Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis

  • Received : 2019.09.23
  • Accepted : 2019.10.15
  • Published : 2019.10.31
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Abstract

Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic intervention. tsRNAs provide more complexity to the physiological role of transfer RNAs by repressing or activating protein synthesis with distinct mechanisms. Here, we highlight the detailed mechanism of tsRNA-mediated dual regulation in protein synthesis and discuss the necessity of novel sequencing technology to learn more about tsRNAs.

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References

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