• Molecules and Cells
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• 제42권10호
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• pp.687-692
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• 2019

Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic intervention. tsRNAs provide more complexity to the physiological role of transfer RNAs by repressing or activating protein synthesis with distinct mechanisms. Here, we highlight the detailed mechanism of tsRNA-mediated dual regulation in protein synthesis and discuss the necessity of novel sequencing technology to learn more about tsRNAs.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.347.1-347.1
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• 2002

In cancer chemotherapy. it is becoming increasingly clear that the DNA topoisomerases play an active role in the expression of the cytotoxic action of drugs. The amino substituted azaanthraquinones have attracted much interest due to their possible role as topoisomerase inhibitors. In connection with our interests in the design and synthesis of potent topoisomerase inhibitor. we herein described the preparation of a series of benzoquinoxalinedione derivatives. These were designed based on the SAR of azaanthraquinones and structural analysis of products which are fitted with doxorubicin.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 가을학술발표대회논문집
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• pp.115-116
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• 2023

In this study, it was confirmed whether kaolin can play a role as a bed materials and a role in reducing clinkers by using kaolin with a bed materials for the purpose of removing clinkers such as slagging and fouling generated in circulating fluidized bed combustion furnaces using solid fuel.

• 한국엔터테인먼트산업학회논문지
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• 제14권7호
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• pp.333-342
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• 2020

유아들은 놀이를 통해 성장 및 발달을 한다. 놀이는 유아들의 일상생활 속에서 친구, 학습 매체 및 도구로서 활용되고 있다. 본 연구는 아버지의 놀이신념과 놀이참여도가 유아 놀이성에 미치는 영향을 실증적으로 분석하는데 목적을 둔 조사연구이다. 본 연구의 목적을 달성하기 위해 서울시 D구에 소재한 유치원에 재원 중인 만5세 유아 284명을 연구대상으로 선정하여 설문조사를 수행하였다. 설문조사를 통해 수집된 자료는 SPSS 프로그램을 이용하여 빈도분석, 기술통계, 신뢰도 검증, 상관관계 분석 및 회귀분석을 실시하여 다음과 같은 연구결과를 도출하였다. 첫째, 아버지의 놀이신념과 놀이 참여도는 신체적 자발성, 사회적 자발성, 인지적 자발성, 즐거움의 표현, 유머 감각의 유아 놀이성에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 아버지의 놀이 신념과 유아 놀이성 관계에서 아버지의 놀이 참여도는 부분매개변수로서 유의한 효과가 있는 것으로 나타났다. 따라서 아버지의 놀이 신념과 놀이 참여도는 유아의 놀이성을 예측할 수 있는 중요인 변인이라는 결론을 도출하였다. 따라서 아버지와 유아 관계에서 놀이를 통한 다양한 상호작용을 할 수 있는 가정 내 분위기 형성과 유아와 놀이 활동에서 아버지의 바람직한 역할에 대한 부모교육 프로그램을 유아교육기관 차원에서 지속적으로 제공하여 유아들의 놀이성 발달을 촉진할 필요가 있을 것이다.

• 한국산학기술학회논문지
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• 제21권2호
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• pp.287-295
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• 2020

본 연구의 목적은 어린이집 교사들의 쌓기놀이에 대한 은유의 경향과 은유의 의미를 알아보는 것이다. 이를 위해 J지역 대학의 보수교육에 참여한 어린이집 교사 165명을 대상으로 문장 완성형 은유방법을 활용하여 자료를 수집하였다. 수집한 자료는 은유분석에 관한 선행연구와 쌓기놀이의 가치에 관한 선행연구에 기초하여 질적 연구방법을 활용한 범주화의 과정을 거쳐 분석하였다. 연구결과 첫째, 어린이집 교사들의 쌓기놀이 은유의 경향은 2개 범주, 9개의 하위내용으로 분류되었다. 범주에서는 '쌓기놀이의 특성', '쌓기놀이의 가치'의 순서로 빈도가 높게 나타났다. 하위내용에서는 '쌓기놀이의 특성' 중 '구성하기'가 가장 높은 빈도를 나타냈고, '쌓기놀이의 가치' 중 '성장·발달의 근간'이 가장 높은 빈도를 나타냈다. 둘째, 어린이집 교사들의 쌓기놀이 은유의 의미는 '쌓기놀이의 특성' 에서 '구성하기', '표현하기', '상상하기', '즐거움', '자유로움'으로 나타났고, '쌓기놀이의 가치' 에서는 '성장·발달의 근간', '정서발달', '사회성발달' '창의성발달'로 나타났다. 연구결과를 기초로 하여 직전교육과 현직교육에서 유아 쌓기놀이의 가치와 교사역할이 더욱 강조되어야 함을 논의하였다.

• 복식
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• 제59권7호
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• pp.86-99
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• 2009

The audience of the performing arts enacted on the stage appreciate acting of the characters in a play to understand its plot, identify with the characters, and comprehend the message and subject matters of the play. Stage make-up in particular should assist audience in comprehending the story without overpowering or distracting the script. Stage make-up is a crucial means to visualize occupation, class, personality, and age of the characters. Thus it is an essential means in producing a high quality performance. The aim of the study is to examine character-emphasis make-up for a play by reviewing theories on the concepts and methods of the stage make-up. The methodology of the study was to analyze character make-up of the adopted play The Madwoman of Chaillot (La Folle de Chaillot) translated from the original French, as a case study. The technique and features of the character make-up of the play were examined, and functions of each factor of the character make-up depending on a role were also examined. The results of the study are as follows. The stage make-up for creating and expressing a distinctive personality of the characters in a play must integrate environmental factors external to a performance such as lighting and scale of a venue. Moreover the stage make-up must adopt and reconstruct internal factors of the play such as interpretation of the original work, subject matters, interpretation of the script, character analysis based on the discussion with a director, and design setting.

• ETRI Journal
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• 제35권6호
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• pp.1058-1067
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• 2013

An approach for game bot detection in massively multiplayer online role-playing games (MMORPGs) based on the analysis of game playing behavior is proposed. Since MMORPGs are large-scale games, users can play in various ways. This variety in playing behavior makes it hard to detect game bots based on play behaviors. To cope with this problem, the proposed approach observes game playing behaviors of users and groups them by their behavioral similarities. Then, it develops a local bot detection model for each player group. Since the locally optimized models can more accurately detect game bots within each player group, the combination of those models brings about overall improvement. Behavioral features are selected and developed to accurately detect game bots with the low resolution data, considering common aspects of MMORPG playing. Through the experiment with the real data from a game currently in service, it is shown that the proposed local model approach yields more accurate results.

• 아동학회지
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• 제33권2호
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• pp.55-68
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• 2012

The goals of this study were to examine how children's recognition of various emotions, emotion expression, and social interactions among their peers differed according to their attachment styles. A total of 65 three to five years old children completed both attachment story-stem doll plays and a standard emotion recognition task. Trained observers documented children's valence of emotion expression and social interactions among their peers in the classroom. Consistent with attachment theory, children who were categorized as secure in the doll play were more likely to express positive emotions than children who were categorized as avoidant in the doll play. Children who were categorized as avoidant in the doll play were more likely to express neutral emotions among their peers than children who were categorized as secure and anxious in the doll play. The findings of this study contribute to the general attachment literature by documenting how attachment security plays a crucial role in having positive emotions in ordinary situations. It does so by also demonstrating how different attachment styles are associated with children's qualitatively different patterns of emotion processing, especially in terms of their expression of emotions.

• IMMUNE NETWORK
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• 제9권6호
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• pp.209-235
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• 2009

There has been an explosion of literature focusing on the role of regulatory T (Treg) cells in cancer immunity. It is becoming increasingly clear that Treg cells play an active and significant role in the progression of cancer, and have an important role in suppressing tumor-specific immunity. Thus, there is a clear rationale for developing clinical strategies to diminish their regulatory influences, with the ultimate goal of augmenting antitimor immunity. Therefore, manipulation of Treg cells represent new strategies for cancer treatment. In this Review, I will summarize and review the explosive recent studies demonstrating that Treg cells are increased in patients with malignancies and restoration of antitumor immunity in mice and humans by depletion or reduction of Treg cells. In addition, I will discuss both the prognostic value of Treg cells in tumor progression in tumor-bearing hosts and the rationale for strategies for therapeutic vaccination and immunotherapeutic targeting of Treg cells with drugs and microRNA.

• The Plant Pathology Journal
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• 제26권1호
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• pp.1-7
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• 2010

Phosphorylation is a major post-translational modification of proteins that regulate diverse signal transduction pathways in eukaryotic cells. 14-3-3 proteins are regulatory proteins that bind to target proteins in a phosphorylation-dependent manner and have been shown to play an important role in plant growth and development, primary metabolism, and signal transduction. Because phosphorylation plays a critical role in signal transduction pathways to trigger plant immunity, involvement of 14-3-3 proteins in plant immunity has been suggested for a long time. Recent studies have provided new evidence to support a role for 14-3-3 proteins in plant immunity. This review will briefly discuss general characteristics of 14-3-3 proteins and their involvement in plant immunity.