• 한국산학기술학회논문지
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• 제11권12호
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• pp.4954-4961
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• 2010

본 배경 : 병원들과 병상 수들의 과잉공급과 의료시장 개방으로 인해 병원들 사이의 경쟁이 매우 심화되고 있다. 더 많은 환자 유치를 위해 환자들이 선호하는 특화서비스에 대해 조사하게 되었다. 방법 : 환자만족도를 조사하기 위해 약 20개 항목의 설문지를 개발하여 병원들 방문한 외래 환자 297명과 입원환자 302명을 조사하였으며 Excel과 SPSS를 이용하여 기술통계와 회귀분석을 하였다. 결과 : 환자의 충성도와 특화된 병원서비스의 관련성이 지인에게 이 병원 이용을 추천하겠다와 관련이 있으며 1) FHR사용과 지속적인 치료 및 관리를 위한 도우미는 외래환자와 PHR사용에서 양의 관련성을 가지고 있었고 FHR은 외래환자에서 양의 관련성을 갖고 있었다. 2) 병원의 재방문 : PHR사용자와 환자치료 도우미의 요구가 있었으며 TV사용료 지불은 부정적 관련성을 가지고 있었다. 결론 : FHR, PHR과 환자치료 도우미들은 환자의 충성도를 증가시키는데 매우 중요한 요인들이었다.

• 한국환경성돌연변이발암원학회지
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• 제26권3호
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• pp.69-76
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• 2006

2,3,7,8-Tetrachlorodibenzo-$\rho$-dioxin(TCDD) is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Although the mechanism of carcinogenesis by TCDD is poorly understood, several studies have shown that the skin is one of target organs far TCDD. In this study, we investigated the neoplastic transformation of human keratinocyte-derived cell line, HaCaT, by chemical transformation method using N-methyl-N'-nitro-N-nitrorsoguanidine(MNNG) and TCDD. We found that subsequent exposure to TCDD for 3 weeks after initial exposure to MNNG markedly induced transformed cells. It was suggested that TCDD can act as a potent promoter in HaCaT cells. Furthermore, these transformed cells showed morphological alternations in soft agar and increased telomerase activity. Therefore, the TCDD treatment of HaCaT cells by initiated with MNNG could promote neoplastic transformation without stimulation by exogenous growth factors. As a result, TCDD had a strong potency as a promoter in nontumorigenic immortalized human epidermal keratinocytes.

• 한국콘텐츠학회논문지
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• 제14권11호
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• pp.164-174
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• 2014

본 연구는 현재 국내의 의료기관에서 개인정보 및 의료정보보호에 적용되고 있는 적용법 간의 서로 상충되는 많은 문제점을 해결할 방안을 모색하고자 외국의 개인정보보호법과 의료정보보호법을 비교 분석하였다. 개인정보의 국제 표준 지침인 OECD와 EU의 가이드라인 분석과 개인정보보호법 및 의료정보보호법이 잘 정비되어 있는 미국, 캐나다, 프랑스를 선정하여 개인정보보호법제 및 의료정보보호법의 특징과 내용을 조사하여 비교하였으며, 현재 국내의 개인정보보호법 가이드라인과 의료정보보호 관련 법률 및 주요 내용을 항목별로 비교하였다. 분석결과 유럽의 여러 나라 중 특징적으로 프랑스가 의료정보보호를 위한 공공보건법을 제정하여 실행해오고 있었고, 미국과 캐나다가 독립된 의료정보보호법이 제정 실행되고 있었으며, 환자의 기록의 발생부터 관리 및 법을 이행하지 못했을 경우의 처벌조항까지 상당히 체계적인 법으로 규정하고 있고 기록의 작성자인 의사와 의료기록의 주체인 환자 간의 기밀 유지와 사생활 보호에 대해 중점적으로 보호책을 법에 규정하고 있음을 알 수 있다. 이는 한국도 환자에 관련된 모든 기록을 체계적으로 보호할 수 있는 독립된 의료정보보호법의 제정이 필요함을 알려준다.

• 한국콘텐츠학회논문지
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• 제13권10호
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• pp.365-374
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• 2013

본 연구는 노후에 대한 인식이 국가 민간의료기관 근로자간에 따라 차이가 있는지, 또한 노후인식이 노후준비에 어떠한 영향을 미치는지를 분석하고자 하였다. 연구대상은 부산의 보건소와 병 의원의 근로자 783명을 대상으로 진행하였다. 자료 분석은 SPSS 21.0 프로그램을 이용하여 빈도분석, t-test, 위계적 회귀분석을 실시하였다. 본 연구의 결과는 다음과 같이 나타났다. 첫째, 국가 민간의료기관의 근로자간에 노후에 대한 인식, 정부정책에 대한 만족도, 노후준비에 대해서 부분적으로 차이가 있었으며, 국가 근로자가 민간 근로자 보다 더 잘 인지하고, 만족하며, 비교적 준비하고 있었다. 또한 노후에 대한 인식과 정부정책 만족도는 모두 보통 수준 이상으로 나타났지만, 노후 준비는 미흡한 것으로 나타났다. 둘째, 노후 준비에 영향을 미치는 요인을 알아본 결과 국가의료기관과 민간의료기관 근로자에서 각각 다르게 나타났다. 또한 노후 준비에 미치는 영향은 부분적으로 차이를 보였다. 결론적으로 국가 민간의료기관 근로자간 노후준비에 미치는 영향에는 차이가 있었다. 본 연구는 노후준비에 대한 교육 및 정책수립을 위한 기초자료로 제공하려한다.

• 대한세포병리학회지
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• 제8권2호
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• pp.199-203
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• 1997

Chordoma is an uncommon neoplasm that accounts for approximately 1% to 4% of all primary bone neoplasms and thought to originate from remnants of the fetal notochordal elements. It usually occurs in adults and has a predilection for the sacrococcygeal and spheno-occipital areas. Chondroid chordoma, first described by Heffelfinger et al, is a rare variant of chordoma; it contains both chordomatous and chondromatous features, and has a considerably better prognosis than either chordoma or chondrosarcoma. The cytologic findings of fine needle aspiration of sacrococcygeal chondroid chordoma in a 57-year-old man are presented. Aspiration cytology showed many sheets and cords of neoplastic cells in a thick amorphous blue-purple mucinous background. The cells had small too medium sized round nuclei with coarse granular chromatin and abundant eosinophilic or bubbly cytoplasm. Some cells had pleomorphic and hyperchomatic nuclei with prominent nucleoli. Cytologic findings were compared to histologic findings. Histologically, areas of chondroid differentiation were noted which were absent in the cytologic smear. Immunohistochemically, both the chondroid and chordoid areas had an epithelial phenotype and stained for cytokeratin, epithelial membrane antigen and S-100 protein. This is the first case of cytologic findings of chondroid chordoma to our knowledge in literature.

• Journal of Pharmaceutical Investigation
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• 제34권1호
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• pp.43-48
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• 2004

The purpose of the present study was to evaluate the bioequivalence of two nizatidine capsules, Axid (Lilly Korea Pharm. Co., Ltd.) and Nex (Bi-nex Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The nizatidine release from the two nizatidine capsules in vitro was tested using KP Apparatus method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). The dissolution prefers of two nizatidine capsules were very similar at all dissolution media. Twenty four normal male volunteers were divided into two groups with a randomized 22 crossover study. After two capsules (300 mg nizatidine) were orally administrated, blood was taken and the concentrations of nizatidine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were determined. The result showed that the differences in $AUC_t$, $C_{max}$ and $T_{max}$ between two nizatidine capsules based on the Axid were -6.16%, -8.26% and -1.82%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(125)(e.g., $log(0.91){\sim}log(0.97)$ and $log(0.85) {\sim}log(0.99)$ for $AUC_t$ and $C_{max}$ respectively), indicting that Nex capsule is bioequivalent to Axid capsule.

• Journal of Animal Science and Technology
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• 제54권6호
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• pp.443-448
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• 2012

This study was conducted to investigate changes of blood metabolites and enzyme activities at different slaughter ages of Hanwoo cattle. Blood samples were taken from six hundred thirty two steers (24~33 months of age) and one hundred twenty eight bulls (17~24 months of age) by venipuncture from caudal vein immediately prior to slaughter. Glucose concentrations were linearly increased (P<0.001) with increases of the slaughter age in steers, and blood urea nitrogen (BUN) concentrations were linearly decreased (P<0.001) with increases of the slaughter age in steers. Likewise, glucose and albumin concentrations in bulls were linearly decreased (P=0.009 and P<0.001, respectively) with increases of the slaughter age. BUN, cholesterol, triglycerides, and total cholesterol concentrations were linearly increased (P<0.001, 0.018 and 0.002, respectively), and creatinine concentrations were quadratically increased (P=0.009) with increases of the slaughter age. Activity of gamma glutamyltransferase (${\gamma}$-GT) and aspartate aminotransferase (AST) was linearly increased (P<0.001) with increases of the slaughter age in both steers and bulls, whereas alanine aminotransferase (ALT) was not affected by increasing slaughter age. In addition, the concentrations of ${\gamma}$-GT and AST were higher (P<0.05) for bulls than those of steers at 24 months of age. Increased levels of ${\gamma}$-GT and AST indicate impaired liver function; it may be associated with increases of concentrate level which is a concomitant of the extended fattening periods in Hanwoo feeding. In conclusion, the results in the present study may be one of the useful information for diagnosis of the metabolic disorder in Hanwoo cattle.

• 보건행정학회지
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• 제23권1호
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• pp.66-77
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• 2013

The purpose of this empirical study is to investigate the factors of self-leadership depending on individual characteristics, job characteristics, and qualities of leader-member exchange. Additionally, this study aims to discover the effect of self-leadership's outcome factors on organizational citizenship behavior and innovative activities. In order to verify research model and hypothesis, questionnaires were collected from department members working at general hospitals, hospitals, and clinics in metropolitan area of Seoul, which were 85 departments and 344 respondents. Collected data were analyzed with SPSS ver. 19.0 and Amos ver. 18.0 statistical package using Structural Equation Model. The results of the analysis showed that both individual characteristics and job characteristics have significant positive effect on self-leadership. Also, self-leadership had significant positive relationship on innovative action and organizational citizenship behavior. The implications of this study are as follow. First, this study empirically explained how self-leadership is applied in healthcare organizations. Second, it verified the relationship between causal factors and outcome factors of self-leadership. Also, prior researches of self-leadership have been conducted on business companies, but this study explored self-leadership at healthcare organizations, which increased external validity. Nowadays, many people are interested in the effect of leadership in order to overcome issues coming from enlarged organizations and to improve performance. Self-leadership will contribute to maximizing voluntary efforts of human resources and performance in a rapidly changing healthcare industry.

• 한국콘텐츠학회논문지
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• 제14권2호
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• pp.355-363
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• 2014

본 연구는 Agnew의 GST에 기반하여 중학생의 휴대폰 의존에 미치는 영향을 알아보려 하였다. 연구대상은 한국아동청소년패널 2010 중1 패널 1차년도 데이터를 이용하여 총 2,151명을 최종 연구에 이용되었다. 연구의 분석방법은 AMOS 21 Ver.를 사용하여 구조방정식으로 검증하였다. 본 연구의 결과는 다음과 같다. 첫째, 최종모형의 적합도 지수는 $X^2=1398.997$, df=144, GFI=.937, NNFI(TLI)=.902, CFI=.918, RMSEA=.061으로 나타나 GST이론을 통해 중학생의 휴대폰 의존에 대해 검증하는데 타당한 것으로 나타났다. 둘째, 중학생의 긴장요인이 부정적 삶의 만족도를 형성하는데 통계학적으로 유의한 정(+)의 영향을 나타내는 것으로 나타났다. 마지막으로, 중학생의 부정적 삶의 만족도는 휴대폰 의존에 통계학적으로 유의한 정(+)의 영향을 미치는 것으로 나타났다. 본 연구는 중학생의 휴대폰 의존에 관한 프로그램 개발, 중재적 방안을 모색하는데 기초적 자료로 제공하려 한다.

• Journal of Biosystems Engineering
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• 제39권4호
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• pp.377-388
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• 2014

Purpose: Determining the spatial structure of data is important in understanding within-field variability for site-specific crop management. An understanding of the spatial structures present in the data may help illuminate interrelationships that are important in subsequent explanatory analyses, especially when site variables are correlated or are a combined response to multiple causative factors. Methods: In this study, correlation, principal component analysis, and single and nested variogram models were applied to soil electrical conductivity and chemical property data of two fields in central Missouri, USA. Results: Some variables that were highly correlated, or were strongly expressed in the same principal component, exhibited similar spatial ranges when fitted with a single variogram model. However, single variogram results were dependent on the active lag distance used, with short distances (30 m) required to fit short-range variability. Longer active lag distances only revealed long-range spatial components. Nested models generally yielded a better fit than single models for sensor-based conductivity data, where multiple scales of spatial structure were apparent. Gaussian-spherical nested models fit well to the data at both short (30 m) and long (300 m) active lag distances, generally capturing both short-range and long-range spatial components. As soil conductivity relates strongly to profile texture, we hypothesize that the short-range components may relate to the scale of erosion processes, while the long-range components are indicative of the scale of landscape morphology. Conclusion: In this study, we investigated the effect of changing active lag distance on the calculation of the range parameter. Future work investigating scale effects on other variogram parameters, including nugget and sill variances, may lead to better model selection and interpretation. Once this is achieved, separation of nested spatial components by factorial kriging may help to better define the correlations existing between spatial datasets.