-60 cells is mediated by depletion of iron and further suggest that activation of p38 kinase lies upstream of cytochrome c release and caspase activation involved in this apoptotic process.

• 과학기술학연구
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• 제17권2호
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• pp.173-208
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• 2017

과학 스스로의 전문성과 사회로부터 자율성 추구는 과학과 사회의 분리를 심화시키는 배경으로 작용하여 왔다. 그러나 사회의 불확실성과 복잡성의 증대는 과학 스스로의 문제 해결과 질적 통제의 한계를 노출하게 하였고 과학에 대한 사회 참여를 요구하는 배경으로 작용하였다. 이에 본 연구는 선행연구에서 제시된 사회 참여 평가 유형을 과학 영역으로 확대하여 사회 속 과학의 실현 방안을 모색하였다. 구체적으로는 전통적 과학 평가, 참여적 과학 평가 및 숙의적 과학 평가로 구분하되 전통적 과학 평가가 전문가 중심으로 운영되어 사회의 보편적 참여를 제한한다는 점에서 본 연구는 참여적 과학 평가와 숙의적 과학 평가를 중심으로 연구하였다. 분석 결과에 의하면, 참여적 과학 평가와 숙의적 과학 평가가 전통적 과학 평가에 비해 이해당사자의 확대라는 점에는 공통점을 가지나, 평가대상, 평가방법, 사회 참여 범위 및 조정자의 역할에 있어 차별성을 가진다는 점을 제시하였다. 한편, 본 연구는 과학에의 사회 참여 평가가 민주주의적 가치 실현 차원에서 당연히 요구되는 사항임에도 불구하고 보편적으로 적용함에 나타나는 장애 요인과 이행 방안을 제시하고 향후 사회 전반의 노력과 체제 개선 외에도 다양한 후속 연구의 필요성을 강조한다.

• 보존과학회지
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• 제37권5호
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• pp.590-605
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• 2021

우리나라의 인쇄기술사의 연구는 현존하는 고문헌, 전적류의 조사와 축적되어온 자료와의 비교를 통하여 이루어진다. 문화재 연구의 특성상 비파괴 검사가 요구되어 육안 또는 현미경에 의한 관찰과 연구자의 경험과 지식에 의존하는 경우가 많다. 목판인쇄, 목활자인쇄, 금속활자인쇄 또는 그 조합으로 이루어진 것으로 추정되는 고문헌과 전적류의 경우, 연구자마다 다양한 견해와 결론을 도출하게 되어 혼란이 가중되기도 하고 사회적 비용이 증가하기도 한다. 그중에서도 목판본과 금속활자본에 대한 판단 기준이 모호하여 우리나라의 인쇄기술 발달사에 대한 학술적 연구의 정체뿐만 아니라 연구자들 간의 갈등이 분출되기도 하고 문화재 분야의 전문기관이 아닌 국가의 수사기관까지 가세하여 상황이 더욱 복잡하게 전개되는 경우가 적지 않았다. 본 연구에서는 복각된 훈민정음(訓民正音) 목판을 사용하여 여러 장의 한지에 직접 인출하는 재현성 실험과 인출된 결과물의 이미지를 정량적으로 분석하여 보다 객관적인 판단 기준으로 활용될 수 있는 인출특성은 무엇인지 조사하였다. 또한 현재까지 목판인쇄본과 금속활자본의 구별방법으로 제시되고 있는 기준의 타당성과 의문점을 살펴보았다. 목판인쇄의 재현실험을 통한 한지상의 인출특성의 조사와 이미지분석법을 활용한 다양한 특징의 정량화를 시도하고 정량분석에 의한 객관성 있는 새로운 판단 기준확보의 가능성을 조사하였다.

• 기독교교육논총
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• 제65권
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• pp.29-54
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• 2021

유럽에서 종교, 문화 언어, 그리고 역사적 배경의 다양성은 거대하다. 이차세계대전과 소비에트연합은 유럽에서 커다란 역할을 한다. 다른 대륙에서 난민의 유입은 다원주의를 증가시킨다. 종교교육은 이러한 차이의 다리 역할에 주목한다. 유럽 대륙에서 언어는 매우 다양하다. 나라와 발음, 심지어 개별 국가에서도 차이가 있다. 이것은 문화 감수성과 세대 간의 집단별 차이를 발생시킨다. 중등교육은 청소년들이 그들 사회에 대한 견고한 뿌리를 내리는 인격 형성의 중요한 역할을 한다. 중등교육에서 청소년의 핵심 가치와 문화적 기반을 검증하는 학습은 필수적이다. 종교교육의 핵심은 그러한 가치를 검토하는 것이다. 그러나 학교는 현재 점차 증가하는 학생들의 비종교성에 적응해야 하는 도전에 직면하고 있다. 종교적 가치는 이러한 상황 속에서 어떠한 역할을 하는가? 학생들은 종교 기관에 적극적으로 참여하는 것에 대해서 어떠한 느낌을 가지는가? 그리고 종교적 신념에 대한 삶의 선택에 대해서 어떠한 생각을 가지는가? 비종교적 가치가 가치 기반의 인격을 지닌 타자의 인격적 기초를 형성하는 것을 파악할 수 있는가? 비종교적 가치는 가치 기반의 인격 형성의 기초를 형성할 수 있는가? 이러한 주제에 대한 연구는 네덜란드에서 20년 이상 지속해 온 것이다. 그리고 현재 체코슬로바키아와 동독 지역으로 확산되고 있다. 이러한 주제는 세속화된 나라에서 그리고 다른 역사에서도 현저하다. 역사와 이러한 국가의 상황은 학습자들에게 중요한 가치를 보여주고 그들의 역할을 가시화한다. 비교 연구는 이러한 유럽 국가의 학습자의 가치를 검토하는 것에 보다 폭 넓은 관점을 제공한다. 이러한 지식은 종교 기반의 세계관 교육의 형성과 계획에 도움이 된다.

• Journal of East Asia Management
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• 제2권1호
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• pp.105-132
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• 2021

The purpose of this study is to summarize recent research on new product development (NPD) and to examine the direction of future research on NPD. In recent years, product development has also become more diversified due to the formation and disappearance of new markets, the increasing commoditization of products, and the emergence of new technological infrastructures such as ICT and crowdsourcing. In addition, NPD research is also in a situation where new research is emerging along with the progress of research in related areas, such as open innovation and customer participation. On the other hand, research on NPD has become increasingly fragmented into themes related to NPD as research progresses, making it more difficult to grasp the overall picture of NPD research, although review articles on NPD have been written. Not many review articles have been written in a way that goes beyond the individual themes of NPD research. However, even though it is impossible to look at NPD research as a whole, this study believe that by daring to conduct an exhaustive review of recent NPD research, rather than individual issues, and by understanding the types of discussions that have taken place in recent NPD research, this study can identify areas that require further discussion. Based on the above, the purpose of this study is to comprehensively examine and organize the topics and issues that have been dealt with in recent NPD research, point out the topics that have not been adequately dealt with in previous research, and indicate the direction of future research. This study found that (1) half of the previous studies this study reviewed dealt with the topic of collaboration in NPD, (2) existing studies on NPD assume that the purpose of NPD is to gain competitive advantage through differentiation, but the formation of the market itself through NPD has not been discussed However, it became clear that there has been no discussion of the formation of the market itself through NPD. While the formation and disappearance of new markets has become a common phenomenon in recent years as the competitive environment changes more and more rapidly, the formation of new markets through NPD may also be discussed as a new research area of NPD. However, the formation of new markets through NPD could be discussed as a new research area of NPD. This study examined the possibility of discussing the formation of new markets through NPD by using market category studies.

• Asia pacific journal of information systems
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• 제19권2호
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• pp.43-72
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• 2009

Recently, user-created content (UCC) have emerged as popular medium of on-line participation among users. The Internet environment has been constantly evolving, attracting active participation and information sharing among common users. This tendency is a significant deviation from the earlier Internet use as an one-way information channel through which users passively received information or contents from contents providers. Thanks to UCCs online users can now more freely generate and exchange contents; therefore, identifying the critical factors that affect content-generating activities has increasingly become an important issue. This paper proposes a set of critical factors for stimulating contents generation and sharing activities by Internet users. These factors were derived from the theories of folklores such as tales and songs. Based on some shared traits of folklores and UCC content, we found four critical elements which should be heeded in constructing UCC contents, which are: context of culture, context of situation, skill of generator, and response of audience. In addition, we selected three major UCC websites: a specialized contents portal, a general internet portal, and an official contents service site, They have different use environments, user interfaces, and service policies, To identify critical factors for generating, sharing and transferring UCC, we traced user activities, interactions and flows of content in the three UCC websites. Moreover, we conducted extensive interviews with users and operators as well as policy makers in each site. Based on qualitative and quantitative analyses of the data, this research identifies nine critical factors that facilitate contents generation and sharing activities among users. In the context of culture, we suggest voluntary community norms, proactive use of copyrights, strong user relationships, and a fair monetary reward system as critical elements in facilitating the process of contents generation and sharing activities. Norms which were established by users themselves regulate user behavior and influence content format. Strong relationships of users stimulate content generation activities by enhancing collaborative content generation. Particularly, users generate contents through collaboration with others, based on their enhanced relationship and specialized skills. They send and receive contents by leaving messages on website or blogs, using instant messenger or SMS. It is an interesting and important phenomenon, because the quality of contents can be constantly improved and revised, depending on the specialized abilities of those engaged in a particular content. In this process, the reward system is an essential driving factor. Yet, monetary reward should be considered only after some fair criterion is established. In terms of the context of the situation, the quality of contents uploading system was proposed to have strong influence on the content generating activities. Among other influential factors on contents generation activities are generators' specialized skills and involvement of the users were proposed. In addition, the audience response, especially effective development of shared interests as well as feedback, was suggested to have significant influence on contents generation activities. Content generators usually reflect the shared interest of others. Shared interest is a distinct characteristic of UCC and observed in all the three websites, in which common interest is formed by the "threads" embedded with content. Through such threads of information and contents users discuss and share ideas while continuously extending and updating shared contents in the process. Evidently, UCC is a new paradigm representing the next generation of the Internet. In order to fully utilize this innovative paradigm, we need to understand how users take advantage of this medium in generating contents, and what affects their content generation activities. Based on these findings, UCC service providers should design their websites as common playground where users freely interact and share their common interests. As such this paper makes an important first step to gaining better understand about this new communication paradigm created by UCC.

• 한국간호교육학회지
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• 제1권1호
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• pp.17-23
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• 1995

One of the biggest problems of Nursing Education in Korea is the division among nursing education programs of the last 3 and 4 years. To solve this problem, Nursing community must do variable trials to achieve the unity of a 4-year educational program. With this, we need to observe the phenomena and reality of the present 4-year nursing educational program that we have. The object of this study is to analyse and discuss that we have. The object of this study is to analyse and discuss the problems and future strategies of 4-year Nursing Baccalaureate program. 1. Problems as nursing department in Medical School. 1) Many 4-year nursing baccalaureate programs are operating under the medical school as nursing department. So the academic development in nursing department is unprogressive and is not approved as unique discipline. 2) The operating system between nursing and medical department are different even though they are in the same school. 3) Inequality between nursing and medical department : In many case, the nursing professor can not attend administraion committees to discuss the medical school's operation because of many differences between nursing and medical organization. 4) Weakness of the leadership and the student activities in nursing student : The nursing student involvement is usually passive because of the difference of curriculum, less number than medical students and the difference between 4-year and 6-year education program. 5) There is the obscurity of the relationship between department of nursing and other departments in whole university. 2. Problems in nursing itself 1) We need to reconstruct nursing discipline. We must change from the disease centered model to health centered model and life cycle centered model so that we can be distinguished from medicine. We also must change from hospital centered nursing to all population centered nursing, 2) The improvement of curriculum ; When the independent framework of nursing discipline become established, we need to improve the curriculum. 3) The education of clinical practice ; Most nursing school programs are divided into professors who are lecturing the theory and clinical teachers who are teaching the nursing technique in the clinic. So, what is needed in nursing discipline is that the professors have a dual position. In America, The professor is required to be a clinical specialist and to have his or her clinic so that the professor become a good role model, teach the clinical practice effectively, and give the student the practice field. 4) To extend fields of nursing : At first, the school nurse must become the school health educator, a real teacher. The nurse must establish and operate a childern's wellbeing center or nursery school, a disabled people's house or senile's wellbeing center, a mental health center, and a health promotion clinic for healthy people. 5) The name 'nursing department' need to be considered. When the focus is to be changed from the disease model to health improvement model, we take into consideration change 'nursing college', 'nursing department' and 'nursing profession' to 'health science college' or 'health wellbeing college'. 6) We must have highly qualified academic students. Each Nursing educational faculties must have the high qualified students through the development of nursing educational program and the increment of scholarship. The Korean Nurses Association and The Korean Clinical Nurses Association need to make an endeavor for the improvement of work condition and payment of clinical nurses of hospitals who consist of 70% of all nursing manpower. 3. Improvement Strategy 1) All nursing educational program must be changed 4-year program gradually. 2) Nursing department need to try to become nursing college. 3) We need to study many researches for improvement of the problem in nursing discipline and nursing education. We need more interdisciplinary researches, and we need to be granted for that research. 4) We need to have many seminars and workshops thoughout the whole country to expand a sense of nursing education. 5) Drawing up a policies plan for the nursing educational improvement : The Korean Nurses Association, The Korean Academic Nursing Association, Korea Nursing College and department President's Committee, and Korea Academic Society of Nursing Education must try for the development of nursing educational improvement and ask for government frame the policy to develop nursing education.

• 치위생과학회지
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• 제8권4호
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• pp.331-336
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• 2008

부모협동보육시설의 보육 특성에 맞는 영유아 구강보건사업을 개발 하는데 필요한 기초자료를 확보할 목적으로 전국의 부모협동보육시설 보육교사 204명을 대상으로 한 설문조사에서 얻은 결과는 다음과 같다. 1. 일상적으로 제공하는 간식과 음료는 과일 78.9%, 채소 44.1%, 과실차 61.8%로 비우식성 식음료의 비중이 높았다. 2. 보육교사들의 3년 이내 구강보건교육 이수비율은 51.5%였으며, 내용은 음식과 영양관련교육 30.0%, 칫솔질 관련 교육 29.4%이었다. 3. 구강건강관련행위 실천여부는 아이들의 음식관련 활동과 교육에 참여 87.9%, 조리담당자 영양교육 78.2%, 생일축하 시 단 음식을 피함 74.0%, 매년 구강검진 실시 33.5%, 아이들의 불소함유치약사용 33.1%이었다. 4. 부모의 구강건강 정책개발 개입에 대한 보육교사의 견해는 매우 동의 35.1%, 동의 53.8%이었다. 5. 부모협동보육시설 내 구강보건주제에 대한 문서화된 지침의 존재여부는 건강정책형성과정에 부모참여 47.8%, 부모에게 치과의료서비스 조언 47.2%, 치아손상 시 대처방법 지도 44.9%, 1년 주기의 치과건강검진 41.7%, 불소치약으로 칫솔질 지도 32.1%이었다. 이상에서 부모협동보육시설은 간식 등의 제공에 있어서 비우식성 식품과 음료를 주로 제공하고 있는 등 영양학적 측면에서 좋은 구강건강환경을 가지고 있으며 부모의 참여에 대한 동의가 높았다. 보육교사를 대상으로 한 구강보건교육은 영양과 칫솔질위주로 이루어지고 있었으며 문서화된 지침은 부족하였다. 따라서 부모협동보육시설을 대상으로 하는 효과적인 구강보건정책개발을 위해서는 보육교사들을 대상으로 다양한 구강보건교육을 개발하고 교육내용을 실현할 수 있는 방안을 강구하며, 문서화된 지침을 갖도록 하는 것이 필요하다.

• 한국재난정보학회 논문집
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• 제11권4호
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• pp.556-569
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• 2015

국민의 75%가 정부의 재난관리 정책을 비판하는 등 세월호 참사와 같은 대형 재난 관리실패는 정부 불신을 초래하고 있다. 세월호 참사와 같은 재난이 다시 발생하지 않도록 재난안전에 있어 골든타임 확보가 중요하며, 주민의 가장 가까운 곳에 위치한 경찰의 재난 위기관리 능력 개선이 필요하다. 재난 안전 역시 경찰 임무의 본질로서 다음과 같이 국가위기관리 단계별로 경찰의 재난안전 관리 시스템의 강화가 필요하다. 첫째, 예방단계에서는 과거 다중운집행사의 경우 수익성 행사의 경우 경찰력을 투입하지 않았으나, 앞으로는 기준을 수익성이 아닌 위험성 여부로 판단해야 한다. 그동안 교통 소통이 우선이었으나 안전 중심으로 교통 정책의 패러다임을 전화하고, 대형 사고를 예방하기 위해 수사 경찰은 비정상적 관행과 건축불법 하도급을 근절하며, 정보 경찰은 '안전'이라는 주제에 대한 정보 수집을 강화해야 한다. 둘째, 대비단계와 관련 최근 경찰관 대상 설문 조사 결과 경찰관의 72%는 안전관리와 경찰이 업무연관성이 없다고 응답하는 등 재난안전에 대한 인식도 개선이 시급하므로 재난 안전 교육 훈련을 강화해야 한다. 위기상황에 대한 민간 자원을 활용할 수 있도록 민 관 경재난 안전 네트워크를 구축해야 한다. 셋째, 대응단계에서 신속한 초동 대응을 위해 재난 통신망을 일원화하고, 경찰기관 상황실에 실시간 영상정보망을 도입해야 하며, 넷째, 복구단계에서는 2차 피해를 최소화하기 위한 복구지원팀을 운영해야 한다.

• 미술이론과 현장
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• 제5호
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• pp.217-229
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• 2007

Many historical research and facet about modern art in Indonesia which formulating background of contemporary Indonesian Art. Indonesian art critic Sanento Yuliman states that Modern art has been rapidly developing in Indonesia since the Indonesian Independence in 1945. Modern Art is a part of the super culture of the Indonesian metropolitan and is closely related to the contact between the Indonesian and Western Cultures. Its birth was part of the nationalism project, when the Indonesian people consists of various ethnics were determined to become a new nation, the Indonesian nation, and they wished for a new culture, and therefore, a new art. The period 1960s, which was the beginning of the creation and development of the painters and the painters associations, was the first stage of the development of modern art in Indonesia. The second stage showed the important role of the higher education institutes for art. These institutes have developed since the 1950s and in the 1970s they were the main education institutes for painters and other artists. The artists awareness of the medium, forms or the organization of shapes were encouraged more intensely and these encouraged the exploring and experimental attitudes. Meanwhile, the information about the world's modern art, particularly Western Art; was widely and rapidly spread. The 1960s and 1970s were marked by the development of various abstractions and abstract art and the great number of explorations in various new media, like the experiment with collage, assemblage, mixed media. The works of the Neo Art Movement-group in the second half of the 1970s and in the 1980s shows environmental art and installations, influenced by the elements of popular art, from the commercial world and mass media, as well as the involvement of art in the social and environmental affairs. The issues about the environment, frequently launched by the intellectuals in the period of economic development starting in the 1970s, echoed among the artists, and they were widened in the social, art and cultural circles. The Indonesian economic development following the important change in the 1970s has caused a change in the life of the middle and upper class society, as has the change in various aspects of a big city, particularly Jakarta. The new genre emerged in 1975 which indicates contemporary art in Indonesia, when a group of young artists organized a movement, which was widely known as the Indonesian New Art Movement. This movement criticized international style, universalism and the long standing debate on an east-west-dichotomy. As far as the actual practice of the arts was concerned the movement criticized the domination of the art of painting and saw this as a sign of stagnation in Indonesian art development. Based on this criticism 'the movement' introduced ready-mades and installations (Jim Supangkat). Takes almost two decades that the New Art Movement activists were establishing Indonesian Installation art genre as contemporary paradigm and influenced the 1980's gene ration like, FX Harsono, Dadang Christanto, Arahmaiani, Tisna Sanjaya, Diyanto, Andarmanik, entering the 1990's decade as "rebellion period" ; reject towards established aesthetic mainstream i.e. painting, sculpture, graphic art which are insufficient to express "new language" and artistic needs especially to mediate social politic and cultural situation. Installation Art which contains open possibilities of creation become a vehicle for aesthetic establishment rejection and social politics stagnant expression in 1990s. Installation art accommodates two major field; first, the rejection of aesthetic establishment has a consequences an artists quest for medium; deconstruction models and cross disciplines into multi and intermedia i.e. performance, music, video etc. Second aspect is artists' social politic intention for changes, both conclude as characteristics of Indonesian Installation Art and establishing the freedom of expression in contemporary Indonesian Art until today.