• Korean Journal of Veterinary Research
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• v.61 no.2
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• pp.14.1-14.7
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• 2021

Biosilica is a silica-based substance derived from the cell walls (frustules) of diatoms. Recently, research into biosilica's biological functions is underway, but little has been reported on the effects of biosilica on immune cells. In this study, we investigated the effect of ionized biosilica water (iBW) on dendritic cells (DCs), which play crucial roles as antigen (Ag)-presenting cells. Treatment with iBW increased the expression of immune response-related markers, closely connected to the maturation of DCs, and the production of tumor necrosis factor-alpha. In addition, iBW-treated DCs (iBW-DCs) had a lower uptake of fluorescein isothiocyanate-dextran than that of control DCs. Mixed leukocyte response analysis used for measuring the Ag-presenting capability of DCs, showed iBW-DCs had a higher capability than that of control DCs. Interestingly, DCs treated with lipopolysaccharide (LPS) and iBW had a lower level of Ag-presenting capability than that of LPS-treated DCs. Taken together, the results indicate that iBW alone can mature DCs, but it decreases the Ag-presenting capability of DCs in the presence of LPS, a representative agent of inflammation. This study may provide valuable information regarding the effect of iBW on immune cells. Further research is needed to investigate how iBW induces the observed biphasic immunomodulatory activity.

• The Journal of the Korea Contents Association
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• v.22 no.6
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• pp.184-193
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• 2022

'Burnout', which has been frequently used recently, is one of the representative expressions representing the psychology of modern people living in fierce competition. In this paper, I approached and analyzed two films, 'Hector and the Search for Happiness' and 'To Each His Own' from the perspective of burnout, which are considered two of the most healing movies for office workers. The symptoms of burnout in the work were lethargy, irritability, anger, insomnia, depression, and suicidal thoughts. In the case of 'Hector and the Search for Happiness' the clash of values from repeated consulting work, and in the case of 'To Each His Own', work overload, performance pressure, and the absence of a community of colleagues were the causes. This burnout state is visually expressed through the dialogues and expressions of the characters, as well as looking down shots of various sizes, low lighting, and placing objects in front of the main character. This intuitively expressed the symptoms of burnout, which is difficult to diagnose. In particular, it was confirmed through the movie that one of the diagnostic criteria for burnout, such as hobbies, physical activity, and the presence or absence of a fellow community, helps to get out of burnout.

• Journal of Korea Entertainment Industry Association
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• v.15 no.4
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• pp.101-111
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• 2021

This paper is a study that analyzes the use and techniques of rap in music that entered Melon Chart, one of the major music sites in Korea, during 2020. Among the songs that entered the chart, reflecting the public's preference, the trend of rap music, an important element of hip-hop music, is analyzed and musical features such as representative artists or frequently used rhythm patterns are analyzed. Through this paper, characteristics of rap music favored by the public and artists in recent popular music have been organized and formalized, and based on this, the elements of etude development for technical polishing are summarized. Through this, it is hoped that just like the long-time analyzed and structured performance techniques such as vocals and instruments, various styles of rap music can develop into a systematic and step-by-step technique system for students who want to learn and practice it.

• Journal of the Korean Society of Safety
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• v.37 no.5
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• pp.42-55
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• 2022

In this study, an accident at an in-house maintenance subcontractor of a manufacturing company was analyzed using representative systemic analysis methods, and the results were compared to determine the socio-technical and organizational structure causal factors. Systemic accident analyses were performed using AcciMap, STAMP-CAST, and a method that utilizes work processing procedures. The causal factors derived from the three methods were classified according to HFACS classification criteria. AcciMap and STAMP-CAST analyses were able to derive legal problems and defects in organizational structure between the company and the subcontractors. The method that utilized the work processing procedures drew the most causal factors of the three methods but showed some limitations in deriving legal and facility-related problems. Most of the causal factors identified through the systemic methods could be classified according to the HFACS classification criteria, except for the legal and organizational structure matters. Socio-technical and organizational problems with a holistic perspective of the company and subcontractors could be found using systemic analysis methods. However, it is necessary to conduct analysis using various methods in order to derive more comprehensive measures to prevent accidents because each analysis method showed some limitations in the derivation or expression of some causal factors. The results of this study can be helpful in selecting and using an appropriate method for accident analysis.

• Journal of the Korea Fashion and Costume Design Association
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• v.24 no.2
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• pp.27-44
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• 2022

The purpose of this study is to attempt to diversify artistic expression through combinations of the twelve zodiac animals and origami techniques and to propose new directions for fashion design by applying these to fashion accessory bag designs. For the research method, this study researched the representative forms and characteristics of twelve zodiac animals based on the cultural background. Also, diverse cases of origami techniques were sought to apply them to the development of bags. The results are as follows. First, expressed forms of the Chinese zodiac were newly expanded by realizing the form of Chinese zodiac animals through various origami techniques. Origami work displays abstract visual effects rather than intuitive feelings or expressions of flat designs. With this, detailed realizations could be made through the characteristics and cultural implications of animals. Second, the work created in this study utilized zero-waste patterns that use origami techniques on one whole piece. During pattern production, folded parts were marked without waste and the outer fabric and lining were produced. Patterns were all symmetrical lines so most forms were expressed with squares and equilateral triangles. Third, through actual work produced using fabric instead of paper, effects that are brought about through folding are determined in diverse ways according to fabric textures or material types and thicknesses. When paper is folded, shapes are created as folded, but fabric requires the use of supportive material to create the effects of origami. Polyester and blended fabric were easy to use with high levels of function and practicality. Through such diverse production attempts, fixing methods, hand sewing, sewing machines, double-sided tape, and leather adhesive were used.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.1
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• pp.33-38
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• 2022

Ultraviolet B (UVB) damages DNA residues in skin keratinocytes. In particular, the formation of cyclobutane pyrimidine dimers (CPD), a pyrimidine residue damage in DNA, is considered a representative indicator of skin photoaging. In this study, we confirmed defensive effect of Glycyrrhiza glabra (G. glabra) extract against UVB induced DNA damage. First of all, we confirmed UVB dependent amount of CPD formation in human keratinocyte cell line. UVB induced CPD was decreased by G. glabra extract by dose dependent manner. In addition, it was confirmed that the expression of mRNA of DNA damage recovery factors was increased by G. glabra extract. Consequently, through this study, it was possible to confirm the DNA protection effect of G. glabra extract in skin keratinocytes.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.6 no.8
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• pp.491-498
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• 2016

This paper proposes a visualization method that expresses users' MBTI personality types based on the categorization method called 'Big Five Personality Traits' and their representative celebrities' facial images. This system has significance for visualizing traits from texts to images effectively. The entire system is composed of making backgrounds to represent traits of each MBTI category using 'Big Five Personality Traits' and showing facial images of celebrities with corresponding MBTI personality types. First, 'Big Five Personality Traits' classifies 16 MBTI types into four categories and each of category traits lays the foundation to make background using visual elements such as colors and lines. Second, celebrities' facial images are substituted for the corresponding literal explanation of each MBTI type. By adjusting the color saturation, users can distinguish relationship between the types intuitively. As a result, this system enables users to take information for their own / opposite / similar MBTI types simultaneously.

• Journal of Ginseng Research
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• v.47 no.4
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• pp.543-551
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• 2023

Background: Panax ginseng Meyer is a representative Chinese herbal medicine with antioxidant and anti-inflammatory activity. 20(S)-Protopanaxadiol (PPD) has been isolated from ginseng and shown to have promising pharmacological activities. However, effects of PDD on pulmonary fibrosis (PF) have not been reported. We hypothesize that PDD may reverse inflammation-induced PF and be a novel therapeutic strategy. Methods: Adult male C57BL/6 mice were used to establish a model of PF induced by bleomycin (BLM). The pulmonary index was measured, and histological and immunohistochemical examinations were made. Cell cultures of mouse alveolar epithelial cells were analyzed with Western blotting, coimmunoprecipitation, immunofluorescence, immunohistochemistry, siRNA transfection, cellular thermal shift assay and qRT-PCR. Results: The survival rate of PPD-treated mice was higher than that of untreated BLM-challenged mice. Expression of fibrotic hallmarks, including α-SMA, TGF-β1 and collagen I, was reduced by PPD treatment, indicating attenuation of PF. Mice exposed to BLM had higher STING levels in lung tissue, and this was reduced by phosphorylated AMPK after activation by PPD. The role of phosphorylated AMPK in suppressing STING was confirmed in TGF-b1-incubated cells. Both in vivo and in vitro analyses indicated that PPD treatment attenuated BLM-induced PF by modulating the AMPK/STING signaling pathway. Conclusion: PPD ameliorated BLM-induced PF by multi-target regulation. The current study may help develop new therapeutic strategies for preventing PF.

• Journal of Korea Entertainment Industry Association
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• v.13 no.6
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• pp.95-102
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• 2019

This paper mainly studies two films created by Huo Jianqi, Nuan and Postman in the Mountains, and analyzes the aesthetic style of Huo Jianqi's local movies in three parts. The first part deals with the characteristics of Huo Jianqi's local movies and discusses the theme selection, theme performance, character creation and emotional expression of the film. The second part elaborates Huo Jianqi's film and television works from three aspects: picture language, voice language and color language, which further reflects Huo Jianqi's aesthetic style. The third part analyses the puzzlement in the development of local films and how to develop them. With its unique oriental aesthetics, unique perspectives, unique rural scenery and characteristics, Chinese local movies have become the most representative of the overall level and style of Chinese movies. Chinese local film is the reflection and care of Chinese local culture, showing strong regional local culture, regionality is its distinct feature. Since the reform and opening up, with the changes of the times and the renewal of film directors, local films have shown distinct characteristics of the times. Through the analysis of Huo Jianqi's aesthetic style of local movies, this paper hopes to provide some valuable reference and inspiration for the development of Chinese local movies.

• Journal of dental hygiene science
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• v.23 no.4
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• pp.296-301
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• 2023

Background: Periodontal disease is a major cause of tooth loss in adults and is a representative oral disease commonly suffered by most people around the world. Mainly the proliferation of Gram-negative bacteria and secreted virulence factors cause an inflammatory response and destroy periodontal tissue. Gossypetin, isolated from Hibiscus sabdariffa L, is known to have various pharmacological effects, including antibacterial and anticancer activities. We aimed to confirm the anti-inflammatory effect of gossypetin through interleukin-6 (IL-6) regulation in human gingival fibroblasts (HGFs) stimulated with lipopolysaccharide (LPS) of Porphyromonas gingivalis, a major cause of adult periodontitis. Methods: CCK-8 assay was performed to confirm the concentration-dependent cytotoxicity of gossypetin against HGFs. The secretion level and mRNA expression of IL-6, an inflammation-related cytokine, and the effect of gossypetin on these in HGFs stimulated with P. gingivalis LPS were confirmed by ELISA and qRT-PCR analysis, respectively. Results: Up to a concentration of 100 µM gossypetin with or without P. gingivalis LPS, the survival rate for HGFs was maintained at over 95% and showed no toxicity. ELISA and qRT-PCR analysis results showed that P. gingivalis LPS increased IL-6 secretion and mRNA levels in HGFs compared to the control group. However, this increase in IL-6 was significantly down-regulated by gossypetin treatment in a dose-dependent manner. In particular, 80 µM gossypetin inhibited IL-6 production to the level of the control group. Conclusion: These results indicated that gossypetin attenuated IL-6 production in HGFs stimulated by P. gingivalis LPS, which may ultimately suppress the inflammatory response in periodontal tissue. Therefore, gossypetin may have potential as a natural ingredient for the prevention and treatment of periodontal disease.