• Korean Chemical Engineering Research
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• 제46권2호
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• pp.205-210
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• 2008

PLGA는 생분해성 고분자이며 생체적합성을 갖는 고분자로서 약물전달을 위한 연구에 많이 이용되고 있는 고분자이다. 그러나 PLGA를 약물전달에 이용할 때 약물의 급격한 초기방출 이후에 일정기간동안 약물이 방출되지 않는 지연시간이 존재하게 된다. 이러한 문제를 해결하기 위하여 PLGA 웨이퍼에 단량체를 첨가하여 제조하였다. 또한 PLGA를 재결정하여 약물의 급격한 방출 현상을 억제하도록 하였다. SEM을 이용하여 재결정된 PLGA의 형태학적 차이를 관찰하였으며 생체외 약물 방출거동은 HPLC를 이용하여 측정하였다. PLGA의 분해과정에서 단량체의 영향을 알아보기 위하여 GPC를 이용하여 분자량 변화를 측정하였다. 본 연구를 통하여 PLGA의 벌크분해에 기인한 지연시간을 없앨 수 있었으며 약물의 방출 기간을 3일까지 앞당길 수 있었다.

• 한국화재소방학회논문지
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• 제32권5호
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• pp.6-14
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• 2018

본 연구는 건축용 목재의 화재위험성에대하여 열방출 특성을 중심으로 조사하였다. 열방출 성질은 cone calorimeter (ISO 5660-1)를 이용하여 측정하였으며 4종의 목재를 사용하였다. 외부 열유속 $25kW/m^2$에서 연소시킨 후 측정된 착화시간은 35 s부터 55 s까지였다. 나왕(lauan)과 적송의 착화 시간은 각각 54 s, 55 s로 가장 지연된 값으로 얻어졌다. 최대열방출율은 $156.87{\sim}235.1kW/m^2$ 였고 화재초기의 위험성은 가문비나무가 가장 높았다. 삼나무의 평균유효연소열은 19.1 MJ/kg였고 시료들 중에서 가장 높게 나타났다. 화재성능지수(FPI)에 의한 목재의 화재위험성은 나왕($0.2468s{\cdot}m^2/kW$) < 적송($0.2339s{\cdot}m^2/kW$) < 가문비나무($0.2308s{\cdot}m^2/kW$) < 삼나무($0.2231s{\cdot}m^2/kW$) 순으로 높았고 화재성장지수(FGI)에 의한 목재의 화재위험성은 나왕($0.5088kW/m^2{\cdot}s$) < 적송($0.511kW/m^2{\cdot}s$) < 삼나무 ($2.8522kW/m^2{\cdot}s$) < 가문비나무($3.0662kW/m^2{\cdot}s$) 순으로 높았다. 그러므로 목재의 열방출 특성에 대한 화재위험성은 가문비나무와 삼나무가 높은 것으로 나타났다.

• Natural Product Sciences
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• 제27권2호
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• pp.86-98
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• 2021

This study was designed to characterize the effect of ginsenoside-Rg2 (Rg2), one of panaxatriol saponins isolated from Korean ginseng root, on the release of catecholamines (CA) in the perfused model of the rat adrenal medulla, and also to establish its mechanism of action. Rg2 (3~30 µM), administered into an adrenal vein for 90 min, depressed acetylcholine (ACh)-induced CA secretion in a dose- and time-dependent manner. Rg2 also time-dependently inhibited the CA secretion induced by 3-(m-chloro-phenyl-carbamoyl-oxy)-2-butynyltrimethyl ammonium chloride (McN-A-343), 1.1-dimethyl-4-phenyl piperazinium iodide (DMPP), and angiotensin II (Ang II). Also, during perfusion of Rg2, the CA secretion induced by high K⁺, veratridine, cyclopiazonic acid, methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro-methyl-phenyl)-pyridine-5-carboxylate (Bay-K-8644) depressed, respectively. In the simultaneous presence of Rg2 and N^ω-nitro-L-arginine methyl ester hydrochloride ʟ-NAME), the CA secretion induced by ACh, Ang II, Bay-K-8644 and veratridine was restored nearly to the extent of their corresponding control level, respectively, compared to those of inhibitory effects of Rg2-treatment alone. Virtually, NO release in adrenal medulla following perfusion of Rg2 was significantly enhanced in comparison to the corresponding spontaneous release. Also, in the coexistence of Rg2 and fimasartan, ACh-induced CA secretion was markedly diminished compared to the inhibitory effect of fimasartan-treated alone. Collectively, these results demonstrated that Rg2 suppressed the CA secretion induced by activation of cholinergic as well as angiotensinergic receptors from the perfused model of the rat adrenal gland. This Rg2-induced inhibitory effect seems to be exerted by reducing both influx of Na⁺ and Ca²⁺ through their ionic channels into the adrenomedullary cells as well as by suppressing Ca²⁺ release from the cytoplasmic calcium store, at least through the elevated NO release by activation of NO synthase, which is associated to the blockade of neuronal cholinergic and AT₁-receptors. Based on these results, the ingestion of Rg2 may be helpful to alleviate or prevent the cardiovascular diseases, via reduction of CA release in adrenal medulla and consequent decreased CA level in circulation.

• 한국인터넷방송통신학회논문지
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• 제22권3호
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• pp.193-200
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• 2022

본 연구에서는 소프트웨어 신뢰성 분야에서 많이 사용하는 Weibull 수명 분포((Goel-Okumoto, Rayleigh, Type-2 Gumbe)에 근거하여 유한 고장 NHPP 소프트웨어 신뢰성 모형을 소프트웨어 개발 모형에 적용한 후, 비용의 속성을 비교하여, 분석하였다. 본 연구를 위하여 소프트웨어 시스템의 정상 운용 중 검출된 고장시간 데이터를 수집하여 사용하였고, 제안된 모형의 모수 추정은 최우추정법을 적용하였으며, 비선형 방정식의 계산은 이분법을 사용하여 해결하였다. 그 결과, 첫째, 소프트웨어 개발 모형의 단위 시간당 테스팅 비용과 단일 고장을 제거하는 비용이 증가하면 비용은 증가하였지만 방출시간은 변하지 않았고, 정상적인 시스템 운용 중에 검출된 고장 수리 비용이 증가하면 비용 증가와 함께 방출 시간도 지연됨을 알 수 있었다. 둘째, 제안된 모형들을 종합적으로 비교 분석한 결과, Type-2 Gumble 모형이 Rayleigh 모형과 Goel-Okumoto 기본 모형 보다 개발비용이 적고, 방출 시간 포인트도 상대적으로 빨라서 가장 효율적인 모형임을 알 수 있었다. 셋째, 본 연구를 통하여 Weibull 분포 모형의 개발비용 속성을 새롭게 분석하였으며, 분석된 데이터는 소프트웨어 개발자들이 개발 비용과 방출 시간에 대한 속성을 탐색하는 데 필요한 설계 데이터로 활용할 수 있을 것으로 기대한다.

• 벤처창업연구
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• 제7권4호
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• pp.49-54
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• 2012

본 논문에서는 시험시간과 오류의 수정개수를 동시에 고려하는 소프트웨어 출시 모형을 제시한다. 소프트웨어의 시험기간은 정해진 시험시간이나 오류수정개수 중 먼저 도래하는 시간까지 지속된다. 고려되는 비용은 시험기간 중의 오류수정비용과 출시 지연비용, 그리고 시험기간 경과 후의 운용 중 발생하는 오류수정비용으로 구성된다. 생명주기는 특별한 제한이 없고, 오류의 검출과정은 비제차 포아송과정을 따른다고 가정한다. 총비용함수가 도출되며 이전의 출시방안들은 제시된 모형의 특별한 경우임을 보인다.

• Fisheries and Aquatic Sciences
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• 제4권4호
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• pp.257-260
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• 2001

The effects of light, desiccation and salinity on the discharge of spores in Korean agarophyte, Gracilaria verrucosa were studied. Among the examined factors, light after darkness was the most effective for spore discharge. The maximum release of tetraspores was induced at 24 h after the treatment. Desiccation also seems to be conductive to the release of tetraspores. However, its effect, as in treatment of distilled water for salinity, was hardly found in induction of carpospore discharge. This may suggest that spore discharge in this alga is primarily related with photoperiodic rhythm. Also it appears that the amount of light energy received by fertile thalli also significantly affects to the spore release, considering relationship between the amount of the discharged spores and the elapsed time after treatment.

• 한국의류학회지
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• 제12권1호
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• pp.69-80
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• 1988

In this study, we have compared the relative importance of various washing condition affecting on soil release for P/C blended fabrics. P/C blended fabrics were soiled by the pad-dry method with aqueous and oily soil. The washing procedures of soiled samples were performed by Atlas Launder-Ometer with 27 wash conditions which are combinations of wash temp. wash time and detergent cone. The degree of soil-release was evaluated with CIE 1976 Lab color difference before and after washing. Multiple regression analysis was used to evaluate the optimum wash conditions and the relative importance of the factors providing maximum soilremoval.

• 제어로봇시스템학회논문지
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• 제11권9호
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• pp.774-780
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• 2005

For the accurate inspection of the resources and space in the ocean, the method of locating the measurement equipments in the seafloor and retrieving these equipments later after a certain period of time. is generally used. In this method, the reliability of retrieving measurement equipments is very important. In our proposed remotely-controlled acoustic release system, an underwater ultrasonic wave recognition algorithm by which we can recognize the sound signal without the influence of disturbances due to underwater environment changes is developed, and a battery is used for the reduction of electric power consumption. we show the effectiveness of our proposed system through experimental results.

• 품질경영학회지
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• 제17권2호
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• pp.27-35
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• 1989

Software developers often allocate a significant amount of effort to software testing. But for most business-related software system it is natural to expect the continued discovery of defects after the software system is released into field. Such defects are usually very expensive to fix and have the potential to cause great damages to the users. It is important to stop testing the software and release it to the users at the correct time. In this paper, we propose the determination of the optimal number of software test oy minimizing a total expected software cost. A numerical example is used when the criterion is the expected profit. The result indicates that the proposed software release policy based on the number of software test can be a good alternative to the existing policy.

• Journal of Mechanical Science and Technology
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• 제18권11호
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• pp.1996-2008
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• 2004

A seamless analysis of material behavior incorporating complex geometry and crack- tip modeling is one of greatly interesting topics in engineering and computational fracture mechanics fields. However, there are still large gaps between the industrial applications and fundamental academic studies due to a time consuming detailed modeling. In order to resolve this problem, a numerical method to calculate an energy release rate by virtual crack closure technique was proposed in this paper. Both free mesh method and finite element method have been utilized and, thereafter, robust local and global elements for various geometries and boundary conditions were generated. A validity of the proposed method has been demonstrated through a series of fracture mechanics analyses without tedious crack-tip meshing.