• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.66-74
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• 2004

Allergic rhinitis is an allergic reaction characterized by sneezing, coughing, itchy nose, mouth and throat, congestion and／or nasal discharge. The offending allergens are usually pollens, molds, dust mites and animal allergens. We aimed to observe inhibitory effects of Bojungikgi-tang on incerase of the number of eosinophil and neutrophil, and protective effects of nasal mucosal tissue in the allergic rhinitis. 1. In Inhibitory Effect of Bojungikgi-tang on Increase of the number of Eosinophil in Serum, Bojungikgi-tang showed significant effects.(p〈0.05) 2. In Inhibitory Effect of Bojungikgi-tang on Increase of the number of Neutrophil in Serum, Bojungikgi-tang showed significant effects.(p〈0.05) 3. In histopathologic change of nasal mucosal tissue, Bojungikgi-tang showed significant protective effects. Depending upon above results, it is considered that Bojungikgi-tang has the inhibitory effects on the process of allergic rhinitis and that it could be used in reliving patients of the symptoms caused by allergic rhinitis.

• 대한한의학회지
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• 제25권1호
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• pp.40-48
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• 2004

Background and Objectives: Aroma therapy using Eucalyptus Globulus essential oil for curing allergic rhinitis is an inhalation treatment which has been applied as an aid to oriental clinics which use a fundamental treatment such as acupuncture and herbs. There have been no studies so far performed on the effect of this oils' use, only . We aimed to find out the therapeutic effect of its exclusive use only on an Animal Model with Allergic Rhinitis. Materials and Methods: Sprague-Dawley rats were induced the allergic rhinitis by ovalbumin solution. And then, rats in the treated group were treated by diffusing Eucalyptus essential oil in a flask for 7 days. Compared with the treated group, rats in the control group were treated by diffusing normal saline in a flask for 7 days. We observed changes in glandular cells and mast cells in nasal mucosa and submucosa; also changes in the number of eosinophils and neutrophils in blood and the succus of rhinenchysis. Results: The number of neutrophils in the succus of rhinenchysis was significantly decreased in treated group compared with control group(p<0.05). The number of neutrophils in blood and mast cells in nasal mucosa were decreased in the treated group but, these were not significant statistically(p>0.05). Histologic changes showed edema; congestion and expansion of grandular cells in nasal submucosa and hypertrophy of epithelium in nasal mucosa were decreased in treated group compared with control group. Conclusions: The results may suggest that the inhalation treatment using Eucalyptus essential oil decreases the inflammatory response on an Animal Model with Allergic Rhinitis.

• 대한한방소아과학회지
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• 제30권3호
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• pp.31-41
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• 2016

Objectives The purpose of this study is to investigate the characteristics of Ryodoraku Score in the children who visited department of pediatrics, hospital of Korean medicine with allergic rhinitis as the chief complaint. Methods Subjects were 80 children with allergic rhinitis. We calculated the average Ryodoraku Score (RS, ${\mu}A$), and compared the average of each meridian system. And we classified the children by several groups (depending on age, additional allergic disease), and accomplished a comparative analysis. Results 1. The average of Ryodoraku Score in 80 children was $76.36{\pm}22.72$. 2. The figure of H3 (心), H5 (三焦), F1 (脾), F2 (肝), F3 (腎), F4 (膀胱), F5 (三焦), F6 (胃) had significant statistical differences compared to the total average. 3. Comparing the group having only allergic rhinitis to group having allergic rhinitis and other allergic disease, showed significant statistical difference in H2 (心包), H3 (心). 4. Analyzed by age, there's a significant statistical difference in F1 (脾), F4 (膀胱). Conclusion We found that H5 (三焦), F1 (脾), F4 (膀胱) showed significant statistical difference in Ryodoraku Score, and F1 (脾) had the highest relevance. The research indicate meaningful difference depending on age, additional allergic disease.

• 보건행정학회지
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• 제30권1호
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• pp.50-61
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• 2020

Background: This study aims to analyze the effects of air pollutants, such as particular matter, to the number of outpatient visits for allergic rhinitis in eup, myeon, and dong administrative boundaries. Methods: Dependent variable was the number of outpatient visits for allergic rhinitis per 10,000 people by region. Independent variables were air pollutants such as PM₁₀, PM_2.5, SO₂, O₃, CO₂, NO₂, and temperature that estimated by using Kriging analysis in all eup, myeon, and dong boundaries. Panel analysis was applied for the analysis to prove the relation between outpatient visits and the concentration of air pollutants. Results: Analysis results showed that particular matter concentration varied by regions and season. Panel analysis showed that outpatient visits for allergic rhinitis had positive relationships with PM₁₀, PM_2.5, SO₂, O₃, and CO₂ in all panel models. Conclusion: Regional variation of particular matter concentration should be considered in establishing regional policies for allergic rhinitis.

• 한방안이비인후피부과학회지
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• 제21권1호
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• pp.16-25
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• 2008

Background & Objectives : Rhinitis is an inflammation of nasal mucosa. The major symtoms are watery rhinorrhea, sneezing, itchy nose, and nasal obstruction. Allergic rhinitis is an immune reaction by allergen. So, we aimed to determine therapeutic effects of Acorus gramineus by observing changes in IL-4, $IFN-{\gamma}$ and the nasal mucosal tissue. Materials and Methods : Fifteen BALC/c mice were divided into three groups : m group(which ate low concentrated herbal medicine ), M group(which ate high concentrated herbal medicine) and control group. Control and experimental group were induced allergic rhinitis by Ovalbumin as the method of Levin and Vaz. Experimental group was orally administered the Acorus gramineus extract for 28days. We observed changes in IL-4, $IFN-{\gamma}$ and trans aminase(AST, ALT) in blood and nasal mucosa and submucosa. Results : There were no significant changes statistically in IL-4 and $IFN-{\gamma}$ in blood(p<0.05). And there were no hepatotoxicity with Acorus gramineus extract. Histologically, almost no inflammatory response in treatment group(m,M) against that there were inflammatory response(increased goblet cells, dilated vessels, edema of bowman's glands and injured olfactory hairs) in control group. Conclusion : According to above results, it is supposed that Acorus gramineus has no immunological effects on allergic rhinitis.

• 한방안이비인후피부과학회지
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• 제29권1호
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• pp.131-144
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• 2016

Objective : This study is to review the effect of herbal medicines on treatment of Allergic Rhinitis in animal models reported in Korean domestic journals.Methods : The Databases(NDSL, Koreantk, OASIS, KISS) are searched with terms as Allergic Rhinitis. among them, only animal study reports were reviewed. Animal model, intervention, and observation methods of measuring indicators were extracted.Results : 27 articles were reviewed. All studies used OVA to induce Allergic Rhinitis. 7 studies used simple herbal medicines, 20 studies used complex herbal medicines, To evaluate the effect of the Herbal medicines, 23 studies used immunological examination, 18 studies used histological examination, 16 studies used hematologic examination, 3 studies used macroscopy The evidences of 5 studies is insufficient to show that Herbal medicines are effective for treatment of Allergic Rhinitis.

• 한방안이비인후피부과학회지
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• 제29권1호
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• pp.1-15
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• 2016

Objective : For various reasons, Obesity & Rhinitis are constantly rising. So Interest of treatment has been expanding. We want to verify The Chungyeol (fire extinguishing) Lisup (Draining) effect of Bangpungtongsungsan on obese model of allergy rhinitis.Material and Methods : BALB/c mouse were divided four groups: control(CON), allergic induction(ARE), Bangpungtongsungsan extract administration(BTT), Bangpungtongsungsan double concentration extract administration (BT2T). Every group except control group were caused allergic rhinitis by Ovalbumin. BTT & BT2T were orally administered the Bangpungtongsungsan for 21days. Since then we observed the liver tissue cell and the nasal mucous membrane.Results : In comparison with ARE, experimental groups show relief of the nasal mucous membrane damage(secretion of mucus decrease, Itching decrease), Th2 eruption control(IL-4 decline), effect of anti-inflamatory(reducing TNF-α creation, decreasing of iNOS through NF-κB activation-inhibition). In addition, experimental groups show a loss in weight, diminished accumulation of fat. (decreasing within liver tissue, reducing TNF-α creation) BT2T is more effective to BTT.Conclusion : Bangpungtongsungsan treat obese model on allergy rhinitis thereby control fat augmentation, relieving inflammation.

• 동서간호학연구지
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• 제25권2호
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• pp.103-116
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• 2019

Purpose: This study investigated the effects of the Seogeum therapy among college students with allergic rhinitis. Method: A non-equivalent control group pretest-posttest non-synchronized design was used. Intervention of Seogeum therapy has been performed from March 2 through March 31, 2017. Sixty college students diagnosed with allergic rhinitis from two different colleges in B and K cities were assigned to the experimental and control group. Data analysis were conducted using descriptive statistics, chi-square test, Fisher's exact test, and t-test. Results: There were significant differences in nose itching (t=4.89, p<.001), sneezing (t=6.26, p<.001), watery rhinorrhea (t= 4.09, p<.001), nasal congestion (t=2.36, p=.022), the percent of eosinophil (t=2.01, p=.049), perceived stress (t=2.05, p=.045), and allergic rhinitis related quality of life (t=4.33, p<.001) between the two groups. However, there were no significant differences in the percent of IgE (t=0.60, p=.553) and level of cortisol (t=0.53, p=.598). Conclusion: The results of this study indicates that the self-management of Seogeum therapy improved physical and psychological status of the college students with allergic rhinitis which ultimately improved their quality of life.

• 한방안이비인후피부과학회지
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• 제28권3호
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• pp.76-87
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• 2015

Objectives : Allergic rhinitis is highly increased in these days. We aimed to investigate therapeutic effect ofShinchulsanby observing changes in blood cells and the protein expression level of IL-4 in spleen of Sprague-Dawley(SD) rats with allergic rhinitis.Methods : Fifteen SD rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitional and intranasal sensitization with 0.1% and 0.4% Ovalbumin solution. ThenShinchulsanwas orally administered only to the sample group for 28 days, while the rats in the control group was given normal saline.Results : 1.Shinchulsanshowed significantly decreased eosinophil level on the serum of the rat model.2.Shinchulsanshowed significantly decreased IgE level on the serum of the rat model.3.Shinchulsanshowed significantly decreased the protein expression levels of IL-4 in spleen of the rat model.4.Shinchulsanhad no hepatoxicity, according to AST and ALT on the serum.Conclusion : According to the above results, it is considered thatShinchulsanis helpful in treatment of allergic rhinitis.

• 대한의용생체공학회:의공학회지
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• 제40권4호
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• pp.125-131
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• 2019

As a non-invasive method for alleviating allergic rhinitis, there has been a recent ongoing research in the treatment of light from light emitting diodes (LEDs) and lasers. A total of 15 subjects diagnosed with allergic rhinitis were selected for this study. Red and near infrared light emitted from LEDs with wavelengths of 660nm and 940nm were illuminated three times daily (three minutes per cycle) for a total of two weeks. The degree of nasal congestion, runny nose, sneezing and nasal itching was evaluated by questionnaires before and after the test. Also, the serum IgE (Immunoglobulin E) was measured and compared before and after the test. As a result, the total score of symptoms of allergic rhinitis was decreased by 67% after the test (P<0.01). The level of IgE was decreased by 17% after the test (P<0.05). In conclusion, the non-invasive LED phototherapy method using red and near-infrared LED light was effective in alleviating symptoms of allergic rhinitis. There were no adverse effects or complications reported during and after the test.