• BMB Reports
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• 제54권2호
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• pp.89-97
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• 2021

Post-transcriptional regulation is an indispensable cellular mechanism of gene expression control that dictates various cellular functions and cell fate decisions. Recently, various chemical RNA modifications, termed the "epitranscriptome," have been proposed to play crucial roles in the regulation of post-transcriptional gene expression. To date, more than 170 RNA modifications have been identified in almost all types of RNA. As with DNA modification-mediated control of gene expression, regulation of gene expression via RNA modification is also accomplished by three groups of proteins: writers, readers, and erasers. Several emerging studies have revealed that dysregulation in RNA modification is closely associated with tumorigenesis. Notably, the molecular outcomes of specific RNA modifications often have opposite cellular consequences. In this review, we highlight the current progress in the elucidation of the mechanisms of cancer development due to chemical modifications of various RNA species.

• 제어로봇시스템학회논문지
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• 제13권10호
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• pp.990-999
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• 2007

We deal with second order NMP(Non-Minimum Phase) systems which are difficult to control with conventional methods because of their inherent characteristics of undershoot. In such systems, reducing the undesirable undershoot phenomenon makes the response time of the systems much longer. Moreover, it is impossible to control the magnitude of undershoot in a direct way and to predict the response time. In this paper, we propose a novel two sliding mode control scheme which is capable of determining the magnitude of undershoot and thus the response time of NMP systems a priori. To do this, we introduce two sliding lines which are in charge of control in turn. One is used to stabilize the system and achieve asymptotic regulation eventually like the conventional sliding mode methods and the other to stably control the magnitude of undershoot from the beginning of control until the state meets the first sliding line. This control scheme will be proved to have an asymptotic regulation property. The computer simulation shows that the proposed control scheme is very effective and suitable for controlling the second order NMP system because it can decide the magnitude of undershoot in a direct and stable way and reduce the response time compared with the conventional ones.

• 아동학회지
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• 제38권1호
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• pp.17-31
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• 2017

Objective: The purpose of this research was to examine the effects of parents' childhood attachment representations and parenting behavior in developing early childhood self-regulation, a developmental skill. Methods: This research was conducted with 171 preschoolers, 171 parent couples, and 22 teachers of 5-year-old classes in kindergartens and children's houses in Seoul. Results: First, there was significant correlation among parental childhood attachment representations, parenting behavior, and child self-regulation. Second, parental attachment representations and parenting behavior were shown to affect self-monitoring, a subvariable of self-regulation, and were influenced by maternal independence-oriented parenting behavior, maternal attachment representation, and parental attachment representation. As factors affecting self-control, a subvariable of self-regulation, they were influenced by maternal attachment representation, and maternal and paternal affectionate parenting behavior. Lastly, as factors affecting self-control, they were influenced by attachment representation to parents of origin, maternal affectionate parenting behavior, and maternal independence-oriented parenting behavior. Conclusion: This research revealed that parental childhood attachment representations and parenting behavior are important variables affecting the development of self-regulation in preschoolers. This finding can be used as basic data for parent education content to help preschoolers grow healthier and happier and as basic data for a program to improve parent-child attachment.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2018년도 전력전자학술대회
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• pp.522-524
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• 2018

A New Direct AC LED Driver has been proposed for wide output power range and precise constant current regulation using an advanced auto commutation topology. The conventional shunt regulation method provides a stepped input current shape by fixed regulation references in the linear regulator of the each channel, which results in poor current regulation and high THD. The conventional method needs to assign a linear regulator in each LED channel so that the number of linear regulator increases when extending the number of channels especially at high power application. The proposed regulation method can drive multiple switches to regulate each LED channel current by a single amplifier with sinusoidal reference so that large number of LED channel can be simply extended with less BOM cost and low THD is obtained with the accurate current regulation thanks to the sinusoidal input current control in the closed loop control. To confirm the validity of the proposed circuit, theoretical analysis and experimental results from a 20-W LED driver prototype are presented.

• 한국환경과학회지
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• 제3권4호
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• pp.445-450
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• 1994

The environmental regulation violation of the Korean firms is causing severe environmental pollution lately. Nevertheless, there are few studies on the firm's pattern of environmental regulation violation. In this paper, for the pattern of environmental regulation violation of the Korean firms, we give a type of statistical data analysis using the correspondence analysis. Therefore, with more effective control and inspection based on this, we have an effective and enforceable system decreasing the violative firms.

• 한국소음진동공학회논문집
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• 제19권8호
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• pp.809-815
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• 2009

The previous work(Cheong et al., 2006) where the characteristics of acoustic emissions of wind turbines has been investigated according to the methods of power regulation, has showed that the acoustic power of wind turbine using the stall control for power regulation is more correlated with the wind speed than that using the pitch control. In this paper, basically extending this work, the noise generation characteristics of large modern upwind wind turbines are experimentally indentified according to the power regulation methods. To investigate the noise generation mechanisms, the distribution of noise sources in the rotor plane is measured by using the beam-forming measurement system(B&K 7768, 7752, WA0890) consisting of 48 microphones. The array results for the 660 kW wind turbine show that all noise is produced during the downward movement of the blades. This result show good agreement with the theoretical result using the empirical formula with the parameters: the convective amplification; trailing edge noise directivity; flow-speed dependence. This agreement implies that the trailing edge noise is dominant over the whole frequency range of the noise from the 660 kW wind turbine using the pitch control for power regulation.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2009년도 춘계학술대회 논문집
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• pp.63-67
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• 2009

The previous work (Cheong et al., 2006) where the characteristics of acoustic emissions of wind turbines has been investigated according to the methods of power regulation, has showed that the acoustic power of wind turbine using the stall control for power regulation is more correlated with the wind speed than that using the pitch control. In this paper, basically extending this work, the noise generation characteristics of large modern upwind wind turbines are experimentally indentified according to the power regulation methods. To investigate the noise generation mechanisms, the distribution of noise sources in the rotor plane is measured by using the Beam-forming measurement system (B&K 7768, 7752, WA0890) consisting of 48 microphones. The array results for the 660 kW wind turbine show that all noise is produced during the downward movement of the blades. This result show good agreement with the theoretical result using the empirical formula with the parameters: the convective amplification; trailing edge noise directivity; flow-speed dependence. This agreement implies that the trailing edge noise is dominant over the whole frequency range of the noise from the 660 kW wind turbine using the pitch control for power regulation.

• 한국보육지원학회지
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• 제15권3호
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• pp.61-81
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• 2019

Objective: This study aimed to examine the effects of collaborative activities by utilizing picture books in order to improve the self-regulation and perspectivetaking abilities among four-year-olds. Methods: A total of 52 four-year-olds(control group 26, experimental group 26) attending two classes at D kindergarten located in B city participated in this study. Before and after the activities, all participants individually took a social perspective taking ability instrument and rated their self-regulation with a teacher. Data were analyzed by conducting ANCOVA in the way of setting pre-test scores as the covariate and post-test scores as the dependent variable. Results: First, the total and subarea of self-regulation in the experimental group was higher than the control group. Second, the cognitive and emotional perspective taking abilities in the experimental group were higher than the control group in all cares. Conclusion/Implications: The results of this study suggest that collaborative activities using picture books are effective in improving young children's selfregulation and perspective-taking abilities.

• 한국콘텐츠학회논문지
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• 제18권1호
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• pp.540-550
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• 2018

본 연구는 간호대학생의 내외통제성 정서조절곤란 및 임상실습스트레스와의 관계를 분석하고자 시도되었다. 연구대상자는 일개 대학 간호학과에 재학 중이며 본 연구의 목적을 이해하고 협조를 수락한 220명을 대상으로 하였으며, 연구설계는 횡단적 조사연구이다. 수집된 자료는 빈도, 백분율, t-test, ANOVA, Pearson correlation coefficient 와 stepwise regression analysis를 사용하여 분석하였다. 그러므로 임상실습스트레스는 내 외통제소재과 정서조절곤란에 정적인 상관관계를 보였으며, 그 영향요인은 정서조절곤란, 실습만족도, 학년, 종교, 내 외통제소재으로 나타났으며, 그 설명력은 17%였다. 그 결과 간호대학생들의 임상실습스트레스를 줄이기 위해서는 정서를 적절하게 조절하고 내적 통제 전략을 통해 임상실습스트레스를 경감할 수 있는 효율적인 교육방안의 모색 및 임상 적응능력 향상 프로그램 개발이 필요하다.

• Journal of Preventive Medicine and Public Health
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• 제54권5호
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• pp.330-339
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• 2021

Objectives: Tobacco control in Indonesia is very lenient compared to international standards. This study explored the perspectives of tobacco control stakeholders (TCSs) on the likelihood of advancing tobacco marketing regulation in Indonesia. Methods: Data were collected from TCSs who were members of the Indonesia Tobacco Control Network group in a modified Delphi study. We collected the data in 2 waves using a questionnaire that comprised a set of closed and open-ended questions. For this paper, we analysed 2 of the 3 sections of the questionnaire: (1) tobacco advertising, promotions, and sponsorship (TAPS) bans, and (2) marketing and retailing regulations. We conducted a descriptive analysis of the scores using Stata/IC.13 and summarised the comments for each item. Results: The TCSs viewed the measures/strategies across all aspects of TAPS and tobacco marketing regulation as highly desirable, but provided varied responses on their feasibility. They rated political feasibility lower than technical feasibility for most measures. Advancing TAPS measures and prohibition of selling to minors were considered more attainable by sub-national governments, while prohibition of tobacco corporate social responsibility was considered as the least feasible measure in the next 5 years. Conclusions: Despite little optimism for substantial national-level change, there is a positive expectation that sub-national governments will strengthen their tobacco control regulation. It is paramount that the government reduce tobacco industry leverage by implementing Article 5.3 of the World Health Organization Framework Convention on Tobacco Control. Extending advocacy networks beyond tobacco control groups and framing tobacco control more effectively are necessary steps.