• Parasites, Hosts and Diseases
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• v.41 no.3
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• pp.147-154
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• 2003

Toxoplasma gondii tachyzoites were isolated from the blood of an ocular patient, and have been successfully passaged in the laboratory, for over a year, by peritoneal inoculation in mice. The isolated parasite was designated the Korean Isolate-1 (KI-1) and its characteristics were compared with those of the RH strain, a well-known virulent strain originating from a child who suffered from encephalitis. The morphology, pathogenicity, infectivity and cell culture characteristics of the KI-1 were similar to those of the RH strain. Both RH and KI-1 antigens were detected by an anti-T gondii monoclonal antibody (mAb), Tg563, against the major surface protein SAG1 (30 kDa), whereas no reaction was observed against an anti-Neospora caninum mAb, 12B4. The KI-1 was confirmed as an isolate of T. gondii. A long-term laboratory maintenance and characterization of a local T gondii isolate is reported for the first time in the Republic of Korea.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.4
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• pp.271-277
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• 2018

Purpose: Familial Mediterranean fever (FMF) is an auto inflammatory disease characterized by periodic fever, synovitis and serositis. Patients may be admitted to gastroenterology units due to gastrointestinal symptoms. In this study; we aimed to analyze endoscopic findings and diagnostic utility of endoscopic procedure in children with FMF. Methods: Patient with FMF that was performed endoscopy for the gastrointestinal symptoms were included to the study (39 of 164 patients, 53 procedure). A control group was randomly designed as age and gender matched four endoscopic procedures per one endoscopic procedure of patients with FMF (n=212). Results: No different was found between the patients and control group in esophagogastroscopy findings. However, the diagnosis of gastrointestinal pathology was made by esophagogastroscopy in 46.2% patients. Colonoscopic examination revealed that the frequency of inflammatory bowel disease (IBD) was higher in undiagnosed patients compared to both the control group (50.0% vs. 6.9%, p<0.05, odds ratio [OR]:13.4 and 95% confidence inteval [95% CI]: 2.1-84.3) and the patients under colchicine treatment (50.0% vs. 8.3%, p<0.05, OR: 11 and 95% CI: 0.8-147.8). Colonoscopic procedure that was made after the diagnosis was found to provide contribution by 16.7% in determining the etiology of the additional symptoms. Conclusion: Patients with FMF may be admitted to pediatric gastroenterology outpatient clinic prior to diagnosis or during the follow-up period. The frequency of IBD is high in undiagnosed patients with FMF. Endoscopic procedures may be helpful in these patients for the diagnosis accompanying mucosal lesions.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1175-1179
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• 2016

The results of this study demonstrate the potential prognostic and predictive values of KRAS and BRAF gene mutations in patients with colorectal cancer (CRC). It has been proven that KRAS and BRAF mutations are predictive biomarkers for resistance to anti-EGFR monoclonal antibody treatment in patients with metastatic CRC (mCRC). We demonstrated the distribution of KRAS (codons 12, 13 and 61) and BRAF (codon 600) gene mutations in 50 mCRCs using direct sequencing and compared the results with clinicopathological data. KRAS and BRAF mutations were identified in 15 (30%) and 1 (2%) patients, respectively. We identified KRAS mutations in codon 12, 13 and 61 in 73.3% (11/15), 20% (3/15) and 6.67% (1/15) of the positive patients, respectively. The KRAS mutation frequency was significantly higher in tumors located in the ascending colon (p=0.043). Thus, we found that approximately 1/3 of the patients with mCRC had KRAS mutations and the only clinicopathological factor related to this mutation was tumor location. Future studies with larger patient groups should yield more accurate data regarding the molecular mechanism of CRC and the association between KRAS and BRAF mutations and clinicopathological features.

• Journal of the Korean Society for Railway
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• v.14 no.3
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• pp.222-227
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• 2011

The dropper supports the contact wire and is attached using various types of dropper clips on the catenary. Droppers are subject to mechanical stress from buckling during the passage of pantographs. In order to investigate failure causes for the high speed line dropper, theoretical analyses and experiments have been carried out. In this paper, mathematical formulas are derived for the pre-sag of the dropper static load. The measured values in the experiment were similar to the theoretical predictions. To analyze the cause on fracture of dropper wire, we have conducted analysis such as SEM(Scanning Electron Microscope) of fractured specimens in the field and new specimens. Finally, we performed measurement for the variation of dynamic load on the dropper when a pantograph moved at 300km/h under the Korean high speed overhead line. If such mechanical load occur repeatedly with every passing pantograph, it is possible that the dropper wire will break due to fatigue. This results will be used for special management of high speed catenary system maintenance and life estimation of dropper.

• Journal of Korean Society of Steel Construction
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• v.23 no.1
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• pp.13-27
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• 2011

This paper presents an investigation of the structural stability of cable-stayed bridges, using geometric nonlinear finite-element analysis and considering various geometric nonlinearities, such as the sag effect of the cables, the beam-column effect of the girder and mast, and the large displacement effect. In this analytic research, a nonlinear frame element and a nonlinear equivalent truss element were used to model the girder, mast, and cable member. The live-load cases that were considered in this research were assumed based on the traffic loads. To perform reasonable analytic research, initial shape analyses in the dead-load case were performed before live-load analysis. In this study, the geometric nonlinear responses of the cable-stayed bridges with different cable arrangement types were compared. After that, parametric studies on the characteristics of the structural stability in critical live-load cases were performed considering various geometric parameters, such as the cable arrangement type, the stiffness ratios of the girder and mast, the area of the cables, and the number of cables. Through this parametric study, the effect of geometric shapes on the structural stability of cable-stayed bridges was investigated.

• Proceedings of the Korean Vacuum Society Conference
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• 1999.07a
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• pp.163-163
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• 1999

MOSFET, MESFET 그리고 MODFET는 Logic ULSIs, high speed ICs, RF MMICs 등에서 중요한 역할을 하고 있으며, 그것의 gate electrode, contact, interconnect 등의 물질로는 refractory metal을 이용한 CoSi2, MoSi2, TaSi2, PtSi2, TiSi2 등의 효과를 얻어내고 있다. 그중 TiSi2는 비저항이 가장 낮고, 열적 안정도가 좋으며 SAG process가 가능하므로 simpler alignment process, higher transconductance, lower source resistance 등의 장점을 동시에 만족시키고 있다. 최근 소자차원이 scale down 됨에 따라 TiSi2의 silicidation 과정에서 C49 TiSi2 phase(high resistivity, thermally unstable phase, larger grain size, base centered orthorhombic structure)의 출현과 그것을 제거하기 위한 노력이 큰 issue로 떠오르고 있다. 여러 연구 결과에 따르면 PAI(Pre-amorphization zimplantation), HTS(High Temperature Sputtering) process, Mo(Molybedenum) implasntation 등이 C49를 bypass시키고 C54 TiSi2 phase(lowest resistivity, thermally stable phase, smaller grain size, face centered orthorhombic structure)로의 transformation temperature를 줄일 수 있는 가장 효과적인 방법으로 제안되고 있지만, 아직 그 문제가 완전히 해결되지 않은 상태이며 C54 nucleation에 대한 physical mechanism을 밝히진 못하고 있다. 본 연구에서는 증착 시 기판온도의 변화(400~75$0^{\circ}C$)에 따라 silicon 위에 DC/RF magnetron sputtering 방식으로 Ti/Si film을 각각 제작하였다. 제작된 시료는 N2 분위기에서 30~120초 동안 500~85$0^{\circ}C$의 온도변화에 따라 RTA법으로 각각 one step annealing 하였다. 또한 Al을 cosputtering함으로써 Al impurity의 존재에 따른 영향을 동시에 고려해 보았다. 제작된 시료의 분석을 위해 phase transformation을 XRD로, microstructure를 TEM으로, surface topography는 SEM으로, surface microroughness는 AFM으로 측정하였으며 sheet resistance는 4-point probe로 측정하였다. 분석된 결과를 보면, 고온에서 제작된 박막에서의 C54 phase transformation temperature가 감소하는 것이 관측되었으며, Al impuritydmlwhswork 낮은온도에서의 C54 TiSi2 형성을 돕는다는 것을 알 수 있었다. 본 연구에서는 결론적으로, 고온에서 증착된 박막으로부터 열적으로 안정된 phase의 낮은 resistivity를 갖는 C54 TiSi2 형성을 보다 낮은 온도에서 one-step RTA를 통해 얻을 수 있다는 결과와 Al impurity가 존재함으로써 얻어지는 thermal budget의 효과, 그리고 그로부터 기대할 수 있는 여러 장점들을 보고하고자 한다.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.12
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• pp.1792-1797
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• 2013

Recently, due to the excessive use of fossil fuels, many studies about the fossil fuels such as solar and fuel cell energy source are progressing. Fuel cell system has high energy conversion efficiency. Also, fuel cell system is environmentally friendly system because the carbon emission is almost not occur. Therefore, the fuel cell system is considered as the core technology of in the fields of the future energy and environmental. Fuel cell system has an effect on distribution power system because another power source of other than large power plants. So, fuel cell system can be reason of power quality in the power system. In this paper, we constructed the system for an assessment on Islanding. The system is composed with power source, Impedance coordination load and linear load, fuel cell system. we are performed assessment on voltage and power quality in customer and the distributed power system during the Islanding of residential fuel cell system. In addition, no change in the impedance of power system, we made a islanding condition only using the actual load, As a variation of generation and load current under islanding, an analysis results based on assessment system showed that the power qualities of distribution system became more aggravation as effect of voltage sag and voltage swell phenomena.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.12
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• pp.1678-1687
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• 2013

This paper describes a prototype of 3-phase 3.3kV/220V 6kVA modular semiconductor transformer developed in the lab for feasibility study. The developed prototype is composed of three single-phase units coupled in Y-connection. Each single-phase unit with a rating of 1.9kV/127V 2kVA consists of a high-voltage high-frequency resonant AC-DC converter, a low-voltage hybrid-switching DC-DC converter, and a low-voltage hybrid-switching DC-AC converter. Also each single-phase unit has two DSP controllers to control converter operation and to acquire monitoring data. Monitoring system was developed based on LabView by using CAN communication link between the DSP controller and PC. Through various experimental analyses it was verified that the prototype operates with proper performance under normal and sag condition. The system efficiency can be improved by adopting optimal design and replacing the IGBT switch with the SiC MOSFET switch. The developed prototype confirms a possibility to build a commercial high-voltage high-power semiconductor transformer by increasing the number of series-connected converter modules in high-voltage side and improving the performance of switching element.

• Proceedings of the KIPE Conference
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• 2006.06a
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• pp.432-434
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• 2006

The additional matters appear to be considered in several aspects for building up power-quality measuring system of transmission system(high voltage system) compared to distribution system(middle or low voltage system). Like in distribution system, input signals are also received from PT and CT source of voltage and current respectively in transmission system and applied in accordance with a certain rate. In this case, very big error rate can be occurred according to the specification of the measuring system as the applying rate is bigger than in distribution system beyond comparison. In addition, when the abnormal signal occurred such as sag/swell, interruption, transient etc., power quality of other sires linked to the system also should be checked to find the accurate cause of the abnormal power-quality signals from the corresponding. site. Accordingly, the accurate diagnosis on the condition of power quality for the system depends on the way how the synchronization system is brought along for each site. This paper will suggest the solution for the most effective system building focused on how to solve the problem of the error rate and synchronization described in the above when building up the measuring system of power quality for transmission system.

• The Transactions of the Korean Institute of Power Electronics
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• v.5 no.6
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• pp.584-591
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• 2000

Power Quality Compensator(PQC) has been installed to protect the sensitive loads against the voltage disturbances, such as voltage sag and interruption. In general, static switch is used for the purpose of link between utility and PQC. So transfer operation of the static switch play a important part in the PQC. Many studies on the structure and control of PQC have been progressed in active, but these researches have been rarely mentioned about any voltage-disturbances-detection method to start the PQC operation. In this paper, a new voltage-disturbances-detection algorithm for computer application loads using the CBEMA/ITIC curve is proposed for transfer operation of the static switch. The proposed detection algorithm is implemented to get fast detecting time through the comparison of instantaneous 3-phase voltage values transferred to DC values in the synchronous reference frame with the operating reference values. To get the robust characteristics against the noise, a first order digital filter is designed. The magnitude falling and phase delay caused by the filter are compensated through the error normalizing and numerical analysis using transfer function, respectively. Finally, the validity of the proposed algorithm is proved by ACSL simulation and experimental results.