• BMB Reports
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• 제37권2호
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• pp.192-198
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• 2004

The hepatitis C virus (HCV) core protein is believed to be one of viral proteins that are capable of preventing virus-infected cell death upon various stimuli. But, the effect of the HCV core protein on apoptosis that is induced by various stimuli is contradictory. We examined the possibility that the HCV core protein affects the ceramide-induced cell death in cells expressing the HCV core protein through the sphingomyelin pathway. Cell death that is induced by $C^2$-ceramide and bacterial sphingomyelinase was analyzed in 293 cells that constitutively expressed the HCV core protein and compared with 293 cells that were stably transfected only with the expression vector. The HCV core protein inhibited the cell death that was induced by these reagents. The protective effects of the HCV core protein on ceramide-induced cell death were reflected by the reduced expression of $p21^{WAF1/Cip1/Sid1}$ and the sustained expression of the Bcl-2 protein in the HCV core-expressing cells with respect to the vector-transfected cells. These results suggest that the HCV core protein in 293 cells plays a role in the modulation of the apoptotic response that is induced by ceramide. Also, the ability of the HCV core protein to suppress apoptosis might have important implications in understanding the pathogenesis of the HCV infection.

• 한국콘텐츠학회논문지
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• 제15권8호
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• pp.326-335
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• 2015

본 연구에서는 고령자의 사회적 건강의 필요성을 주장하고, 고령자의 사회적 건강이 삶의 만족도에 미치는 영향을 파악하고자 함이 주된 연구의 목적이다. 본 연구의 조사대상은 경기도 A시와G시에 거주하고 있는 65세 이상 고령자 중 노인대학의 프로그램에 참가하는 고령자를 선정하였고 총167부를 최종분석에 사용하였다. 주된 연구결과는 다음과 같다. 사회인구학적 요인과 사회적 건강의 상관관계에 있어서는 경제적수준, 주관적 건강과 사회적 건강은 정(+)적인 상관관계를 나타냈다. 사회적 건강이 삶의 만족도에 미치는 영향에 있어서는 평균수입, 주관적 건강상태, 사회적 건강은 고령자의 삶의 만족도를 25.6%설명해 줄 수 있다고 할 수 있다. 주관적 건강상태와 사회적 건강 그리고 평균수입은 삶의 만족도에 정(+)적인 영향을 미친다고 할 수 있다. 이 상의 연구결과를 바탕으로 몇 가지 제언을 제시하였다.

• 한국콘텐츠학회논문지
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• 제15권12호
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• pp.355-369
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• 2015

본 연구는 노인의 연명치료에 대한 태도를 유형화함으로써 생의 마지막 단계를 살아가는 노인에게 맞는 적절한 간호전략의 개발을 위한 자료를 마련하고자 시도되었다. 주관적이고 개별화된 노인의 연명치료에 대한 태도를 개관적으로 측정할 수 있는 Q 방법론을 적용하였다. 노인의 연명치료에 대한 태도는 모두 4가지 유형으로 분류되었으며 그 결과는 다음과 같다. 제I유형: '상황적, 자기결정권 우선형'으로 현실적 상황에 따라 연명치료의 여부를 결정하고 결정의 주체는 자신이 가장 우선되어야 함을 강하게 긍정하였다. 제II유형: '운명적, 연명치료 거부형'으로 죽음의 상황을 운명이라 생각하고 삶의 한 과정으로써 자연스럽게 받아들이며 무의미한 연명치료에 대해 강하게 거부하는 성향을 지니고 있었다. 제III유형: '회피적, 가족결정 중시형'으로 자신의 죽음에 대해 생각하는 것을 꺼리고 연명치료에 대한 결정이 본인에게 맡겨지는 것을 회피하면서 가족의 결정에 의지하려는 태도를 가진 집단이다. 제IV유형: '생명중시적, 연명치료 찬성형'으로 연령이나 현재 상황보다는 생명을 가장 중시하여 연명치료에 대해 찬성하며 끝까지 최선을 다해야 한다는 태도를 보였다. 노인들이 생의 마지막 순간까지 품위 있는 삶을 유지하도록 돕기 위해서 노인에게 맞는 적절한 간호중재법 개발에 대한 노력이 필요하리라 판단된다.

• 한국보건간호학회지
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• 제13권1호
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• pp.1-11
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• 1999

This study was performed to estimate stressful life events, self-esteem and perceived health status in the elderly persons and to compare degree of self-esteem and perceived health status according to experience of stressful life events and general characteristics. The data was collected from 179 elders in a rural community. Data collection was done from October 20 to December 6, 1997. A comparison of self-esteem and perceived health status by experience of stressful life events and general characteristics was summarized as follows : 1) Eighty three persons, $46.4\%$ of the surveyed, have experienced stressful life events, including disease(54 persons) and death of family member(l2 persons). 2) Thirty eight percents of the surveyed persons evaluated they are not healthy. The average score of perceived health status of the elderly was 2.88± .92 for the scale of 5, which represents the healthiest status. 3) There were significant differences on the self-esteem score in the elderly according to having a spouse or not(t=3.51. p=.00l), having family members living together or not(t=2.98. p=.003) and socioeconomic status(F=7.08. p=.00l). 4) There were significant differences on the perceived health status in the elderly according to experience of stressful life events(t=3.51. p=.00l), having family members living together or not(t=2.09, p= .038) and socioeconomic status(F=6.56, p=.002). 5) Positive correlation was observed between self-esteem and perceived health(r= .5037, p=.000). The above results imply that support of family and society should be reinforced to improve self-respect and health of aged persons, and that it is desirable to build up social and economic environment promoting health status through daily life.

• Journal of the Korean Data and Information Science Society
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• 제27권4호
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• pp.925-934
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• 2016

21세기에 접어들면서 사람들은 건강 및 삶의 질에 관심을 많이 가지고 있다. 이에 본 연구에서는 사람들이 질병에 걸리면 치료에 많은 비용과 시간이 소요되므로 미리 아건강 상태를 진단하여 적극적인 치료 계획을 수립한다면 건강관리가 수월하고 사회적 비용을 줄일 수 있을 것으로 생각이 되어 특정 집단의 구성원을 대상으로 생활관리와 아건강 설문지에 각각 응답한 자료를 바탕으로 통계적 분석을 수행하였다. 분석 결과는 성별에 따른 생활관리와의 차이분석에서는 유의수준 5%에서 차이가 없는 것으로 나타났으며, 성별에 따른 아건강과의 차이 분석에서는 유의수준 5%에서 면역계, 장, 뇌신경, 호르몬 및 비뇨기에 대해서는 여학생이 남학생보다 건강 상태가 좋지 않은 것으로 나타났다. 또한 단과대학에 따른 생활관리와는 차이가 없는 것으로 나타났으며, 아건강과도 유의한 차이가 없는 것으로 나타났다. 생활관리와 아건강과의 분석 결과에서는 유의수준 5%에서 소화계, 장, 뇌신경, 호르몬 및 호흡기와는 관계가 있는 것으로 나타났다. 마지막으로 의사결정나무분석 결과는 호르몬과 골격계의 불량 비율이 생활관리의 불량 비율보다 월등히 높은 비율을 보여주었다. 이들을 종합해보면 생활관리를 잘 조절한다면 아건강 상태를 양호하게 할 수 있다는 것을 보여주는 결과라고 할 수 있다.

• 동아시아식생활학회지
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• 제3권2호
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• pp.29-40
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• 1993

A variety of studies show that a centraized rather than a generalized pattern of subcutaneous fat distribution is more directly associated with disorers of carbohydrate and lipid metabolism, as possibly hypertension, This study was an attempt to observe the relationship of body fat distribution, blood lipids, blood pressure and exercise in 85 healthy men and women. Within this group there was a gradation of fat distribution progressing from LBSO and UBSO defined on the basis of WHR. This paper reports the relationship of body fat distribution defined by WHR to plasma glucose, lipids, blood pressure, and exercise in this population. Although the obesity indices(RBW and BMI) were slightly higher in the UBSO group, significant differences existed between UBSO and LBSO groups with respect to WHR blood pressure, and total cholesterol concentration in female. WHR values were substantially different and this was primarily due to greater degrees of differences in waist as opposed to hips circum ference. Although no significant differences existed between UBSO and LBSO groups with respect to age, body weight, and hips circumference, energy intake, total cholesterol, LDL-cholesterol and WHR values were substantially different in male. Positive, significant correlations were found between WHR and both systolic and diastolic blood pressure and between WHR and the total plasma cholesterol concentration and age. When 26 pairs of exercise and nonexercise groups were matched according to sex, age and body weight, blood pressure and blood lipids were significantly lower in the exercise groups than those in the nonexercise groups. In conclusion, these findings suggest that an altered blood lipid profiles will manifast in men and women with upper body obese. Furthermore these findings suggest that exercise and physical activity may be beneficial for controlling blood lipids and blood pressure in healthy adults.

• 복식
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• 제62권4호
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• pp.195-206
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• 2012

Today, people are obsessed with fashion, makeup, hair care, weight control, and plastic surgery. In order to be satisfied with their appearance and attract attention, they invest so much time and money. The core values of many people are influenced heavily by materialism and appearance. Belly dancing is effective not only in just weight loss, but it also improves the health and corrects body postures like pelvis correction, and it also gives the dancers the pleasure of dancing to exotic music. A growing number of women in their 40s or older and senior citizens have become maniacs of belly dancing. The studies suggest that the participation in belly dancing helps increase life satisfaction and self-respect of the middle aged who often suffer from depression. Belly dancing has a strong effect in the life style of the middle-aged women. The costume and accessories necessary for belly dancing class help the participants) focus on the dance. These costumes and accessories reflect the desire of the wearer to be recognized in society. It is well shown in belly dancing that "fashion and beauty related services and products are used as an indicator to tell social status and position of the wearer as external elements like clothes, accessories, and physical appearance and have a highly important effect on interactions among people in society as a means of expressing oneself". In this respect, this study aims to examine middle-aged women's involvement in fashion and beauty depending on their participation in belly dancing.

• 한국학교ㆍ지역보건교육학회지
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• 제8권2호
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• pp.19-34
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• 2007

Background & Objectives: The current study aims to convey correct knowledge of dementia that is be on the rise as the most significant social problem and provide basic data for implementing immediate school health education for dementia which is the basis of improving quality of life for patients with dementia, their family and the society by analyzing recognition level for dementia among male and female students in the 2nd grade of middle school and the necessity of school health education for dementia. Methods: The current study conducted a survey with a total of 150 students. 25 male and female students respectively selected from three middle school taking into account regional characteristics. The study also processed the survey results using SPSS-PC Program 12.0 and gained the following results by implementing Frequency Analysis. Cross-tabulation Analysis and ANOVA Analysis. Results: As for respect for grandparents, 55.3% of the respondents said they respect their grandparents. while 39.3% answered so-so and 5.3% said they don't respect their grandparents. As for the number of they meet grandparents, 36.0% of the respondents said they meet grandparents once or twice a month, which was the most frequent answer. On the other hand, 24.7% are once or twice every six months, 13.3% are once or twice a year and a week, respectively, and 6.7% said that they seldom meet their grandparents. In a question about whether they had recognized dementia after explaining dementia in detail, 82.7% said' yes' while 17.3% said' no'. But few students recognized it when they were asked using a terminology' dementia' first. The average score of knowledge level integrating the most fundamental 16 questions about dementia was $11.20{\pm}1.73$. Also 83.3% of the respondents answered that they had no experience in health education about dementia while 16.7% said presented positive answers. In the necessity of health education about dementia, 73.3% of them said' necessary' while 21.3% said' so-so' and 5.3% said 'not necessary. Conclusions: From the above study results, it was found that it is time to emphasize the necessity and importance of school health education for improving respect for the old and a sense of responsibility for support and converting recognition for dementia in Korea that has social structure of the trend toward the nuclear family and heads for an aged society. However, the fact that the above things are not implemented at all in reality can expand disparate views among family members in the future and further can cause even more serious problem by neglecting senior problems. Therefore, the government, social organizations, especially school organizers should recognize the necessity and importance of school health education and actively begin cultivations of students' character by implementing the education about dementia at the early stage.

• 한국도로학회논문집
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• 제17권1호
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• pp.69-75
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• 2015

PURPOSES : The objective of this study is to evaluate the effectiveness of a geogrid reinforced subbase of permeable flexible pavement structures with respect to permanent deformation. METHODS : Experimental trials employing a repeated triaxial load test scheme were conducted for both a geogrid reinforced subbase material and a control specimen to obtain the permanent deformation properties based on the VESYS model. Along with this, a finite element-based numerical analysis was conducted to predict pavement performance with respect to the rutting model incorporated into the analysis. RESULTSAND CONCLUSIONS : The results of the experimental study reveal that the geogrid reinforcement seems to be effective in mitigating permanent deformation of the subbase material. The permanent deformation was mostly achieved in the early stages of loading and then rapidly reached equilibrium as the number of load applications increased. The ultimate permanent deformation due to the geogrid reinforcement was about 1.5 times less than that of the control specimen. Numerical analysis showed that the permeable, flexible pavement structure with the geogrid reinforced subbase also exhibits less development of rutting throughout the service life. This reduction in rutting led to a 20% decrease in thickness of the subbase layer, which might be beneficial to reduce construction costs unless the structural adequacy is not ensured. In the near future, further verification must be conducted, both experimentally and numerically, to support these findings.

• 동력기계공학회지
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• 제9권3호
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• pp.71-78
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• 2005

A high-pressure hose includes rebar layers of the synthetic fiber such as nylon or a steel wire to control internal pressure. The hose assembly is manufactured through the swaging process to clamp the hose into the metal fittings. Usually, the hose behavior is affected by the resultant of the longitudinal and circumferential forces produced by the internal pressure. The rebar layers can appear the most ideal rebar effect when they are arranged to the same direction as the resultant force. The braid angle applied in the rebar layers is an important factor in determining ultimate burst pressure and overall hose life. Failure can occur on the contacted parts of a hose with the metal fittings under severe operating conditions such as high pressure and temperature of the inner fluid. In this paper, the mechanical behavior between the hose and the metal fittings during the swaging process and the stress variation characteristics of a high-pressure hose under a constant applied pressure are analyzed with respect to the braid angle of steel wire using the finite element method.