• Biomolecules & Therapeutics
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• 제23권3호
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• pp.251-260
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• 2015

Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment in spatial learning and memory from repeated neonatal propofol administration in animals. Yet, none of those studies has explored the sex-specific long-term physical changes and behavioral alterations such as social (sociability and social preference), emotional (anxiety), and other cognitive functions (spatial working, recognition, and avoidance memory) after neonatal propofol treatment. Seven-day-old Wistar-Kyoto (WKY) rats underwent repeated daily intraperitoneal injections of propofol or normal saline for 7 days. Starting fourth week of age and onwards, rats were subjected to behavior tests including open-field, elevated-plus-maze, Y-maze, 3-chamber social interaction, novel-object-recognition, passive-avoidance, and rotarod. Rats were sacrificed at 9 weeks and hippocampal protein expressions were analyzed by Western blot. Results revealed long-term body weight gain alterations in the growing rats and sex-specific impairments in spatial (female) and recognition (male) learning and memory paradigms. A markedly decreased expression of hippocampal NMDA receptor GluN1 subunit in female- and increased expression of AMPA GluR1 subunit protein expression in male rats were also found. Other aspects of behaviors such as locomotor activity and coordination, anxiety, sociability, social preference and avoidance learning and memory were not generally affected. These results suggest that neonatal repeated propofol administration disrupts normal growth and some aspects of neurodevelopment in rats in a sex-specific manner.

• 한국광학회:학술대회논문집
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• 한국광학회 1989년도 제4회 파동 및 레이저 학술발표회 4th Conference on Waves and lasers 논문집 - 한국광학회
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• pp.95-98
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• 1989

A new associative memory model using the SDF filter, one of the multiple filter for pattern recognition, is suggested in this paper. The SDF filter characteristics such as pattern classification lets the memorized patterns have orthogonal characteristics one another, so that enhances the associative memory's retrieval ability to the original pattern. The computer simulation shows that this new model is very useful in case that the imput patterns are seriously distorted and the cross-correlation between the memorized patterns is very high.

• 수면정신생리
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• 제4권1호
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• pp.29-38
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• 1997

치매는 기억력을 포함한 다양한 영역의 인지기능의 손상을 특징으로 하는 질병군으로 정의된다. 그러므로 현재 치매진단을 위하여 사용되고 있는 대부분의 진단기준들은 치매의 진단에 있어 기억 장애를 필수요소로 포함하고 있다. 기억력의 감퇴는 노화과정의 결과로서 나타날 수 있다. 치매와는 달리 노화에서의 기억력의 감퇴는 노화에 따른 정상으로 간주되며 사회적 그리고 직업적 기능의 영역에서 심각한 어려움이나 손상을 초래하지 않는다. 우울증 또한 기억장애를 동반할 수 있다. 하지만 치매와는 달리 우울증에서는 언어성 지연회상과 재인기억의 감소는 나타내지 않는다. 치매환자들에서의 기억장애도 병소의 위치에 따라 다른양상으로 나타날 수 있다. 피질성치매에서의 기억장애는 정보의 부호화와 기억강화과정의 이상에 의해 초래된 것인데, 피질하치매에서의 기억장애는 인출의 장애에 의한 것이다.

• 재활간호학회지
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• 제13권2호
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• pp.161-170
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• 2010

Purpose: This study was to confirm the influence of memory intensive training program on the elderly people's cognitive function, memory performance, and self-esteem. Method: Using a quasi-experimental or experimental design, 60 elderly aged over 60 years randomly assigned the experimental and control groups completed pretest-post evaluation. The experimental group participated in the memory intensive training program was offered to the participants in the experimental group for three weeks (2times/week). The t-test and $X^2$-test using SAS program. Results: 1) The cognitive function was significantly higher in the experimental group compared to that in the control group (t=3.26, p=.002). 2) The memory performance that included immediate word recall tasks, word recognition tasks and delayed word recall tasks was significantly higher in the experimental group than in the control group (t=5.30, p<.001). The experimental group showed significantly higher scores for memory performance than the control group (t=5.30, p<.001). 3) The self-esteem was higher in the experimental group than in the control group, but there was no significant difference between the two groups (t=1.94, p=.058). Conclusion: The Memory Intensive Training Program could be an effective intervention for improving cognitive function, and memory performance of the elderly people.

• 한국산업융합학회 논문집
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• 제24권5호
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• pp.531-536
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• 2021

As artificial intelligence technology advances, it is being applied to various application fields. Artificial intelligence is performing well in the field of image recognition and classification. Chip design specialized in this field is also actively being studied. Artificial intelligence-specific chips are designed to provide optimal performance for the applications. At the design task, memory component optimization is becoming an important issue. In this study, the optimal algorithm for the memory size exploration is presented, and the optimal memory size is becoming as a important factor in providing a proper design that meets the requirements of performance, cost, and power consumption.

• IMMUNE NETWORK
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• 제23권1호
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• pp.11.1-11.11
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• 2023

Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a "memory-like" T-cell population, termed virtual memory T (T_VM) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, T_VM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of T_VM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.

• 대한임베디드공학회논문지
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• 제8권3호
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• pp.179-184
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• 2013

A voice recognition technology as a technology fundament plays an important role in medical devices with smart functions. This paper describes the implementation of a control system that can be utilized as a part of illumination equipment for medical applications (IEMA) based on a voice recognition. The control system can essentially be divided into five parts, the microphone, training part, recognition part, memory part, and control part. The system was implemented using the RSC-4x evaluation board which is included the micro-controller for voice recognition. To investigate the usefulness of the implemented control system, the experiments of the recognition rate was carried out according to the input distance for voice recognition. As a result, the recognition rate of the control system was more than 95% within a distance between 0.5 and 2m. The result verified that the implemented control system performs well as the smart control system based for an IEMA.

• Nutrition Research and Practice
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• 제9권5호
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• pp.480-488
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• 2015

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide ($A{\beta}$) and oxidative stress in the brain are the most common causes of AD. MATERIALS/METHODS: Caffeic acid (CA) is an active phenolic compound that has a variety of pharmacological actions. We studied the protective abilities of CA in an $A{\beta}_{25-35}$-injected AD mouse model. CA was administered at an oral dose of 10 or 50 mg/kg/day for 2 weeks. Behavioral tests including T-maze, object recognition, and Morris water maze were carried out to assess cognitive abilities. In addition, lipid peroxidation and nitric oxide (NO) production in the brain were measured to investigate the protective effect of CA in oxidative stress. RESULTS: In the T-maze and object recognition tests, novel route awareness and novel object recognition were improved by oral administration of CA compared with the $A{\beta}_{25-35}$-injected control group. These results indicate that administration of CA improved spatial cognitive and memory functions. The Morris water maze test showed that memory function was enhanced by administration of CA. In addition, CA inhibited lipid peroxidation and NO formation in the liver, kidney, and brain compared with the $A{\beta}_{25-35}$-injected control group. In particular, CA 50 mg/kg/day showed the stronger protective effect from cognitive impairment than CA 10 mg/kg/day. CONCLUSIONS: The present results suggest that CA improves $A{\beta}_{25-35}$-induced memory deficits and cognitive impairment through inhibition of lipid peroxidation and NO production.

• 대한간호
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• 제35권4호
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• pp.64-74
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• 1996

In general. social cognition for a disabled person seemed that he was limited aspects of emotion and psychology. Thus he was rejected. avoided. worthless and not accepted. People who have been raised in an ethnic collectivity often acquire from that experience not only basic conceps and attitudes toward health and illness but also fundamental styles of interpersonal behavior and concerns about the world. The effects of this enculuration carryover into health- care situation and also become an important influence on personal activities devoted to health maintenance and disease prevention. Our Korean culture is a state of tradition Confucianism. respects his honor and external feature. Therefore recognition of a disabled person is more specipic. This study uses Walker and Avant's process of concept analysis. The concep of recognition of disabilty can be defined as follows : Recognition of disability is a person's conscious process of sensation. perception. memory and thought and is constructed from value. attitude. emotion and expierince which is dynamics. and in everyday life is feeling that basic activity is not free and occurs interaction of envionment. Attributes of disability recognition are defined as 1) It is feeling that basic activity of his daily life is not free in everyday life. 2) It is a person's conscious process of sensation. perception. memory and thought. 3) It occurs interaction of enviornment. 4) It is constructed from value. attitude. emotion and experience. 5) it is dynamics ( changing but not stasis). Nurse is always suppoted and pushed him. She plans institutional and situational surroundings.

• 전자공학회논문지C
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• 제35C권11호
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• pp.63-75
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• 1998

한국어 연속 음성에서 발생하는 조음결합문제를 해결하기 위하여 단어를 기본 인식 단위로 사용할 경우 각 단어의 효율적인 표현 방법, 연속된 단어로 이루어진 여러 문장의 표현 방법 그리고 입력된 연속음성을 연속된 여러 단어로의 정합 방법에 관한 연구가 선행되어야 한다. 본 논문에서는 은닉 마르코프 모델과 레벨빌딩 알고리즘을 이용한 한국어 연속 음성 인식 시스템을 제안한다. 각 단어는 은닉 마르코프 모델로 표현하고 문장을 표현하기 위하여 단어 모델을 연결한 형태인 인식 네트워크를 구성한다. 인식네트워크의 탐색 알고리즘으로는 레벨 빌딩 알고리즘을 사용한다. 제안한 방법은 항공기 예약 시스템에 적용한 실험에서 인식율과 인식속도면에서 실용적이었으며 또한 비교적 적은 저장공간으로 전체 문장을 표현하고 쉽게 확장할 수 있다는 장점을 가지고 있다.