• Title/Summary/Keyword: Science Product

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Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella paramesenteroides

  • Taehyun Kim;Jin-Woo Kim;Huitae Min;Jisu Park;Taejung Kim;Geun-Hyeong Kim;Byung-Joon Park;Jeong Kook Kim;Young-Tae Park;Jin-Chul Kim;Jungyeob Ham
    • Microbiology and Biotechnology Letters
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    • v.51 no.3
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    • pp.250-256
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    • 2023
  • Cannabis sativa (CS) has been in the spotlight not only for its medical uses but also as a raw material for cosmetics. As fermented cosmetics are known to have various health benefits, they have been extensively researched. Here, we investigated the characteristics of CS stems fermented using various gut microbes. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and melanin content analysis revealed that melan-a cells containing CS stems fermented with Weissella paramesenteroides (CSWP) showed considerably reduced melanin content. Additionally, CSWP downregulated the expression of several melanogenesis factors, tyrosinase-related protein-1, and tyrosinase-related protein-2. This study suggests that the anti-melanogenic effect of CSWP could provide a new basis for the development of skin-lightening agents.

SOME FORMULAS FOR THE GENERALIZED HARDIE-JANSEN PRODUCT AND ITS DUAL

  • Oda, Nobuyuki;Shimizu, Toshiyuki
    • Journal of the Korean Mathematical Society
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    • v.36 no.3
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    • pp.527-544
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    • 1999
  • The generalized Hardie-Jansen product and its dual are defined and the fundamental results on these products are obtained. By studying the adjoint maps, we give proofs to them. Moreover we characterize the generalized Hardie-jansen product making use of the ${\Gamma}W$-Whitehead product. We also obtain a characterization of the dual of the generalized Hardie-Jansen product using $({\Gamma}W)$-Whitehead product.

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Product elements for the safety assessment (안전성 평가를 위한 제품요소)

  • Park, Ji-Yong;Cho, Am
    • Proceedings of the Safety Management and Science Conference
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    • 2008.04a
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    • pp.239-245
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    • 2008
  • In this study has investigated and considered product planning methods at the existing product design process and being used the safety evaluation methods at the product planning stage, and has deduced the 16 safety evaluation elements to have to be considered for executing the safety evaluation at the product planning stage. When the safety evaluation is executed from the product planning stage, more safe products will be designed.

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The Role of Strategic Learning in New Product Development Management (신제품개발 관리에서 전략적 학습의 역할)

  • Kim, Ji-Dae;Lee, Sung-Seok
    • Korean Management Science Review
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    • v.25 no.1
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    • pp.149-167
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    • 2008
  • One of characteristics of firms having successfully developed new products is that they are practicing strategic learning, that is, organizational learning for preparing the future. In this context, we attempts to examine the effect of strategic learning on the proficiency of new product development activities and new product outcome, in an empirical way. In addition, we Investigated the moderating effect of new product innovativeness on the relationship among strategic learning, proficiency of new product development activities, and new product outcome. The analysis results show that the strategic learning has a positive impact on both the proficiency of new product development activities and new product outcome. And it was found that the impact of strategic learning on the proficiency of new product development activities is increasing when firms developing new products with high degree of innovativeness. However, the impact of strategic learning on new product outcome was not different according to new product innovativeness. This results shed some insight on the role of strategic learning in the new product development management.

Cancer Chemopreventive Effects of Korean Seaweed Extracts

  • Lee, Saet-Byoul;Lee, Joo-Young;Song, Dae-Geun;Pan, Cheol-Ho;Nho, Chu-Won;Kim, Min-Cheol;Lee, Eun-Ha;Jung, Sang-Hoon;Kim, Hyung-Seop;Kim, Yeong-Shik;Um, Byung-Hun
    • Food Science and Biotechnology
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    • v.17 no.3
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    • pp.613-622
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    • 2008
  • Cancer chemopreventive effects can be exerted through the induction of phase II detoxification enzymes and the inhibition of inflammatory responses. In this study, the cancer chemopreventive effects and anti-inflammatory responses of 30 seaweed extracts were examined. The extracts of Dictyota coriacea and Cutleria cylindrica exhibited the high chemoprevention index, having 4.36 and 4.66, respectively. They also activated antioxidant response element at $100\;{\mu}g/mL$ by about 3-fold while did not activate xenobiotic response element. Seven seaweed extracts, Ishige okamurae, Desmarestia ligulata, Desmarestia viridis, Dictyopteris divaricata, D. coriacea, Sargassum horneri, and Sargassum yezoense, showed significant inhibition on nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) production in a dose-dependant manner in $5-20\;{\mu}g/mL$. These seaweed extracts could be used as food materials for cancer chemoprevention. D. coriacea could contain potential chemopreventive agents not only that regulate genes via an ARE-dependent mechanism but also prevent the inflammation through inhibition of NO and $PGE_2$ production.

COHOMOLOGY RING OF THE TENSOR PRODUCT OF POISSON ALGEBRAS

  • Zhu, Can
    • Journal of the Korean Mathematical Society
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    • v.57 no.1
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    • pp.113-129
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    • 2020
  • In this paper, we study the Poisson cohomology ring of the tensor product of Poisson algebras. Explicitly, it is proved that the Poisson cohomology ring of tensor product of two Poisson algebras is isomorphic to the tensor product of the respective Poisson cohomology ring of these two Poisson algebras as Gerstenhaber algebras.

Product data model for PLM system

  • Li, Yumei;Wan, Li;Xiong, Tifan
    • International Journal of CAD/CAM
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    • v.11 no.1
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    • pp.1-10
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    • 2011
  • Product lifecycle management (PLM) is a new business strategy for enterprise's product R&D. A PLM system holds and maintaining the integrity of the product data produced throughout its entire lifecycle. There is, therefore, a need to build a safe and effective product data model to support PLM system. The paper proposes a domain-based product data model for PLM. The domain modeling method is introduced, including the domain concept and its defining standard along the product evolution process. The product data model in every domain is explained, and the mapping rules among these models are discussed. Mapped successively among these models, product data can be successfully realized the dynamic evolution and the historical traceability in PLM system.

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Improvement of Weldlines of an Injection Product in Using Movement of a High Temperature Gas (고온기체 유동을 이용한 사출성형품의 웰드라인 개선)

  • Jung, Jae-Sung;Lee, Young-Joo;Min, Kyung-Bae;Song, Bo-Keun;Kim, Hee-Sung;Kim, Sun-Kyung
    • Design & Manufacturing
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    • v.8 no.1
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    • pp.19-22
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    • 2014
  • Today, looking at the trend of product development, interests of injection technology to reduce weldline are growing because of increases of polymer composite materials that containing functional elements and demand of no-painted injection in accordance with environmental regulations. In this paper, surface temperatures of mold increased using high temperature gas for elimination of weldline and characteristics of weldline are analyzed according to mold temperature($60^{\circ}C{\sim}120^{\circ}C$).

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- Development of Design Support Methodology Using Product Function Analysis - (제품기능분석을 이용한 설계지원 방법론 개발)

  • 김형준;이내형;서광규
    • Journal of the Korea Safety Management & Science
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    • v.5 no.2
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    • pp.111-127
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    • 2003
  • In this paper, a new method of product function analysis is presented to categorize various design information generated in product development processes. In order to improve product functions, designers must understand unit functions and modified parts of products. The product function analysis (PFA) is based on the designer's understanding of product functions. The proposed PFA provides the methodology to classify the various functions systematically and understand the relation between functions easily. Using this approach, efficient design support system can be developed and used for designers to support decision-making with design knowledge.