• Toxicological Research
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• v.26 no.1
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• pp.15-19
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• 2010

Mesenchymal stem cells (MSCs) have greater potential for immediate clinical and toxicological applications, due to their ability to self-renew, proliferate, and differentiate into a variety of cell types. To identify novel candidate genes that were specifically expressed during transdifferentiation of human MSCs to neuronal cells, we performed a differential expression analysis with random priming approach using annealing control primer-based differential display reverse transcription-polymerase chain reaction approach. We identified genes for acyl-CoA thioesterase, tissue inhibitor of metalloproteinases-1, brain glycogen phosphorylase, ubiquitin C-terminal hydrolase and aldehyde reductase were up-regualted, whereas genes for transgelin and heparan sulfate proteoglycan were down-regulated in MSC-derived neurons. These differentially expressed genes may have potential role in regulation of neurogenesis. This study could be applied to environmental toxicology in the field of testing the toxicity of a chemical or a physical agent.

• Molecules and Cells
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• v.38 no.3
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• pp.202-209
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• 2015

Hepatocellular carcinoma (HCC), a highly malignant disease and the third leading cause of all cancer mortalities worldwide, often responses poorly to current treatments and results in dismal outcomes due to frequent chemoresistance and tumor relapse. The heterogeneity of HCC is an important attribute of the disease. It is the outcome of many factors, including the cross-talk between tumor cells within the tumor microenvironment and the acquisition and accumulation of genetic and epigenetic alterations in tumor cells. In addition, there is accumulating evidence in recent years to show that the malignancy of HCC can be attributed partly to the presence of cancer stem cell (CSC). CSCs are capable to self-renew, differentiate and initiate tumor formation. The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. In this review, we will discuss the recent findings on hepatic CSCs, with special emphasis on their putative origins, relationship with hepatitis viruses, regulatory signaling networks, tumor microenvironment, and how these factors control the stemness of hepatic CSCs. We will also discuss some novel therapeutic strategies targeted at hepatic CSCs for combating HCC and perspectives of future investigation.

• East Asian Journal of Business Economics (EAJBE)
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• v.11 no.2
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• pp.1-13
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• 2023

Purpose - The purpose of this study is to identify emotional intelligence (EI) profiles according to the sub-factors of the ability EI model, namely, self-emotional appraisal, others' emotional appraisal, regulation of emotion, and use of emotion. In addition, this study aims to reveal whether there is a difference in job satisfaction, affective commitment, and turnover intention depending on the profile. Research design, data, and methodology - For the study, 536 survey responses were analyzed using SPSS 22 and MPlus 8.4. Result - The analysis identified four EI profiles. These were 1) middle-low generalized EI (all sub-factors of EI were slightly lower than the average level), 2) middle-high generalized EI (all sub-factors of EI were slightly higher than the average), 3) low generalized EI (all EI sub-factors were much lower than the average), and 4) high generalized EI (all EI sub-factors were much higher than average). Furthermore, significant differences were found in job satisfaction, affective commitment, and turnover intention according to each profile. Conclusion - This study expands the EI theory by revealing the profile of EI. In addition, this study investigated the impact of EI profile on job satisfaction, affective commitment, and turnover intention.

• Journal of Practical Engineering Education
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• v.12 no.1
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• pp.41-47
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• 2020

This study aims to investigate effects of brain-based learning. 27 primary studies were selected through rigorous search process and analyzed through meta-analytic methods. Research findings are as follows. First, the total effect size was .67. Second, the effect of dependent variables was academic achievement, cognitive domain, and affective domain in order. Third, with respect to types of cognitive domain, the effect was self-regulation, creativity, competence, communication, and research ability in order. Fourth, the effect of affective domains was sociality, learning interest, and subject attitude in order. Fifth, regarding development of cognitive ability, the effect size was combined, brain training, learning environments, and right brain activities in order. Sixth, the effect of learning activities was memory improvement and attention enhancement in order.

• Korean Journal of Community Nutrition
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• v.19 no.4
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• pp.342-360
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• 2014

Objectives: This study aimed to develop nutrition education program for consumers to reduce sodium intake based on social cognitive theory (SCT). Methods: The main factors of SCT related to low sodium diet were investigated by using focus group interview (FGI) with 30 women who participated in consumer organizations. Results: The main target groups for the education program were housewives (H), parents (P), and the office workers (OW), for which we considered their influences on other people and the surroundings. According to the results of FGI, in carrying out low sodium diet, 'positive outcome expectation' were prevention of chronic disease and healthy dietary habit, and 'negative outcome expectation' were low palatability of foods, difficulty in cooking meals, and limited choice of foods. The contents of the program and education materials were individualized by each group to raise self-efficacy and behavioral capability, which reflected the results of the FGI. The program included 'salt intake and health' to raise positive outcome expectation. For improving the ability to practice low-sodium diet, the program contained the contents that focused on 'cooking' and 'food purchasing' for H, on 'purchasing and selection of low-sodium food with the children' for P, and on 'way of selecting restaurant menu' for OW. Also the program included 'way of choosing the low-sodium foods when eating out' with suggestions on sodium content of the dishes and snacks. Further, 'dietary guidelines to reduce sodium intake' was also suggested to help self-regulation. Conclusions: This nutrition education program and education materials could be utilized for the community education and provide the basis for further consumer targeted education program for reducing sodium intake.

• Korean Medical Education Review
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• v.24 no.3
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• pp.205-214
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• 2022

The purpose of this study was to analyze the results of a study on the psychological state, lifestyle, self-management ability, and academic adaptation of medical students, and to present examples of improvement of a student support center based on the results. A medical school in Daegu has been surveying the living conditions of students every year for 6 years since 2016. More than 60% of medical students experienced depression and more than 70% experienced stress, but these rates have significantly improved over the past 5 years. There were many cases of drinking or smoking to relieve stress, but the frequency of drinking recently decreased substantially. Some students had difficulties in emotional regulation (11.5%) and time management (16.6%), and challenges in planning and self-management increased significantly during the coronavirus disease 2019 (COVID-19) pandemic. The satisfaction and adaptability of medical students are high, but the number of students who are not satisfied with but negative response rate is 2%-3% in every year. However, satisfaction has significantly increased in tandem with curriculum changes and COVID-19. Based on these data, the counseling system was reorganized to support psychological stability, the medical humanities curriculum was improved, and changes in actual quality of life were induced by developing and operating non-curricular programs. Furthermore, standardized questionnaires will be developed and data from many medical schools will be shared, which is expected to support medical students more effectively.

• Journal of Digital Convergence
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• v.11 no.10
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• pp.653-660
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• 2013

In this research, students majoring in public health were tested with their interpersonal and emotional intelligence and its impact on psychological well being, studied by identifying the factors to promote and foster the students' emotions. The survey was conducted from May 15, 2003 for two weeks using only students majoring in Public Health. Factor analysis, emotional intelligence, emotion regulation, self-emotional awareness, emotions, taking advantage of others and emotional awareness was divided into four sub-factors. Emotional regulation and emotional advantage and recognition had a positive impact on interpersonal relationships, psychological wellbeing and emotional self-awareness. Emotional impact showed a positive advantage. On emotional intelligence, interpersonal factors that influence others and emotional awareness was highest in the psychological process. Students improve their interpersonal relationships and promote a more psychological well being as the emotion of anger and ability to set goals and to motivate efforts to strengthen the emotional awareness is more important. College students studying in Department of Health Services, as well as medical professionals provide better health care services for the sake of happiness that can inspire a systematic program development and is considered to require constant attention.

• The Journal of Korean Academy of Sensory Integration
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• v.7 no.2
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• pp.63-76
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• 2009

Objective : The purpose of this study was to identify effects of intensive sensory integration (SI) treatment and home-program for a child who has a sensory integration disorder. This study also examined whether the positive effect is long-lasting by a follow-up test. Method : A boy with sensory integration dysfunction underwent an intensive SI treatment for 2 weeks. The intervention was consisted of 9 sessions and duration of the each session was 40 minutes. Sensory diet and Wilbarger protocol was provided as home program. The child's sensory function was evaluated before and after the SI intervention. Five month later, re-evaluation was executed for follow-up purpose. Results : In the evaluation after the Si intervention, the child's sensory defensiveness was decreased. Praxis, visual perception, sensory regulation dysfunction (sleep function), affective stabilization and performance of activities of daily living are also improved. In the re-evaluation after the 5 month later, the self-regulation ability, especially sleep function, has been maintained and the visual perception was developing continually. However, the child showed some affective regulation such as bothering his mother and losing his temper. Conclusions : The intensive SI intervention showed positive effects in terms of SI function improvement and the effect lasted long without any additional therapeutic intervention.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.197-207
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• 2017

This study was conducted to evaluate changes in self-awareness in response to dating members of the opposite sex among college students. The point of view of college students who have experienced the dating, it has put the purpose of clarifying the nature of the change in the strength and self-awareness. To accomplish this, interviews of 18 people who met the study criteria were conducted. This study was a qualitative investigation. Respondents were placed in one of five categories: 'change in perception of role', 'understanding of communication skills', 'strengthened coping ability', 'behavioral change in emotion regulation', or 'awareness of self-maturity'. Changes in perceptions experienced by college students through dating were shown to improve the quality of college students' future life and applied in the strength to adapt to social life. Therefore, the significance of this study was discovered a positive outcome in the individuals' life, trying to present the grounds that to strengthen the various regions.

• The Journal of the Korea Contents Association
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• v.11 no.9
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• pp.469-484
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• 2011

The purpose of this study was to examine the effect of arousal control training conjugated heart rate biofeedback for national substitute three archery players. The arousal control training programs was developed on previous researches and 3 archery experts and 1 sport psychologist had meetings. The training programs contained as orientation, breathing regulation, progressive relaxation technique, heart rate biofeedback, cognitive restructuring, routine and consisted of 24 weeks. XCOACH was utilized as heart rate biofeedback instrument. The effects was examined on competitive state anxiety inventory-2, archery score and ranking, observation, interviews and self assessment. As the results, the score of subfactor was improved on somatic state anxiety, cognitive state anxiety and self-confidence. As the results of observation, interviews and self assessment, the ability of arousal control was enhanced by using effective psychological skills conjugated heart rate biofeedback.