• Journal of Plant Biotechnology
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• 제29권1호
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• pp.59-62
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• 2002

Samyang Genex succeeded in commercialization of anticancer agent-paclitaxel by plant cell culture technology. The core technology of Samyang Genex relating paclitaxel production includes cell line development, cell line preservation, cell culture, scale-up technology, and purification technology. On the basis of the research, Samyang Genex built the factory operated by CGMP (current good manufacturing practice). The paclitaxel-Genexol$^{TM}$-is commercially available in Korea, and it will be launched to world market including USA after approval of US FDA.

• 천문학회보
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• 제44권1호
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• pp.49.2-49.2
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• 2019

Clusters of galaxies shape up through a series of hierarchical mergers. It is believed that major mergers lead to cluster-wide shock waves, which are manifested as radio relics. The 1RXS J0603.0+4213 and CIZA J2242.8+5301 clusters, for instance, contain Mpc-size giant radio relics in the outskirts. Synchrotron emission from these radio relics reveals the presence of relativistic electrons and the magnetic fields of a few ${\mu}G$ strength. The presence of such magnetic fields in the ICM has been explained by the so-called small-scale turbulent dynamo. To get quantitative measures for magnetic fields in clusters of galaxies, we investigate the development of turbulence and the follow-up amplification of magnetic fields through three-dimensional numerical magnetohydrodynamical (MHD) simulations. The turbulence is induced in highly stratified cluster media, and driven sporadically by major mergers. We here present the results, aiming to answer whether the turbulence dynamo scenario can explain the observed strength and scale of magnetic fields in clusters. Also, we discuss whether the observed properties of giant radio relics can be reproduced in our simulations.

• Journal of Microbiology and Biotechnology
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• 제2권2호
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• pp.98-101
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• 1992

Continuous production of fructo-oligosaccharides employing a packed bed reactor charged with immobilized cells of Aureobasidium pullulans was investigated. The optimum conditions for reactor operation were a feed concentration of 860 g/l; a feed rate, expressed as superficial space velocity of $0.2\;h^{-1}$, and a temperature of $50^\circ{C}$. Under these optimum conditions, the productivity of the reactor was $180\;g/l\cdot{h}$. Initial activity was maintained for more than 100 days. The reactor was successfully scaled up to a production scale of 1000l.

• Korean Chemical Engineering Research
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• 제44권6호
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• pp.659-668
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• 2006

실험계획법을 이용하여 nitromethane을 초임계수산화(SCWO)로 분해시키는 공정의 최적화 연구를 진행하였다. Lab scale 반응설비를 이용하여 처리수의 COD와 T-N을 최소화하는 SCWO 공정의 최적 운전조건을 도출하였으며, scale-up 문제점을 파악하기 위해 SCWO pilot plant 실험 결과와 lab scale 최적화 실험 결과를 비교하였다. 처리수의 COD와 T-N을 최적화 목적 변수(KPOV)로 설정하였으며, 예비실험을 통해 반응 온도(temp)와 nitromethane과 암모니아수의 몰 비(NAR)를 주요 운전 변수(KPIV)로 설정하였다. 최적화 실험은 통계적 실험계획법인 중심합성설계법을 사용하였으며, 실험결과의 해석은 반응표면법을 활용하였다. 주 효과 분석결과 처리수의 COD는 Temp 증가에 따라 급격하게 감소하며, NAR 증가에 따라 약간 감소하는 것으로 나타났으며, T-N은 Temp 와 NAR 증가에 따라 감소하였다. Temp가 $420{\sim}430^{\circ}C$로 낮을 때에는 NAR 증가에 따라 T-N이 급격히 감소하였으나, $450^{\circ}C$ 이상으로 높을 때에는 큰 변화가 없었다. 최적화 실험 결과를 회귀분석 하여 처리수의 COD와 T-N 을 예측할 수 있도록 Temp와 NAR이 변수인 2차식으로 회귀식을 도출하였으며, 결정계수($r^2$)와 표준화잔차의 정규성을 분석하여 회귀식이 실험결과를 잘 모사하는 것을 확인하였다. 회귀식을 이용하여 COD < 2 mg/L, T-N<40 mg/L를 동시에 만족시키며 부식 위험이 적은 nitromethane 분해 최적 운전 조건은 Temp $450-460^{\circ}C$, NAR 1.03-1.08로 설정하였다. SCWO pilot plant를 이용하여 nitromethane 분해 최적 조건을 검증하고, SCWO 공정의 scale-up 문제점을 파악하는 연구를 실시하였다. SCWO pilot plant 실험 결과를 lab scale 반응설비에서 도출한 COD와 T-N의 회귀식과 비교한 결과 오차가 증가하지만 회귀식이 pilot plant 실험결과도 잘 나타내는 것을 확인할 수 있었다. Pilot plant 실험결과에 대한 회귀식의 적합성은 실험값과 예측값의 비교도와 표준화잔차의 정규성으로 검증하였다.

• 한국측량학회지
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• 제5권1호
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• pp.23-31
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• 1987

지도제작이 대축척화됨에 따라서 측지선의 증대율은 점점 커져서 측지선과 그것에 대응하는 지도상의 측선사이에는 그 굴곡이 점차적으로 증대하기 때문에 일정한 투영도법하에서도 축척의 대소에 따라서 투영법의 선택이 필요하다. 본 연구에서는 우리나라의 지도제작에 사용되고 있는 가우스ㆍ크뤼거투영법을 검토분석하여 대축척지도제작에서 채용할 최적지도투영법을 제시하였다.

• Environmental Engineering Research
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• 제16권1호
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• pp.47-51
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• 2011

The oxygen transfer rate is a parameter that characterizes the gas-liquid mass transfer in surface aerators. Gas-liquid transfer mechanisms in surface aeration tanks depend on two different extreme lengths of time; namely, macromixing and micromixing. Small scale mixing close to the molecular level is referred to as micromixing; whereas, macromixing refers to mixing on a large scale. Using experimental data and numerical simulations, macro- and micro-scale parameters describing the two extreme time scales were investigated. A scale up equation to simulate the oxygen transfer rate with micromixing times was developed in geometrically similar baffled surface aerators.

• 한국해양공학회지
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• 제21권3호
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• pp.26-32
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• 2007

A series of large-scale experiments were carried out in order to examine wave-induced liquefaction in a loosely packed sandbed, its afterward high densification and liquefaction by oscillatory pore pressure. The experiments were conducted in a Large Hydro-Geo Flume that can nearly solve the problems of scale effects of the sandbed, and the 50% sieve diameter of sand was 0.2 mm. The generation of residual pore pressure and its afterward high densification which had observed by Takahashi et al. (1999) in a wave flume experiment using fine sand with the size of 0.08 mm. As a result, the relative density of the sandbed after high densification was increased up to 79% and liquefaction by oscillatory pore pressure was not observed.

• Journal of the Korean Data and Information Science Society
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• 제25권4호
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• pp.961-970
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• 2014

This article deals with the problem of testing the equality of the scale parameters of several inverted exponential distributions. We propose Bayesian hypothesis testing procedures for the equality of the scale parameters under the noninformative prior. The noninformative prior is usually improper which yields a calibration problem that makes the Bayes factor to be defined up to a multiplicative constant. So we propose the default Bayesian hypothesis testing procedures based on the fractional Bayes factor and the intrinsic Bayes factors under the reference priors. Simulation study and an example are provided.

• Journal of the Korean Data and Information Science Society
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• 제23권6호
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• pp.1299-1308
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• 2012

This article deals with the problem of testing the equality of the scale parameters in nonregular Pareto distributions.We propose Bayesian hypothesis testing procedures for the equality of the scale parameters under the noninformative prior. The noninformative prior is usually improper which yields a calibration problem that makes the Bayes factor to be de ned up to a multiplicative constant. So we propose the default Bayesia hypothesis testing procedures based on the fractional Bayes factor and the intrinsic Bayes factors under the reference priors. Simulation study and a real data example are provided.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1473-1478
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• 2003

Scale is formed when hard water is heated or cooled in heat transfer equipments such as heat exchangers, condensers, evaporators, cooling towers, boilers, and pipe walls. When scale deposits in a heat exchanger surface, it is traditionally called fouling. The objective of the present study is to investigate the formation of fouling in a heat exchanging system. A lab-scale heat exchanging system is built-up to observe and measure the formation of fouling experimentally. Water analyses are conducted to obtain the properties of HAN river water. In the present study a microscopic observation is conducted to visualize the process of scale formation. Hardness of HAN-river water is higher than that of tap water in Seoul.