• Title/Summary/Keyword: Safety activity

Search Result 2,341, Processing Time 0.026 seconds

A Study on the Performance of Ni Catalysts in Biogas Steam Reforming: Impact of Supports and Precipitation Agent Injection Rates (바이오가스 수증기 개질 반응용 Ni 촉매 성능 연구: 지지체 및 침전제 주입 속도에 따른 영향)

  • Ji-Hyeon Gong;Min-Ju Kim;Kyung-Won Jeon;Won-Jun Jang
    • Clean Technology
    • /
    • v.29 no.4
    • /
    • pp.327-332
    • /
    • 2023
  • This study investigated synthesis gas production via steam reforming of biogas. Ni-Al2O3 and Ni-CeO2 catalysts were synthesized using the co-precipitation method, with controlled precipitation agent injection rates. Catalytic performances were tested at various temperatures, with a gas composition ratio of CH4:CO2:H2O = 1:0.67:3 and a gas hourly space velocity (GHSV) of 647,000 mL h-1 gcat-1. The rate of precipitation agent injection influenced the characteristics of the catalysts depending on the type of support used. As the temperature increased, both the CO2 reforming of methane and the reverse water gas shift reactions occurred. The Ni-Al2O3 catalyst, synthesized with a single injection of the precipitation agent, exhibited the best catalytic activity under conditions with sufficient steam supply among the prepared catalysts, due to its high Ni dispersion.

A Study on the Analysis of the Walking Environment in the Residential Area for the Elderly in Busan Using Spatial Analysis (공간 분석 기법을 적용한 부산 노인 주거지의 보행환경 분석에 대한 연구)

  • Whiho LEE;Jihyun KIM
    • Journal of the Korean Association of Geographic Information Studies
    • /
    • v.26 no.4
    • /
    • pp.251-265
    • /
    • 2023
  • The purpose of this study is to deduce key indicators in evaluating the pedestrian environment for the elderly in Busan, which has entered an aging society, and to propose policy improvement measures. The key indicators were selected based on prior research and surveys, and the effectiveness of those indicators were measured through evaluations conducted on three places which have the highest proportion of the elderly population in Busan. The summaries of analysis are as follow. First, the three places are hillslide residential areas, and areas of activity that the elderly have were very narrow due to the restrictions on their movement caused by slope. Second, the areas were filled with a number of illegally parked vehicles. And the degree of segregation of pedestrian and vehicle and the level of safety were very low. Third, the streets with steep slopes of the target site force the elderly to move vertically, and for this reason, the elderly are expressing difficulties in outdoor activities. Fourth, it was found that the target site lacked a space for relaxation during outdoor activities. The poor walking environment not only limit the essential and social activities of the elderly, but also adversely affects the health and quality of life of the elderly. In order to maintain the health of the elderly and improve the quality of life, actions should be taken to improve the walking factors that affect the movement and external activities of the elderly.

Immune Checkpoint Inhibitor with or without Radiotherapy in Melanoma Patients with Brain Metastases: A Systematic Review and Meta-Analysis

  • Pyeong Hwa Kim;Chong Hyun Suh;Ho Sung Kim;Kyung Won Kim;Dong Yeong Kim;Eudocia Q. Lee;Ayal A. Aizer;Jeffrey P. Guenette;Raymond Y. Huang
    • Korean Journal of Radiology
    • /
    • v.22 no.4
    • /
    • pp.584-595
    • /
    • 2021
  • Objective: Immune checkpoint inhibitor (ICI) therapy has shown activity against melanoma brain metastases. Recently, promising results have also been reported for ICI combination therapy and ICI combined with radiotherapy. We aimed to evaluate radiologic response and adverse event rates of these therapeutic options by a systematic review and meta-analysis. Materials and Methods: A systematic literature search of Ovid-MEDLINE and EMBASE was performed up to October 12, 2019 and included studies evaluating the intracranial objective response rates (ORRs) and/or disease control rates (DCRs) of ICI with or without radiotherapy for treating melanoma brain metastases. We also evaluated safety-associated outcomes. Results: Eleven studies with 14 cohorts (3 with ICI combination therapy; 5 with ICI combined with radiotherapy; 6 with ICI monotherapy) were included. ICI combination therapy {pooled ORR, 53% (95% confidence interval [CI], 44-61%); DCR, 57% (95% CI, 49-66%)} and ICI combined with radiotherapy (pooled ORR, 42% [95% CI, 31-54%]; DCR, 85% [95% CI, 63-95%]) showed higher local efficacy compared to ICI monotherapy (pooled ORR, 15% [95% CI, 11-20%]; DCR, 26% [95% CI, 21-32%]). The grade 3 or 4 adverse event rate was significantly higher with ICI combination therapy (60%; 95% CI, 52-67%) compared to ICI monotherapy (11%; 95% CI, 8-17%) and ICI combined with radiotherapy (4%; 95% CI, 1-19%). Grade 3 or 4 central nervous system (CNS)-related adverse event rates were not different (9% in ICI combination therapy; 8% in ICI combined with radiotherapy; 5% in ICI monotherapy). Conclusion: ICI combination therapy or ICI combined with radiotherapy showed better local efficacy than ICI monotherapy for treating melanoma brain metastasis. The grade 3 or 4 adverse event rate was highest with ICI combination therapy, and the CNS-related grade 3 or 4 event rate was similar. Prospective trials will be necessary to compare the efficacy of ICI combination therapy and ICI combined with radiotherapy.

Soil Residues and Absorption-translocation into Red Lettuce and Young Radish Crops of Veterinary Antibiotics According to Agricultural Water Irrigation Method (농업용수 관개방법에 따른 축산용 항생제의 토양중 잔류와 적상추와 열무 작물로의 흡수·이행)

  • Park, Young-Jae;Jeon, Hee-Su;Cho, Jae-Young
    • Korean Journal of Organic Agriculture
    • /
    • v.32 no.1
    • /
    • pp.107-125
    • /
    • 2024
  • Three types of veterinary antibiotics, including oxytetracycline (OTC) and chlortetracycline (CTC) of tetracycline class and amoxicillin (AMX) of penicilline class, were artificially introduced into the irrigation water. The residue of veterinary antibiotics in the soil, the absorption-translocation of veterinary antibiotics into the red lettuce and young radish plant, and crops yield were investigated according to the agricultural water irrigation method (surface drip irrigation, underground drip irrigation, and sprinkler irrigation). There was no significant difference in the residue and translocation of veterinary antibiotics in the soils and crops according to the irrigation method and type of veterinary antibiotics (p>0.05). For the edible parts of red lettuce and young radish, all three types of veterinary antibiotics were found to be below the detection limit, indicating that the safety of the crops was secured. The translocation factor of red lettuce and young radish were found to be less than 0.3 and 0.2, respectively. However, continuous introduction of veterinary antibiotics in agricultural arable lands may have negative effects by affecting soil microbial activity and soil microbe species diversity, so continuous management is deemed necessary.

Indigo Naturalis in Inflammatory Bowel Disease: mechanisms of action and insights from clinical trials

  • Hyeonjin Kim;Soohyun Jeong;Sung Wook Kim;Hyung-Jin Kim;Dae Yong Kim;Tae Han Yook;Gabsik Yang
    • Journal of Pharmacopuncture
    • /
    • v.27 no.2
    • /
    • pp.59-69
    • /
    • 2024
  • This study investigates the therapeutic potential of Indigo Naturalis (IN) in treating a Inflammatory Bowel Disease (IBD). The objective is to comprehensively examine the effects and pharmacological mechanisms of IN on IBD, assessing its potential as an novel treatment for IBD. Analysis of 11 selected papers is conducted to understand the effects of IN, focusing on compounds like indirubin, isatin, indigo, and tryptanthrin. This study evaluates their impact on Disease Activity Index (DAI) score, colon length, mucosal damage, and macrophage infiltration in Dextran Sulfate Sodium (DSS)-induced colitis mice. Additionally, It investigate into the anti-inflammatory mechanisms, including Aryl hydrocarbon Receptor (AhR) pathway activation, Nuclear Factor kappa B (NF-κB)/nod-like receptor family pyrin domain containing 3 (NLRP3)/Interleukin 1 beta (IL-1β) inhibition, and modulation of Toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MYD88)/NF-κB and Mitogen Activated Protein Kinase (MAPK) pathways. Immunomodulatory effects on T helper 17 (Th17)/regulatory T cell (Treg cell) balance and Glycogen synthase kinase-3 beta (GSK3-β) expression are also explored. Furthermore, the study addresses the role of IN in restoring intestinal microbiota diversity, reducing pathogenic bacteria, and increasing beneficial bacteria. The findings reveal that IN, particularly indirubin and indigo, demonstrates significant improvements in DAI score, colon length, mucosal damage, and macrophage infiltration in DSS-induced colitis mice. The anti-inflammatory effects are attributed to the activation of the AhR pathway, inhibition of inflammatory pathways, and modulation of immune responses. These results exhibit the potential of IN in IBD treatment. Notably, the restoration of intestinal microbiota diversity and balance further supports its efficacy. IN emerges as a promising and effective treatment for IBD, demonstrating anti-inflammatory effects and positive outcomes in preclinical studies. However, potential side effects necessitate further investigation for safe therapeutic development. The study underscores the need for future research to explore a broader range of active ingredients in IN to enhance therapeutic efficacy and safety.

A Review on the Improvement of the Meaning and Composition Requirements of Interference with Fire Protection Activities - Focusing on Interference with 119 EMS Activities - (소방활동방해죄의 의미와 구성요건 개선에 관한 검토 -119구급활동 방해를 중심으로-)

  • Young Pyo Hong
    • The Korean Society of Law and Medicine
    • /
    • v.24 no.3
    • /
    • pp.105-124
    • /
    • 2023
  • Modern society is facing an unstable environment due to unexpected accidents and hazardous situations. For example, incidents such as the collapse of the Bundang Bridge and the crushing accident in Itaewon could serve as examples. In addition to these, critical emergencies like sudden cardiac arrests and strokes frequently occur, requiring swift actions and smooth transfers to specialized medical institutions for effective responses. In response to these risks, the country has been establishing various systems to protect the lives and safety of its citizens. Among these, the 119 First Aid Activities plays a crucial role within the emergency medical system. Its goal is to promptly respond to critical emergency situations involving severe trauma patients or patients with serious illnesses, minimizing damage and safeguarding lives by swiftly transferring them to emergency medical institutions for specialized treatment. The core activity related to this is emergency rescue operations. In particular, the 119 First Aid system serves as a crucial institution responsible for the hospital transportation of emergency patients. However, rescue personnel still encounter cases of interference with their activities during their duties. Despite efforts from the police, these interference cases persist, and they share similarities with the crime of obstructing official duties. Interference with emergency activities exhibits a comparable nature to instances such as physical assaults and equipment damage against emergency medical practitioners working within the emergency medical system. Therefore, a comprehensive understanding and improvement efforts regarding the issues of interference that arise during the process of emergency medical activities, including the 119 First Aid system, are necessary. The solution to these problems is to establish and improve the conditions for obstruction of first aid activities, focusing on the "Framework Act on Firefighting" and the "Act on 119 Rescue and Emergency."

Distribution Behavior of Natural Radionuclide Pb in Molten Fe to Metal/Slag/Gas Phase (용융 Fe 중 천연방사성핵종 Pb의 금속/슬래그/가스상으로의 분배거동)

  • So-Yeong Lee;Hyeon-Soo Kim;Jong-Hyeon Lee;Ho-Sang Sohn
    • Resources Recycling
    • /
    • v.33 no.2
    • /
    • pp.54-61
    • /
    • 2024
  • When steel contaminated with Pb, produced by the decay of natural radionuclides, is remelted, Pb distributes among the metal, slag, and gas phases. In this study, 5 wt%Pb was added to Fe and melted with CaO-SiO2-Al2O3-MgO slag to investigate Pb's distribution in the metal/slag/gas. As slag basicity ((wt%CaO)/(wt%SiO2)) increased, Pb solubility in Fe slightly increased, while Pb in the slag tended to decrease. Consequently, the slag/metal distribution ratio of Pb decreased with increasing basicity. Thermodynamic calculations revealed that the slag/Fe phase distribution ratio of Pb remained very low irrespective of the activity coefficient of PbO in the slag, consistent with the experimental results. The calculated evaporation rate of Pb in Fe-Pb was approximately 22 times that of Fe; hence, most of the Pb evaporated into the gas phase.

Suggestion for revising the play-centered early childhood curriculum Awareness of daycare center extended child care teacher's experience and play centered curriculum operation (어린이집 연장보육전담교사의 일과운영경험과 놀이중심교육과정 운영에 대한 인식)

  • Ji, In-Sook;Park, Ji-Hee
    • The Journal of the Convergence on Culture Technology
    • /
    • v.10 no.5
    • /
    • pp.473-483
    • /
    • 2024
  • This study attempted to explore the operational experience of teachers in the extended class and the difficulties of teachers in the extended class for the implementation of play-oriented education in the extended class. The results of the interview analysis are as follows. First, I had a perception that the extended class teacher was an assistant teacher rather than a regular teacher. Second, since there is no separate classroom for extended classes, it helps teachers in charge of their absence rather than recognizing it as a sense of belonging and regular responsibility and cares for children without getting hurt. Third, teachers in the extended class put children's safety first with the care of mixed classes and the inconsistent return time of infants and toddlers. Fourth, most teachers were aware of the play-based curriculum and did not receive training, and most teachers said that it was impossible to implement the play-based curriculum in extended childcare. As a result, teachers in charge of the extended class need a guidebook for the extended class and an education and guidebook on the activity connection of the extended childcare class on what is the role of the teacher in charge of the extended class.

Exploring the Direction for Establishing Green Schools in Elementary Education - Current Status and Management Characteristics of Indoor Plants in Schools - (초등학교의 그린학교 조성 방향 설정 탐색 - 학교 실내식물 도입현황 및 관리특성 분석 -)

  • Jeong, Na-Ra;Han, Seung-Won;Kim, Jai-Soon;Kim, Woo-Young;Lee, Hyeong-Seok
    • The Journal of Sustainable Design and Educational Environment Research
    • /
    • v.23 no.3
    • /
    • pp.14-26
    • /
    • 2024
  • This study analyzes the current status and management characteristics of plants introduced into indoor spaces to identify strategies for developing green elementary schools. Indoor plants are predominantly potted and primarily introduced into shared spaces, including entrances and hallways, rather than classrooms. Although the positive effects of indoor plants have been acknowledged, there is also an awareness of negative sentiments, including the difficulties in managing them. Although some level of plant maintenance is carried out, there are recognized challenges, such as budget allocation, designation of responsible personnel, and availability of management information. To ensure proper maintenance, concerns like budget support, assignment of duties, and increased interest need to be addressed. Compared to other staff, teachers express a greater need for plants to be introduced, which should be evaluated in terms of maintenance, environmental purification, and safety. In future restructuring projects to create spaces for learning, relaxation, and other activities by introducing plants indoors, the following should be considered: selection of plants suitable for environmental characteristics; establishment of maintenance plans including the budget; and expert support. Moreover, strategies to approach plant maintenance as an educational activity through student participation programs and the development of educational materials should be considered.

Oestrogenic Activity of Parabens in Uterotrophic Assay (자궁비대시험 연구에서 에틸, 프로필, 이소프로필, 부틸, 이소부틸 파라벤의 내분비독성)

  • Jo Eun-Hye;Jung Ji-Youn;Park Cheol-Beom;Park Sun-Hee;Shim Yhong-Hee;Kang Dae-Hyuck;Lee Sung-Ho;Yu Jong-Hoon;Kim Sun-Jung;Lee Sung-Hoon;Park Jung-Ran;Lee Yong-Soon;Kang Kyung-Sun
    • Journal of Food Hygiene and Safety
    • /
    • v.21 no.2
    • /
    • pp.118-128
    • /
    • 2006
  • This study was conducted to determination of the endocrine distruptor function of 'Parabens' by dosing ethyl paraben, propyl paraben, isopropyl paraben, butyl paraben and isobutyl paraben to the immature SD rats. 18 groups were given vehicle control group, negative control group (Dibutyl phthalate), postive control group ($1'7-{\alpha}$ Ethynylestrdiol) and each paraben groups involved 3 dose level. Rats were injected with 62.5, 250 and 1,000mg/kg from postnatal day 19 till 21 once a day in subcutaneous and a total 3, times. There was no treatment related death. but, subcutaneous nodule, edema, alopecia and scrub formation on injection site was observed. These signs was become worse in high dose level. these signs was cause from physical stimulation by test substance which parabens were mix with com oil as vehicle. In the analysis of organ weights, absolute and relative weights of brain, spleen, liver, thymus, heart, kidneys, adrenals, ovaries and vagina were no difference with control group. but, wet and blotted weight of uterus was increased in every high dose parabens treat group. Especially, all dose level of isobutyl paraben was showed increment of uterus weight. uterus dilatation of parabens treated group was observed in gross anatomic pathology and these result was agree with wet and blotted weight of uterus. In the result of this study, estrogenic effect as endocrine distruptor was observed in ethyl paraben, propyl paraben, isopropyl paraben, butyl paraben and isobutyl paraben. and it was considered isobutyl paraben has highest estrogrnic effect under the condition of this study.