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http://dx.doi.org/10.6114/jkood.2015.28.3.076

The Effect of Shinchulsan on the Rat Model with Allergic Rhinitis  

Bae, Hyeon-Jin (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Jo, Ga-Won (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Heo, Eun-Sun (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Hwang, Chung-Yeon (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.28, no.3, 2015 , pp. 76-87 More about this Journal
Abstract
Objectives : Allergic rhinitis is highly increased in these days. We aimed to investigate therapeutic effect ofShinchulsanby observing changes in blood cells and the protein expression level of IL-4 in spleen of Sprague-Dawley(SD) rats with allergic rhinitis.Methods : Fifteen SD rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitional and intranasal sensitization with 0.1% and 0.4% Ovalbumin solution. ThenShinchulsanwas orally administered only to the sample group for 28 days, while the rats in the control group was given normal saline.Results : 1.Shinchulsanshowed significantly decreased eosinophil level on the serum of the rat model.2.Shinchulsanshowed significantly decreased IgE level on the serum of the rat model.3.Shinchulsanshowed significantly decreased the protein expression levels of IL-4 in spleen of the rat model.4.Shinchulsanhad no hepatoxicity, according to AST and ALT on the serum.Conclusion : According to the above results, it is considered thatShinchulsanis helpful in treatment of allergic rhinitis.
Keywords
Allergic Rhinitis; Shinchulsan; Ovalbumin; Total IgE; Eosinophil; IL-4;
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