• Journal of the Institute of Convergence Signal Processing
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• v.8 no.1
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• pp.73-77
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• 2007

In this paper, we propose a VLSI architecture of an LMS filter based on a Cyclo-static scheduler for fast computation of LMS filteing algorithm which is widely used in adptive filtering area. This process is composed of two steps: scheduling and circuit synthesis. The scheduling step accepts a fully specified flow graph(FSFG) as an input, and generates an optimal Cyclo-static schedule in the sense of the sampling rate, the number of processors, and the input-output delay. Then the generated schedule is transformed so that the number of communication edges between the processors. The circuit synthesis part translates the modified schedule into a complete circuit diagram by performing resource allocations. The VLSI layout generation can be performed easily by an existing silicon compiler.

• Journal of the Institute of Convergence Signal Processing
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• v.10 no.2
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• pp.127-131
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• 2009

In the digital waveguide theory, traveling waves are represented by general solution to the wave equation that is second-order linear partial differential equation. The movement of these waves can be implemented using only delay lines. An unit delay in the general digital waveguide describes a sampling time interval. However, in the space-based digital waveguide the unit delay implies the spatial sampling distance. In consideration of these differences between two models, it is known that the space-based digital waveguide model is adequate to synthesize pitch-shifted sounds such as vibrato because the propagation distance can be directly control. In this paper, the time-based digital waveguide model which also synthesizes pitch-shifted sounds is proposed and compared with space-based digital waveguide.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.39 no.2
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• pp.159-166
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• 2013

In order to develop new skin whitening agents, we prepared the EtOAc layer (AJE) after enzyme treatment of 75% EtOH extract of the Alnus Japonica Steud. We measured their tyrosinase inhibitory activity in vitro and melanin synthesis inhibitory activity in B16-F1 melanoma cells. They did not show inhibitory activity against mushroom tyrosinase but showed melanin synthesis inhibitory activity in a dose-dependent manner. In a melanin synthesis inhibition assay, AJE suppressed melanin production up to 52% at a concentration of $40{\mu}g/mL$. To elucidate the mechanism of the inhibitory effects of AJE on melanogenesis, we measured expression of melanogenesis-related proteins by the western blot assay. As a result, AJE suppressed the expression of tyrosinase related protein 1 (TRP-1) and microphthalmia associated transcription factor (MITF). Moreover, AJE increased the expression of phosphorylated extracellular signal-regulated kinase (p-ERK). These results conclude that ERK activation by AJE reduces melanin synthesis via MITF downregulation and is subsequent to the inhibition of TRP-1 expression. Therefore, we suggest that AJE could be used as active ingredients for skin whitening.

• The Journal of Korean Medicine
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• v.19 no.2
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• pp.36-49
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• 1998

HERBA SAURURI (HS) has been known to use antiinflammatory drug. To investigated the mechanism of HS-induced NO synthesis, I evaluated the ability of protein kinase C (PKC) inhibitors such as staurosporine (STSN) or polyymyxin B to block HS-induced effects. HS alone had only a small effect, whereas in combination with $rIFN-{\gamma}$, markedly increased NO synthesis in a dose dependent manner. STSN and polymyxin B decreased NO synthesis, which had been induced by $rIFN-{\gamma}$, plus HS. Furthermore, prolonged incubation of the cells with phorbol ester, which down-regulates PKC activity abolished synergistic cooperative effect of HS with $rIFN-{\gamma}$ on NO synthesis. STSN and Polymyxin B potently inhibited HS-induced $TNF-{\alpha}$ secretion by $rIFN-{\gamma}$ plus HS. However, $rIFN-{\gamma}$ plus $TNF-{\alpha}-induced$ NO synthesis was not blocked by STSN or polymyxin B. On the other hand, tyrosine kinase inhibitor, genistein, blocked the NO synthesis and $TNF-{\alpha}$ secretion by $rIFN-{\gamma}$ plus HS. In conlusion, the present results strongly suggest that the capacity of HS to increase NO synthesis from $rIFN-{\gamma}-primed$ macrophages is the result of HS-induced $TNF-{\alpha}$ secretion via the signal transduction pathway of PKC and tyrosine kinase.

• The Journal of the Acoustical Society of Korea
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• v.28 no.2
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• pp.119-126
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• 2009

This paper describes the non-stringed guitar composed of laser strings, frets, sound synthesis algorithm and a processor. The laser strings that can depict stroke and playing arpeggios comprise laser modules and photo diodes. Frets are implemented by voltage divider. The guitar body does not need to implement physically because commuted waveguide synthesis is used. The proposed frets enable; players to represent all of chords by the chord glove as well as guitar solo. Sliding, hammering-on and pulling-off sounds are synthesized by using parameters from the voltage divider. Because the pitch shifting corresponds to the time-varying propagation speed in the digital waveguide model, the proposed model can synthesize vibrato as well. After transformation of signals from the laser strings and frets into parameters for synthesis algorithm, the digital signal processor, TMS320F2812, performs the real-time synthesis algorithm and communicates with the DAC. The demonstration movieclip available via the Internet shows one to play a song, 'Arirang', synthesized by proposed algorithm and interfaces in real-time. Consequently, we can conclude that the proposed synthesis algorithm is efficient in guitar solo and there is no problem to play the non-stringed guitar in real-time.

• Journal of the Institute of Convergence Signal Processing
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• v.7 no.4
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• pp.178-183
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• 2006

As a lot of researches on the speech signal processing are performed due to the recent rapid development of the information-communication technology. the pitch period is used as an important element to various speech signal application fields such as the speech recognition. speaker identification. speech analysis. or speech synthesis. A variety of algorithms for the time and the frequency domains related with such pitch period detection have been suggested. One of the pitch detection algorithms for the time domain. AMDF (average magnitude difference function) uses distance between two valley points as the calculated pitch period. However, it has a problem that the algorithm becomes complex in selecting the valley points for the pitch period detection. Therefore, in this paper we proposed the modified AMDF(M-AMDF) algorithm which recognizes the entire minimum valley points as the pitch period of the speech signal by using the rotation transform of AMDF. In addition, a threshold is set to the beginning portion of speech so that it can be used as the selection criteria for the pitch period. Moreover the proposed algorithm is compared with the conventional ones by means of the simulation, and presents better properties than others.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.3
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• pp.95-99
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• 2008

This paper proposes a new minimal resource high-level synthesis algorithm for low power design automation. The proposed algorithm executes an efficient approach to minimize the power consumption of the functional units in a circuit during the high level synthesis. In this paper, we visit all control steps one by one to reduce the switching activity in CDFG. The register sharing algorithm determines the minimum register after the life time analysis of all variable. According to property of input signal for functional unit, the proposed method visits all control step one by one and determines the resource allocation with minimal power consumption at each control step in a greedy fashion. The effect of the proposed algorithm has been proved through various filter benchmark to adopt a new scheduling and allocation algorithm considering the low rover.

• The Journal of the Acoustical Society of Korea
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• v.15 no.6
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• pp.99-103
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• 1996

Most waveform coding techniques attempt to reduce redundancy of speech signal while preserving the shape of the waveform. In speech synthesis, wavefrom coding methods are used to the synthesis by rule for high quality speech. However, it is difficult to apply the waveform coding to the synthesis by rule because the parameters of the wavefrom coding cannot be classified as either the excitation or the vocal tract parameters. The proposed method shows little spectrum distortion of 2.7% or less for 50% pitch changes. It also achieves smooth connection of wavefrom magnitudes among the frames by compensating the phase in time domain.

• YAKHAK HOEJI
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• v.59 no.4
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• pp.177-183
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• 2015

The mechanism of melanogenesis induced by cyclosporin A (CsA) was investigated in B16 melanoma cells. CsA stimulated the production of melanin in a dose-dependent manner in the cells. In addition, CsA increased intracellular $Ca^{2+}$ concentration in a dose-related fashion. Treatment with BAPTA/AM, an intracellular $Ca^{2+}$ chelator significantly inhibited the CsA-induced intracellular melanin synthesis. CsA profoundly induced $Cl^-$ efflux, which was significantly blocked by niflumic acid (NFA) and flufenamic acid (FFA), specific and nonspecific inhibitors of $Ca^{2+}$-activated $Cl^-$ channels (CaCCs), respectively. Furthermore, these inhibitors of CaCCs significantly inhibited the CsA-induced stimulation of melanin synthesis. Taken together, these results suggest that the activation of CaCCs may play an important role in the CsA-induced stimulation of melanin synthesis in B16 cells. These results further suggest that CaCCs may be a good target for the management of hyperpigmentation of the skin reported in the patients treated with CsA.

• The Journal of the Acoustical Society of Korea
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• v.11 no.4
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• pp.14-21
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• 1992

The waveform coding is concerned with simply preserving the wave shape of speech signal through a redundancy reduction process. In area of the speech synthesis, the waveform codings with high quality are mainly used to the synthesis by analysis. However, because the parameters of this coding are not classified as either excitation parameters and vocal tract parameters, it is difficult to applying the waveform coding to the synthesis by rule. In this paper, we proposed a new pitch alternation method that can change the pitch periods in the waveform coding by using the cepstrum analysis. Thus, it is possible that the waveform coding is carried out the synthesis by rule in speech processing.