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Comparison on genomic prediction using pedigree BLUP and single step GBLUP through the Hanwoo full-sib family

  • Eun-Ho Kim;Ho-Chan Kang;Cheol-Hyun Myung;Ji-Yeong Kim;Du-Won Sun;Doo-Ho Lee;Seung-Hwan Lee;Hyun-Tae Lim
    • Animal Bioscience
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    • 제36권9호
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    • pp.1327-1335
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    • 2023
  • Objective: When evaluating individuals with the same parent and no phenotype by pedigree best linear unbiased prediction (BLUP), it is difficult to explain carcass grade difference and select individuals because they have the same value in pedigree BLUP (PBLUP). However, single step GBLUP (ssGBLUP), which can estimate the breeding value suitable for the individual by adding genotype, is more accurate than the existing method. Methods: The breeding value and accuracy were estimated with pedigree BLUP and ssGBLUP using pedigree and genotype of 408 Hanwoo cattle from 16 families with the same parent among siblings produced by fertilized egg transplantation. A total of 14,225 Hanwoo cattle with pedigree, genotype and phenotype were used as the reference population. PBLUP obtained estimated breeding value (EBV) using the pedigree of the test and reference populations, and ssGBLUP obtained genomic EBV (GEBV) after constructing and H-matrix by integrating the pedigree and genotype of the test and reference populations. Results: For all traits, the accuracy of GEBV using ssGBLUP is 0.18 to 0.20 higher than the accuracy of EBV obtained with PBLUP. Comparison of EBV and GEBV of individuals without phenotype, since the value of EBV is estimated based on expected values of alleles passed down from common ancestors. It does not take Mendelian sampling into consideration, so the EBV of all individuals within the same family is estimated to be the same value. However, GEBV makes estimating true kinship coefficient based on different genotypes of individuals possible, so GEBV that corresponds to each individual is estimated rather than a uniform GEBV for each individual. Conclusion: Since Hanwoo cows bred through embryo transfer have a high possibility of having the same parent, if ssGBLUP after adding genotype is used, estimating true kinship coefficient corresponding to each individual becomes possible, allowing for more accurate estimation of breeding value.

통일신라시대(統一新羅時代) 불교건축(佛敎建築)의 변화(變化) (The Change in the Buddhist Architecture of the Unified Silla Period (668-935))

  • 김성우
    • 건축역사연구
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    • 제1권2호
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    • pp.68-84
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    • 1992
  • The development of Buddhist architectures of the Unified Silla period have been generally understood to have paired pagoda instead of one which had been popular until before the unification. Besides the stylistic categorization of paired pagoda system, there had been no further investigation reported concerning whether there was any detailed process of change within the development of paired pagoda style. This paper aims to identify such change inside the development of paired pagoda style, which, externally, seems to be the same pattern of site design maintained throughout the period of Unified Silla that lasted for about three centuries. Since the temple sites of study are in the same pattern of layout, the method of investigation has to be such that can identify the subtle changes that, in external appearance, are not easily discernible. Hence, this research compared the dimensions of important measurement of five temple sites to be able to clarify the process of minor changes. Among many sites of Silla temples, only five were suitable for the research since detailed measurement were possible through field research or the report of excavation. They are the sites of Sachonwang-sa, Mangduk-sa, site of Kunsuri, and Bulguk-sa. Although the five sites have the same style of paired pagoda, it is clear that there were consistant flow of change. Even though the motivation of such change were not strong enough to change the site pattern itself, it resulted continuous minor changes such as the size and location of architectures. The size of image hall, for example, was growing larger and larger as time goes on, while, the size of Pagoda was getting smaller. In the same way, the size of middle gate became smaller while the size of lecture hall became larger, although the rate of change in these cases were not as severe as that of image hall and pagoda. At the same time, pagoda was coming closer to the middle gate leaving larger space in front of the image hall. Such aspect is even more meaningful considering the fact that the pagoda, from the 8th century in Japan and China, moved outside of the major precinct. The image hall, too, moved toward the middle gate slightly so that the space in front of the lecture hall became more spacious. Such changes, of course, were not accidental but they are the same continuous motivation of change that caused the changes before the period of unification. Enlargement of image hall and reduction of pagoda, for example, represent the changing relative importance of religious meaning. Hence, it is evident that one can not easily imterprete the development of one style only by categorizing it to be one same style. In the veiwpoint of the underlying motivation of change, the fact that one style persisted for a certain period of time, does not mean there had been no change, but means that it was the time of motivational accumulation, causing minor changes within the same style, to be able to create major change coming after.

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기술혁신의 관점에서 본 균등요건의 치환자명성과 특허요건의 진보성의 관계 (Obviousness Standard and Ease of Interchangeability in the Doctrine of Equivalents)

  • 구대환
    • 법제연구
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    • 제41호
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    • pp.201-228
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    • 2011
  • 대법원은 97후2200에서 균등관계가 성립하기 위한 5가지 요건을 제시하였다. 이 중에서 세 번째 요건인 '치환자명성'이 특허요건 중 하나인 진보성을 판단할 때의 자명성과 같은 수준의 것으로 해석할 수 있는 것인지의 여부에 대하여 논쟁이 있다. 이들을 다르게 해석해야 한다는 입장에서는, 치환자명성 요건이 자명성 요건에 비하여 협소하다고 설명한다. 그리고 이들을 동일하게 볼 경우 특허발명에 대하여 진보성이 인정되지 않는 한 모두 균등영역에 포함되는 것으로 보게 되어 균등침해의 영역을 과도하게 확장하게 되는 문제가 있다고 한다. 반면에 이들을 같은 정도의 것으로 해석해야 한다는 입장에서는, 특허발명으로부터 용이하게 실시할 수 있는 기술 즉, 특허발명에 대하여 진보성이 없는 영역에 속하는 확인대상발명은 모두 균등침해에 해당하는 것으로 보아야 한다고 주장한다. 또한 균등론상 치환자명성과 진보성의 자명성을 서로 다르게 해석할 경우 특허법이 작용할 수 없는 소위 '회색영역'이 존재하게 되는 문제가 있다는 점을 지적한다. 이러한 견해의 차이는 권리범위확인 또는 균등론에 의한 침해 여부를 판단함에 있어서 상반되는 결과를 가져올 수 있다. 즉, 치환자명성 요건을 자명성 요건보다 좁게 보는 경우는 이들을 동일하게 보는 경우에 비하여 특허권의 권리범위를 좁게 해석하기 때문에 회색영역에 속하는 확인대상발명에 대하여 침해를 부인하게 된다. 그러나 반대로 이들을 동일하게 보는 경우 회색영역은 사라지고 확인대상발명은 균등론에 의하여 침해의 영역에 속하게 된다. 이 논문은 이러한 문제를 해결해 보고자 하는 시도에서 출발한 것이다. 이를 위하여 특허요건의 진보성 판단과 균등론의 치환자명성 판단을 각각 검토하고, 이들을 동일하게 보는 경우와 다르게 보는 경우를 기술혁신의 경제학적 관점에서 서로 대비한 결과 동일하게 보는 것이 합리적이라는 결론을 얻을 수 있었다.

CONVERGENCE OF THE NEWTON METHOD FOR AUBIN CONTINUOUS MAPS

  • Argyros, Ioannis K.
    • East Asian mathematical journal
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    • 제25권2호
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    • pp.153-157
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    • 2009
  • Motivated by optimization considerations we revisit the work by Dontchev in [7] involving the convergence of Newton's method to a solution of a generalized equation in a Banach space setting. Using the same hypotheses and under the same computational cost we provide a finer convergence analysis for Newton's method by using more precise estimates.