• Archives of Pharmacal Research
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• 제22권2호
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• pp.157-164
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• 1999

LB50016 was characterized as a selective and potent$ 5-HT_{1A}$ receptor agonist and evaluate it anxiolytic and antidepressant activities. It shows high affinity for $ 5-HT_{1A}$receptor, moderate affinity for $\alpha$2 adrenergic and $ 5-HT_{2A}$receptors and no significant affinity for other receptors tested. Hypothermia and increased serum corticosterone level were observed in LB50016-treated rats, which are mediated mostly by post synaptic $ 5-HT_{1A}$ receptor activation. In the mouse forced swim model for depression, LB50016-elicited dose-dependent reductions in immobility time, showing $ED_{50}$ of approximately 3 mg/kg i.p., which was blocked by pretreatment of NAN-190, $ 5-HT_{1A}$antagonist. In face-to-face test for anxiolytic activity in mice, estimated $ED_{50}$ was 2 mg/kg, i.p.. In isolation-induced aggression test with mice, fifty-fold increases in latency to attack were observed at 30 min and last up to 4 h after LB50016 treatment (3 mg/kg, i.p.). Taken together, LB50016-induced pharmacological activities are mediated by activation of $ 5-HT_{1A}$receptors, offering an effective therapeutic candidate in the management of anxiety and depression in humans.

• 한국융합학회논문지
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• 제12권10호
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• pp.71-79
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• 2021

제조업 분야에서는 경쟁력 강화를 위하여 다품종 생산으로의 전환이 이루어지고 있으며, 하이브리드 제조기술이 증가하고 있다. 특히 제조실행시스템과 ERP 등의 도입을 통하여 생산 품질 향상에 많은 노력을 기울이고 있기에, 신속하고 효과적인 관리를 위한 MES 운영이 필요하다. MES는 제품 생산과 관련된 모든 단계를 관리하면서, 생산 활동에 비효율적인 부분은 개선하고, 공정 변경의 경우에 시스템에 변경 사항을 반영해야 한다. 그러나 대부분의 MES는 시스템 관리자를 통하여 수동적이고, 반복적으로 비효율적인 작업을 계속 하고 있는 상황이다. 본 논문에서는 생산과 관련된 요구사항을 시스템 관리자가 특정 라인의 장비에 대한 참조 정보를, 다른 라인의 동일한 장비에도 일괄 적용할 수 있는 모델을 제안한다. 제안 모델을 통하여 참조 정보의 일괄 적용과 선택 적용의 구분으로 생산 라인에 대한 유연한 대처가 가능할 것으로 기대된다.

• Journal of Microbiology and Biotechnology
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• 제31권8호
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• pp.1045-1059
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• 2021

Various abiotic stressors like drought, salinity, temperature, and heavy metals are major environmental stresses that affect agricultural productivity and crop yields all over the world. Continuous changes in climatic conditions put selective pressure on the microbial ecosystem to produce exopolysaccharides. Apart from soil aggregation, exopolysaccharide (EPS) production also helps in increasing water permeability, nutrient uptake by roots, soil stability, soil fertility, plant biomass, chlorophyll content, root and shoot length, and surface area of leaves while also helping maintain metabolic and physiological activities during drought stress. EPS-producing microbes can impart salt tolerance to plants by binding to sodium ions in the soil and preventing these ions from reaching the stem, thereby decreasing sodium absorption from the soil and increasing nutrient uptake by the roots. Biofilm formation in high-salinity soils increases cell viability, enhances soil fertility, and promotes plant growth and development. The third environmental stressor is presence of heavy metals in the soil due to improper industrial waste disposal practices that are toxic for plants. EPS production by soil bacteria can result in the biomineralization of metal ions, thereby imparting metal stress tolerance to plants. Finally, high temperatures can also affect agricultural productivity by decreasing plant metabolism, seedling growth, and seed germination. The present review discusses the role of exopolysaccharide-producing plant growth-promoting bacteria in modulating plant growth and development in plants and alleviating extreme abiotic stress condition. The review suggests exploring the potential of EPS-producing bacteria for multiple abiotic stress management strategies.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권2호
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• pp.695-712
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• 2021

As the use of smart devices is being increased rapidly by the development of internet and IT technology, the contents production and utilization rate are showing higher increase, too. In addition, the type of contents also shows very diverse forms such as education, game, video, UCC, etc. In the meantime, the contents are reproduced in diverse forms by reprocessing the original contents, and they are being serviced through the contents service platform. Therefore, the platform to make the contents reprocessing easy and fast is needed. As the diverse contents distribution channels such as YouTube, SNS, App Service, etc, easier contents distribution platform is needed, and the development of the relevant area is expected. In addition, as the selective consumption of the contents having easy accessibility through diverse smart devices is distinguished, the demand for the platform and service that can identify the contents consumption propensity by individual is being increased. Therefore, in this study, to vitalize the online contents distribution, the contents reproduction and publishing platform, was designed and materialized, which can reproduce and distribute the contents based on the real-time contents editing technology in URL unit and the consumer propensity analysis technology using the data management-based broadcasting contents distribution metadata technology and the edited image contents streaming technology. In addition, in the results of comparing with other platforms through the experiment, the performance superiority of the suggested platform was verified. If the suggested platform is applied to the areas of education, broadcasting, press, etc, the multi-media contents can be reproduced and distributed easily, through which the vitalization of contents-related industry is expected.

• Journal of Ginseng Research
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• 제43권1호
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• pp.1-9
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• 2019

Background: Korean ginseng is an important cash crop in Asian countries. However, plant yield is reduced by pathogens. Among the Ilyonectria radicicola-species complex, I. mors-panacis is responsible for root-rot and replant failure of ginseng in Asia. The development of new methods to reveal the existence of the pathogen before cultivation is started is essential. Therefore, a quantitative real-time polymerase chain reaction method was developed to detect and quantify the pathogen in ginseng soils. Methods: In this study, a species-specific histone H3 primer set was developed for the quantification of I. mors-panacis. The primer set was used on DNA from other microbes to evaluate its sensitivity and selectivity for I. mors-panacis DNA. Sterilized soil samples artificially infected with the pathogen at different concentrations were used to evaluate the ability of the primer set to detect the pathogen population in the soil DNA. Finally, the pathogen was quantified in many natural soil samples. Results: The designed primer set was found to be sensitive and selective for I. mors-panacis DNA. In artificially infected sterilized soil samples, using quantitative real-time polymerase chain reaction the estimated amount of template was positively correlated with the pathogen concentration in soil samples ($R^2=0.95$), disease severity index ($R^2=0.99$), and colony-forming units ($R^2=0.87$). In natural soils, the pathogen was recorded in most fields producing bad yields at a range of $5.82{\pm}2.35pg/g$ to $892.34{\pm}103.70pg/g$ of soil. Conclusion: According to these results, the proposed primer set is applicable for estimating soil quality before ginseng cultivation. This will contribute to disease management and crop protection in the future.

• 문화기술의 융합
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• 제5권1호
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• pp.451-456
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• 2019

우리사회는 우리나라 학생들의 학업성적과 삶의 만족도가 반비례 한다는 보고가 나와 충격을 받고 있다. 경제협력개발기구(OECD)가 발표한 국제학업성취도평가(PISA) '2015 학생 삶의 질 만족도 보고서'에 의하면 한국 학생들의 학력수준은 OECD 국가 가운데 최상위층이지만 '삶의 만족도'는 비 OECD국가를 포함한 OECD국가 48개국 중 47위로 최하위권으로 나타났다.[1] 이것은 집단적인 성적위주 평가방식의 일방적인 교육이 그 요인이라고 보고 블록 체인 기술을 활용한 개인맞춤형 통합 모델을 연구하고자 한다. 보안성, 투명성, 분산성이 특징인 블록체인 기술을 활용하여 공급자 일방의 교육 및 일방적인 개인성적 공개위주 시스템에서 선택교육 및 개인승인을 통한 개인맞춤형 교육 및 평가시스템 모델을 연구하였다. 이 연구를 통하여 교육의 본질을 고려하면서 개인별 맞춤교육 및 평가관리시스템이 학생 삶의 질 개선에 기여한 의의를 가지고자 한다.

• 디지털융복합연구
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• 제19권1호
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• pp.355-360
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• 2021

본 연구는 초기 사용자 경험 단계에서 발생 할 수 있는 확증 편향의 요인에 관해 요인별 사용자 경험 요소를 도출하여 허니콤 모형으로 분석하였다. 초기 사용자 경험 단계에서 확증 편향은 인상의 단계에서 발생한다. 기억의 처리단계에서는 감각기억과 작동 기억 그리고 선택적 기억을 저장하고 인출하는 장기 기억과 밀접한 관련이 있었다. 확증편향은 사용성 부분에서 가시성, 상관성, 기억성, 명확성, 보편성으로 분류되었고 감정요인으로는 만족감, 기쁨, 불만족이 도출되었다. 허니콤 모형으로 분석한 결과 사용성 요인에서 시각성, 명확성, 보편성과 감정 요인에서 기쁨은 확증편향에 미치는 영향이 미미하였으며 상관성과 기억성 그리고 감정 요인에서는 만족감과 불만족이 확증 편향의 주요요인으로 분석되었다. 본 연구는 확증 편향 요인에 대해 디자인 패턴을 커스텀화 하는 기업의 경우 참고 자료로 유용하게 활용될 수 있다는 점에서 의의를 가진다.

• 식물병연구
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• 제27권2호
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• pp.49-60
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• 2021

Cashew (Anacardium occidentale L.) is an important cash crop in Tanzania as a source of income to cashew growers and provides foreign exchange for the country. Despite its significance, the crop is threatened by fast spreading disease known as cashew Fusarium wilt caused by Fusarium oxysporum. Field assessment and laboratory tests were conducted to determine incidences of the disease, severity, ecological factors that influence them and explored the pathogen host specificity in six cashew growing districts. The results revealed significant (P<0.001) variation of disease incidences and severity among the studied districts. The results further revealed that there is both positive and negative correlation between the incidence and severity of the disease versus the evaluated ecological factors. The soil pH, soil temperature, air temperature, and relative humidity depicted positive correlation of disease incidence and severity versus ecological factors at ρ=0.50 and ρ=0.60, ρ=0.20 and ρ=0.94, ρ=0.11 and ρ=0.812, ρ=0.05 and ρ=0.771 respectively while nitrogen, phosphorus, and carbon depicted negative correlations at ρ=-0.22 and ρ=-0.58, ρ=-0.15 and ρ=-0.94, ρ=-0.19 and ρ=-0.12 respectively. In terms of host range, none of the weed species was found to be a carrier of Fusarium pathogen implying that it is host specific or semi selective. The results revealed that the tested ecological parameters favor the growth and development of Fusarium pathogen. Thus, management of the disease requires nutrients replenishment and soil shading as essential components in developing appropriate strategies for the control and prevention of further spread of the disease.

• 한국컴퓨터정보학회논문지
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• 제26권3호
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• pp.1-7
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• 2021

본 논문에서는 Hybrid CDN/P2P 구조를 기반으로 최적화된 미디어 데이터 탐색과 전송을 수행하며 사용자의 요청 가능성 예측을 통한 선별적 저장을 통해 사용자로의 끊김없는 데이터 전송과 불필요한 트래픽의 감소를 가능하게 한다. 또한 전송지연 및 패킷 손실의 가능성을 최소화하여 실시간으로 미디어를 활용할 수 있도록 하는 새로운 미디어 관리 기법을 제안한다. 이를 위해 각 미디어를 논리적인 세그먼트로 나누어 구성하고 각 세그먼트에 대한 가중치를 지속적으로 계산하며 계산된 가중치에 따라 세그먼트 데이터의 저장 여부를 결정하도록 한다. 또한 네트워크상에 산재되어 있는 컴퓨팅 노드들을 거리에 따라 지역적 그룹으로 지정하고 해당 그룹 내에서 저장 공간을 효율적으로 공유하고 활용하도록 한다. 제안하는 기법의 효율성을 검증하기 위해 수행된 실험을 통해 제안하는 방식이 기존의 방법들에 비해 비교적 좋은 성능 평가가 도출되는 것을 확인하였으며 이는 전송과정에서 발생되는 초기 지연시간 감소와 끊김 없는 전송 모두를 가능하게 할 수 있음을 알 수 있다.

• BMB Reports
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• 제54권12호
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• pp.592-600
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• 2021

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly population and is caused by the loss of dopaminergic neurons. PD has been predominantly attributed to mitochondrial dysfunction. The structural alteration of α-synuclein triggers toxic oligomer formation in the neurons, which greatly contributes to PD. In this article, we discuss the role of several familial PD-related proteins, such as α-synuclein, DJ-1, LRRK2, PINK1, and parkin in mitophagy, which entails a selective degradation of mitochondria via autophagy. Defective changes in mitochondrial dynamics and their biochemical and functional interaction induce the formation of toxic α-synuclein-containing protein aggregates in PD. In addition, these gene products play an essential role in ubiquitin proteasome system (UPS)-mediated proteolysis as well as mitophagy. Interestingly, a few deubiquitinating enzymes (DUBs) additionally modulate these two pathways negatively or positively. Based on these findings, we summarize the close relationship between several DUBs and the precise modulation of mitophagy. For example, the USP8, USP10, and USP15, among many DUBs are reported to specifically regulate the K48- or K63-linked de-ubiquitination reactions of several target proteins associated with the mitophagic process, in turn upregulating the mitophagy and protecting neuronal cells from α-synuclein-derived toxicity. In contrast, USP30 inhibits mitophagy by opposing parkin-mediated ubiquitination of target proteins. Furthermore, the association between these changes and PD pathogenesis will be discussed. Taken together, although the functional roles of several PD-related genes have yet to be fully understood, they are substantially associated with mitochondrial quality control as well as UPS. Therefore, a better understanding of their relationship provides valuable therapeutic clues for appropriate management strategies.