• Biomolecules & Therapeutics
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• v.22 no.6
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• pp.563-569
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• 2014

Materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. This study was designed to evaluate bone response to titanium alloy containing Ti-32Nb-5Zr with nanostructure, anodic oxidation, heat treatment, and ibandronate coating. Rats were randomly assigned to two groups for implantation of titanium alloy (untreated) as the control group and titanium alloy group coated with ibandronate as the experimental group. Then, the implants were inserted in both tibiae of the rats for four weeks. After implantation, bone implant interface, trabecular microstructure, mechanical fixation was evaluated by histology, micro-computed tomography (${\mu}CT$) and the push-out test, respectively. We found that the anodized, heat-treated and ibandronate-coated titanium alloy triggered pronounced bone implant integration and early bone formation. Ibandronate-coated implants showed elevated values for removal torque and a higher level of BV/TV, trabecular thickness and separation upon analysis with ${\mu}CT$ and mechanical testing. Similarly, higher bone contact and a larger percentage bone area were observed via histology compared to untreated alloy. Furthermore, well coating of ibandronate with alloy was observed by vitro releasing experiment. Our study provided evidences that the coating of bisphosphonate onto the anodized and heat-treated nanostructure of titanium alloy had a positive effect on implant fixation.

• Journal of Radiation Industry
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• v.3 no.1
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• pp.39-45
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• 2009

Three mineral phosphate solubilizing (MPS) bacteria where isolated from rhizosphere soil samples of common bean and weed plants. 16S rDNA analysis indicated that the isolate P2 and P3 are closely related to Pantoea dispersa while isolate P4 is closely related to Pantoea terrae. Isolates P2 and P3 recorded $381.60{\mu}g\;ml^{-1}$ and $356.27{\mu}g\;ml^{-1}$ of tricalcium phosphate (TCP) solubilization respectively on 3 days incubation. Isolate P4 recorded the TCP solubilization of $215.85{\mu}g\;ml^{-1}$ and the pH was dropped to 4.44 on 24 h incubation. Further incubation of P4 sharply decreased the available phosphorous to $28.94{\mu}g\;ml^{-1}$ and pH level was raised to 6.32. Gamma radiation induced mutagenesis was carried out at $LD_{99}$ dose of the wild type strains. The total of 14 mutant clones with enhanced MPS activity and 4 clones with decreased activity were selected based on solubilization index (SI) and phosphate solubilization assay. Mutant P2-M1 recorded the highest P-solubilizing potential among any other wild or mutant clones by releasing $504.21{\mu}g\;ml^{-1}$ of phosphorous i.e. 35% higher than its wild type by the end of day 5. A comparative evaluation of TCP solubilization by wild type isolates of Pantoea and their mutants, led to select three MPS mutant clones such as P2-M1, P3-M2 and P3-M4 with a potential to release >$471.67{\mu}g\;ml^{-1}$ of phosphorous from TCP. These over expressing mutant clones are considered as suitable candidates for biofertilization.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.4
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• pp.101-115
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• 2019

Objectives : The purpose of this study is to analyze the use of herbal medicine as a treatment method in the case studies on warts in Korea, to identify trends in herbal medicines and herbal prescriptions according to the characteristics of individual patients and to systematically analyze concurrent therapies. Methods : Domestic databases (OASIS, RISS, NDSL, KTKP, KISS, KISTI, KISTI) were used to search for case studies related to the herbal medicine treatment of warts. There was no restriction on the time of publication. A total of 9 papers were selected. Results : A total of 13 prescriptions were presented 23 times in 18 cases. Among them, bojungikgi-tang gamibang(補中益氣湯加減方) was the most frequently prescribed. Gwakhyangjeonggi-san gamibang(藿香正氣散加減方) and Damsoeun-tang gagam were the next most frequently prescribed. 69 herbs were used in a total of 13 prescriptions. Herbs were commonly classified as heat-clearing medicine(淸熱藥), exterior-releasing medicine(解表藥), and tonifying and replenishing medicine(補益藥) in descending order. The herbs used more than 6 times included Coicis Semen(薏苡仁), Glycyrrhizae Radix et Rhizoma(甘草) (10 times), Bupleuri Radix(柴胡), and Scutellariae Radix(黃芩) (6 times). Concurrent therapies were performed except for 1 study, and they were acupuncture, moxibustion, pharmacopuncture, external agents, and cupping therapy. Conclusions : This is the first study to analyze the use of herbal medicine as a treatment method for warts in case studies performed in Korea. We hope that this study would give helpful information about the treatment of warts in clinical practices.

• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.1
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• pp.80-88
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• 2018

The function of a vehicle holding device (VHD) is to securely hold a launch vehicle on the launch pad and release the launch vehicle at maximum thrust after engine ignition to allow lift-off of the launch vehicle. During the release of the launch vehicle, to prevent the Ka doing a doing a doing mode, which is the vertical oscillation of the entire liquid propellant, the release of the launch vehicle should be gradual. In this study, for the gradual release of a launch vehicle, a hydraulic system comprising an accumulator and pyro valve to operate a hydraulic cylinder and control the speed of the cylinder with an orifice is introduced. Through a test, the influence of design variables on the cylinder speed is analyzed. Based on this, the design values of the hydraulic cylinder are determined. Through this study, the engineering basis for developing a VHD releasing a launch vehicle at maximum thrust is provided.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.42
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• pp.30.1-30.7
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• 2020

Background: Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs). Methods: This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively. Results: Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP. Conclusions: Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.

• Clinical and Experimental Reproductive Medicine
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• v.45 no.4
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• pp.183-188
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• 2018

Objective: The purpose of this retrospective study was to evaluate the appropriateness of various follicle-stimulating hormone (FSH) starting doses in expected normal responders based on the nomogram developed by La Marca et al. Methods: A total of 117 first in vitro fertilization cycles performed from 2011 to 2017 were selected. All women were expected normal responders and used a recombinant FSH and flexible gonadotropin-releasing hormone antagonist protocol. The FSH starting dose was empirically determined (150, 225, or 300 IU). The FSH starting dose indicated by La Marca's nomogram was determined using female age and serum $anti-M{\ddot{u}}llerian$ hormone or basal FSH levels. If the administered dose was exactly the same as the proposed dose, the cycle was assigned to the concordant group (34 cycles). If not, it was assigned to the discordant group (83 cycles). Optimal ovarian response was defined as a total of 8-14 oocytes, hypo-response as < 8 oocytes, and hyper-response as > 14 oocytes. Results: Between the concordant and discordant group, ovarian response (optimal, 32.4% vs. 27.7%; hypo-response, 55.9% vs. 54.2%; and hyper-response, 11.8% vs. 18.1%) and the number of total or mature oocytes were similar. Ovarian hyperstimulation syndrome was rare in both groups (0% vs. 1.2%). The implantation rate, clinical pregnancy rate, miscarriage rate, and live birth rate were all similar. Conclusion: The use of the proposed FSH starting dose determined using La Marca's nomogram did not enhance the optimal ovarian response rate or pregnancy rate in expected normal responders. Individualization of the FSH starting dose by La Marca's nomogram appears to have no distinct advantages over empiric choice of the dose in expected normal responders.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.6
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• pp.1225-1236
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• 2020

Fuzzing is an automated software testing methodology that dynamically tests the security of software by inputting randomly generated input values outside of the expected range. KISA is releasing open source for standard cryptographic algorithms, and many crypto module developers are developing crypto modules using this source code. If there is a vulnerability in the open source code, the cryptographic library referring to it has a potential vulnerability, which may lead to a security accident that causes enormous losses in the future. Therefore, in this study, an appropriate security policy was established to verify the safety of block cipher source codes such as SEED, HIGHT, and ARIA, and the safety was verified using differential fuzzing. Finally, a total of 45 vulnerabilities were found in the memory bug items and error handling items, and a vulnerability improvement plan to solve them is proposed.

• Convergence Security Journal
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• v.20 no.4
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• pp.113-123
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• 2020

The fourth industrial revolution can be called the hyper-connected-based intelligent revolution triggered by advanced information technology and intelligent technology, and the basis for implementing these technologies is 'data'. This study proposes a way to strategically use data in order to lead this intelligent revolution in the defense area. First of all, implications through analysis of domestic and international trends and prior research and current status of defense data management were analyzed, and four directions for development were presented. If the government composes conditions for building, releasing, sharing, distribution, and convergence of defense data considering the environment of national defense in the future, it is expected that it will serve as a foundation and a shortcut to be a digitalized strong military through smart defense innovation in the era of the fourth industrial revolution.

• Korean Journal of Organic Agriculture
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• v.30 no.1
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• pp.1-20
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• 2022

With the recent rapid increase in single-person households, food companies are releasing small packaging and small-capacity products regardless of product line such as beverages, fresh foods, and home snacks, and food consumption patterns are also changing. Meanwhile, as a series of accidents related to food safety occurred during cost-effective consumption pursuing price-performance, more consumers wanted to choose products that have been proven safe even with higher money due to food safety anxiety. Considering the concept of 'safety' of food, this study by using the 'ordered probit model' empirically investigated whether there is a difference in the degree of preference for safety in food consumption behavior between single-person and multi-person households. Summarizing the results, it was found that women rather than men, and elderly households among young and single-person households had a higher demand for food safety. The results of marginal effects considering food safety variables show that respondents with low frequency of delivery and take-out use are considering food safety more, and that single-person households are considering safety more than multi-person households. In the future, the population structure of Korea will continue to increase in single-person and elderly households, and women's economic activities will also continue to increase. Therefore, the growing home convenience food market needs marketing strategies to secure and emphasize food safety, such as sterilizing treatment technology for hygiene and safe container development from environmental hormones, and needs a lot of support and attention to meet changes in food culture trends and demographic structure.

• Journal of Korea Entertainment Industry Association
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• v.13 no.8
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• pp.69-76
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• 2019

Backed by the fourth industrial revolution as the background of the research, VR, AR and MR have increased interest and wireless Oculus Quest is releasing, creating hardware recall and continuing virtual reality devices, and game software develop or service VR games using such devices. As a result, it is expected that VR game markets will continue to grow in the future. For this purpose, we understand the technical factors of presence and immersion that appear in virtual reality games and should be able to apply them when we produce VR games. Through the process, we analyzed elements of VR game concept, immersion, and presence and analyzed three games that were commercialized. As a suggestion, we need to take into account presence and immersion characteristics when developing and experiencing virtual reality games in the future.