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Release Behavior of 5-FU from 5-FU/PLGA Wafer using Recrystallized PLGA and Monomer  

Park, Jung Soo (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Choi, Myoung Kyu (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Kim, Yun Tae (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Jun Hee (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Mo, Jong Hyun (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Khang, Gilson (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Rhee, John Moon (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Shin, Hyung Shik (BK21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Hai Bang (Nanobiomaterials Lab, KRICT)
Publication Information
Korean Chemical Engineering Research / v.46, no.2, 2008 , pp. 205-210 More about this Journal
Abstract
Poly(D,L-lactide-co-glycolide) (PLGA) has been widely used as carriers in controlled release delivery systems due to its biodegradability and relatively good biocompatibility. However, Release pattern of carriers fabricated using PLGA have disadvantage an initial burst within a few days, lag time several days and then sudden release changes. To solve these problems of PLGA, we fabricated PLGA wafer including monomer. Also, drug release behavior restraint sudden burst effect using recrystallization of PLGA. Recrystallized PLGA was characterized the morphological difference by SEM and in vitro release behavior measured by HPLC. The PLGA molecular weight analyzed to recognize monomer influence during degradation process of polymer using GPC. In this study, drug release duration cut short up to three days and was eliminated the lag time based on the bulk erosion.
Keywords
PLGA; Recrystallization; 5-FU; Monomer;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Khang, G., Choi, H. S., Rhee, J. M., Yoon, S. C., Cho, J. C. and Lee, H. B., "Controlled Release of Gentamicin Sulfate from PHBV Wafers for the Treatment of Osteomyelitis," Korea Polymer J., 8(6), 253-250(2000)
2 Kim, G. Y., Tyler, B. M., Tupper, M. M., Karp, J. M., Langer, R. S., Brem, H. and Cima M. J., "Resorbable Polymer Microchips Releasing BCNU Inhibit Tumor Growth in the Rat 9L Flank Model," J. Control. Release, 123(2), 172-178(2007)   DOI   ScienceOn
3 Kim, M. S., Seong, H. S., Cho, S. H., Lee, H. B., Chae, K. S., Lee, J. S. and Khang, G., "Synthesis and Characterization of Polyanhydride for Local BCNU Delivery Carriers," Bio-Med. Mater. Eng., 15(3), 229-238(2005)
4 Choi, B. S., Kim, S. H., Yun, S. J., Ha, H. J., Kim, M. S., Yang, Y. I., Son, Y., Khang, G., Rhee, J. M. and Lee, H. B., "Deminerlaized Bone Particle Suppressed the Inflammatory Reaction of poly(lactide-co-glycolide) Scaffold," Tissue Eng. Regen. Med., 3(3), 295-300(2006)
5 Gupte, A. and Ciftci, K., "Formulation and Characterization of Paclitaxel, 5-FU and Paclitaxel+5-FU Microspheres," Int. J. Pharm., 276(1), 93-106(2001)   DOI   ScienceOn
6 Seo, K. S., Hong, K. D., Hyun, H., Kim, M. S., Khang, G. and Lee, H. B., "Sustained Release of Proteins Using Temperature Sensitive MPEG-PCL Hydrogel," Tissue Eng. Regen. Med., 2(2), 109-114(2005)
7 Fu, Y., Shyu, S., Su, F. and Yu, P., "Development of Biodegradable co-poly(D,L-lactic/glycolic acid) Microspheres for the Controlled Release of 5-FU by the Spray Drying Method," Colloid. Surf. B: Biointerfaces., 25(4), 269-279(2002)   DOI   ScienceOn
8 Choi, H. S., Khang, G., Shin, H., Rhee, J. M. and Lee, H. B., "Preparation and Characterization of Fentanyl-loaded PLGA Microspheres; In vitro Release Profiles," Int. J. Pharm., 234, 195 (2002)   DOI   ScienceOn
9 Park, J. S., Shin, J. H., Lee, D. H., Rhee, J. M., Kim, M. S., Lee, H. B. and Khang, G., "BCNU Release Behaviour from BCNU/PLGA Wafer Prepared by Vacuum Drying Method," Polymer(Korea), 31(3) 201-205(2007)   과학기술학회마을
10 Seong, H., An, T, K., Khang, G., Choi, S., Lee, C. and Lee, H. B., "BCNU-loaded poly(D,L-lactic-co-glycolic acid) Wafer and Antitumor Activity Against XF-498 Human CNS Tumor Cells in Vitro," Int. J. Pharm., 251, 1-12(2003)   DOI   ScienceOn
11 Hyun, H,, Seo, K. S., Cho, Y. H., Lee, J. W., Lee, C. R., Kim, M. S., Khang, G. and Lee, H. B., "Preparaton and Characterization of MPEG-PCL Diblock Copolymers with Thermosensitive Solgel- sol Phase Transition," J. Polym. Sci. Part A: Polym. Chem., 44, 5413-5423(2006)   DOI   ScienceOn
12 Hong, K. D., Ahn, Y. S., Go, J. T., Yuk, S. H., Shin, H. S., Rhee, J. M. and Khang, G., "Preparation of Double Layered Nanaosphere Using Biodegradable Polymer Dextran and PLGA," Polymer(Korea), 29(3), 260-265(2005)   과학기술학회마을
13 Dunne, M., Corrigan, O. I. and Ramtoola, Z., "Influence of Particle Size and Dissolution Conditions on the Degradation Properties of poly(L-lactide-co-glycolide) Particle," Biomaterials, 21(16), 1659-1668(2000)   DOI   ScienceOn
14 Iwasaki, Y., Sawada, S., Nakabayashi, N., Khang, G., Lee, H. B. and Ishihara, K., "Reduction of Surface-induced Inflammatory Reaction on PLGA/MPC Polymer Blend," Biomaterials, 23, 3877-3903(2002)
15 Zolnik, B. S. and Burgess, D. J., "Effect of Acidic pH on PLGA Microsphere Degradation and Release," J. Control Release., 122(3), 338-344(2007)   DOI   ScienceOn
16 Yoo, J. Y., Kim, J. M., Khang, G., Kim, M. S., Cho, S. H., Lee, H. B. and Kim, Y. S., "Effect of Lactide/Glycolide Monomers on Release Behaviors of Gentamicin Sulfate-loaded PLGA Discs," Int. J. Pharm., 276, 1-9(2004)   DOI   ScienceOn
17 Seo, S., Choi, H. S., Lee, D. H., Khang, G, Rhee, J. M. and Lee, H. B., "Characteristics of Nifedipine Loaded PLGA Wafer," Polymer(Korea), 25, 884-892(2001)
18 Gopferich, A. and Tessmar, J., "Polyanhydride Degradation and Erosion," Adv. Drug Deliv. Rev., 54, 911-931(2002)   DOI   ScienceOn
19 Park, J. S., Lee, J. H., Choi, M. G., Rhee, J. M., Kim, M. S., Lee, H. B. and Khang, G., "Effect of Recrystallized PLGA on Release Behavior of 5-Fluorouracil," Polymer(Korea), 31(5), 447-453(2007)   과학기술학회마을
20 Khang, G., Jeong, J. K. and Lee, J. S., "Recent Develpoment Trends of the Improving Bioavailability by Polymeric Nanovehicles of Poorly Water-Soluble Drugs," Polymer Sci. Tech., 13(3), 342-359(2002)
21 Dang, W., Daviau, T., Ying, P., Zhao. Y., Nowotnik, D., Clow, C. S., Tyler, B. and Brem, H., "Effects of GLIDEL Wafer Initial Molecular Weight on the Erosion of Wafer and Release of BCNU," J. Control. Release, 42(1), 83-92(1996)   DOI   ScienceOn
22 Ghaderi, G., Struesson, C. and Carlfors, J., "Effect of Preparative Parameters on the Characteristics of Poly(d,l-lactide-co-glycolide) Microspheres Made by the Double Emulsion Method," Int. J. Pharm., 141, 205(1996)   DOI   ScienceOn
23 Park, T. G., "Degradation of Poly(d,l-lactic acid) Microspheres: Effect of Molecular Weight," J. Control Release., 30, 161(1994)   DOI   ScienceOn
24 Kang, G. D., Cheon, S. H., Khang, G. and Song, S., "Thermosensitive Poly(organophosphazene) Hydrogels for a Controlled Drug Delivery," Eur. J. Pharm. Biopharm., 63, 340-346(2006)   DOI   ScienceOn